CJC-1295 with DAC Dosage Guide, Benefits & Side Effects
CJC-1295 with DAC extends GH and IGF-1 elevation for up to a week per dose, supporting lean mass, recovery, and sleep. Explore the research.
Chemical Makeup
29
Amino Acids
CJC-1295 with DAC
Tyr
Position 1
Ala
Position 2
Asp
Position 3
Position 4
Ile
Position 5
Phe
Position 6
Thr
Position 7
Gln
Position 8
Ser
Position 9
Position 10
Arg
Position 11
Lys
Position 12
Val
Position 13
Leu
Position 14
Position 15
Position 16
Position 17
Position 18
Position 19
Position 20
Position 21
Position 22
Position 23
Position 24
Position 25
Position 26
Position 27
Position 28
Position 29
As seen on
CJC-1295 with DAC Dosage Guide for Fat Loss / MuscleCJC-1295 with DAC Dosage Calculator
CJC-1295 with DAC is a long-acting peptide that keeps growth hormone levels steadily elevated over time.
Vial size
2 mg
Bacteriostatic water
2 mL
Dosing
1–2 mg
Frequency
Weekly
Cycle
8–12 weeks
Benefit
Fat Loss / Muscle
What is CJC-1295 with DAC?
CJC-1295 with DAC is a longer-acting version of CJC-1295 that sticks to a protein in your blood, which lets it stay active in the body for about a week instead of just hours. This means it keeps growth hormone levels elevated with far fewer injections, often just once or twice a week. It's used in research and some clinical settings for growth hormone support, body composition, and anti-aging goals.
Weight
Research targets include appetite regulation, fat metabolism, and body composition.
Growth
Research targets include growth hormone signaling, IGF-1 pathways, and tissue development.
cjc1
Is CJC-1295 with DAC FDA approved?
CJC-1295 with DAC is not an FDA-approved drug. It is intended for research purposes only and is not approved for human consumption, diagnostic, or therapeutic use.
Research Use Only
CJC-1295 with DAC has not been evaluated by the FDA for safety or efficacy in humans.
No Clinical Oversight
Not manufactured under FDA-regulated quality or clinical standards.
Unregulated Sourcing
Purity, dosing, and sourcing are not verified through FDA testing or oversight.
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How Does CJC-1295 with DAC Work?
It binds the same pituitary receptor as the natural hormone GHRH, prompting the gland to release growth hormone. A special chemical tag lets it grab onto a protein that's always floating in the blood, turning it into a slow-release depot that can keep growth hormone elevated for over a week per dose.
Binds the GHRH receptor
Prompts the pituitary gland to release growth hormone.
Locks onto a blood protein
A chemical tag lets it attach to albumin, always present in the blood.
Slow-release depot
Keeps growth hormone elevated for over a week per dose.
CJC-1295 with DAC Targeted areas
How to reconstitute CJC-1295 with DAC
The materials you'll need and step-by-step instructions for safely mixing CJC-1295 with DAC with bacteriostatic water.
Materials needed
Your CJC-1295 with DAC vial (lyophilized)
Alcohol swabs
Bacteriostatic sterile water
3 mL syringes (Luer Lock tip)
25G or 27G needles (Luer Lock). Other gauges may also be acceptable.
Sharps container (optional)
Remove the caps
Sanitize the rubber stoppers
Attach the needle
Draw the bac water
Pull back on the plunger to draw your desired volume of bacteriostatic water. If you overfill, just push the excess back in until you reach the right marker on the syringe.
Insert the needle into the CJC-1295 with DAC vial
With the bac water in your syringe, insert the needle into the CJC-1295 with DAC vial at a slight angle to avoid pressure buildup.
Release the water gently
Let the water run gently down the side of the vial. Don't inject it forcefully.
Swirl to dissolve
Avoid shaking. Gently swirl, flip, and roll the vial to dissolve the powder.
Check for full dissolution
Cap, dispose, and store
How to Store CJC-1295 with DAC
Freeze the dry powder for up to two years. Once mixed with liquid, refrigerate and use within about a month; don't freeze it again once mixed.
Lyophilized Storage
-20°C, stable up to 24 months.
Reconstituted Storage
2–8°C, use within 28 days.
Handling Notes
Do not freeze after reconstitution.
What Are the Benefits of CJC-1295 with DAC?
What research says it may help with, and how it works in the body.
growth hormone
Provides a steady release of growth hormone that lasts six to eight days from a single injection.
Raises levels of the hormone IGF-1 substantially, and keeps them elevated for an extended period.
Only needs to be taken about once a week, making it simple to use.
body composition
Keeping growth hormone levels raised continuously helps the body break down and use stored fat for energy.
Creates ongoing conditions in the body that favor building muscle, supporting the process of making new muscle protein.
antiaging
Speeds up healing and recovery after exercise or injury.
What Are the Side Effects of CJC-1295 with DAC?
Who should avoid it, warning signs to watch for, and what to know before combining it with other compounds.
Who Should Avoid It
Diabetes history
Cancer history
Predisposed sleep apnea
Stop Right Away If You Notice
Severe joint pain or carpal tunnel syndrome
Excessive water retention affecting daily life
Numbness or tingling in extremities
Significant blood glucose dysregulation
Signs of acromegaly (jaw growth, hand/feet enlargement)
Persistent lethargy indicating adrenal effects
Milder Signs to Watch For
How Long Should a CJC-1295 with DAC Cycle Last?
This breaks down how long a typical CJC-1295 with DAC cycle runs and what research suggests happens at each stage. Research shows that staying on a peptide continuously, without a break, may make it less effective over time.
That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again.
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Cheat Sheets Featuring CJC-1295 with DAC
See how CJC-1295 with DAC fits into a broader research stack with these free downloadable cheat sheets. Each one includes reference dose ranges, dosing frequency, and half-life for every peptide it covers. For research purposes only.
13 peptides
78 peptides
19 peptides
CJC-1295 with DAC Research References
It is a phase 2 compound
CJC-1295 with DAC is a phase 2 compound
12 subjects; sustained GH and IGF-1 elevation for 6-10 days post-injection with peak 2-4x baseline.
2006
Frequently Asked Questions About CJC-1295 with DAC
Straight answers on reconstitution, dosing, and safety, everything you need to research with confidence. For research reference only.
What is CJC-1295 with DAC and how does it work?
CJC-1295 with DAC is a synthetic analog of growth hormone-releasing hormone (GHRH) modified with a Drug Affinity Complex (DAC), a molecular tag that binds covalently to albumin in the blood. This albumin binding protects the peptide from rapid enzymatic breakdown, allowing it to keep stimulating the pituitary gland to release growth hormone (and, downstream, IGF-1) over an extended period rather than in a single short pulse. It is sold and studied strictly as a research chemical.
What is the difference between CJC-1295 with DAC and CJC-1295 without DAC (Mod GRF 1-29)?
The core peptide sequence is essentially the same GHRH analog, but the DAC-modified version has a half-life of roughly 5-8 days because it binds albumin, versus about 30 minutes for the non-DAC version (also called Mod GRF 1-29). Because of this, CJC-1295 with DAC is typically dosed once or twice per week to produce a sustained elevation in GH/IGF-1, while the no-DAC version is dosed daily or multiple times a day to produce shorter GH pulses that more closely mimic the body's natural release pattern.
What dosing protocols are commonly discussed for CJC-1295 with DAC?
In research and community protocols, doses in the range of roughly 1-2 mg (1,000-2,000 mcg) once or twice weekly are commonly cited, with some sources suggesting a more conservative starting point around 0.5 mg (500 mcg) weekly. These figures come from vendor and community protocol pages rather than approved clinical dosing guidance, and actual protocols used in published research vary.
Is CJC-1295 with DAC commonly stacked with other peptides?
Yes, it is frequently discussed alongside a growth hormone secretagogue such as Ipamorelin or Ipamorelin/GHRP combinations, on the reasoning that combining a GHRH analog with a ghrelin-receptor agonist may produce a more pronounced GH release than either compound alone. This combination is widely referenced in vendor and enthusiast literature but is not a clinically validated, standardized protocol.
What side effects are reported with CJC-1295 with DAC?
Commonly reported effects include injection-site redness or irritation, flushing, headache, water retention, and joint or muscle stiffness associated with elevated GH/IGF-1. Because it raises GH and IGF-1 for extended periods, sources also note potential effects on blood glucose/insulin sensitivity and, with prolonged continuous use, concern about pituitary desensitization or reduced sensitivity to repeated GHRH stimulation. These reports come from research literature and user/vendor sources rather than controlled long-term safety trials.
Do people cycle CJC-1295 with DAC or take breaks?
Community and vendor protocols often recommend periodic breaks, sometimes cited as every 12-16 weeks, based on the idea that continuous sustained GHRH stimulation could lead to reduced pituitary responsiveness over time. Some who prioritize a shorter, more pulsatile GH release for extended-duration use opt for the non-DAC version instead. There is no standardized, clinically established cycling protocol.
How should CJC-1295 with DAC be stored and reconstituted?
As commonly described for lyophilized (freeze-dried) peptides, the unreconstituted vial is generally stored frozen or refrigerated, protected from light and moisture. Bacteriostatic water is typically used to reconstitute it, added slowly down the side of the vial and mixed by gentle swirling (not shaking) to avoid degrading the peptide. Once reconstituted, it is generally recommended to store the solution refrigerated (roughly 2-8°C) and use it within about 2-4 weeks, without freezing the reconstituted solution.
Is CJC-1295 with DAC legal and approved for human use?
CJC-1295 with DAC is not approved by the FDA or comparable regulators for human use and is sold by suppliers labeled 'for research/laboratory use only, not for human consumption.' Its legal status for personal use varies by country and jurisdiction, and information about dosing, effects, and safety is drawn from preclinical/clinical research literature and community reporting rather than approved medical guidance.