Despite extremely widespread community use as part of CJC-1295 + ipamorelin stacks, there is no published human RCT of ipamorelin in healthy adults with body composition as a primary endpoint. The clinical data lives in postoperative ileus (Helsinn/Lupin's Phase 2b POI program), not muscle gain.
0 human studies · 4 animal studies
Zero published human composition RCTs of ipamorelin monotherapy.
Phase 2b POI program (Helsinn) explored bowel-motility recovery, not body composition.
All composition claims extrapolate from MK-677, sermorelin, and GHRP-6 literature.
Top citations
Raun 1998 — Selectivity / mechanism only
Our take
Real GH pulses, no published human composition data. Use it because the GH pulses are real, not because there's a randomized trial saying it builds muscle.