Skip to main contentSkip to article
Access through your organization Purchase PDF
Abstract
Besides a superior protection of the pentadecapeptide BPC 157 (an essential fragment of an organoprotective gastric juice peptide BPC) against different gastrointestinal and liver lesions, an acute anti-inflammatory and analgetic activity was also noted. Consequently, its effect on chronic inflammation lesions, such as adjuvant arthritis, and non-steroidal anti-inflammatory agents (NSAIAs)-induced gastrointestinal lesions was simultaneously studied in rats. In gastrointestinal lesions (indomethacin (30 mg/kg sc), aspirin (400 mg/kg ig) and diclofenac (125 mg/kg ip) studies, BPC 157 (10 μg or 10 ng/kg ip) was regularly given simultaneously and/or 1 h prior to drug application (indomethacin). In the adjuvant arthritis (tail-application of 0.2 mL of Freund's adjuvant) studies (14 days, 30 days, 1 year) BPC 157 (10 μg or 10 ng/kg ip), it was given as a single application (at 1 h either before or following the application of Freund's adjuvant) or in a once daily regimen (0–14th day, 14–30th day, 14th day–1 year). Given with the investigated NSAIAs, BPC 157 consistently reduced the otherwise prominent lesions in the stomach of the control rats, as well as the lesions in the small intestine in the indomethacin groups. In the adjuvant arthritis studies, the lesion's development seems to be considerably reduced after single pentadecapeptide medication, and even more attenuated in rats daily treated with BPC 157. As a therapy of already established adjuvant arthritis, its salutary effect consistently appeared already after 2 weeks of medication and it could be clearly seen also after 1 year of application. Taking together all these results, the data likely point to a special anti-inflammatory and mucosal integrity protective effect.
Access through your organization
Check access to the full text by signing in through your organization.Access through your organization
References (50)
et al.
Management of NSAID-induced gastrointestinal disturbance
Ann Rheum Dis
(1987) H Kuwayama et al.
Effect of water immersion restraint stress and chronic indomethacin ingestion gastric antral and fundic epithelial proliferation
Gastroenterology
(1985) A Robert
Cytoptotection by prostaglandins
Gastroenterology
(1979) TY Shen
Chemical and biological studies on indomethacin, sulindac and their analogs
Adv Drug Res
(1977) P Sikiric et al.
The influence of dopamine agonists and antagonists on indomethacin lesions in stomach and small intestine in rats
Eur J Pharmacol
(1988) P Sikiric et al.
A new gastric juice peptide, BPC-an overview of stomach/stress/organoprotection hypothesis and BPC beneficial effects
J Physiol (Paris)
(1993) SG Willoughby et al.
Changes in the rate of epithelial proliferation of rat mucosa in response to acute inflammation induced by turpentine
Archs Oral Biol
(1986) M Banic et al.
Effect of methylprednisolone on small bowel, spleen and liver changes in a murine model of inflammatory bowel disease
Aliment Pharmacol Ther
(1993) ZJ Bosnjak et al.
Protective effects of newly isolated gastric peptide following hypoxic and reoxygenation injury in the isolated guinea pig heart
FASEB J
(1994) T Brkic et al.
A model of inflammatory bowel disease induced by 2,4-dintirofluorobenzene in previously sensitized BALB-c mice
Scand J Gastroenterol
(1992) T Brkic et al.
The influence of methylprednisolone on inflammatory bowel lesions induced with 2,4-dinitrofluorobenzene in previously sensitized BALB-c mice
Exp Clin Gastroenterol
(1992) JH Brown et al.
Effect of duration of administration of cyclophosphamide and steroidal anti-inflammatory drugs on the severity of polyathritis
Arch Int Pharmacodyn
(1971) I Caruso et al.
Gastroscopic evaluation of anti-inflammatory agents
Br Med J
(1980) J Damas et al.
The mechanism of the anti-inflammatory effect of turpentine in the rat
Naunyn-Schmiedeberg's Arch Pharmacol
(1984) HPM Festen
Diagnosis of gastrointestinal lesions during treatment with non-steroidal anti-inflammatory drugs
Aliment Pharmacol Therap
(1988) EM Glenn et al.
Adjuvant-induced polyarthritis in rats
Am J Vet Res
(1965) A Guglietta
Possible clinical use of peptide growth factors in the GI tract: perspectives and obstacles
Exp Clin Gastroenterol
(1992) K Gyires et al.
The use of the writhing in mice for screening different types of analgesics
Arch Int Pharmacodyn Ther
(1984) DE Hernandez et al.
The role of adrenal gland in cytoprotection against stress induced gastric ulcers in rats
J Neurosci Res
(1984) P Holzer
Peptidergic sensory neurons in the control of vascular functions: Mechanisms and signficance in the cutaneous and splanchnic vascular beds
Rev Physiol Biochem Pharmacol
(1991) DG Malone et al.
In vivo effects of nonsteroidal anti-inflammatory drugs on rat skin and synovial mast cell-induced vasopermeability
Arthritis Rheumatism
(1991) PW Mantyh
Substance P and the inflammatory and immune response
Ann NY Acad Sci
(1991) S Marabini et al.
Substance P and somatostatin levels in rheumatic arthritis, ostearthritis, and psoriatic arthritis synovial fluid
Ann NY Acad Sci
(1991) GP Morris et al.
An animal model for chronic granulomatous inflammation of the stomach and the colon
Gastroenterology
(1984) BB Newbould
Chemotherapy of arthrititis induced in rats by mycobacterial adjuvant
Br J Pharmacol
(1963)View full text
Copyright © 1997 Published by Elsevier Ltd.