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Somatropin (Genotropin) for Subcutaneous Injection: Long-term Treatment of Children who have Growth Failure Due to an Inadequate Secretion of Endogenous Growth Hormone [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Jan.
Somatropin (Genotropin) for Subcutaneous Injection: Long-term Treatment of Children who have Growth Failure Due to an Inadequate Secretion of Endogenous Growth Hormone [Internet].
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Table 1Cost Comparison Table for Genotropin for Pediatric Growth Hormone Deficiency
Drug/ Comparator Strength Dosage Form Price ($) Recommended Dose Average Daily Drug Costa ($) Average Annual Drug Cost ($) Genotropinb 5.3 mg 12 mg Pen ▬ ▬ 0.16 mg/kg to 0.24 mg/kg body weight per week in 6 to 7 doses ▬ – ▬ ▬ - ▬ 0.6 mg 0.8 mg 1.0 mg 1.2 mg 1.4 mg 1.6 mg 1.8 mg 2.0 mg Syringe ▬ ▬ ▬ ▬ ▬ ▬ ▬ ▬ ▬ – ▬ ▬ – ▬ Humatrope 5 mg 24 mg Vial 233.35 999.99 0.18 mg/kg to 0.30 mg/kg body weight per week in 3 to 7 doses 41 to 77 14,985 to 27,976 6 mg 12 mg Cartridge 280.02 560.04 46 to 77 16,785 to 27,976 Nutropin 10 mg Vial 389.44 Up to 0.3 mg/kg per week in divided daily doses Up to 64 Up to 23,344 Nutropin AQ 10 mg Cartridge 392.55 Up to 64 Up to 23,530 Omnitrope 5 mg 10 mg Vial 155.80 311.60 (0.18 to 0.25 mg/kg per week) 30 to 42 10,896 to 15,254 Drug/ Comparator Strength Dosage Form Price ($) Recommended Dose Average Daily Drug Costa ($) Average Annual Drug Cost ($) Saizen 3.33 mg 5 mg 8.8 mg Vial 149.25 224.05 358.47 0.2 to 0.27 mg/kg per week in 3 to 7 doses 45 to 59 16,279 to 24,493 6 mg 12 mg 20 mg Cartridge 268.83 537.66 896.10 49 to 59 17,905 to 24,486
Prices are from the Saskatchewan Formulary (accessed Aug 23, 2013) unless otherwise indicated and do not include dispensing fees. a
Weight-based doses use an average weight of 38.32 kg as reported in Takeda et al.1 for pediatric patients with GHD who were between ages 9 and 16. Assumes daily doses and wastage of excess for single-dose syringes. b
Manufacturer’s confidential submitted price.
From: 1, INTRODUCTION
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