OP Labs formerly Oxford Peptides. Batch HPLC tested at 98.5%+ purity. Store frozen long term or in fridge when ready to be used. Sold for research purposes only. Contact us for Wholesale Orders.
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Tesamorelin
Synonyms / Designations: Tesamorelin, TH9507, Growth Hormone–Releasing Hormone (GHRH) analogue CAS Number: 901758-09-6 Molecular Formula: C223H370N72O69S Molecular Weight: ~5135.91 g/mol Peptide Length: 44 amino acids Peptide Type: Synthetic GHRH analogue Purity: ≥ 99 % (HPLC, typical) Appearance: White to off-white lyophilised powder Pack Size: 5 mg (typical) Storage: Desiccated, protected from light, stored at –20 °C or below Solubility: Soluble in water and buffered aqueous solutions
Description & Mechanism
Tesamorelin is a synthetic peptide analogue of human growth hormone–releasing hormone (GHRH 1–44) designed for experimental investigation of hypothalamic–pituitary signalling and growth hormone regulation. Structural modifications enhance stability relative to native GHRH, making Tesamorelin suitable for controlled laboratory research.
In biochemical and cellular research systems, Tesamorelin interacts with the GHRH receptor expressed on pituitary-derived cells, activating intracellular signalling cascades associated with growth hormone synthesis and secretion. Experimental studies examine receptor binding kinetics, cAMP-mediated signalling, and downstream transcriptional responses under defined exposure conditions. Observed effects are dependent on concentration, duration, and experimental model and are used to investigate GHRH receptor signalling rather than defined physiological outcomes.
Applications in Research
As a molecular probe for studying GHRH receptor activation and signalling pathways. Investigation of growth hormone regulatory mechanisms in pituitary cell models. In vitro studies examining peptide stability and receptor selectivity. Use as a reference compound in neuroendocrine and peptide signalling research.
Specifications Summary
Purity: (HPLC): ≥ 99 % Appearance: White to off-white lyophilised powder Molecular Weight: ~5135.91 g/mol Peptide Type: Synthetic GHRH analogue Solubility: Water, buffered aqueous solutions Storage: –20 °C, desiccated, protected from light Pack Size: 5 mg
Handling, Reconstitution & Stability
Weigh under dry conditions; peptide is hygroscopic. Reconstitute in sterile water or appropriate buffered aqueous solution. Avoid vigorous agitation during dissolution. Filter sterilize if required (e.g. 0.22 μm) prior to use. Aliquot and store reconstituted solutions at –20 °C or lower. Avoid repeated freeze–thaw cycles.
Precautions & Notes
Experimental behaviour of Tesamorelin is influenced by receptor expression, peptide concentration, and exposure duration. Buffer composition, pH, and ionic strength may affect peptide stability. Appropriate controls are recommended to distinguish receptor-specific from non-specific effects. Intended strictly for laboratory research use; not for human or veterinary application.
References
Thorner M.O. et al. Growth hormone–releasing hormone and its analogues. Endocrine Reviews, 1997. https://pubmed.ncbi.nlm.nih.gov/9107404/
Bowers C.Y. Growth hormone–releasing peptides and neuroendocrine regulation. Endocrine Reviews, 2001. https://pubmed.ncbi.nlm.nih.gov/11159057/
Vance M.L. Growth hormone releasing hormone and pituitary signalling. Journal of Clinical Endocrinology & Metabolism, 2003. https://pubmed.ncbi.nlm.nih.gov/12629096/
Keywords: Tesamorelin, TH9507, GHRH Analogue, Growth Hormone Regulation, Synthetic Peptide
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