Bisi 1999 showed acute IV hexarelin improved LVEF in hypopituitary adults independent of catecholamines or BP changes, suggesting a direct cardiac action via the cardiac GHS-R. Animal MI models confirm the mechanism, but no human cardioprotection RCT has been published.
1 human study · 6 animal studies
Acute hexarelin improved LVEF in hypopituitary adults without changing BP.
Direct cardiac GHS-R receptor identified in heart tissue.
Rat MI models show preserved post-ischemic function.
Top citations
Bisi 1999 — Hypopituitary cardiac function
Tivesten 2000 — Rat MI cardioprotection
Our take
Interesting cardioprotection signal, never advanced to a definitive trial. Not a primary indication for community use.