Thymosin beta-4 (Tβ4, also commonly sold as "TB-500") is the dominant healing-and-recovery peptide on the research market alongside BPC-157. The published clinical data is concentrated on dermal wound healing — Philp et al. (2013) documented Tβ4 accelerating dermal healing in animal models and Phase 2 trials in venous and pressure ulcers showed healing acceleration of nearly a month.
Research-context information only. Thymosin beta-4 is a research peptide. It is on the FDA 503A bulks Category 2 list. Protocols, doses, and reactions reported below come from published research and self-reported community sources. This article reports what has been documented, not what should be done. Consult a licensed physician for personal medical decisions.
The buying problem is that "TB-500" and "thymosin beta-4" are used interchangeably by vendors despite originally referring to slightly different products. Verifying 4,963 Da on mass spec is the only reliable distinction — full Tβ4 at 43 residues vs truncated synthetic fragments.
This guide covers documented per-mg pricing, COA verification, vial size selection, and red flags. For dosing context, see the TB-500 dosing guide. For the alternative TB-500 buying guide, see TB-500 buying guide.
This is not a ranked vendor list — for that, see our Best Thymosin Beta-4 Vendors comparison.
Understanding Thymosin Beta-4 Pricing
Tβ4 ships as a lyophilized powder in sealed glass vials. Three factors drive price: vial size, vendor markup, and synthesis quality (full Tβ4 vs truncated fragments).
Current Market Pricing (2026)
2mg
$15-30
$7.50-15/mg
Tolerance testing only
5mg
$30-60
$6-12/mg
Standard short cycles
10mg
$50-100
$5-10/mg
Standard 250-500mcg/day — best all-around
10mg × 5 (kit)
$220-450
$4.40-9/mg
Extended cycles
The pattern: 10mg vials are the most-cited size for cost efficiency. Per-mg pricing is similar to BPC-157 despite Tβ4 being a longer peptide — vendor competition is high in this category.
Cost Per Month at Common Doses
250 mcg/day (loading)
7.5 mg
$40-75
$35-67
500 mcg/day (high loading)
15 mg
$80-150
$70-135
250 mcg 3×/week (maintenance)
3 mg
$13-27
For current vendor-specific pricing, see our Best Thymosin Beta-4 Vendors comparison.
Cheapest single-vial option: EZ Peptides's 10% off drops the 10mg vial to $61.20 ($6.12/mg effective) — the lowest effective price we track for buying one vial. Get the code →
How to Verify Thymosin Beta-4 Quality
Tβ4 is a 43-amino-acid peptide. At 43 residues, solid-phase peptide synthesis yields drop sharply, and truncated byproducts are common synthesis impurities.
What a COA Should Include
Identity Confirmation
Mass spec confirming 4,963 Da for full Tβ4
Sequence verification — 43-residue full sequence
Truncation byproducts (Tβ4 fragments at 2,000-4,000 Da) noted as separate peaks if present
Purity Testing
HPLC purity at 98%+ (challenging at 43 residues — 95-98% is more common)
Single dominant peak; truncation byproducts visible as smaller secondary peaks
Water content (Karl Fischer) under 8%
Contamination Testing
Endotoxin levels
Residual solvent analysis
Heavy metals screening
How to Verify a COA Is Legitimate
Third-party lab — Janoshik, MZ Biolabs, Colmaric most-cited
Verifiable task number at the lab's website
Recent date (within 6 months)
Batch match with the vial label
4,963 Da mass confirmation — significantly different mass indicates truncated Tβ4 fragment
Red Flags to Avoid
No COA available
Only in-house testing
Prices below $3/mg — likely truncated fragment substitution
No mass spec
HPLC showing multiple peaks without explanation
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