Answer:
BPC-157 and TB-500 are both synthetic (laboratory-made) peptides that have been promoted for many uses based mainly on findings in animal studies: BPC-157 for improving bone and joint health, stomach ulcers, bladder pain, athletic performance enhancement, and anti-aging effects, and TB-500 for wound healing, injury recovery, strength and endurance.
However, as we discuss, neither compound can be legally sold in the U.S. or Canada as an ingredient in dietary supplements and neither is approved as a drug, as there is a lack of human clinical research demonstrating their efficacy and safety.
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For information about supplements that have been investigated in humans for athletic performance and joint health, see our Reviews of Muscle and Workout Supplements, Collagen Supplements, Nitric Oxide Supplements, and Joint Health Supplements. Also, see our article about supplements for peptic (stomach) ulcers.
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In addition the results of its expert testing, ConsumerLab uses only high-quality, evidence based, information sources. These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. On evolving topics, studies from pre-print journals may be sourced. All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. The following sources are referenced in this article:
BPC-157 Briefing Document, July 2026 Brcic, J Physiol Pharmacol 2009 Delcourt, Drug Test Anal 2023 FDA, 4-22-2026 FDA, 6/20/2023 Huang, Drug Des Devel Ther 2015 Krivic, J Orthop Res 2006 Lee, Altern Ther Health Med 2021 Lee, Altern Ther Health Med 2024 Liang, BMJ 2026 TB-500 Briefing Document, July 2026 USADA, BPC-157; last updated 3/3/2020 Vasireddi, Am J Gastroenterol 2025
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