posted Thu, 12/06/2012 - 05:57
15150
+ 4 my experience with CJC-1295 with dac
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I want to write this topic because after having tested a lot of compounds I belive cjc-1295 with Dac is the most promising, exciting, amazing, effective, safe substance I have ever come across. To start off I enclose some general information about the substance. Basically CJC-1295 is a long acting growth hormone releasing hormone (GHRH) analog. GHRH, also known as growth hormone releasing factor or somatocrinin, is 44-amino acid peptide hormone which is produced by the arcuate nucleus in the hypothalamus. It stimulates secretion of growth hormone from the pituitary gland and is released in a pulsatile manner to ultimately stimulate pulsatile release of growth hormone. This pulsatile release in various peptides is the root cause for half life of the peptide due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV). Thus the need for increasing the life and bioavailability of peptide compelled pharmaceutical companies to come up with technologies like PEGylation to make peptides even more effective. Thus CJC-1295 which is a synthetic modification of GHRH with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively, is applied with Drug Affinity Complex (DAC) technology to its GHRH to increase its half-life. CJC-1295 DAC peptide carefully and covalently combines to circulate albumin after subcutaneous (SC) administration leading to lengthen its half life from seven minutes to more than seven days. With the help of highly effective bioconjugation process, hardly I % of CJC-1295 remain unreacted in vivo and CJC-1295 molecule attach itself to albumin easily for prolong half-life. There are several benefits that can be assured with CJC-1295 DAC after conducting its effective test on mice in clinical lab. Its main function is to increase protein synthesis and stimulate new muscle tissue growth. It effectively curbs growth hormone (GH) deficiency in children to let them grow normally. CJC-1295 DAC leads to an increase in muscle mass and also adds to physical strength. It is also helpful in controlling skin aging and effective in reducing wrinkles. CJC-1295 DAC leads to re-growth of internal organs atrophied with age and result in hyperplasia to increase the number of muscle cells. Besides there are other benefits like increased bone density, strong immunity, faster recovery from injuries and lipolysis promotion to reduce body fat. As per dose recommendation, it is tested that a dose of 30 or 60 μg/kg is ideal to increase GH and insulin like growth factor (IGF-1) in healthy adults. Also due to long half-life and stability, taking CJC-1295 DAC 1-2 times per week would do the required job. There are not many studies about this substance but I have found a few very useful. Click on the lins below to open the abstract. http://jcem.endojournals.org/content/91/3/799.long http://www.ncbi.nlm.nih.gov/pubmed/17018654 My experience tell me that at 60 mcg/kg is the best dose/effect ratio to get amazing results. For istance my weight is 80 kg and if I decided to run 60mcg/kg my weekly dosage should be 4 mg. I have been running 4 mg of cjc-1295 with dac for two months injecting it weekly with amazing results. I noticed a constant increase of muscle mass,more cut and lose of fat weight. If you take for granted that before starting cjc-1295 I was running hgh for 5 months you will consider my evidence reliable. The only side I have felt so far is very hot flush 10 min after injection that last about 30/40 min. I absolutely consider cjc-1295 with dac the best valid alternative to hgh administration and I feel to recommend it to who would like to start a hgh cycle without spending a lot of money.
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