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Product Code. 17843253
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200 μg
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1mg
200μg
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Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select. Product Code. Quantity unitSize 17843253 1 mg 1mg 17803513 200 μg 200μg
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Product Code. 17843253 Supplier GibcoTM Supplier No. AF10011R31MG
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Description
Recombinant Protein
Recombinant Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potency in vitro, IGF-I LR3 has an increased half-life and a binding aversion to native proteins within the body that make it ideal for both research and large-scale culturing.
Specifications
Specifications
Accession Number P05019 For Use With (Application) Functional Assay Formulation protein with no preservative Gene ID (Entrez) 3479 Molecular Weight (g/mol) 9.1 kDa Name Human IGF-I LR3, Animal-Free Quantity 1 mg Source E. coli Regulatory Status RUO Endotoxin Concentration <0.1 EU/ μg Gene Alias IGF-I Common Name IGF-I LR3 Gene Symbol IGF1 Biological Activity The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg Conjugate Unconjugated Recombinant Recombinant Sequence MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA Content And Storage -20°C Expression System E. coli Form Lyophilized Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses. Show More Show Less
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