TB-500 5mg — Thymosin Beta-4
Thymosin Beta-4 is found in nearly every mammalian cell type — platelets, white blood cells, wound fluid. It is one of the most conserved actin-regulating proteins in nature. TB-500 is the synthetic form: all 43 amino acids, including the critical LKKTETQ motif at positions 17-23 that gives it high-affinity actin binding. Published research on this compound spans Nature, The FASEB Journal, and The Journal of Investigative Dermatology.
Specifications
Full Sequence Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser Active Region LKKTETQ (amino acids 17-23) Molecular Formula C212H350N56O78S Molecular Weight 4963.44 g/mol CAS Number 77591-33-4 PubChem CID 16132042 Form Lyophilized powder Quantity 5mg per vial
The research record
Malinda et al. reported a 41% increase in re-epithelialization within 4 days in full-thickness dermal wound models, concluding that “Tβ4 is a potent wound healing factor with multiple activities” (J Investigative Dermatology, 1999; PubMed 10469335).
Bock-Marquette et al. published findings in Nature showing enhanced cardiomyocyte migration and survival through integrin-linked kinase (ILK) and Akt signaling activation in myocardial infarction models (Nature, 2004; PubMed 15565145).
Philp et al. characterized angiogenesis and directional cell migration in both normal and aged rodent models through endothelial tube formation and ECM remodeling (Annals NYAS, 2004; PubMed 15037013).
Goldstein et al. reviewed NF-κB signaling modulation, pro-inflammatory cytokine reduction, and decreased inflammatory cell infiltration in tissue models (Expert Opinion on Biological Therapy, 2012; PubMed 22074294).
TB-500 vs BPC-157
Different mechanisms for different systems. TB-500 research centers on actin regulation, cell migration, blood vessel formation, and cardiac tissue. BPC-157 research centers on gastrointestinal integrity, connective tissue, and nitric oxide pathways. Published protocols treat them as complementary, not interchangeable. Heritage Labs USA offers both individually and as a BPC-TB blend.
Research applications
Cell migration and wound closure assays Actin polymerization dynamics and G-actin/F-actin equilibrium Angiogenesis pathway screening ECM remodeling and collagen expression Inflammatory signaling profiling Cardiac cell survival and ILK activation
Frequently paired with
BPC-157 5mg — Available as BPC-TB Blend. GHK-Cu 50mg — Available in Glow 50/10/10.
Quality and testing
Every batch is independently tested with mass spectrometry identity confirmation. Pure lyophilized peptide — no mannitol, no bulking agents, no excipients. Batch-specific COAs available.
Storage
Lyophilized: -20°C (up to 12 months sealed) Reconstituted: 2-8°C, use within 30 days Protection: Shield from light and moisture; avoid freeze-thaw cycles Handling: Let the vial reach room temperature before opening to prevent condensation
References
Malinda KM, et al. J Investigative Dermatology. 1999;113(3):364-368. PubMed 10469335 Bock-Marquette I, et al. Nature. 2004;432(7016):466-472. PubMed 15565145 Philp D, et al. Annals NYAS. 2004;1012:44-52. PubMed 15037013 Goldstein AL, et al. Expert Opinion on Biological Therapy. 2012;12(1):37-51. PubMed 22074294 Kleinman HK, Sosne G. Vitamins and Hormones. 2016;102:251-275. PubMed 27450738
FAQ
What is TB-500?
A synthetic 43-amino-acid peptide corresponding to Thymosin Beta-4, an endogenous actin-sequestering protein. Subject of extensive preclinical research in wound repair, cardiac tissue, inflammation, and cell migration.
TB-500 vs Thymosin Beta-4?
Same molecule. TB-500 is the synthetic research-grade form of the naturally occurring protein. The terms are interchangeable in the literature.
Is TB-500 approved for human use?
No. TB-500 is a research compound, not approved by the FDA for any human use. Heritage Labs USA products are strictly for laboratory research.
For laboratory research use only. Not for human or veterinary use. Not a drug, food, or cosmetic.