Abstract Published: November 1984
M Maes1, R Wolter1, P Malvaux1 & ... M Vanderschueren1
Pediatric Research volume 18, page 1218 (1984) Cite this article
Abstract
To evaluate the role of hGH, plasma testosterone (T) and dihydrotestosterone (DHT) were measured before and 72h after an IM injection of hCG (1500 I.U./m2) in seven prepubertal GH-deficient children before and after three months of hGH therapy. There were no significant differences (P > 0.05) between basal and 72h plasma T levels (mean ± SE) before and after hGH (basal : 0.60 ± 0.15 nM vs 0.39 ± 0.08 nM; 72h : 4.02. ± 1.10 nM vs 4.17 ± 1.13 nM). Like for T, no significant differences were found for DHT. To evaluate the role of Gn, the testicular response to hCG of 11 GH- and Gn-deficient children was compared to that of 16 prepubertal boys with GH deficiency and intact Gn secretion. As shown in the Table, 72h-T were significantly greater in the children with Gn (P < 0.001). No other differences for T or DHT were significant. In conclusion, the testicular response to hCG is not modified by GH. In contrast, the greater response in the presence of Gn suggests a permissive role of Gn on the testicular responsiveness to hCG.
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THE BELGIAN STUDY GROUP FOR PAEDIATRIC ENDOCRINOLOGY. Universities of Louvain, Bruxelles, Gent, Antwerpen, Liège and Leuven, Belgium
M Maes, R Wolter, P Malvaux & M Vanderschueren
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M Maes R Wolter P Malvaux M Vanderschueren
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Maes, M., Wolter, R., Malvaux, P. et al. Effects of human Growth Hormone (hGH) and Gonadotropins (Gn) on the testicular response to human chorionic gonadotropin (hCG) in prepubertal GH-deficient children. Pediatr Res 18, 1218 (1984). https://doi.org/10.1203/00006450-198411000-00102
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Issue date: November 1984
DOI: https://doi.org/10.1203/00006450-198411000-00102