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The Prohibited List | World Anti Doping

The List of Prohibited Substances and Methods (List) indicates what substances and methods are prohibited in sport and when. Get the latest version of the List The List is updated at least annually. The latest version is published on WADA’s website in October and comes into force on 1 January. The official text is published by WADA in English and French. Get your copy This link will open in a new window. The Prohibited List Go to search results Important disclaimer See more Important disclaimer See more 14 results found. S0 NON-APPROVED SUBSTANCES All times All prohibited substances in this class are Specified Substances. Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times. This cl

Context first

Study findings do not automatically establish clinical benefit, safety, dosing, or suitability for an individual.

The List of Prohibited Substances and Methods (List) indicates what substances and methods are prohibited in sport and when.

Get the latest version of the List

The List is updated at least annually. The latest version is published on WADA’s website in October and comes into force on 1 January. The official text is published by WADA in English and French.

Get your copy This link will open in a new window.

The Prohibited List Go to search results

Important disclaimer

See more

Important disclaimer

See more

14 results found.

S0

NON-APPROVED SUBSTANCES

All times

All prohibited substances in this class are Specified Substances.

Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g. drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times.

This class covers many different substances including but not limited to BPC-157, 2,4-dinitrophenol (DNP), ryanodine receptor-1-calstabin complex stabilizers [e.g. S-107, S48168 (ARM210)] and troponin activators (e.g. reldesemtiv and tirasemtiv).

S1

ANABOLIC AGENTS

All times

All prohibited substances in this class are non-Specified Substances.

Anabolic agents are prohibited.

S1.1. ANABOLIC ANDROGENIC STEROIDS (AAS)

WHEN ADMINISTERED EXOGENOUSLY, INCLUDING BUT NOT LIMITED TO:

1-Androstenediol (5α-androst-1-ene-3β, 17β-diol) 1-Androstenedione (5α-androst-1-ene-3, 17-dione) 1-Androsterone (3α-hydroxy-5α-androst-1- ene-17-one) 1-Epiandrosterone (3β-hydroxy-5α-androst- 1-ene-17-one) 1-Testosterone (17β-hydroxy-5α-androst-1- en-3-one) 4-Androstenediol (androst-4-ene-3β,17β- diol) 4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one) 5-Androstenedione (androst-5-ene-3,17- dione) 7α-Hydroxy-DHEA 7β-Hydroxy-DHEA 7-Keto-DHEA 11ß-Methyl-19-nortestosterone 17α-Methylepithiostanol (epistane) 19-Norandrostenediol (estr-4-ene-3,17-diol) 19-Norandrostenedione (estr-4-ene-3,17- dione) Androst-4-ene-3,11,17-trione (11-ketoandrostenedione, adrenosterone) Androstanolone (5α-dihydrotestosterone, 17β-hydroxy-5α-androstan-3-one) Androstenediol (androst-5-ene-3β,17β-diol) Androstenedione (androst-4-ene-3,17- dione) Bolasterone Boldenone Boldione (androsta-1,4-diene-3,17-dione) Calusterone Clostebol Danazol ([1,2]oxazolo[4’,5’:2,3]pregna-4-en- 20-yn-17α-ol) Dehydrochlormethyltestosterone (4-chloro- 17β-hydroxy-17α-methylandrosta-1,4-dien- 3-one) Desoxymethyltestosterone (17α-methyl-5α- androst-2-en-17β-ol and 17α-methyl-5α- androst-3-en-17β-ol) Dimethandrolone (7ɑ,11ß-Dimethyl-19-nortestosterone) Drostanolone Epiandrosterone (3β-hydroxy-5α-androstan- 17-one) Epi-dihydrotestosterone (17β-hydroxy-5β- androstan-3-one) Epitestosterone Ethylestrenol (19-norpregna-4-en-17α-ol) Fluoxymesterone Formebolone Furazabol (17α-methyl [1,2,5] oxadiazolo[3’,4’:2,3]-5α-androstan-17β-ol) Gestrinone Mestanolone Mesterolone Metandienone (17β-hydroxy-17α- methylandrosta-1,4-dien-3-one) Metenolone Methandriol Methasterone (17β-hydroxy-2α,17α- dimethyl-5α-androstan-3-one) Methyl-1-testosterone (17β-hydroxy-17α- methyl-5α-androst-1-en-3-one) Methylclostebol Methyldienolone (17β-hydroxy-17α- methylestra-4,9-dien-3-one) Methylnortestosterone (17β-hydroxy-17α- methylestr-4-en-3-one) Methyltestosterone Metribolone (methyltrienolone, 17β-hydroxy- 17α-methylestra-4,9,11-trien-3-one) Mibolerone Nandrolone (19-nortestosterone) Norboletone Norclostebol (4-chloro-17β-ol-estr-4-en-3- one) Norethandrolone Oxabolone Oxandrolone Oxymesterone Oxymetholone Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one) Prostanozol (17β-[(tetrahydropyran-2-yl) oxy]-1’H-pyrazolo[3,4:2,3]-5α-androstane) Quinbolone Stanozolol Stenbolone Testosterone Tetrahydrogestrinone (17-hydroxy-18a- homo-19-nor-17α-pregna-4,9,11-trien-3- one) Tibolone Trenbolone (17β-hydroxyestr-4,9,11-trien-3- one) Trestolone (7ɑ-Methyl-19-nortestosterone, MENT)

and other substances with a similar chemical structure or similar biological effect(s) including their esters.

S1.2. OTHER ANABOLIC AGENTS

INCLUDING, BUT NOT LIMITED TO:

Clenbuterol Osilodrostat Ractopamine Selective androgen receptor modulators [SARMs, e.g. andarine, enobosarm (ostarine), LGD-4033 (ligandrol), RAD140, S-23 and YK-11] Zeranol Zilpaterol

S2

PEPTIDE HORMONES, GROWTH FACTORS, RELATED SUBSTANCES AND MIMETICS

All times

All prohibited substances in this class are non-Specified Substances.

The following substances, and other substances with similar chemical structure or similar biological effect(s), are prohibited:

S2.1. ERYTHROPOIETINS (EPO) AND AGENTS AFFECTING ERYTHROPOIESIS, INCLUDING, BUT NOT LIMITED TO:

S2.1.1 ERYTHROPOIETIN-RECEPTOR AGONISTS, E.G.

Darbepoetins (dEPO) Erythropoietins (EPO) EPO-based constructs [e.g. EPO-Fc, methoxy polyethylene glycol-epoetin beta (CERA)] EPO-mimetic agents and their constructs (e.g. CNTO-530, peginesatide, pegmolesatide)

S2.1.2 HYPOXIA-INDUCIBLE FACTOR (HIF) ACTIVATING AGENTS, E.G.

Cobalt Daprodustat (GSK1278863) IOX2 Molidustat (BAY 85-3934) Roxadustat (FG-4592) Vadadustat (AKB-6548) Xenon

S2.1.3 GATA INHIBITORS, E.G.

K-11706

S2.1.4 TRANSFORMING GROWTH FACTOR -BETA (TGF-Β) SIGNALING INHIBITORS, E.G.

Luspatercept Sotatercept

S2.1.5 INNATE REPAIR RECEPTOR AGONISTS, E.G.

Asialo EPO Carbamylated EPO (CEPO)

S2.2. PEPTIDE HORMONES AND THEIR RELEASING FACTORS

S2.2.1 TESTOSTERONE-STIMULATING PEPTIDES IN MALES INCLUDING, BUT NOT LIMITED TO:

chorionic gonadotrophin (CG) luteinizing hormone (LH) gonadotrophin- releasing hormone (GnRH, gonadorelin) and its

agonist analogues (e.g. buserelin, deslorelin, goserelin, histrelin, leuprorelin,

nafarelin and triptorelin) kisspeptin and its agonist analogues

S2.2.2 CORTICOTROPHINS AND THEIR RELEASING FACTORS, E.G. CORTICORELIN AND TETRACOSACTIDE

S2.2.3 GROWTH HORMONE (GH), ITS ANALOGUES AND FRAGMENTS, INCLUDING, BUT NOT LIMITED TO:

growth hormone analogues, e.g. lonapegsomatropin, somapacitan and somatrogon growth hormone fragments, e.g. AOD-9604 and hGH 176-191

S2.2.4 GROWTH HORMONE RELEASING FACTORS, INCLUDING, BUT NOT LIMITED TO:

growth hormone-releasing hormone (GHRH) and its analogues (e.g. CJC-1293, CJC-1295, sermorelin and tesamorelin) growth hormone secretagogues (GHS) and their mimetics [e.g. anamorelin, capromorelin, ibutamoren (MK-677), ipamorelin, lenomorelin (ghrelin), macimorelin and tabimorelin] GH-releasing peptides (GHRPs) [e.g. alexamorelin, examorelin (hexarelin), GHRP-1, GHRP-2 (pralmorelin), GHRP-3, GHRP-4, GHRP-5 and GHRP-6]

S2.3. GROWTH FACTORS AND GROWTH FACTOR MODULATORS

INCLUDING, BUT NOT LIMITED TO:

Fibroblast growth factors (FGFs) Hepatocyte growth factor (HGF) Insulin-like growth factor 1 (IGF-1, mecasermin) and its analogues Mechano growth factors (MGFs) Platelet-derived growth factor (PDGF) Thymosin-β4 and its derivatives e.g. TB-500 Vascular endothelial growth factor (VEGF)

and other growth factors or growth factor modulators affecting muscle, tendon or ligament protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity or fibre type switching.

S3

BETA-2 AGONISTS

All times

All prohibited substances in this class are Specified Substances.

All selective and non-selective beta-2 agonists, including all optical isomers, are prohibited.

INCLUDING, BUT NOT LIMITED TO:

Arformoterol Fenoterol Formoterol Higenamine Indacaterol Levosalbutamol Olodaterol Procaterol Reproterol Salbutamol Salmeterol Terbutaline Tretoquinol (trimetoquinol) Tulobuterol Vilanterol

EXCEPTIONS

Inhaled salbutamol: maximum 1600 micrograms over 24 hours in divided doses not to exceed 600 micrograms over 8 hours starting from any dose Inhaled formoterol: maximum delivered dose of 54 micrograms over 24 hours in divided doses not to exceed 36 micrograms over 12 hours starting from any dose; Inhaled salmeterol: maximum 200 micrograms over 24 hours in divided doses not to exceed 100 micrograms over 8 hours starting from any dose Inhaled vilanterol: maximum 25 micrograms over 24 hours

NOTE

The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is not consistent with therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of a therapeutic dose (by inhalation) up to the maximum dose indicated above.

S4

HORMONE AND METABOLIC MODULATORS

All times

Prohibited substances in classes S4.1 and S4.2 are Specified Substances. Those in classes S4.3 and S4.4 are non-Specified Substances.

The following hormone and metabolic modulators are prohibited.

S4.1. AROMATASE INHIBITORS

INCLUDING, BUT NOT LIMITED TO:

2-Androstenol (5α-androst-2-en-17-ol) 2-Androstenone (5α-androst-2-en-17-one) 2-Phenylbenzo[h]chromen-4-one (ɑ-naphthoflavone; 7,8-benzoflavone) 3-Androstenol (5α-androst-3-en-17-ol) 3-Androstenone (5α-androst-3-en-17-one) 4-Androstene-3,6,17 trione (6-oxo) Aminoglutethimide Anastrozole Androsta-1,4,6-triene-3,17-dione (androstatrienedione) Androsta-3,5-diene-7,17-dione (arimistane) Exemestane Formestane Letrozole Testolactone

S4.2. ANTI-ESTROGENIC SUBSTANCES [ANTI-ESTROGENS AND SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS)]

INCLUDING, BUT NOT LIMITED TO:

Bazedoxifene Clomifene Cyclofenil Elacestrant Fulvestrant Ospemifene Raloxifene Tamoxifen Toremifene

S4.3. AGENTS PREVENTING ACTIVIN RECEPTOR IIB ACTIVATION

INCLUDING, BUT NOT LIMITED TO:

Activin A-neutralizing antibodies Activin receptor IIB competitors such as:

Decoy activin receptors (e.g. ACE-031) Anti-activin receptor IIB antibodies (e.g. bimagrumab) Myostatin inhibitors such as:

Agents reducing or ablating myostatin expression Myostatin-binding proteins (e.g. follistatin, myostatin propeptide) Myostatin- or precursor - neutralizing antibodies (e.g. apitegromab, domagrozumab, landogrozumab, stamulumab)

S4.4. METABOLIC MODULATORS

S4.4.1

Activators of the AMP-activated protein kinase (AMPK), e.g. 5-N,6-N-bis(2- fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine (BAM15), AICAR, mitochondrial open reading frame of the 12S rRNA-c (MOTS-c); Peroxisome proliferator-activated receptor delta (PPARδ) agonists, e.g. 2-(2-methyl- 4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methylthio)phenoxy) acetic acid (GW1516, GW501516) and; Rev-erbɑ agonists, e.g. SR9009, SR9011

S4.4.2 INSULINS AND INSULIN-MIMETICS, e.g. S519, S597

S4.4.3 MELDONIUM

S4.4.4 TRIMETAZIDINE

S5

DIURETICS AND MASKING AGENTS

All times

All prohibited substances in this class are Specified Substances.

All diuretics and masking agents, including all optical isomers, e.g. d- and l- where relevant,

are prohibited.

Including, but not limited to:

Diuretics such as:

Acetazolamide; amiloride; bumetanide; canrenone; chlortalidone; etacrynic acid; furosemide; indapamide; metolazone; spironolactone; thiazides, e.g. bendroflumethiazide, chlorothiazide and hydrochlorothiazide; torasemide; triamterene; xipamide; Vaptans, e.g. conivaptan, mozavaptan, tolvaptan; Plasma expanders by intravenous administration such as: Albumin, dextran, hydroxyethyl starch, mannitol; Desmopressin; Probenecid;

and other substances with a similar chemical structure or similar biological effect(s).

EXCEPTIONS

Drospirenone; pamabrom; and topical ophthalmic administration of carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide) Local administration of felypressin in dental anaesthesia

NOTE

The detection in an Athlete’s Sample at all times or In-Competition, as applicable, of any quantity of the following substances subject to threshold limits: formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine, in conjunction with a diuretic or masking agent (except topical ophthalmic administration of a carbonic anhydrase inhibitor or local administration of felypressin in dental anaesthesia), will be considered as an Adverse Analytical Finding (AAF) unless the Athlete has an approved Therapeutic Use Exemption (TUE) for that substance in addition to the one granted for the diuretic or masking agent.

M1

MANIPULATION OF BLOOD AND BLOOD COMPONENTS

All times

All prohibited methods in this class are non-Specified.

The following are prohibited:

M1.1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous blood, or red blood cell products of any origin into the circulatory system.

The withdrawal of blood or blood components (including by apheresis), unless performed for 1) analytical purposes including medical tests or Doping Control, or for 2) donation purposes in a collection center accredited by the relevant regulatory authority of the country in which it operates.

M1.2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13); voxelotor and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation.

M1.3. Any form of intravascular manipulation of the blood or blood components by physical or chemical means.

M1.4 The use of re-breathing systems or equipment to deliver carbon monoxide, unless performed as a diagnostic procedure under the supervision of a medical or scientific professional.

M2

CHEMICAL AND PHYSICAL MANIPULATION

All times

All prohibited methods in this class are non-Specified except methods in M2.2. which are Specified Methods.

The following are prohibited:

M2.1. Tampering, or Attempting to Tamper, to alter the integrity and validity of Samples collected during Doping Control. Including, but not limited to: Sample substitution and/or adulteration, e.g. addition of proteases to Sample.

M2.2. Intravenous infusions and/or injections of more than a total of 100 mL per 12-hour period except for those legitimately received in the course of hospital treatments, surgical procedures or clinical diagnostic investigations.

M3

GENE AND CELL DOPING

All times

All prohibited methods in this class are non-Specified.

The following, with the potential to enhance sport performance, are prohibited:

M3.1. The use of nucleic acids or nucleic acid analogues that may alter genome sequences and/ or alter gene expression by any mechanism. This includes but is not limited to gene editing, gene silencing and gene transfer technologies.

M3.2. The use of normal or genetically modified cells or cell components (e.g. nuclei and organelles such as mitochondria and ribosomes).

S6

STIMULANTS

In competition

All prohibited substances in this class are Specified Substances except those in S6.A, which are non-Specified Substances.

Substances of Abuse in this section: cocaine and methylenedioxymethamphetamine (MDMA / “ecstasy”).

All stimulants, including all optical isomers, e.g. d- and l- where relevant, are prohibited.

Stimulants include:

S6.A: NON-SPECIFIED STIMULANTS

Adrafinil Amfepramone Amfetamine Amfetaminil Amiphenazole Benfluorex Benzylpiperazine Bromantan Clobenzorex Cocaine Cropropamide Crotetamide Fencamine Fenetylline Fenfluramine Fenproporex Fladrafinil (2-[Bis(4-fluorophenyl) methylsulfinyl]-N-hydroxyacetamide) Flmodafinil (2-[Bis(4-fluorophenyl) methylsulfinyl]acetamide) Fonturacetam [4-phenylpiracetam (carphedon)] Furfenorex Hydrafinil (fluorenol) Lisdexamfetamine Mefenorex Mephentermine Mesocarb Metamfetamine(d-) p-methylamfetamine Modafinil Norfenfluramine Phendimetrazine Phentermine Prenylamine Prolintane

A stimulant not expressly listed in this section is a Specified Substance.

S6.B: SPECIFIED STIMULANTS

INCLUDING, BUT NOT LIMITED TO:

2-phenylpropan-1-amine (ß-methylphenylethylamine, BMPEA) 3-Methylhexan-2-amine (1,2-dimethylpentylamine) 4-Fluoromethylphenidate 4-Methylhexan-2-amine (1,3-dimethylamylamine, 1,3 DMAA, methylhexaneamine) 4-Methylpentan-2-amine (1,3-dimethylbutylamine) 5-Methylhexan-2-amine (1,4-dimethylamylamine, 1,4-dimethylpentylamine, 1,4-DMAA) Benzfetamine Cathine** Cathinone and its analogues, e.g. mephedrone, methedrone, and α - pyrrolidinovalerophenone Dimetamfetamine (dimethylamphetamine) Ephedrine*** Epinephrine**** (adrenaline) Etamivan Ethylphenidate Etilamfetamine Etilefrine Famprofazone Fenbutrazate Fencamfamin Heptaminol Hydroxyamfetamine (parahydroxyamphetamine) Isometheptene Levmetamfetamine Meclofenoxate Methylenedioxymetham- phetamine Methylephedrine*** Methylnaphthidate [((±)-methyl-2-(naphthalen-2-yl)-2-(piperidin-2-yl)acetate] Methylphenidate Midodrine Nikethamide Norfenefrine Octodrine (1,5-dimethylhex- ylamine) Octopamine Oxilofrine (methylsynephrine) Pemoline Pentetrazol Phenethylamine and its derivatives Phenmetrazine Phenpromethamine Propylhexedrine Pseudoephedrine***** Selegiline Sibutramine Solriamfetol Strychnine Tenamfetamine (methylenedioxyamphet- amine) Tesofensine Tuaminoheptane

and other substances with a similar chemical structure or similar biological effect(s).

EXCEPTIONS

Clonidine, guanfacine; Imidazole derivatives for dermatological, nasal, ophthalmic or otic use (e.g. brimonidine, clonazoline, fenoxazoline, indanazoline, naphazoline, oxymetazoline, tetryzoline, tramazoline, xylometazoline) and those stimulants included in the 2026 Monitoring Program*

* Bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradrol, and synephrine: These substances are included in the 2026 Monitoring Program and are not considered Prohibited Substances.

** Cathine (d-norpseudoephedrine) and its l-isomer: Prohibited when its concentration in urine is greater than 5 micrograms per millilitre.

*** Ephedrine and methylephedrine: Prohibited when the concentration of either in urine is greater than 10 micrograms per millilitre.

**** Epinephrine (adrenaline): Not prohibited in local administration, e.g. nasal, ophthalmologic, or co-administration with local anaesthetic

agents.

***** Pseudoephedrine: Prohibited when its concentration in urine is greater than 150 micrograms per millilitre.

S7

NARCOTICS

In competition

All prohibited substances in this class are Specified Substances.

Substance of Abuse in this section: diamorphine (heroin).

The following narcotics, including all optical isomers, e.g. d- and l- where relevant, are prohibited.

Buprenorphine Dextromoramide Diamorphine (heroin) Fentanyl and its derivatives Hydromorphone Methadone Morphine Nicomorphine Oxycodone Oxymorphone Pentazocine Pethidine Tramadol

S8

CANNABINOIDS

In competition

All prohibited substances in this class are Specified Substances.

Substance of Abuse in this section: tetrahydrocannabinol (THC).

ALL NATURAL AND SYNTHETIC CANNABINOIDS ARE PROHIBITED, E.G.

In cannabis (hashish, marijuana) and cannabis products Synthetic cannabinoids that mimic the effects of THC Natural and synthetic tetrahydrocannabinols (THCs)

EXCEPTIONS

Cannabidiol

S9

GLUCOCORTICOIDS

In competition

All prohibited substances in this class are Specified Substances.

All glucocorticoids are prohibited when administered by any injectable, oral [including oromucosal (e.g. buccal, gingival, sublingual)] or rectal route.

INCLUDING, BUT NOT LIMITED TO:

Beclometasone Betamethasone Budesonide Ciclesonide Cortisone Deflazacort Dexamethasone Flunisolide Fluocortolone Fluticasone Hydrocortisone Methylprednisolone Mometasone Prednisolone Prednisone Triamcinolone acetonide

Note:

Other routes of administration (including inhaled, and topical: dental-intracanal, dermal, intranasal, ophthalmological, otic and perianal) are not prohibited when used within the manufacturer’s licensed doses and therapeutic indications

P1

BETA-BLOCKERS

In particular sports

All prohibited substances in this class are Specified Substances.

Beta-blockers are prohibited In-Competition only, in the following sports, and also prohibited Out-of-Competition where indicated (*).

Archery (WA)* Automobile (FIA) Billiards (all disciplines) (WCBS) Darts (WDF) Golf (IGF) Mini-Golf (WMF) Shooting (ISSF, IPC)* Underwater sports (CMAS)* in all subdisciplines of freediving, spearfishing and target shooting

*Also prohibited Out-of-Competition

INCLUDING, BUT NOT LIMITED TO:

Acebutolol Alprenolol Atenolol Betaxolol Bisoprolol Bunolol Carteolol Carvedilol Celiprolol Esmolol Labetalol Metipranolol Metoprolol Nadolol Nebivolol Oxprenolol Pindolol Propranolol Sotalol Timolol

Frequently asked questions

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