Sermorelin (acetate) (Synonyms: Growth Hormone-releasing Factor (1-29) amide, hGH-RH(1-29)-NH2, hGRF(1-29)NH2, hpGRF(1-29)NH2, Somatotropin Releasing-Hormone (1-29) amide) カタログ番号GC49592 One-Click Copy Product Info
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Cas No.: 516482-86-3
Sample solution is provided at 25 μL, 10mM.
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Description of Sermorelin (acetate)
Sermorelin is a 29-residue N-terminal analog of growth hormone-releasing hormone (GHRH) that retains the ability to stimulate growth hormone (GH) release.1 Sermorelin (1 μg/kg, i.v.) increases serum GH levels in rats by approximately 17% compared with saline control after 15 minutes.2 It also increases GH release in pigs when administered at a dose of 250 ng/kg.3 Sermorelin (1 μM) increases proliferation of NCI-H727 human bronchial carcinoid cells by 30% and increases vascular endothelial growth factor (VEGF) secretion.4 It increases phosphorylation of focal adhesion kinase (FAK) and expression of VEGF in A549 lung cancer cells when used at a concentration of 0.1 μM.5 Formulations containing sermorelin have been used to diagnose and treat growth hormone deficiency.
1.Rivier, J., Spiess, J., Thorner, M., et al.Characterization of a growth hormone-releasing factor from a human pancreatic islet tumourNature300(5889)276-278(1982) 2.Izdebski, J., Pinski, J., Horvath, J.E., et al.Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormoneProc. Natl. Acad. Sci. USA92(11)4872-4876(1995) 3.Lance, V.A., Murphy, W.A., Sueiras-Diaz, J., et al.Super-active analogs of growth hormone-releasing factor (1-29)-amideBiochem. Bioph. Res. Commun.119(1)265-272(1984) 4.Stepie, T., Sacewicz, M., Lawnicka, H., et al.Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitroNeuropeptides43(5)397-400(2009) 5.Siejka, A., Barabutis, N., and Schally, A.V.GHRH antagonist inhibits focal adhesion kinase (FAK) and decreases expression of vascular endothelial growth factor (VEGF) in human lung cancer cells in vitroPeptides37(1)63-68(2012)
Chemical Properties of Sermorelin (acetate)
Cas No. 516482-86-3 SDF 同義語 Growth Hormone-releasing Factor (1-29) amide, hGH-RH(1-29)-NH2, hGRF(1-29)NH2, hpGRF(1-29)NH2, Somatotropin Releasing-Hormone (1-29) amide Canonical SMILES NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N[H])CC1=CC=C(O)C=C1)=O)C)=O)CC(O)=O)=O)C)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)CC3=CC=C(O)C=C3)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)CCSC)=O)=O)=O.CC(O)=O Formula C149H246N44O42S • XC2H4O2 M.Wt 3357.9 溶解度 Water: 1 mg/ml Storage -20°C General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
Complete Stock Solution Preparation Table of Sermorelin (acetate)
Prepare stock solution 1 mg 5 mg 10 mg 1 mM 297.8 μL 1.489 mL 2.9781 mL 5 mM 59.6 μL 297.8 μL 595.6 μL 10 mM 29.8 μL 148.9 μL 297.8 μL
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In vivo Formulation Calculator (Clear solution) of Sermorelin (acetate)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent. 2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. 3. All of the above co-solvents are available for purchase on the GlpBio website.
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