Synonyms GDF-8, Gdf8, Growth/differentiation factor 8, Mstn, Myostatin Species Human/Mouse/Rat Expression Host HEK293 Cells Sequence Lys262-Ser375 Accession O14793 Calculated Molecular Weight 13.1 kDa Observed Molecular Weight 12-15 kDa Tag None Bio-activity Not validated for activity Form Lyophilized powder Purity > 95 % as determined by reducing SDS-PAGE. Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method. Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. Shipping This product is provided as lyophilized powder which is shipped with ice packs. Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. Reconstitution Please refer to the printed manual for detailed information. Background Growth/differentiation factor 8(Mstn, GDF-8) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. It is expressed specifically in developing and adult skeletal muscle. It exists as a homodimer, and interacts with WFIKKN2, leading to inhibit its activity. This protein can act specifically as a negative regulator of skeletal muscle growth. It regulates cell growth and differentiation in both embryonic and adult tissues.
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