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Highlights
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HPM-3 could alleviate alcohol-induced liver injury in mice. •
HPM-3 could mediate Keap1/Nrf2 signaling pathway to alleviate the liver injury. •
HPM-3 could preserve the diversity of the gut microbiota affected by alcohol. •
Ruminococcaceae was observed to increase during HPM-3 treatment. •
L-glutamine was the key metabolite for HPM-3 in reducing alcohol-induced injury.
Abstract
Alcoholic liver disease is one of the main causes of global liver disease-related deaths, which has emerged as a major health concern for people. In this study, a peptide was prepared from Pinctada Martensii meat (named HPM-3), and its protective effect against alcohol-induced liver damage in mice was investigated. The results indicated that intervention of HPM-3 significantly decreased the levels of transaminase and lactate dehydrogenase in serum, and improved the antioxidant enzyme activities in the liver. Besides, HPM-3 could alleviate alcohol-induced liver injury by mediating Keap1/Nrf2 signaling pathway. Moreover, HPM-3 could preserve the diversity of the gut microbiota, and restore the relative abundance of some microbial communities that were impacted by alcohol intervention. HPM-3 intervention also affected the secretion of L-glutamine and other associated metabolites and mediated the related metabolic pathways. The results would help to clarify the mechanisms of protective effects of marine peptides against alcohol-induced liver injury.
Keywords
Pinctada martensii meat
Bioactive peptides
Alcohol liver injury
Gut microbiota
Metabolism
Data availability
Data will be made available on request.
1
These two authors contributed equally to this study.
© 2024 The Author(s). Published by Elsevier Ltd.