Protocol Overview
Synergy & Mechanism
HGH Mechanism
Exogenous HGH provides a reliable, dose-dependent supply of growth hormone that directly activates GH receptors throughout the body. It stimulates IGF-1 production in the liver, promotes lipolysis, supports protein synthesis, and provides the foundation for anti-aging and body composition effects. The limitation is that it can suppress natural pituitary GH production over time.
Ipamorelin Synergy
Adding ipamorelin allows lower HGH doses while maintaining optimal GH levels. Ipamorelin preserves natural pituitary pulsatility at moderate HGH doses, meaning the evening dose triggers natural GH pulses that augment the morning HGH injection. This results in 30-50% lower HGH requirements with comparable IGF-1 levels, reducing side effects and cost.
Combined Dosing Protocol
Anti-Aging
HGH 1-2 IU/day AM
Ipa 200mcg PM
AM HGH, PM Ipa
16-24 weeks
Body Comp
HGH 2-3 IU/day AM
Ipa 200mcg 2x/day
AM HGH+Ipa, PM Ipa
12-16 weeks
Performance
HGH 3-4 IU/day split
Ipa 300mcg 2x/day
AM/PM both
12 weeks
Reconstitution & Preparation
HGH Preparation
HGH pens: pre-mixed, dial dose to IU
HGH vials: reconstitute with BAC water per mg
10 IU vial + 1mL BAC = 10 IU/mL
Store refrigerated 2-8°C
Ipamorelin Preparation
Ipamorelin: 5mg vial lyophilized
Reconstitute with 2mL BAC = 2,500mcg/mL
200mcg = 8 units | 300mcg = 12 units
Refrigerate, use within 30 days
Stacking Schedule (AM/PM Timing)
AM Protocol
Fasted AM: HGH 1-3 IU SubQ, abdomen
Optional AM: Ipamorelin 200mcg (body comp protocol)
Wait 30-60 min before eating
Fasted cardio amplifies fat burning
PM Protocol
Before bed (fasted 2+ hrs): Ipamorelin 200-300mcg SubQ
Synergizes with natural nocturnal GH pulse
HGH not taken PM to avoid suppressing sleep GH
Do not eat after injection
Expected Timeline
Side Effects & Monitoring
Common Side Effects
Water retention / edema (HGH, dose-dependent)
Carpal tunnel symptoms (tingling hands)
Joint pain/stiffness (HGH, transient)
Increased hunger (ipamorelin)
Headache (first week, uncommon)
Precautions
Active cancer - absolute contraindication for HGH
Monitor IGF-1 closely (target 200-350 ng/mL)
HGH can impair glucose tolerance
Long-term HGH requires physician oversight
Start low and titrate up
Blood Work Recommendations
GH/IGF-1
IGF-1, GH (fasted)
Baseline, Week 6, Week 12, Week 24
Metabolic
Fasting glucose, insulin, HbA1c
Baseline, Week 8, Week 16
Thyroid
TSH, free T3, free T4
Baseline, Week 12
Basic
CBC, CMP
Baseline, Week 8
IGF-1 monitoring is paramount. HGH can suppress thyroid function - check TSH and free T3/T4. Glucose important as GH is diabetogenic at high doses.
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