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Catalog No.
P1619
Recombinant Human Tβ4 (E.coli, Tag Free, Lyophilized)
Background Infomation Quality Control
Background
Thymosin Beta 4 is a naturally occurring peptide encoded by the TMSB4X gene located on Chr. X in humans. It is found in high concentrations in blood platelets, wound fluid and other tissues in the body. Tβ-4 is a major actin regulating peptide and the primary function is to stimulate the productions of T cells, which plays important part of the immune system. The thymosin beta-4 peptide, if used after a heart attack, might reactivate cardiac progenitor cells to repair damaged heart tissue.
Reference
1. Moon EY, Song JH, Yang KH. 2007. Oncol Res, 16: 507-16
2. Oh SY, Song JH, Gil JE, et al. 2006. Exp Cell Res, 312: 1651-7
3. Oh JM, Ryoo IJ, Yang Y, et al. 2008. Cancer Lett, 264: 29-35.
Information
Gene ID 7114 Accession # P62328 Alternate Names Fx Source Escherichia coli. M.Wt Approximately 4.9 kDa, a single non-glycosylated polypeptide chain containing 43 amino acids. AA Sequence SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 3 years from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4. Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. Biological Activity Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5 - 10 μg/ml. Shipping Condition Gel pack. Handling Centrifuge the vial prior to opening. Usage For Research Use Only! Not to be used in humans.
Quality Control
Quality Control & DataSheet
View current batch:
Purity > 97 % by SDS-PAGE and HPLC analyses. Endotoxin: Less than 1 EU/μg of rHuTβ4 as determined by LAL method. COA (Certificate Of Analysis) Datasheet