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Where These Numbers Come From
CJC-1295 clinical research primarily used the DAC version, but the pharmacology informs no-DAC protocols.
Pivotal human study: Teichman et al. examined CJC-1295 (with DAC) in 36 healthy adults (21-61 years). Single doses of 30-120 mcg/kg produced dose-dependent GH and IGF-1 increases, with IGF-1 elevated 1.5-3 fold for 6-14 days (Teichman et al., 2006).
Preserved pulsatility: A follow-up confirmed that despite continuous GHRH stimulation, pulsatile GH secretion was maintained -- GH pulse frequency preserved with 2-fold increases in mean GH and pulse mass (Ionescu & Bhatt, 2006).
Animal studies: CJC-1295 normalized growth in GHRH knockout mice with once-daily dosing (Alba et al., 2006).
Why no-DAC is preferred by many: Short half-life produces pulsatile rather than sustained GH elevation, more closely mimicking natural GHRH/GH secretion. Lower baseline GH between pulses. Controllable timing windows. Optimal synergy with timed GHRP co-injection.
Stacking Protocols
Gold Standard
CJC-1295 no DAC 200 mcg + Ipamorelin 100-200 mcg (PM, same injection)
GHRH + GHRP synergy, cleanest side effect profile
Higher Potency
CJC-1295 no DAC 200 mcg + GHRP-2 100-200 mcg (PM)
Stronger GH release, moderate hunger/cortisol
Maximum GH
CJC-1295 no DAC 200 mcg + Hexarelin 100-200 mcg (PM)
Highest GH output, most side effects, desensitization risk
Stacking tips: Community protocols describe injecting GHRH + GHRP simultaneously for synergistic effect. Community sources describe drawing both into one insulin syringe. Community protocols describe the fasted state as critical for GH response. Community sources consistently describe the pre-bed injection as the highest-priority timing window.
For the detailed blend protocol, see our CJC-1295 + Ipamorelin Dosing Guide.
Side Effects & Safety
Flushing/warmth -- very common in first 1-2 weeks, transient (15-30 min post-injection)
Head rush/dizziness -- brief, typically resolves quickly
Injection site reactions -- mild redness, occasional irritation
Water retention -- mild, GH-mediated sodium retention
Tingling/numbness -- occasional, related to GH effects
Vivid dreams -- frequently reported, likely from enhanced deep sleep
Insulin resistance -- chronic GH elevation can impair glucose tolerance (monitor fasting glucose)
Contraindications -- active malignancy, diabetic retinopathy, pregnancy
mg to Units Conversion
On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL). Once CJC-1295 is reconstituted, the conversion from a target dose to syringe units depends on the chosen dilution.
The two reconstitution ratios most often described in community protocols are below.
Reconstitution A: 10 mg vial + 3 mL BAC water (3.33 mg/mL) — the standard dilution from the Quick Reference above.
100 mcg
0.03 mL
3 units
200 mcg
0.06 mL
6 units
300 mcg
0.09 mL
9 units
400 mcg
0.12 mL
12 units
Reconstitution B: 10 mg vial + 5 mL BAC water (2 mg/mL) — more BAC water for larger, easier-to-measure draws.
0.05 mL
5 units
0.1 mL
10 units
0.15 mL
15 units
0.2 mL
20 units
These conversions reflect the dilutions documented in community reconstitution protocols. They report how the math is described, not a recommended dosing schedule.
Core Supplies for This Protocol
The three essentials for running any reconstituted injectable: cold storage, accurate syringes, and metabolic tracking.
Cooluli Classic 4L Mini Fridge
Compact thermoelectric mini-fridge with heat/cool toggle. The most-mentioned dedicated peptide-storage fridge in research community sources — fits ~20 vials and runs quietly.
BD Ultra-Fine 31G 0.3cc 5/16" Insulin Syringes (Box of 90)
0.3cc 31G syringes — each gradation marks 1 unit (vs 2 units on 1cc), making sub-50-unit peptide doses accurate. BD Ultra-Fine is the most widely-cited brand in peptide community sources.
CONTOUR NEXT GEN Glucose Meter All-In-One Kit
Ascensia's CONTOUR NEXT GEN — the most clinically-validated home glucose meter. Includes 20 test strips + lancing device. Tracks the blood-sugar response GLP-1 users care about, especially during dose escalation.
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