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Somatrogon (Ngenla): CADTH Reimbursement Review: Therapeutic area: Growth hormone deficiency [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2022 May.
Somatrogon (Ngenla): CADTH Reimbursement Review: Therapeutic area: Growth hormone deficiency [Internet].
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Table 8CADTH Cost Comparison Table for Human Growth Hormones to Treat Growth Hormone Deficiency
Treatment Strength / concentration Form Price ($) Recommended dosage Daily cost ($) Annual cost ($) Somatrogon (Ngenla) 24 mg/1.2 mL
(20 mg/mL) Pre-filled pen 345.8400a 0.66 mg/kg weekly 26.53 9,684 60 mg/1.2 mL
(50 mg/mL) 864.6000a Daily growth hormone treatment Somatropin (Genotropin) 5.3 mg
12 mg Pre-filled pen 147.8700
334.8000 0.16 to 0.24 mg/kg per week, in 6 to 7 doses 12.56 to 18.64 4,584 to 6,802 0.6 mg
0.8 mg
1.0 mg
1.2 mg
1.4 mg
1.6 mg
1.8 mg
2.0 mg Single use pre-filled syringe 16.7400
22.3200
27.9000
33.4800
39.0600
44.6400
50.2200
55.8000 12.30 to 18.42 4,492 to 6,724 Somatropin (Humatrope) 5 mg Vial 233.3500 0.18 to 0.30 mg/kg per week in 3 to 7 doses 19.82 to 65.21 8,634 to 14,234 6 mg / 3.15 mL
12 mg / 3.15 mL
24 mg / 3.15 mL Cartridge 288.4200
576.8400
1,153.6800 24.50 to 40.30 8,941 to 14,709 Somatropin
(Norditropin) 5 mg / 1.5 mL
10 mg / 1.5 mL
15 mg / 1.5 mL Pre-filled pen 194.7000
389.4000
584.1000 Up to 0.3 mg/kg per week, divided in daily doses Up to 33.07 Up to 12,071 Somatropin
(Nutropin AQ) 5 mg / 2 mL
10 mg / 2 mL
20 mg / 2mL Cartridge 203.7100
407.4200
814.8400 Up to 0.3 mg/kg per week, divided in daily doses Up to 34.60 Up to $12,630 Somatropin
(Omnitrope) 5 mg
10 mg Vial 155.8000
311.6000 0.18 to 0.25 mg/kg per week 15.79 to 21.77 5,765 to 7,946 15 mg / 1.5 mL Cartridge 467.4000b 16.65 to 21.77 6,076 to 7,945 Somatropin (Saizen) 3.33 mg
5 mg
8.8 mg Vial 149.2500
224.0500
358.4700 0.20 to 0.27 mg/kg per week in 3 to 7 doses 25.17 to 33.76 9,186 to 12,322 6 mg (5.83 mg/mL)
12 mg (8 mg/mL)
20 mg (8 mg/mL) Cartridge 268.8300
537.6600
896.1000 24.99 to 33.81 9,122 to 12,342
Note: All prices are from the Ontario Exceptional Access Program13 (accessed July 2021), unless otherwise indicated, and do not include dispensing fees. Weight-based doses use an average weight of 19.30 kg as per CP-4-006. Annual costs based on number vials, pens, cartridges, or syringes needed in a calendar year rounded up to the nearest whole vial. Daily costs based on annual costs divided by 365. No other wastage costs have been considered. a
Sponsor’s submitted price.2 b
Saskatchewan Formulary.14