GHRP-6 5MG
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For this product you will need: BACTERIOSTATIC WATER For reconstitution.
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Bacteriostatic Water 10ML
What Is GHRP-6 5MG?
Growth hormone-releasing peptide 6 (GHRP-6) is a synthetic hexapeptide that mimics the action of GHRH. It binds with growth hormone receptor in the pituitary gland and stimulates the release of growth hormone (GH). Plus, it acts as an agonist of ghrelin, a hormone produced in the gut, which is involved in appetite regulation and GH release.
It was first developed in 1980 and became the first member of the class growth hormone secretagogue. Research shows that GHRP-6 can increase body mass, enhance strength, improve memory and reduce scar formation. It is used in research settings and scientific experiments. On our website, GHRP-6 for sale is restricted to research purposes.
Structure Of GHRP-6 5MG
From Pubchem
IUPAC Name: ((2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamideSynonym: GH-Releasing peptide, 87616-84-0Molecular Formula: C46H56N12O6Molecular Weight: 873.0 g/molSequence: HWAWFKCAS Number: 87616-84-0PubChem CID: 9919153
GHRP-6 5MG Uses In Research
1. GHRP-6 and Heart Health
GHRP-6 has been shown to have beneficial cardiovascular effects. In a study, researchers assessed the role of GHRP-6 on myocardial infarct size following occlusion of the coronary artery in pigs. Animals were randomly assigned to receive either GHRP-6 or normal saline. The result found reduced infarct mass and thickness by 78% and 50% respectively. Further, researchers noticed a decrease in reactive oxygen species and suggested that the anti-oxidant activity of GHRP-6 played a role in reducing myocardial ischemic damage [1].
Another study assessed the effect of growth hormone-releasing peptides on chronic heart failure. Rats with chronic heart failure, induced by abdominal aortic binding, were given either growth hormone-releasing peptides, including GHRP-6, or saline water twice a day for three days. Researchers observed increased left ventricular ejection fraction and end-diastolic pressure of left ventricles. Further, the progression of cardiac cachexia, characterized by muscle wasting, was decelerated, and reduced levels of ANP, renin, and aldosterone were detected. It was suggested that these effects were achieved by blocking stress-induced neurohormonal activations and cardiomyocyte apoptosis [2].
2. GHRP-6 and Memory
Research on animal models shows that GHRP-6 may improve memory and cognitive function. One study in the rat model of Alzheimer's Disease found that GHRP-6 administration significantly improved cognitive function through Barne’s maze task [3].
Scientific evidence indicates that ghrelin mediates its effect on memory by releasing glutamate levels at the presynaptic stage, which bind to NMDA receptors postsynaptically. Further, it increases the expression of NR2B-subunits, facilitating memory-related processes. These effects appear to result from the activation of the GHS-R1a receptor [4].
3. GHRP-6 and Gastric Emptying Time
Ghrelin is a gut hormone that has been known to influence various parameters of the gastrointestinal tract. Recent research shows that it increases gastric motility and affects gastric emptying time. One study investigated the effect of GHRP-6 in diabetic rats with gastroparesis, a process characterized by delayed gastric emptying. Researchers found increased gastric emptying time with the administration of GHRP-6. However, it failed to accelerate gastric emptying time in the presence of a growth hormone secretagogue receptor antagonist, indicating the importance of GHRP-6 in affecting gastric emptying time [5].
Another study conducted on mice with septic ileus found increased gastric emptying time with ghrelin and GHRP-6, indicating its potential to be used for the treatment of gastric ileus [6]. Activation of the peripheral cholinergic pathway in the enteric nervous system by ghrelin or GHRP-6 might be involved in mediating these effects.
4. GHRP-6 and Stroke
GHRP-6 has been shown to protect neuronal cells from injury. In one study, researchers found that co-administration of epidermal growth factor and GHRP-6 following the ischemic insult improved survival and reduced infarct size as compared to placebo. Further, it can improve memory after the stroke attack [7].
5. GHRP6 and Wound Healing:
SResearch on animal models shows that GHRP-6 can improve wound closure, reduce scar formation and decrease inflammation through CD36 activation. CD36 is a receptor that when activated promotes blood vessel growth in wounds [8].
6. Current Status of GHRP-6
GHRP-6 is a synthetic peptide and the first member of the class, growth hormone secretagogue. Scientists are currently exploring its effect on cardiovascular problems, stroke, brain health and memory. It’s only used in research settings as FDA hasn’t approved it yet. We offer GHRP-6 purchase for research only. Shop from Element Sarm to buy GHRP-6 for your research.
Referenced Citations
Berlanga, J., et al., Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction. Clinical Science, 2007. 112(4): p. 241-250.
Xu, X.-B., et al., GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 2005. 289(4): p. H1643-H1651.
Madhavadas, S., B.M. Kutty, and S. Subramanian, Amyloid beta lowering and cognition enhancing effects of ghrelin receptor analog [D-Lys (3)] GHRP-6 in rat model of obesity. Indian J Biochem Biophys, 2014. 51(4): p. 257-62.
Ghersi, M.S., et al., Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor. Psychopharmacology, 2015. 232(10): p. 1843-1857.
Qiu, W.C., et al., Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis. World J Gastroenterol, 2008. 14(9): p. 1419-24.
De Winter, B.Y., et al., Effect of ghrelin and growth hormone-releasing peptide 6 on septic ileus in mice. Neurogastroenterology & Motility, 2004. 16(4): p. 439-446.
Subirós, N., et al., Assessment of dose–effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy. Neurological Research, 2016. 38(3): p. 187-195.
Mendoza Marí, Y., et al., Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds. Plast Surg Int, 2016. 2016: p. 4361702.
Certificate of Analysis (COA)
High Performance Liquid Chromatography (HPLC)
Mass Spectrometry (MS)
GHRP-6 5MG — Research Grade
C46H56N12O6
873.0 g/mol
87616-84-0
ES-GH-6
GHRP-6 is a synthetic hexapeptide and one of the earliest characterised members of the GHRP compound class. As a GHSR-1a agonist, it activates the ghrelin receptor independently of GHRH receptor pathways and serves as a standard reference compound in GHRP pharmacology research.
Used in research examining GHSR-1a binding affinity, competitive displacement assays relative to endogenous ghrelin, and intracellular signalling cascade activation in GHSR-1a-expressing cell line models.
Element SARMs supplies GHRP-6 at 5mg per vial. USA-manufactured via solid-phase methodology and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitute with bacteriostatic water. Store lyophilised at -20C.
WARNING: For research purposes only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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