Abstract
The regulation of growth hormone (GH) secretion in humans is a complex entity involving primary regulators and secondary modifiers that influence both the amount and pattern of GH release. The primary regulators are the hypothalamic hormones: somatostatin (SRIH) and growth hormone releasing hormone (GHRH). Some of the known modulators of GH release include gonadal steroid concentrations, body composition (weight), ingestion of food, age, and physical exercise. The importance of GH in the adult is now being recognized as influencing muscle mass, muscle strength, and nutrient utilization. With the discovery of GHRH and growth hormone releasing peptides (GHRPs), several issues have arisen regarding the feasibility and advisability of increasing GH secretion in adults. The primary issues are (i) Is the pattern of exposure to GH important in maximizing its effects? (ii) Is continuous exposure to GH harmful? and (iii) Is it possible to effect pulsatile growth hormone secretion with the use of GHRH or a GHRP?
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Authors
Mary Lee Vance Joseph A. Aloi Mark L. Hartman Susan E. Kirk Michael O. Thorner
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Editors and Affiliations
Division of Endocrinology and Metabolism Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA
Marc R. Blackman M.D.
Division of Geriatric Medicine and Gerontology Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA
Jesse Roth M.D. & Jay R. Shapiro M.D. &
Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA
S. Mitchell Harman M.D., Ph.D.
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© 1995 Springer Science+Business Media New York
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Vance, M.L., Aloi, J.A., Hartman, M.L., Kirk, S.E., Thorner, M.O. (1995). Growth Hormone Releasing Hormone and Growth Hormone Releasing Peptides. In: Blackman, M.R., Roth, J., Harman, S.M., Shapiro, J.R. (eds) GHRH, GH, and IGF-I. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0807-5_3
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DOI: https://doi.org/10.1007/978-1-4612-0807-5_3
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-6908-3
Online ISBN: 978-1-4612-0807-5
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