Insulin-like growth factor-1 (IGF-1) is a peptide hormone under control of the growth hormone. IGF-1 promotes cell proliferation, growth and survival. Six specific binding proteins, IGFBP 1-6, allow for a more nuanced control of IGF activity.The IGF-1 receptor (IGF-1R) is a transmembrane tyrosine kinase protein. IGF-1-induced receptor activation results in autophosphorylation followed by an enhanced capability to activate downstream pathways. Activated IGF-1R phosphorylates SHC and IRS-1. SHC along with adapter molecules GRB2 and SOS forms a signaling complex that activates the Ras/Raf/MEK/ERK pathway. ERK translocation to the nucleus results in the activation of transcriptional regulators ELK-1, c-Jun and c-Fos which induce genes that promote cell growth and differentiation. IRS-1 activates pathways for cell survival via the PI3K/PDK1/AKT/BAD pathway. IRS-1 also activates pathways for cell growth via the PI3K/PDK1/p70RSK pathway. IGF-1 also signals via the JAK/STAT pathway by inducing tyrosine phosphorylation of JAK-1, JAK-2 and STAT-3. SOCS proteins are able to inhibit the JAKs thereby inhibiting this pathway.The adapter protein GRB10 interacts with IGF-IR. GRB10 also binds the E3 ubiquitin ligase NEDD4 and promotes ligand stimulated ubiquitination, internalization, and degradation of the IGF-IR as a means of long-term attenuation of signaling.
Explore Genes related to IGF-1 Signaling
AKT1 icon_0140_ls_gen_dna_rna-s
Human
AKT serine/threonine kinase 1
AKT2 icon_0140_ls_gen_dna_rna-s
Human
AKT serine/threonine kinase 2
AKT3 icon_0140_ls_gen_dna_rna-s
Human
AKT serine/threonine kinase 3
BAD icon_0140_ls_gen_dna_rna-s
Human
BCL2 associated agonist of cell death
CASP9 icon_0140_ls_gen_dna_rna-s
Human
caspase 9
CCN1 icon_0140_ls_gen_dna_rna-s
Human
cellular communication network factor 1
CCN2 icon_0140_ls_gen_dna_rna-s
Human
cellular communication network factor 2
CCN3 icon_0140_ls_gen_dna_rna-s
Human
cellular communication network factor 3
CSNK2A1 icon_0140_ls_gen_dna_rna-s
Human
casein kinase 2 alpha 1
CSNK2A2 icon_0140_ls_gen_dna_rna-s
Human
casein kinase 2 alpha 2
CSNK2A3 icon_0140_ls_gen_dna_rna-s
Human
casein kinase 2 alpha 3
CSNK2B icon_0140_ls_gen_dna_rna-s
Human
casein kinase 2 beta
ELK1 icon_0140_ls_gen_dna_rna-s
Human
ETS transcription factor ELK1
ERAS icon_0140_ls_gen_dna_rna-s
Human
ES cell expressed Ras
FOS icon_0140_ls_gen_dna_rna-s
Human
Fos proto-oncogene, AP-1 transcription factor subunit
FOXO1 icon_0140_ls_gen_dna_rna-s
Human
forkhead box O1
FOXO3 icon_0140_ls_gen_dna_rna-s
Human
forkhead box O3
GRB10 icon_0140_ls_gen_dna_rna-s
Human
growth factor receptor bound protein 10
GRB2 icon_0140_ls_gen_dna_rna-s
Human
growth factor receptor bound protein 2
HRAS icon_0140_ls_gen_dna_rna-s
Human
HRas proto-oncogene, GTPase
IGF1 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor 1
IGF1R icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor 1 receptor
IGFBP1 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 1
IGFBP2 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 2
IGFBP3 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 3
IGFBP4 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 4
IGFBP5 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 5
IGFBP6 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 6
IGFBP7 icon_0140_ls_gen_dna_rna-s
Human
insulin like growth factor binding protein 7
IRS1 icon_0140_ls_gen_dna_rna-s
Human
insulin receptor substrate 1
IRS2 icon_0140_ls_gen_dna_rna-s
Human
insulin receptor substrate 2
JAK1 icon_0140_ls_gen_dna_rna-s
Human
Janus kinase 1
JAK2 icon_0140_ls_gen_dna_rna-s
Human
Janus kinase 2
JUN icon_0140_ls_gen_dna_rna-s
Human
Jun proto-oncogene, AP-1 transcription factor subunit
KRAS icon_0140_ls_gen_dna_rna-s
Human
KRAS proto-oncogene, GTPase
MAP2K1 icon_0140_ls_gen_dna_rna-s
Human
mitogen-activated protein kinase kinase 1
MAP2K2 icon_0140_ls_gen_dna_rna-s
Human
mitogen-activated protein kinase kinase 2
MAPK1 icon_0140_ls_gen_dna_rna-s
Human
mitogen-activated protein kinase 1
MAPK14 icon_0140_ls_gen_dna_rna-s
Human
mitogen-activated protein kinase 14
MAPK3 icon_0140_ls_gen_dna_rna-s
Human
mitogen-activated protein kinase 3
MAPK8 icon_0140_ls_gen_dna_rna-s
Human
mitogen-activated protein kinase 8
MRAS icon_0140_ls_gen_dna_rna-s
Human
muscle RAS oncogene homolog
NEDD4 icon_0140_ls_gen_dna_rna-s
Human
NEDD4 E3 ubiquitin protein ligase
NRAS icon_0140_ls_gen_dna_rna-s
Human
NRAS proto-oncogene, GTPase
PDPK1 icon_0140_ls_gen_dna_rna-s
Human
3-phosphoinositide dependent protein kinase 1
PIK3C2A icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
PIK3C2B icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
PIK3C2G icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
PIK3C3 icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol 3-kinase catalytic subunit type 3
PIK3CA icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
PIK3CB icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
PIK3CD icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
PIK3CG icon_0140_ls_gen_dna_rna-s
Human
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
PIK3R1 icon_0140_ls_gen_dna_rna-s
Human
phosphoinositide-3-kinase regulatory subunit 1
PIK3R2 icon_0140_ls_gen_dna_rna-s
Human
phosphoinositide-3-kinase regulatory subunit 2
PIK3R3 icon_0140_ls_gen_dna_rna-s
Human
phosphoinositide-3-kinase regulatory subunit 3
PIK3R4 icon_0140_ls_gen_dna_rna-s
Human
phosphoinositide-3-kinase regulatory subunit 4
PIK3R5 icon_0140_ls_gen_dna_rna-s
Human
phosphoinositide-3-kinase regulatory subunit 5
PIK3R6 icon_0140_ls_gen_dna_rna-s
Human
phosphoinositide-3-kinase regulatory subunit 6
PRKACA icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-activated catalytic subunit alpha
PRKACB icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-activated catalytic subunit beta
PRKACG icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-activated catalytic subunit gamma
PRKAG1 icon_0140_ls_gen_dna_rna-s
Human
protein kinase AMP-activated non-catalytic subunit gamma 1
PRKAG2 icon_0140_ls_gen_dna_rna-s
Human
protein kinase AMP-activated non-catalytic subunit gamma 2
PRKAR1A icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-dependent type I regulatory subunit alpha
PRKAR1B icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-dependent type I regulatory subunit beta
PRKAR2A icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-dependent type II regulatory subunit alpha
PRKAR2B icon_0140_ls_gen_dna_rna-s
Human
protein kinase cAMP-dependent type II regulatory subunit beta
PRKCI icon_0140_ls_gen_dna_rna-s
Human
protein kinase C iota
PRKCZ icon_0140_ls_gen_dna_rna-s
Human
protein kinase C zeta
PTK2 icon_0140_ls_gen_dna_rna-s
Human
protein tyrosine kinase 2
PTPN11 icon_0140_ls_gen_dna_rna-s
Human
protein tyrosine phosphatase non-receptor type 11
PXN icon_0140_ls_gen_dna_rna-s
Human
paxillin
RAF1 icon_0140_ls_gen_dna_rna-s
Human
Raf-1 proto-oncogene, serine/threonine kinase
RALA icon_0140_ls_gen_dna_rna-s
Human
RAS like proto-oncogene A
RALB icon_0140_ls_gen_dna_rna-s
Human
RAS like proto-oncogene B
RAP1A icon_0140_ls_gen_dna_rna-s
Human
RAP1A, member of RAS oncogene family
RAP1B icon_0140_ls_gen_dna_rna-s
Human
RAP1B, member of RAS oncogene family
RAP2A icon_0140_ls_gen_dna_rna-s
Human
RAP2A, member of RAS oncogene family
RAP2B icon_0140_ls_gen_dna_rna-s
Human
RAP2B, member of RAS oncogene family
RASA1 icon_0140_ls_gen_dna_rna-s
Human
RAS p21 protein activator 1
RASD1 icon_0140_ls_gen_dna_rna-s
Human
ras related dexamethasone induced 1
RASD2 icon_0140_ls_gen_dna_rna-s
Human
RASD family member 2
RPS6KB1 icon_0140_ls_gen_dna_rna-s
Human
ribosomal protein S6 kinase B1
RPS6KB2 icon_0140_ls_gen_dna_rna-s
Human
ribosomal protein S6 kinase B2
RRAS icon_0140_ls_gen_dna_rna-s
Human
RAS related
RRAS2 icon_0140_ls_gen_dna_rna-s
Human
RAS related 2
SFN icon_0140_ls_gen_dna_rna-s
Human
stratifin
SHC1 icon_0140_ls_gen_dna_rna-s
Human
SHC adaptor protein 1
SOCS1 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 1
SOCS2 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 2
SOCS3 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 3
SOCS4 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 4
SOCS5 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 5
SOCS6 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 6
SOCS7 icon_0140_ls_gen_dna_rna-s
Human
suppressor of cytokine signaling 7
SOS1 icon_0140_ls_gen_dna_rna-s
Human
SOS Ras/Rac guanine nucleotide exchange factor 1
SOS2 icon_0140_ls_gen_dna_rna-s
Human
SOS Ras/Rho guanine nucleotide exchange factor 2
SRF icon_0140_ls_gen_dna_rna-s
Human
serum response factor
STAT3 icon_0140_ls_gen_dna_rna-s
Human
signal transducer and activator of transcription 3
YWHAB icon_0140_ls_gen_dna_rna-s
Human
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
YWHAE icon_0140_ls_gen_dna_rna-s
Human
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
YWHAG icon_0140_ls_gen_dna_rna-s
Human
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
YWHAH icon_0140_ls_gen_dna_rna-s
Human
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
YWHAQ icon_0140_ls_gen_dna_rna-s
Human
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
YWHAZ icon_0140_ls_gen_dna_rna-s
Human
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta