Description
BPC-157 & TB-500 — Research Peptide Blend
BPC-157 (Pentadecapeptide BPC-157) 10mg and TB-500 10mg (synthetic thymosin beta-4 analog) are laboratory peptides explored separately in preclinical models for roles in tissue protection and repair. Together, they are often studied as a complementary blend: BPC-157 for endothelial/angiogenic and matrix-oriented signaling; TB-500 for cytoskeletal dynamics, cell migration, and wound remodeling.
What They Are
BPC-157: 15-amino-acid pentadecapeptide studied for effects on endothelial integrity, angiogenic signaling, nitric-oxide–linked pathways, and collagen matrix organization. TB-500: 43-amino-acid analog of thymosin ?4, examined for actin binding/sequestration, cell motility, microtubule/cytoskeleton remodeling, and re-epithelialization in injury models.
Proposed Mechanisms (Preclinical)
BPC-157
Endothelial protection & pro-angiogenic signaling (NO-linked pathways; early-growth-response factors). Matrix/collagen support and fibroblast migration in tendon/ligament models. Inflammation modulation and potential neuroprotective signaling (model-dependent).
TB-500
Actin-binding motif LKKTETQ associated with cytoskeletal reorganization and cell motility. Wound-healing biology: re-epithelialization, angiogenesis, granulation-tissue quality (model-dependent). Inflammation-pathway modulation (e.g., miR-146a/IRAK1/TRAF6 axis, exploratory).
Selected Research Highlights
Skin/Wound Models: TB-500 (T?4) associated with faster re-epithelialization and contraction vs. controls in animal studies; small clinical datasets in chronic wounds have explored dose-response over multi-week protocols. Tendon/Ligament: TB-family peptides reported more organized collagen and improved mechanical properties post-injury; BPC-157 associated with fibroblast migration and collagen deposition in tendon explants. Muscle: BPC-157 explored in steroid-injury muscle models for functional restoration; TB-family peptides investigated for cytoskeletal remodeling and angiogenesis in cardiac ischemia models. Angiogenesis & Matrix: Both peptides studied for capillary density/neo-vessel formation and ECM organization under injury stressors.
Chemical Information
BPC-157 — Formula: C62H98N16O22 · MW: 1419.5 g/mol TB-500 — Formula: C212H350N56O78S · MW: 4963 g/mol
Specifications
Form: Lyophilized powders (research-grade) Purity: ?99% (HPLC); COA per lot available Packaging: Sealed vials suitable for laboratory handling
Storage & Handling
Store lyophilized vials in a cool, dry place, protected from light. After reconstitution: refrigerate at 2–8 °C. For long-term stability: store at ?20 °C; avoid repeated freeze–thaw cycles.