Sermorelin (5 mg Vial) Dosage Protocol
Sermorelin Dosage Chart
Sermorelin is dosed at 200 mcg–500 mcg daily via subcutaneous injection in educational protocols. A 5 mg vial reconstituted with bacteriostatic water yields about 1.67 mg/mL. This information is for research and educational use only.
Reconstitute: Add 3.0 mL bacteriostatic water → ~1.67 mg/mL concentration.
Typical daily range: 200–500 μg once daily at bedtime (gradual titration).
Easy measuring: At 1.67 mg/mL, 1 unit = 0.01 mL ≈ 16.7 μg on a U‐100 insulin syringe.
Storage: Lyophilized: refrigerate at 2–8 °C (36–46 °F); after reconstitution, refrigerate at 2–8 °C (36–46 °F) and use within 10–14 days[4].
Sermorelin is a synthetic growth hormone–releasing hormone (GHRH) analog that stimulates endogenous pituitary GH secretion[1]. Originally approved for pediatric growth hormone deficiency, it is studied for adult off‐label use to support physiologic GH output and IGF‐1 levels[2]. This educational protocol presents a once‐daily subcutaneous approach administered at bedtime to align with natural nocturnal GH release[3].
Research context: For evidence on mechanisms, human and preclinical research, limitations, and safety, read Sermorelin Peptide: Benefits, Uses, Side Effects, Dosage, and Research.
Standard / Gradual Approach (3 mL = ~1.67 mg/mL)
Weeks 1–2
200 μg
12 units (0.12 mL)
Weeks 3–4
300 μg
18 units (0.18 mL)
Weeks 5–6
400 μg
24 units (0.24 mL)
Weeks 7–8
500 μg
30 units (0.30 mL)
Frequency: Inject once daily subcutaneously at bedtime. Bedtime administration is strongly recommended because endogenous GH secretion peaks during sleep[3]. This schedule uses the largest practical dilution (3.0 mL) to keep per‐injection units ≥10 for better accuracy. For ≤10‐unit (≤0.10 mL) administrations, consider 30‐ or 50‐unit insulin syringes for improved readability.
Reconstitution Steps
Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; gently swirl to dissolve (do not shake vigorously)[2].
Label with reconstitution date and refrigerate at 2–8 °C (36–46 °F), protected from light[2][4].
Wipe vial stopper with alcohol before each use; use a new sterile needle and syringe for each injection[2].
Supplies Needed
Plan based on an 8–week daily protocol with gradual titration (56 injections total).
Peptide Vials (Sermorelin, 5 mg each):
8 weeks (total ~19.6 mg consumed): 4 vials (20 mg total)
12 weeks (similar daily range): 6–7 vials
Tip: Have 1 extra vial as backup in case of spillage or loss.
Insulin Syringes (U‐100):
Per week: 7 syringes (1/day)
8 weeks: 56 syringes (recommend 1 × 100‐count box)
12 weeks: 84 syringes (1 × 100‐count box)
Preferred: 0.3–0.5 mL size with 28G–31G needle, 5/16′′ to 1/2′′ length for subcutaneous use.
Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
8 weeks (4 vials): 12 mL → 2 × 10 mL bottles
12 weeks (7 vials): 21 mL → 3 × 10 mL bottles
Contains benzyl alcohol preservative; do not use if allergic.
Alcohol Swabs: One for the vial stopper + one for the injection site each day.
Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100‐count boxes
12 weeks: 168 swabs → recommend 2 × 100‐count boxes