Description
PEG-MGF 2 mg — PEGylated Mechano Growth Factor Analog for Muscle & Repair Research
PEG-MGF is a pegylated analog of Mechano Growth Factor (MGF), an IGF-1 splice-variant peptide that has been investigated in preclinical models for roles in muscle repair, local growth responses, and tissue remodeling after mechanical or injury stress. PEGylation (polyethylene glycol attachment) is used to extend circulation time and modify peptide pharmacokinetics in research settings.
What It Is
Class: PEGylated IGF-1 splice-variant peptide analog Origin concept: Based on the E-domain sequence of IGF-1 (Mechano Growth Factor), which is upregulated in muscle after mechanical overload or injury in animal models. Modification: Conjugation to polyethylene glycol (PEG) to prolong stability and exposure compared with non-PEGylated MGF peptides.
Proposed Mechanisms (Preclinical)
Muscle & Satellite-Cell Biology
Investigated for effects on muscle satellite cells, including activation, proliferation, and differentiation in response to overload or injury. Explored for support of muscle fiber repair and local growth signals in mechanically stressed tissue. Model-dependent influences on markers of protein synthesis, myogenic factors, and structural remodeling.
PEGylation & Pharmacokinetics
PEGylation is used to extend peptide half-life and reduce rapid degradation/clearance in vivo. Prolonged exposure vs. non-PEG MGF may change the time course and magnitude of signaling at target tissues. Part of broader research into PEGylated peptide therapeutics and depot-like delivery profiles.
Selected Research Highlights
Muscle-Injury Models: MGF-type peptides have been studied in rodent models of mechanical or toxin-induced muscle damage for effects on regeneration and functional recovery. Overload & Hypertrophy: IGF-1 splice variants including MGF are reported to be upregulated in mechanically loaded muscle; analogs like PEG-MGF are used to probe these pathways experimentally. Tissue Repair & Remodeling: Experimental work has evaluated MGF-like peptides in broader contexts of tissue remodeling, angiogenesis, and structural adaptation following stress.
Chemical & Handling Information
Type: PEGylated peptide analog of Mechano Growth Factor Backbone: IGF-1 E-domain–derived peptide sequence with PEG attachment (exact PEG size and linkage may vary by lot/specification) Appearance: White to off-white lyophilized powder
Specifications
Peptide: PEG-MGF Amount: 2 mg per vial Form: Lyophilized powder Purity: ≥99% (HPLC); COA per lot available Packaging: Sealed vials suitable for standard laboratory handling
Storage & Stability
Store lyophilized vials in a cool, dry place, protected from light. Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, according to laboratory SOPs. After reconstitution, store at 2–8 °C for short-term use. For long-term storage, aliquot and freeze at −20 °C or below; avoid repeated freeze–thaw cycles.