CJC-1295 NO DAC
Description
Research
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CJC-1295 NO DAC is a research peptide used in laboratory studies of GHRH receptor activity, peptide stability, and controlled signaling pathways in experimental models. This product is supplied strictly for research use only. It is not approved or intended for human or animal use, and any discussion of biological activity refers only to preclinical or in vitro research.
In contrast to DAC (Drug Affinity Complex) versions, which remain active for extended periods because of the affinity complex that binds to serum proteins, the NO-DAC form is intentionally brief in duration. This characteristic allows for more precise timing, closer alignment with natural GH pulsatility, and a cleaner signaling window that is often advantageous in controlled studies. Research protocols examining circadian influences, acute cellular responses, metabolic pathways, and tissue-specific GH interactions frequently utilize this short-acting design for data accuracy.
For laboratory applications, CJC-1295 NO DAC is typically supplied as a high purity, LPS-free peptide, manufactured under controlled conditions to support experimental consistency. Each batch is produced as an endotoxin-free peptide, with research peptides endotoxin tested to help ensure suitability for sensitive in-vitro and ex-vivo research environments. These quality attributes are particularly important in studies where immune activation, inflammatory signaling, or cellular stress responses may influence experimental outcomes.
This compound is intended strictly for research purposes only. Not for human or animal use.
Overview
CJC-1295 NO DAC is a laboratory research material used to study receptor signaling, peptide kinetics, and time-dependent endocrine pathway behavior in controlled experimental systems. References to biological effects are provided for scientific context only and must not be interpreted as claims of therapeutic, diagnostic, or clinical benefit. This product is not offered for human or veterinary use.
CJC-1295 (No DAC) : Structure
Type: GHRH (1–29) analog Peptide Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 Length: 29 amino acids Molecular Formula: C152H252N44O42 Molecular Weight: ~3368.7 g/mol
Research Context
This compound is used in laboratory settings to examine short-acting receptor-mediated signaling and downstream pathway responses. Any mention of pulse timing, signaling windows, or experimental precision relates only to research methodology and does not imply human-use benefits.
Key Areas of Interest
Receptor-binding research
Short-acting peptide kinetics
Signal-duration studies
Experimental pathway analysis
Circadian timing models
Protein signaling research
Laboratory assay development
All uses are limited to research settings only. This product is not intended for diagnosis, treatment, prevention, or consumption.
Mechanism of Action in Research
In laboratory models, this peptide is used to investigate receptor-mediated signaling events and downstream experimental readouts. Any references to endocrine pathways, IGF-1, or timing-dependent signaling are included only to describe research context and must not be interpreted as claims of human or animal use.
Product and Supply Information
Licensed Peptides supplies research-grade CJC-1295 NO DAC for laboratory use only. All materials are labeled for research purposes and are intended solely for in vitro, ex vivo, or other controlled laboratory applications. This product is not offered as a clinical, diagnostic, or therapeutic material.
Frequently Asked Questions (FAQ)
(All responses are research-focused and do not imply human or animal application.)
1. What is CJC-1295 NO DAC?
CJC-1295 NO DAC is a laboratory research peptide used to study receptor signaling and peptide kinetics in controlled models.
2. How is it used in research?
It is used to examine short-duration signaling responses and related assay behavior in experimental settings.
3. What research areas may use it?
Researchers may use it in receptor-binding studies, pathway analysis, and assay development.
4. Does this page describe human-use benefits?
No. Any scientific discussion on this page is limited to research context only and should not be interpreted as a human or animal use claim.
5. How does high purity impact experimental reliability?
A high purity peptide reduces variability caused by synthesis byproducts or impurities. This allows researchers to achieve more consistent, reproducible results when studying GH-related signaling and molecular interactions.
6. Is this peptide suitable for use in sensitive cell-based assays?
Yes, when supplied as an endotoxin free peptide and verified as research peptides endotoxin tested, CJC-1295 NO DAC is well-suited for controlled laboratory studies, including cell culture and mechanistic research applications.
CJC-1295 No DAC: Research
CJC-1295 No DAC & Intestine
Researchers developed several stable analogues of growth hormone-releasing factor (GRF) to explore their therapeutic potential. One potent analogue, GRF-6, caused severe diarrhea in monkeys during prolonged infusion but had no adverse effects in rats. Since GRF shares structural similarities with VIP/PACAP peptides, which are known to cause diarrhea when overproduced, the study examined whether GRF analogues interact with VIP/PACAP receptors.
Key Results:
Native hGRF(1-29) had weak binding to rat and human VPAC1/VPAC2 receptors, while VIP bound strongly.
GRF-6 showed weak binding to rat receptors but higher affinity for the human VPAC1 receptor (not VPAC2).
In guinea pig pancreatic cells, all GRF analogues acted as full agonists, triggering enzyme release.
Conclusion
Unlike natural hGRF, GRF-6 selectively interacts with the human VPAC1 receptor, which likely explains the diarrhea observed in monkeys. The study highlights important species differences in receptor responses, stressing the need to test peptide agonists on human or closely related cells before therapeutic use.
Thyroid Hormone Therapy Restores Growth Hormone Response to GRF in Hypothyroidism
People with hypothyroidism often show reduced growth hormone (GH) responses. This study tested how GH reacts to growth hormone–releasing factor (GRF) in 14 patients with primary hypothyroidism, both before and after thyroid hormone (T4) replacement therapy.
When patients received daily T4 treatment, their GH response to GRF significantly improved. Peak GH levels nearly doubled, and the overall GH release (measured by the area under the curve) increased in most patients.
Thyroid hormone replacement helps restore the pituitary gland’s ability to respond to GRF, showing that proper thyroid function is important for normal GH regulation in people with hypothyroidism.
Referenced Citations
Ito T, Igarashi H, Pradhan TK, Hou W, Mantey SA, Taylor JE, Murphy WA, Coy DH, Jensen RT. GI side-effects of a possible therapeutic GRF analogue in monkeys are likely due to VIP receptor agonist activity. Peptides. 2001 Jul;22(7):1139-51. doi: 10.1016/s0196-9781(01)00436-3. PMID: 11445245.
Valcavi R, Jordan V, Dieguez C, John R, Manicardi E, Portioli I, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon MF. Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clin Endocrinol (Oxf). 1986 Jun;24(6):693-8. doi: 10.1111/j.1365-2265.1986.tb01666.x. PMID: 3098458.
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products available on this website are intended solely for in-vitro research purposes (Latin: “in glass”), meaning they are used in experiments conducted outside a living organism. These products are not medicines or drugs, have not been evaluated or approved by the U.S. Food and Drug Administration (FDA), and are not intended to diagnose, treat, cure, or prevent any disease or medical condition. Any administration to humans or animals, whether by ingestion, injection, or other means, is strictly prohibited by law.
Research
Our peptides are produced exclusively for laboratory and scientific research purposes.
Licensed PeptidesTM products are developed using industry-standard synthesis and purification protocols, making them suitable for in vitro research, analytical testing, and experimental models.
Research-Grade Standards
Synthesized via Solid Phase Peptide Synthesis (SPPS)
Purified using advanced HPLC methods
Verified through analytical quality control processes
Screened for heavy metals and endotoxins
Consistency Across Batches
Strict process controls ensure reproducibility, allowing researchers to work with confidence across experiments.
Applications
Our peptides are commonly used in research involving:
Cellular signaling pathways
Tissue remodeling and repair mechanisms
Extracellular matrix regulation
Molecular biology and biochemical studies
Important Notice
All products are intended for research use only and are not for human or animal consumption, therapeutic use, or clinical application.
Why Buy From Us
At Licensed PeptidesTM, quality isn’t a claim. it’s a controlled, repeatable process.
Every peptide we produce follows a strict, pharma-grade workflow designed to ensure purity, stability, and consistency from synthesis to delivery.
What sets us apart:
ISO-Certified Cleanroom Manufacturing
All peptides are synthesized in sterile, controlled environments to eliminate contamination risk and ensure batch consistency.
>99% Verified Purity (HPLC Tested)
We use advanced High-Performance Liquid Chromatography (HPLC) to separate and verify peptide purity with precision.
Comprehensive Safety Testing
Each batch undergoes heavy metal and endotoxin screening to ensure it is free from hidden contaminants.
Pharma-Grade Raw Materials
We start with rigorously tested amino acids and reagents, ensuring integrity at the molecular level.
Lyophilized for Stability
Freeze-dried peptides maintain long-term stability, potency, and reliability for research applications.
Nitrogen-Sealed Vials
Every vial is protected from oxygen and moisture, preserving structural integrity during storage and transit.
Built for Serious Research
From synthesis to delivery, every step is engineered to meet the expectations of professionals who require accuracy, consistency, and reliability.
Shipping
We understand that timing and product integrity are critical for research.
Same-Day Shipping (USA)
All in-stock orders placed before our daily cutoff are shipped the same day from within the United States.
Fast Domestic Delivery (1–3 Days)
We use expedited carriers to ensure your peptides arrive quickly and reliably nationwide.
Cold Chain Protection
Products are stored in industrial-grade freezers prior to shipment to maintain stability and purity.
Secure & Protective Packaging
Each order is carefully packed to protect against temperature fluctuations, moisture exposure, and physical damage during transit.
Real-Time Tracking
You’ll receive tracking information immediately upon shipment so you can monitor delivery progress.
Consistency You Can Rely On
No long international delays, no customs issues. Just fast, dependable delivery from a U.S.-based operation.