Product ID G2968
Cas No. 158861-67-7
Purity ≥95%
Product Unit Size Cost Quantity Stock
Description Product Info Shipping and Storage Downloads References Custom Order
Description
Growth hormone releasing peptide 2 (GHRP-2) is a peptide that induces the release of growth hormone and secretion of cAMP, adrenocorticotropic hormone (ACTH), and insulin-like growth factor 1 (IGF-1) in vitro and in vivo through binding the ghrelin receptor. GHRP-2 exhibits orexigenic, gastrointestinal modulatory, antioxidative, and anti-inflammatory activities. In animal models, GHRP-2 increases food intake and inhibits gastrointestinal contractility. GHRP-2 stimulates release of ghrelin and also decreases morphine-induced analgesia in various animal models. In vitro and in vivo, GHRP-2 decreases levels of superoxide anions and lipoxygenase, decreasing production of peroxides and accumulation of lipids. In animal models of lung injury, GHRP-2 attenuates LPS-induced increases in TNF-α and IL-6 and suppresses activation of NF-κB.
Product Info
Cas No.
158861-67-7 Purity
≥95% Formula
C45H54O6N9 Formula Wt.
818.0 IUPAC Name
6-amino-2-[[2-[[2-[2-[(2-amino-3-naphthalen-2-ylpropanoyl)amino]propanoylamino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-N-(2-aminopropanoyl)hexanamide Synonym
Pralmorelin, KP 102, GHRP-2 Appearance
White to off white powder
Shipping and Storage
Store Temp
-20°C Ship Temp
Ambient
References
Zeng P, Chen JX, Yang B, et al. Attenuation of systemic morphine-induced analgesia by central administration of ghrelin and related peptides in mice. Peptides. 2013 Dec;50:42-9. PMID: 24113541.
Peroni CN, Hayashida CY, Nascimento N, et al. Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient little mice. Clinics (Sao Paulo). 2012;67(3):265-72. PMID: 22473409.
Tsukamoto N, Otsuka F, Miyoshi T, et al. Functional interaction of bone morphogenetic protein and growth hormone releasing peptide in adrenocorticotropin regulation by corticotrope cells. Mol Cell Endocrinol. 2011 Sep 15;344(1-2):41-50. PMID: 21742013.
Li G, Li J, Zhou Q, et al. Growth hormone releasing peptide-2, a ghrelin agonist, attenuates lipopolysaccharide-induced acute lung injury in rats. Tohoku J Exp Med. 2010 Sep;222(1):7-13. PMID: 20805679.
Titterington JS, Sukhanov S, Higashi Y, et al. Growth hormone-releasing peptide-2 suppresses vascular oxidative stress in ApoE-/- mice but does not reduce atherosclerosis. Endocrinology. 2009 Dec;150(12):5478-87. PMID: 19819949.
Kudoh K, Shibata C, Funayama Y, et al. The effect of growth hormone releasing peptide-2 on upper gastrointestinal contractile activity and food intake in conscious dogs. J Gastroenterol. 2009;44(4):297-304. PMID: 19271111.