製品説明
Myostatin inhibitory peptide 2 (compd 2) is a myostatin inhibitor with a Kd of 35.9 nM. Myostatin inhibitory peptide 2 can be used for researches of muscle atrophic disorders[1]. Cellular Effect
Cell Line Type Value Description References HepG2 IC50
4.1 μM
Compound: 2
Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene a
Inhibition of human recombinant myostatin pre-incubated with compound for 1 hr before addition to human HepG2 cells assessed as reduction in myostatin-mediated downstream transcriptional response by myostatin-responsive (CAGA)12-luciferase reporter gene a [PMID: 25569186] 体内実験
Myostatin inhibitory peptide 2 (0.75 mM, 40 μL, i.m., once every two weeks for 4 weeks) increases the muscle weight of skeletal muscles in muscular dystrophy model mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 分子量
2956.49 分子式
C133H227N43O33 CAS 番号
1621169-52-5 Appearance
Solid Color
White to off-white Sequence
Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-Leu-NH2 Sequence Shortening
AWRQNTRYSRIEAIKIQILSKLRL-NH2 輸送条件
Room temperature in continental US; may vary elsewhere. 保管条件
Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent -80°C 6 months -20°C 1 month 溶剤 & 溶解度
体外:
H2O : ≥ 25 mg/mL (8.46 mM)
*"≥" means soluble, but saturation unknown.
Preparing Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3382 mL 1.6912 mL 3.3824 mL 5 mM 0.0676 mL 0.3382 mL 0.6765 mL 10 mM --- --- ---
View the Complete Stock Solution Preparation Table
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Molarity Calculator
Dilution Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Mass
= Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
一般には略語で表示されます:C1V1 = C2V2 濃度 (開始)
C1
× 体積 (開始)
V1
= 濃度 (終了)
C2
× 体積 (終了)
V2
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage
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Animal weight (per animal)
g
Dosing volume (per animal)
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE). 純度とドキュメンテーション
純度: 99.75%
Select Batch:
COA (253 KB) RP-HPLC (254 KB) MS (235 KB) Elemental Analysis Report (111 KB)
取扱説明書 (2659 KB) 参考文献
[1]. Takayama K, et al. Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition. J Med Chem. 2015 Feb 12;58(3):1544-9. [Content Brief]
[1]. Takayama K, et al. Identification of the minimum peptide from mouse myostatin prodomain for human myostatin inhibition. J Med Chem. 2015 Feb 12;58(3):1544-9.
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.3382 mL 1.6912 mL 3.3824 mL 8.4560 mL 5 mM 0.0676 mL 0.3382 mL 0.6765 mL 1.6912 mL
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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Molarity Calculator
Dilution Calculator
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
一般には略語で表示されます:C1V1 = C2V2
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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
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