Follistatin-344 (FS-344) is the predominant isoform of follistatin, an endogenous glycoprotein that functions as a high-affinity binding protein for multiple members of the TGF-β superfamily. By sequestering ligands including activins, myostatin (GDF-8), and selected bone morphogenetic proteins (BMPs), Follistatin-344 prevents receptor engagement and downstream Smad-dependent signal transduction. Experimental studies have utilized FS-344 to investigate activin receptor signaling, myostatin-associated regulatory pathways, TGF-β superfamily biology, ligand-receptor interaction dynamics, and Smad2/3- and Smad1/5/8-mediated transcriptional regulation. Its broad ligand-binding profile and well-characterized mechanism make Follistatin-344 a valuable research tool for studies of growth factor signaling networks, extracellular ligand sequestration, pathway cross-talk within the TGF-β superfamily, and comparative investigations of myostatin and activin antagonism.
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Follistatin-344 1mg1 vial | KIT (10 vials)