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Ipamorelin
Synonyms / Designations: Ipamorelin, Ipamorelin Acetate, NNC 26-0161, Ipamorelin pentapeptide CAS Number: 170851-70-4 Molecular Formula: C38H49N9O5 Molecular Weight: ~711.85 g/mol Peptide Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 Peptide Classification: Synthetic growth hormone secretagogue; selective ghrelin receptor agonist Purity: ≥ 99 % (HPLC, typical) Appearance: White to off-white lyophilised powder Pack Size: 5 mg Storage: Desiccated, protected from light, stored at –20 °C Solubility: Soluble in sterile water and buffered aqueous solutions
Description & Mechanism
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue derived from GHRP-1 through structural optimisation. It was the first selective growth hormone-releasing peptide (GHRP) receptor agonist developed, demonstrating selectivity similar to that of growth hormone-releasing hormone (GHRH) for stimulating growth hormone release.
In biochemical and cellular research systems, ipamorelin acts as an agonist at the ghrelin/growth hormone secretagogue receptor (GHSR-1a) expressed on pituitary somatotroph cells. Unlike earlier GHRP compounds such as GHRP-6 and GHRP-2, ipamorelin exhibits a distinct selectivity profile: experimental studies have demonstrated that it does not release adrenocorticotropic hormone (ACTH) or cortisol at growth hormone-stimulating concentrations. This selectivity makes ipamorelin a valuable research tool for investigating GH secretion pathways independently of hypothalamic-pituitary-adrenal (HPA) axis activation. In animal models, ipamorelin has been reported to induce longitudinal bone growth in a dose-dependent manner under controlled experimental conditions.
Applications in Research
Investigation of GHSR-1a receptor binding, selectivity, and signalling pathways Study of growth hormone secretagogue mechanisms independent of HPA axis activation Research into pituitary somatotroph function and GH release dynamics In vitro and in vivo comparison with other GHRP compounds (GHRP-2, GHRP-6, Hexarelin) Models examining GH/IGF-1 axis regulation and bone growth signalling Use as a selective reference compound in neuroendocrine and peptide signalling research
Handling, Reconstitution & Stability
Weigh under dry conditions; peptide is hygroscopic Reconstitute in sterile water or appropriate buffered aqueous solution depending on assay requirements Avoid vigorous agitation during dissolution Filter sterilize if required (e.g. 0.22 μm) immediately prior to use Aliquot and store reconstituted solutions at –20 °C (or lower) to minimise degradation Avoid repeated freeze–thaw cycles
Specifications Summary
Purity (HPLC): ≥ 99 % Appearance: White to off-white lyophilised powder Peptide Type: Synthetic growth hormone secretagogue (GHSR-1a agonist) Molecular Formula: C38H49N9O5 Molecular Weight: ~711.85 g/mol Solubility: Water, buffered aqueous solutions Storage: –20 °C, desiccated, protected from light Pack Size: 5 mg
Precautions & Notes
Experimental behaviour of ipamorelin is influenced by receptor expression, concentration, and exposure duration Unlike GHRP-6 and GHRP-2, ipamorelin does not stimulate ACTH or cortisol release at GH-stimulating concentrations Buffer composition, pH, and ionic strength may affect peptide stability and assay performance Appropriate controls are recommended to distinguish receptor-specific from non-specific effects Intended strictly for laboratory research use; not for human or veterinary application
References
Raun K. et al. Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 1998. https://pubmed.ncbi.nlm.nih.gov/9849822/
Sinha D.K. et al. Beyond the androgen receptor: the contribution of growth hormone secretagogues to changes in body composition. Growth Hormone & IGF Research, 2020. https://pmc.ncbi.nlm.nih.gov/articles/PMC7108996/
Johansen P.B. et al. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Hormone & IGF Research, 1999. https://pubmed.ncbi.nlm.nih.gov/10373343/
Keywords: Ipamorelin, Ipamorelin Acetate, NNC 26-0161, Growth Hormone Secretagogue, GHSR-1a Agonist, Ghrelin Receptor Agonist, Selective GHRP, Synthetic Peptide, Neuroendocrine Research
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