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Catalog No.
A3481
Growth hormone (GH) secretagogue
Background Chemical Properties Quality Control User Guide
Background
Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue. Ibutamoren mesylate (MK-0677) stimulates GH release through a pituitary and hypothalamic receptor that is different from the GH-releasing hormone receptor. MK-677is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. Ibutamoren mesylate (MK-0677) also alters metabolism of body fat and so may have application in the treatment of obesity.
Chemical Properties
Physical Appearance A crystalline solid Storage Store at -20°C M.Wt 624.77 Cas No. 159752-10-0 Formula C28H40N4O8S2 Synonyms MK-677;Crescendo;MK 0677;MK-0677;MK0677 Solubility Soluble in DMSO Chemical Name 2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid Canonical SMILES CC(C)(C(=O)NC(COCC1=CC=CC=C1)C(=O)N2CCC3(CC2)CN(C4=CC=CC=C34)S(=O)(=O)C)N.CS(=O)(=O)O Shipping Condition Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. General tips We do not recommend long-term storage for the solution, please use it up soon.
Quality Control
Chemical structure
User Guide
General User Guide for APExBIO Small Molecule Compounds