Research article
Author links open overlay panel, , , , , , , , , , , , , , ,
Abstract
The protection of stomach and duodenum in conjecture with anti-inflammatory effect was demonstrated for a novel 15 amino acid peptide, coded BPC 157, a fragment of the recently discovered gastric juice peptide BPC. BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restriant stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment). Only BPC 157 regimes were consistently effective in all of the tested models. On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were in effective (restraint stress). A dose-dependent protection (cysteamine) and/or partial positive effect (related to treatment conditions) (ethanol), was obtained with glucagon, NPY and secretin whereas CCK/26– 30/ was not effective. Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.
References (20)
et al.
Neurosci. Biobehav.
(1986) S. Szabo et al.
Gastroenterology
(1985) P.H. Guth et al.
Gastroenterology
(1975) A. Guglietta
Exp. Clin. Gastroenterol.
(1993) J.C. Thompson et al.
Gastrointestinal Endocrinology
(1987) P. Sikiric et al.
Exp. Clin. Gastroenterol.
(1991) P. Sikiric et al.
Acta Physiol. Hung.
(1992) P. Sikiric et al.
J. Physiol. (Paris)
(1993) Gy. Mózsik et al.
Exp. Clin. Gastroenterol.
(1991) S. Szabo et al.
There are more references available in the full text version of this article.
View full text