Product Description
BPC-157 plus TB-500 is a two-compound research formulation combining two of the most extensively studied peptides in tissue repair research, supplied in a single lyophilized vial. Each compound is studied independently for its role in tissue regeneration, but through mechanisms that act at different points in the repair process, which is the basis for combining them.
BPC-157 is a 15-amino acid pentadecapeptide originally derived from a partial sequence of a protective protein found in human gastric juice, studied primarily for its role in angiogenesis through VEGFR2-Akt-eNOS signalling and its effects on connective tissue repair across muscle, tendon, ligament, and bone models. TB-500 is a synthetic peptide derived from the active region of thymosin beta-4, studied for its function as a G-actin sequestering protein that expands the pool of actin available for rapid cell migration during tissue repair, and for promoting angiogenesis through VEGF and MMP-2 upregulation, a mechanism mechanistically distinct from BPC-157’s VEGFR2-mediated pathway.
Pepta Supply provides this combination as a single lyophilized vial containing 5 mg of each compound, independently HPLC-tested and batch-verified before dispatch.
Composition
BPC-157 5 mg TB-500 5 mg Total Net Content 10 mg
Product Specifications
Product Name BPC-157 + TB-500 Form Lyophilized powder (multi-compound) Net Content 10 mg (5 mg BPC-157 + 5 mg TB-500) Purity 99% or above per compound (HPLC-verified) Verification Third-party HPLC, Certificate of Analysis via QR batch system Storage 2 to 8 degrees Celsius, protected from light and moisture Intended Use Research use only. Not for human or veterinary use.
Research Background
The rationale for combining BPC-157 and TB-500 comes from the fact that tissue repair is not a single process but a sequence of overlapping mechanisms, including vascular remodelling, cell migration, and matrix reconstruction, and these two compounds are studied for distinct contributions to that sequence.
BPC-157: Angiogenesis and Connective Tissue Repair
BPC-157’s most consistently studied property is its effect on angiogenesis. Research has shown that BPC-157 activates the VEGFR2 receptor and triggers the downstream VEGFR2-Akt-eNOS signalling pathway, a mechanism central to both new blood vessel formation and vascular repair. Because tendons and ligaments have comparatively low native vascularity, this angiogenic mechanism has made BPC-157 a particular focus for researchers studying connective tissue healing, where adequate blood supply is often the limiting factor in repair outcomes. Published preclinical studies have also documented BPC-157-associated increases in fibroblast activity and collagen synthesis across muscle, tendon, ligament, and bone injury models.
TB-500: Actin Sequestration and Cell Migration
TB-500’s defining mechanism is its function as a G-actin sequestering protein, derived from its parent molecule thymosin beta-4. By binding monomeric G-actin and holding it in a rapidly mobilisable reserve, TB-500 increases the pool of actin available for cells to polymerise into the filamentous structures required for migration toward an injury site. This mechanism supports fibroblast migration, endothelial cell sprouting, and progenitor cell mobilisation. TB-500 also promotes angiogenesis independently through upregulation of VEGF and matrix metalloproteinase-2 (MMP-2), a pathway mechanistically distinct from BPC-157’s VEGFR2-mediated route.
Why These Mechanisms Are Considered Complementary
BPC-157 and TB-500 are frequently described in the published literature as complementary rather than redundant because they act through different points in the same overall repair process. BPC-157 concentrates on vascular remodelling and growth factor signalling via VEGFR2 activation. TB-500 concentrates on the cellular migration level, expanding the actin reserve that fibroblasts, endothelial cells, and progenitor cells draw on to physically move toward an injury site, while contributing its own independent angiogenic signal through VEGF and MMP-2. Researchers studying multi-pathway tissue repair models combine the two compounds specifically to examine how vascular signalling and cell migration mechanisms interact when studied together rather than in isolation.
Note: Most available data on both compounds comes from preclinical and animal models. Human clinical evidence remains limited for BPC-157, and for TB-500 the most developed human data exists under separate development programs for the related full thymosin beta-4 molecule (RGN-259, RGN-137), which are not identical compounds to TB-500. Neither BPC-157 nor TB-500 has received regulatory approval for any therapeutic indication.
Batch Verification and Quality
Each batch of BPC-157 plus TB-500 is tested by an independent third-party laboratory using HPLC. Both compounds within the vial are verified for identity and purity at 99% or above before the batch is released. The Certificate of Analysis is accessible via the QR code on the vial or at peptasupply.com/v/ using the batch number.
Storage and Handling
Refrigerate at 2 to 8 degrees Celsius immediately upon receipt. Protect from direct light and moisture at all times. Reconstitute with bacteriostatic water for research use, following standard laboratory protocols. Do not freeze the reconstituted solution. Both compounds are stable as lyophilized powder when stored correctly.
Research Use Only. This product is supplied exclusively for scientific and laboratory research. Not intended for human consumption, therapeutic, diagnostic, clinical, or veterinary use. Pepta Supply B.V. accepts no liability for misuse or non-compliant use. Buyers are responsible for compliance with all applicable regulations in their country.
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About the Formulation
What is BPC-157 + TB-500?
BPC-157 plus TB-500 is a two-compound research formulation supplied by Pepta Supply as a single lyophilized vial containing 5 mg of BPC-157 and 5 mg of TB-500. It is intended for researchers studying the combined behaviour of these two tissue repair peptides without sourcing and preparing two separate vials.
What is the composition of each vial?
Each vial contains 5 mg of BPC-157 and 5 mg of TB-500, for a total net peptide content of 10 mg. The two compounds are co-formulated as a lyophilized powder in a single vial, batch-coded and verified before dispatch.
Why are BPC-157 and TB-500 combined in this formulation?
Both compounds are studied for their roles in tissue repair, but through different mechanisms that act at different points in the repair process. BPC-157 drives angiogenesis and vascular remodelling through VEGFR2-Akt-eNOS signalling. TB-500 expands the actin reserve cells use for migration toward an injury site and contributes its own independent angiogenic signal through VEGF and MMP-2. Because these mechanisms are considered complementary rather than redundant, researchers studying multi-pathway repair models often examine the two compounds together.
How does this formulation differ from the standalone BPC-157 and TB-500 vials?
Pepta Supply offers BPC-157 and TB-500 separately at 10 mg each, as well as this pre-combined 5 mg plus 5 mg formulation. The combined vial is for researchers who want to study the two compounds together at equal ratios in a single batch-verified unit. Standalone vials provide full independent dosing control for protocols that require it.
Is BPC-157 + TB-500 the same formulation included in Glow Blend or Klow Blend?
Glow Blend and Klow Blend both contain BPC-157 (10 mg) and TB-500 (10 mg) alongside GHK-Cu (and, in the case of Klow Blend, KPV). The standalone BPC-157 plus TB-500 product contains only these two compounds at 5 mg each, without the additional copper peptide or anti-inflammatory component found in the larger blends.
Quality and Testing
What purity does this formulation meet?
Both BPC-157 and TB-500 in each vial are tested to a purity of 99% or above by independent third-party HPLC analysis. The test data is linked to the batch identifier on the vial and accessible via peptasupply.com/v/ or the QR code.
Where can I access the Certificate of Analysis?
Scan the QR code on the vial, or visit peptasupply.com/v/ and enter the batch number. The batch-specific Certificate of Analysis and HPLC data will be displayed. This documentation is publicly accessible and does not require a login or completed purchase.
Ordering and Shipping
What is the price and availability of BPC-157 + TB-500?
BPC-157 plus TB-500 is priced at 59.99 euros per vial, containing 10 mg of lyophilized multi-compound peptide, in stock and available for EU shipping with same-day dispatch for orders placed before 3:00 PM on working days.
What is the delivery timeline for EU orders?
Orders placed before 3:00 PM on working days are dispatched the same day. Most EU destinations receive their order within 1 to 3 business days. Free shipping applies to orders over 150 euros.
How should this product be stored after delivery?
Transfer the vial to refrigerated storage at 2 to 8 degrees Celsius upon receipt. Keep it away from direct light and moisture. Once reconstituted for research use, do not freeze the resulting solution.
Compliance
Is BPC-157 + TB-500 approved for human use?
No. Neither BPC-157 nor TB-500 has received regulatory approval for any human therapeutic use in any jurisdiction. Pepta Supply supplies this formulation exclusively for scientific and laboratory research by qualified professionals in controlled environments.
Who can purchase this product from Pepta Supply?
BPC-157 plus TB-500 is available to qualified researchers and professionals in laboratory settings. By completing a purchase, buyers confirm they are acquiring the compound for legitimate research purposes and accept full responsibility for ensuring their use complies with all applicable laws and regulations in their country.
Content prepared for research-use-only positioning on peptasupply.com. No statements constitute medical claims or endorsement for human use. Prepared by SERPISTAN for Pepta Supply B.V.