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Human Recombinant Follistatin
Overview
Follistatin, a glycosylated monomeric protein, is a modulator of transforming growth factor beta (TGF-β) superfamily signaling. It binds to and inhibits the function of activin, myostatin, growth differentiation factors, and bone morphogenetic proteins (BMP) (Hansen & Plomgaard). Follistatin inhibits mesoderm induction, suppresses synthesis and secretion of pituitary follicle-stimulating hormone, regulates liver regeneration, and causes infertility (Guo et al.; Iemura et al.). Follistatin exhibits anti-inflammatory effects, and it could be used as a biomarker in cancer (Hansen & Plomgaard).
Cytokines
Mesoderm, PSC-Derived
Human
Stem Cell Biology
≥ 95%
Data Figures
(A) The biological activity of Human Recombinant Follistatin was tested by neutralization of human activin A induced cytotoxicity of MPC- 11 cells. Cell viability was measured after 66 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell viability is at 50% of maximum. The EC50 in the above example is 0.04 μg/mL. (B) 1 μg of Human Recombinant Follistatin was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78109, 78109.1
Lot #
All
Language
English
Catalog #
78109, 78109.1
Lot #
All
Language
English
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Research Area
Workflow Stages
Quality Statement:
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.