GHRP-2 5MG
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What Is GHRP-2 5MG?
Growth hormone-releasing peptide 2 (GHRP-2) also called pralmorelin is a synthetic agonist of ghrelin and GH receptor. It is a secretagogue that binds with receptors in the pituitary gland and triggers the release of growth hormone (GH). It may slightly affect levels of cortisol, ACTH and prolactin. It also blocks the release of somatostatin and binds to the ghrelin receptor in the gut, which is involved in growth hormone release and appetite regulation.
GHRP-2 is known for enhancing muscle mass and strength and promoting better recovery from injuries. Further, it might be involved in appetite regulation, sleep improvement and age-related decline. This synthetic hexapeptide is not yet approved by FDA for clinical use. It also belongs to the list of drugs prohibited by WADA. On our website, GHRP-2 for sale is limited to educational and research purposes.
Structure Of GHRP-2 5MG
From Pubchem
IUPAC Name:(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-aminopropanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamideSynonym: Pralmorelin, 158861-67-7 and KP-102Molecular Formula: C45H55N9O6Molecular Weight: 818.0 g/molSequence: AXAWFKCAS Number: 158861-67-7PubChem CID: 6918245
GHRP-2 5MG Uses In Research
1. GHRP-2 and Anti-Inflammatory Effect
Research shows that ghrelin exhibits anti-inflammatory properties and blocks proinflammatory cytokines like TNF-a by the growth hormone secretagogue receptor pathway. One study was conducted to assess the anti-inflammatory effect of GHRP-2 in LPS-treated rats. LPS administration in rats damages the liver cells and raises the level of transaminases, nitrates, and hepatic TNF-a. Researchers found that rats treated with GHRP-2 experienced the reduced effects of LPS on transaminases, nitrates and TNF-a. Further, the anti-inflammatory effect on non-parenchymal cells in the liver was observed [1].
In another study, the anti-inflammatory effect was observed in arthritis rats. Male wiser rats with arthritis-induced Freund’s adjuvant were either treated with saline water or GHRP-2 for eight days. The result found that GHRP-2 administration alleviated the external symptoms of arthritis in addition to reducing the levels of IL-6. Further researchers investigated if ghrelin or its agonist (GHRP-2) can modulate the release of IL-6 directly from immune cells. They incubated peritoneal macrophage cultures with GHRP-6 and found that it prevented IL-6 and nitrate release from cells under study. This indicates that GHRP-6 has an anti-inflammatory activity that might be mediated by ghrelin receptors present in immune cells [2].
2. GHRP-2 and Appetite
Ghrelin and its agonists are involved in appetite regulation. A clinical trial involving 10 prepubertal children was conducted to assess the effect of GHRP-2 on appetite. Participants received GHRP-2 900ug/kg twice a day for 12 months. The results found that 7 out of 10 patients reported an increase in appetite during the first 6 months of the study [3].
In another study, 7 healthy males received a subcutaneous infusion of GHRP-2 or saline water. Researchers found that participants who took GHRP-2 ate 26-46% more as compared to the control group [4].
3. GHRP-2 and Heart Health
GHRP-2 has been shown to promote heart health. One study conducted on myocardial stunning in a rabbit model found that GHRP-2 treatment for 14 days prevented diastolic dysfunction while recombinant human growth hormone didn’t show this effect [5].
Further, it can prevent cardiac remodeling following a heart attack and improve ventricular dysfunction. Research on the hamster model showed that GHRP-2 administration reduced myocardial fibrosis and slowed down the progression of left ventricular remodeling and dysfunction. Further, it was suggested that suppression of oxidative myocardial stress by GHRP-2 led to these beneficial effects [6].
4. GHRP-2 and Sleep
Research shows that GHRP-2 can extend the 2nd and 3rd stages of the sleep cycle by 50%. Furthermore, it has the potential to decrease the occurrence of deviations from regular sleep patterns by up to one-third [7]. On the contrary, one study didn’t find any significant association between GHRP-2 and slow-wave sleep [8].
5. GHRP2 and Muscle Health
One study in Yaks found that GHRP-2 injections caused an increase in myofiber diameter and area of skeletal muscle. This might be due to the increased secretion of growth hormone and IGF-1 by GHRP-2. Further, it promoted protein synthesis and upregulated the mRNA expression of IGF-1 and GH in the liver and skeletal muscles [9].
GHRP-2 has also been shown to prevent muscle proteolysis followed by injury. In one study, researchers investigated how GHRP-2 affects E3 ubiquitin ligase expression (associated with muscle breakdown) in rats with thermal injury. Administration of GHRP-2 through slow in vivo release for 24 hours via minipump effectively reduced the mRNA expression of IL-6, as well as the E3 ubiquitin ligases, MuRF-1 and MAFbx. Moreover, GHRP-2 decreased the total and myofibrillar protein breakdown in the rat EDL muscle caused by burns [10].
6. Current Status of GHRP-2
GHRP-2 is a synthetic agonist of the GH receptor and ghrelin. It might have a beneficial effect on sleep, appetite, heart and muscle mass. Despite its potential therapeutic properties, it has not yet been approved by the FDA. We need more studies to confirm its safety and efficacy in humans. GHRP-2 purchase is limited to educational and research institutions. Buy GHRP-2 for your research from Element Sarms for quality and authenticity.
Referenced Citations
Granado, M., et al., GH-releasing peptide-2 administration prevents liver inflammatory response in endotoxemia. American Journal of Physiology-Endocrinology and Metabolism, 2008. 294(1): p. E131-E141.
Granado, M., et al., Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. American Journal of Physiology-Endocrinology and Metabolism, 2005. 288(3): p. E486-E492.
Mericq, V., et al., Changes in appetite and body weight in response to long-term oral administration of the ghrelin agonist GHRP-2 in growth hormone deficient children. J Pediatr Endocrinol Metab, 2003. 16(7): p. 981-5.
Laferrère, B., C. Abraham, C.D. Russell, and C.Y. Bowers, Growth Hormone Releasing Peptide-2 (GHRP-2), Like Ghrelin, Increases Food Intake in Healthy Men. The Journal of Clinical Endocrinology & Metabolism, 2005. 90(2): p. 611-614.
Weekers, F., E. Van Herck, J.r. Isgaard, and G. Van den Berghe, Pretreatment with Growth Hormone-Releasing Peptide-2 Directly Protects against the Diastolic Dysfunction of Myocardial Stunning in an Isolated, Blood-Perfused Rabbit Heart Model**Presented in part at the Annual Meeting of the Belgian Endocrine Society, Brussels, November 20, 1999 (Young Investigator Award Winning abstract). This work was in part supported by a FUTURA Research Award (Voorzorgskas voor Geneesheren) 1998–1999 (to F.W.), research grants from the University of Leuven (OT 99/32 to G.V.d.B.), the Belgian Fund for Scientific Research (FWO G. 0144.00 & FWO G.3C05.95N) (to G.V.d.B.), and the Belgian Foundation for Research in Congenital Heart Diseases (to G.V.d.B. and F.W.). Endocrinology, 2000. 141(11): p. 3993-3999.
Kato, Y., et al., Beneficial effects of growth hormone-releasing peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters. Circ J, 2010. 74(1): p. 163-70.
Copinschi, G., et al., Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man. Neuroendocrinology, 1997. 66(4): p. 278-86.
Moreno-Reyes, R., et al., Evidence against a role for the growth hormone-releasing peptide axis in human slow-wave sleep regulation. American Journal of Physiology-Endocrinology and Metabolism, 1998. 274(5): p. E779-E784.
Hu, R., et al., Effects of GHRP-2 and Cysteamine Administration on Growth Performance, Somatotropic Axis Hormone and Muscle Protein Deposition in Yaks (Bos grunniens) with Growth Retardation. PLoS One, 2016. 11(2): p. e0149461.
Sheriff, S., et al., Ghrelin receptor agonist, GHRP-2, attenuates burn injury-induced MuRF-1 and MAFbx expression and muscle proteolysis in rats. Peptides, 2009. 30(10): p. 1909-1913.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
Mass Spectrometry (MS)
GHRP-2 5MG — Research Grade
C45H55N9O6
817.9 g/mol
158861-67-7
ES-GH-2
GHRP-2 is a synthetic hexapeptide and potent agonist at the growth hormone secretagogue receptor (GHSR-1a). As a second-generation GHRP, it demonstrates greater potency at GHSR-1a than GHRP-6 in receptor binding assays and has been extensively characterised in both in vitro binding studies and cell-based secretagogue assay models.
GHRP-2 is used in research examining GHSR-1a pharmacology, receptor occupancy kinetics, and intracellular second messenger dynamics in GHSR-1a-expressing cell lines. Its modest off-target receptor activation makes it useful for comparative studies of receptor selectivity across the GHRP compound class.
Element SARMs supplies GHRP-2 at 5mg per vial. USA-manufactured via solid-phase synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitute with bacteriostatic water. Store lyophilised at -20C.
WARNING: For research purposes only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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