Tesamorelin 5mg + Ipamorelin 5mg (10mg Blend) Dosage Protocol
Tesamorelin 5mg + Ipamorelin 5mg Dosage Chart
Tesamorelin is dosed at 125 mcg–1 mg daily by subcutaneous injection in educational protocols, typically at night. A 10mg blend reconstituted with bacteriostatic water yields about 3.33 mg/mL. This information is for research and educational use only.
Reconstitute: Add 3.0 mL bacteriostatic water to the 10 mg vial → ~3.33 mg/mL total (1.67 mg/mL each peptide).
Typical daily range: 250–2000 mcg tesamorelin + 125–1000 mcg ipamorelin (gradual titration).
Easy measuring: At 3.33 mg/mL total, 1 unit = 0.01 mL ≈ 16.7 mcg of each peptide on a U‐100 insulin syringe.
Storage: Lyophilized: refrigerate at 2–8 °C (35.6–46.4 °F); after reconstitution, use immediately or refrigerate and use within 24–48 hours[5].
This blend combines tesamorelin, a synthetic GHRH analog, with ipamorelin, a selective ghrelin mimetic (growth hormone secretagogue). When administered together, GHRH analogs and ghrelin mimetics produce synergistic GH pulses[1][2]. The FDA‐approved tesamorelin dose is 2 mg SC daily[3], while ipamorelin is commonly studied at 100–300 mcg SC daily[4]. This educational protocol presents a once‐daily subcutaneous approach with gradual titration using a 1:1 blend ratio.
Related research: For distinct compound, component, or formulation evidence and safety context, read Tesamorelin Peptide: Benefits, Uses, Side Effects, Dosage, and Research and Ipamorelin Peptide: Benefits, Uses, Side Effects, Dosage, and Research. These links are comparisons only; the compounds and formulations should not be treated as interchangeable.
Standard / Gradual Approach (3 mL = ~3.33 mg/mL total)
Route: Subcutaneous (SC) | Frequency: Once daily
Weeks 1–2
250 mcg (0.25 mg)
125 mcg (0.125 mg)
23 units (0.23 mL)
Weeks 3–4
500 mcg (0.5 mg)
45 units (0.45 mL)
Weeks 5–6
1000 mcg (1.0 mg)
90 units (0.90 mL)
Weeks 7–10
1500 mcg (1.5 mg)
750 mcg (0.75 mg)
135 units (1.35 mL)
Weeks 11–16
2000 mcg (2.0 mg)
180 units (1.80 mL)
Note: The 1:1 blend ratio means tesamorelin and ipamorelin are present in equal amounts per mL. At 3.0 mL reconstitution: 1 mL = 1.67 mg tesamorelin + 1.67 mg ipamorelin. Higher‐volume injections (≥1.0 mL) may be split across two sites if preferred for comfort.
Reconstitution Steps
Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake).
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light; use within 24–48 hours[5].
Supplies Needed
Plan based on an 8–16 week daily protocol with gradual titration.
Peptide Vials (Tesamorelin 5 mg + Ipamorelin 5 mg, 10 mg blend each):
8 weeks ≈ 10 vials
12 weeks ≈ 19 vials
16 weeks ≈ 31 vials
Insulin Syringes (U‐100):
Per week: 7 syringes (1/day)
8 weeks: 56 syringes
12 weeks: 84 syringes
16 weeks: 112 syringes
Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
8 weeks (10 vials): 30 mL → 3 × 10 mL bottles
12 weeks (19 vials): 57 mL → 6 × 10 mL bottles
16 weeks (31 vials): 93 mL → 10 × 10 mL bottles
Alcohol Swabs: One for the vial stopper + one for the injection site each day.
Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100‐count boxes
12 weeks: 168 swabs → recommend 2 × 100‐count boxes
16 weeks: 224 swabs → recommend 3 × 100‐count boxes