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Dermorphin, a new opioid peptide, stimulates thyrotropin

Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects E Roti et al. J Endocrinol Invest. 1984 Jun. Abstract The effect of a recently described, potent opioid peptide, dermorphin (DER), on TSH secretion in euthyroid subjects has been studied. DER infused at a rate of 5.5 micrograms/Kg/min for 30 min induced a significant increase in serum TSH concentration at 60, 90, and 120 min after the infusion was begun. Treatment with naloxone administered 30 min before the DER infusion with a bolus dose of 4 mg, followed by a constant infusion of 1 microgram/Kg/min for 150 min, prevented the rise in serum TSH. Naloxone administered alone did not induce any change in TSH concentration. The present findings suggest that DER has a stimulatory effect on TSH secretion, probably mediated by opioid receptors. These results, however, do not solve the question as to whether opioids have a physiological role in the control of pituitary TSH secretion. PubMed Disclaimer Referen

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Dermorphin, a new opioid peptide, stimulates thyrotropin secretion in normal subjects

E Roti et al. J Endocrinol Invest. 1984 Jun.

Abstract

The effect of a recently described, potent opioid peptide, dermorphin (DER), on TSH secretion in euthyroid subjects has been studied. DER infused at a rate of 5.5 micrograms/Kg/min for 30 min induced a significant increase in serum TSH concentration at 60, 90, and 120 min after the infusion was begun. Treatment with naloxone administered 30 min before the DER infusion with a bolus dose of 4 mg, followed by a constant infusion of 1 microgram/Kg/min for 150 min, prevented the rise in serum TSH. Naloxone administered alone did not induce any change in TSH concentration. The present findings suggest that DER has a stimulatory effect on TSH secretion, probably mediated by opioid receptors. These results, however, do not solve the question as to whether opioids have a physiological role in the control of pituitary TSH secretion.

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References

Int J Pept Protein Res. 1982 May;19(5):536-42 - PubMed

Br J Pharmacol. 1981 Jul;73(3):625-31 - PubMed

Arch Int Pharmacodyn Ther. 1958 Oct 1;117(1-2):151-7 - PubMed

Int J Pept Protein Res. 1981 Mar;17 (3):275-83 - PubMed

Life Sci. 1981 Oct 12;29(15):1537-44 - PubMed

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