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Peptide
Growth Hormone Releasing Peptide-6 SKF-110679 GHRP6
Price range: $20.00 through $37.00
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5–9
$18.80 each (save $1.20/unit)
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Class Peptide
Also Known As Growth Hormone Releasing Peptide-6, SKF-110679, GHRP6
CAS Number 87616-84-0
Molecular Formula C46H56N12O6
Molecular Weight 873.01 g/mol
Purity ≥99%
Amino Acid Sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Research Areas
GH secretagogue receptor Appetite signaling Ghrelin receptor biology Pituitary function View on PubChem
What is GHRP-6?
GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide and one of the earliest discovered growth hormone secretagogues, first characterized by Bowers et al. in the 1980s. It acts as an agonist at the growth hormone secretagogue receptor (GHSR/ghrelin receptor), stimulating GH release from anterior pituitary somatotrophs. GHRP-6 contains two unnatural D-amino acids (D-tryptophan and D-phenylalanine) that confer metabolic stability and receptor selectivity. Historically, GHRP-6 played a critical role in the discovery and characterization of the ghrelin receptor — the search for the endogenous ligand of the GHRP-6 binding site ultimately led to the discovery of ghrelin by Kojima et al. in 1999. In addition to GH release, GHRP-6 is known for its appetite-stimulating properties, which are attributed to GHSR activation in hypothalamic feeding centers.
Mechanism of Action
GHRP-6 has been investigated for its agonist activity at the growth hormone secretagogue receptor 1a (GHS-R1a). Researchers observed that GHRP-6 binding activates Gq-coupled signaling, leading to phospholipase C activation, inositol trisphosphate (IP3) generation, and intracellular calcium mobilization in pituitary somatotrophs. This calcium influx triggers exocytosis of GH-containing secretory granules. Studies suggest that GHRP-6 also modulates hypothalamic signaling by stimulating GHRH neurons in the arcuate nucleus and suppressing somatostatin release from periventricular neurons, creating favorable conditions for GH pulse generation. GHRP-6 demonstrates notable appetite-stimulating effects attributed to GHSR activation in the hypothalamic feeding centers, including neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons. Researchers observed that this orexigenic effect distinguishes GHRP-6 from more selective secretagogues like ipamorelin, which releases GH with minimal appetite stimulation.
Published Research
Role in Ghrelin Discovery
Kojima et al. (1999) identified ghrelin as the endogenous ligand of the GHS-R, the receptor originally characterized through GHRP-6 binding studies. This landmark discovery established the physiological basis for growth hormone secretagogue pharmacology [1].
GH Secretagogue Characterization
Bowers CY (1998) reviewed the history and pharmacology of GHRPs, describing how GHRP-6 was one of the first synthetic peptides shown to release GH through a receptor distinct from the GHRH receptor [2].
Appetite and GH Effects
Arvat et al. (2001) investigated GHRP-6 in human subjects and characterized its dual effects on GH release and appetite stimulation. The study quantified the orexigenic response and compared it to other GH secretagogues [3].
Product Specifications
Product GHRP-6 Lyophilized Powder Available Sizes 5mg, 10mg Purity ≥99% (HPLC verified) CAS Number 87616-84-0 Sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 Molecular Formula C46H56N12O6 Molecular Weight 873.01 g/mol Appearance White lyophilized powder in glass vial Storage Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 21 days. Testing Third-party tested — Certificate of Analysis available
Storage & Stability
Avoid freeze/thaw cycles Protect from light Keep cold
Lyophilized powder Store at -20°C
Reconstituted 2–8°C, use within 21 days
Store lyophilized at -20°C. Reconstituted solution at 2-8°C, use within 21 days.
Certificate of Analysis
Third-Party Tested HPLC-UV + Mass Spec Identity & Purity
Every batch is third-party tested to ≥99% purity before release
Purity (HPLC-UV / MS) ≥99% Pass Identity Confirmed by HPLC-UV / MS Verified Appearance White lyophilized powder in glass vial Pass
Third-party tested by HPLC-UV coupled with mass spectrometry. A lot-specific Certificate of Analysis is available on request.
Frequently Asked Questions
GHRP-6 is a synthetic hexapeptide that activates the growth hormone secretagogue receptor (GHSR). It was one of the earliest GH secretagogues discovered and played a key role in ghrelin receptor research.
The CAS registry number for GHRP-6 is 87616-84-0.
Yes, GHRP-6 is known for its appetite-stimulating properties due to GHSR activation in hypothalamic feeding centers. This distinguishes it from more selective GH secretagogues like ipamorelin.
Store lyophilized GHRP-6 at -20°C. Once reconstituted, store at 2-8°C and use within 21 days.
GHRP-6 and ghrelin both activate the same receptor (GHS-R1a). Research on GHRP-6 binding sites directly led to the discovery of ghrelin as the endogenous ligand in 1999.
GHRP-2 is generally considered more potent for GH release with less appetite stimulation. GHRP-6 produces robust GH release but has a more pronounced orexigenic (appetite-stimulating) effect.
References
1
Kojima M, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-660. PMID: 10604470 View source
2
Bowers CY. Growth hormone-releasing peptide (GHRP). Cell Mol Life Sci. 1998;54(12):1316-1329. PMID: 9893710 View source
3
Arvat E, et al. Endocrine activities of ghrelin, a natural growth hormone secretagogue, in humans. Eur J Endocrinol. 2001;145(5):R11-R14.
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