Peptide record
Function
BPC-157 is a Signal peptide.
This Peptide is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects111
Mechanism
BPC-157 is a synthetic 15-amino-acid fragment of a gastric cytoprotective protein that promotes angiogenesis and tissue protection primarily by modulating VEGFR2 signaling, Src/caveolin-1–dependent eNOS activation, and nitric oxide production111
BPC-157 is a Signaling modulator.
Receptor
VEGFR2 (vascular endothelial growth factor receptor 2) on endothelial cells, with downstream eNOS and nitric-oxide–mediated signaling11
Length
15 amino acids
Organism or Origin
Synthetic peptide derived from a naturally occurring human gastric 'Body Protection Compound' isolated from human gastric juice111
Gene
Not assigned in the current dataset.
Sequence
GEPPPGKPADDAGLV 111
Glycine, Glutamic acid, Proline, Proline, Proline, Glycine, Lysine, Proline, Alanine, Aspartic acid, Aspartic acid, Alanine, Glycine, Leucine, Valine
15 residuesapprox. 1401.55 Dacharge +1 / -3 / net -2special 7 • acidic 3 • basic 1 • hydrophobic 4
Sequence-derived properties
Length
15 residues
Molecular weight
1419.57 Da
Average hydrophobicity
-0.69
Unique amino acids
8
Residue class composition
special
7 (46.7%)
hydrophobic
4 (26.7%)
acidic
3 (20%)
basic
1 (6.7%)
Charge-category composition
neutral
11 (73.3%)
negative
3 (20%)
positive
1 (6.7%)
Amino acid composition
Proline (Pro/P)
4 (26.7%)
Glycine (Gly/G)
3 (20%)
Alanine (Ala/A)
2 (13.3%)
Aspartic acid (Asp/D)
2 (13.3%)
Glutamic acid (Glu/E)
1 (6.7%)
Leucine (Leu/L)
1 (6.7%)
Lysine (Lys/K)
1 (6.7%)
Valine (Val/V)
1 (6.7%)
Sources
1BPC-157 Research — Mechanism of Action, Preclinical Studies ..., https://peptide.co/research/bpc-157/ 11BPC-157 - Wikipedia, https://en.wikipedia.org/wiki/BPC-157
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