Ipamorelin Dosing Protocol: 5 mg Vial — Daily Dosing Schedule & Supplies
Week-by-week ipamorelin dosing guide using the 5 mg vial — the cleanest GHRP for precise, cortisol-free growth hormone stimulation.
Quickstart highlights
Ipamorelin (Ala-His-D-2-Nal-D-Phe-Lys-NH2) is a pentapeptide ghrelin receptor agonist (GHSR-1a) that selectively stimulates GH release without activating ACTH/cortisol or prolactin axes — distinguishing it from GHRP-2 and GHRP-6.
Concentration: 2 mg/mL (5 mg vial + 2.5 mL bacteriostatic water).
At 2 mg/mL: 200 μg = 10 units, 300 μg = 15 units.
Ipamorelin does not elevate cortisol or prolactin — the most selective GHRP available.
Combine with CJC-1295 or sermorelin for 2–4x greater GH secretion versus ipamorelin alone.
Inject in fasted state (2+ hours post-meal); food-driven insulin blunts GH response.
Dosing table
For educational reference only. Your prescribing provider may adjust doses based on your clinical profile and response.
1-4
200
10
Once daily (before bed)
200 μg — 10 units; single nightly injection; one vial provides 25 doses
5-12
300
15
Once or twice daily
300 μg — 15 units; add morning injection for enhanced GH pulsatility if desired
13+
2–3x daily
300 μg 2–3x daily for maximum GH secretion; space 4+ hours between doses
Your free Ipamorelin tracker
Dose reminders
Injection logging
Cycle progress
Reconstitution steps
Draw 2.5 mL bacteriostatic water; inject slowly down the vial wall.
Swirl gently until powder fully dissolves; do not shake.
Final concentration: 2 mg/mL (2,000 μg/mL). At this concentration: 200 μg = 10 units, 300 μg = 15 units.
Label with date; refrigerate at 2–8 °C. Use within 28 days.
Supplies needed
4-week plan
1 vial
28 syringes
3 mL bac water
28 alcohol swabs
8-week plan
2 vials
56 syringes
5 mL bac water
56 alcohol swabs
12-week plan
84 syringes
84 alcohol swabs
Protocol overview & cycle notes
Stimulate clean, pulsatile GH release through ghrelin receptor agonism with ipamorelin — the most selective GHRP available, producing meaningful GH secretion without cortisol, prolactin, or significant cortisol elevation.
Cycle length: 12 weeks on.
Off-cycle: 4 weeks off after every 12-week cycle.
Storage & handling
Injection & tracking tips
Inject subcutaneously in fasted state or 2 hours post-meal; insulin elevation suppresses GH response to ipamorelin.
Ipamorelin does not elevate cortisol or prolactin — a key advantage over GHRP-2 and GHRP-6 at equivalent doses.
When combining with CJC-1295 or sermorelin, inject both peptides simultaneously or within 5 minutes — GHRH + GHRP synergy is immediate.
Tracking
Logging helps you and your provider spot patterns and adjust dose or timing.
Measure IGF-1 at baseline and 6 weeks; ipamorelin typically raises IGF-1 by 30–50 ng/mL per 12-week cycle.
Track sleep quality nightly (wearable deep sleep data or subjective 0–10 scale).
Monitor fasting glucose monthly — GH elevation can transiently increase glucose at higher doses.
How this works & references
Sources
Ipamorelin, the first selective growth hormone secretagogue. Raun K et al. — Eur J Endocrinol — 1998
Source: Bowers CY — Unnatural growth hormone-releasing peptide begets natural ghrelin. J Clin Endocrinol Metab. 2001
Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Gobburu JV et al. — Pharm Res — 1999
Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Beck DE et al. — Int J Colorectal Dis — 2014
Frequently asked questions
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This content is for informational purposes only and does not constitute medical advice. Consult a licensed healthcare provider before starting any peptide therapy. Dosing and protocols may vary by formulation and prescriber.
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