You’ve learned about nvg-291 and planned all of this in 6 weeks?? My injury (c6 incomplete) was 9 months ago and didn’t learn about NVG-291 til about 4 months ago. I’ve learned a lot though but you sound like a beast with a plan. I love it! Excited to see reports are you posting in this thread?
Just be careful what you are doing. We work with a company developing peptides for treatments, the standards and quality control for peptide synthesis, purity, and lot to lot consistency for endotoxins are extremely high. Not to mention that obtaining the quantity of peptides you seek is enormously expensive.
Testing a lot of drug with endotoxin levels above acceptable quantity can be fatal. Further, often proteins and peptides require special diluents to ensure stability. Some use specific buffers and maintain specific pH to prevent aggregation, breakdown, oxidation, etc.
For reference, peptides are usually produced in ecoli, sometimes in yeast, and rarely purely synthetically. Know your source and the possible contaminants. Sometimes it's essential to produce peptides in highly specific strains of ecoli that are genetically modified to not produce certain endotoxins or induce specific types of post translational modifications. Post translational modifications can completely change the properties of a peptide. That information may be out there, it may even be in a patent.
I understand the need for help, but in reality we don't know if these peptides will work and or who they will work for. I don't think anyone can advise you to do what you are talking about doing, so use caution moving forward if that's what you choose to do.
Edit: I also don't think the peptides used in animals are the same for clinical trials. They needed to develop new peptides that don't possess animal antigens that cause immune reactions, there might also be compatibility issues between the two in terms of their activity on PTP sigma.
Your doing gods work
How's the first week going? Fingers crossed.
How is this going?
I'm the guy who tried ISP with the rat wedge.
At the time we were advised by a reliable source that the rat and human versions only differed for patent reasons, not functional.
We had it synthed by GenScript and 3rd party tested for purity/contaminants/etc.
The first shipment was seized by customs as it was 100 glass vials which they suspected to be something illicit.
The second batch was shipped in a single container and put in vials on arrival.
On the plus side, it's a few years on and I've had no negative side effects to speak of.
There is a person who tried this. Here’s a link to what they did. Note that they were ASIA A.
“I used ISP at 10mg/day for 50 days. Subcutaneous admin. Had no results, contacted Dr. Silver and told him, he said intrathecal admin will probably be necessary.
ISP Sequence:
NH2-GRKKRRQRRRCDMAEHMERLKANDSLKLSQEYESI-NH2
Was manufactured by Genscript and 3rd party HPLC tested at 98% purity.”
https://reddit.com/r/spinalcordinjuries/s/sngXBXEenH
Following
Following.
god. this is so interesting. i'm t4 asia B. closely following. ive had the urge to get my hands on this myself and just start injecting myself. i have nothing to lose. cool to see someone doing it. i'd love to have an indepth phone call with you. i have scoured countless pubmed articles
NVG-291, Wow am totally impressed with your work and understanding. How far are you from testing yourself, a guess?
I found NervGen about 18 months ago by accident. Am not a patient myself but have invested in them and have been following progress.
There is a new podcast found yesterday interviewing trial manager at hospital. Here is my take on that. https://blinkofaneye.org/blinkofaneyepodcast/
Having slept on it, do see this interview as being significant. Logically thinking this through:
We are getting almost real time info on what is going on in tests. The interviewer is well known podcaster in SCI community, Louise Phipps Senft. She is giving out family member observations during the drug trial. This is public info in recorded interview, not rumors being spread on internet by unknown person. "Blink of an EyeTM nonprofit exists for those who know how life can change in the blink of an eye. Our mission is to transform the spinal cord injury experience for families and medical teams into an Extraordinary Experience, despite the devastation, in the first days and months of injury. "
The interviewee is a manager of the trial at hospital. She does not deny what Louise says about family members saying they are seeing encouraging signs of improvement very early in trial. She points out it is double blind. Part of this is not just movement or patient reported perceptions, it is measurable nervous system activity. Meghan does know by now how those data readouts are going. She knows if half the group has increased nervous system activity in injured areas. Keeping that in mind, listening to her tone, what is her attitude? She is very upbeat and proud to be part of the trial. 42 mins here https://blinkofaneye.org/blinkofaneyepodcast/
She does not try to shutdown Louise saying she is hearing good things. If she knows the drug is failing from data readouts to prevent false hope and bad info being propagated on trial, she would of said all the normal super cautious warnings we hear, but she did not.
I am encouraged with this and have to think this tips the scale to over 50% it is working in humans. Also, because this info has come out this fast, gotta think in 1-2 months we will get further info on how it is going. And we are only 6-8 months from getting official results (summer said Meghan).
I did some work on determining from about 40 years of tests that if a drug works very well in animals (NVG-291 does for multiple diseases) that the odds are about 75% that it will work 50% as well or better in humans. So it will not be shocking at all if NVG-291 works for humans. The mkt cap is tiny considering the possible upside.
Cheers
How are the trails going.. any updates???
I'd love to hear an update on this
This is awesome; keep us posted!
Hi I appreciate your post and your attempt. Thanks for sharing your info and for keeping us updated along the process.
In regards to using the peptide ISP which I do agree is very simlar to NVG291, make sure to follow the same dosing schedule as the phase 2 study which is daily subcutaneous inections for 3 months I believe. So you may have to extend your trial to 90 days to see significant results.
Also because your are somewhat early into your injury, you may have a better response to the peptide.
Wishing you much success.
I have a T10 incomplete SCI for the past 5 years so will be following.