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Where These Numbers Come From
CJC-1295 DAC is unique among GH secretagogues in having direct human clinical trial data.
Pivotal study: Teichman et al. studied CJC-1295 DAC in 36 healthy adults (21-61 years). Single doses of 30, 60, or 120 mcg/kg produced dose-dependent GH and IGF-1 increases. IGF-1 increased 1.5-3 fold and remained elevated for 6-14 days. Mean half-life: 5.8-8.1 days (Teichman et al., 2006).
Preserved pulsatility: Despite continuous GHRH stimulation, pulsatile GH secretion was maintained. GH pulse frequency preserved with 2-fold increases in mean GH and pulse mass (Ionescu & Bhatt, 2006).
Animal studies: CJC-1295 normalized growth in GHRH knockout mice with once-daily dosing (Alba et al., 2006).
Community doses (1-4 mg twice weekly) target upper-normal IGF-1 based on clinical dose ranges and empirical blood work confirmation.
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Stacking Protocols
DAC + Bedtime GHRP
CJC-1295 DAC 2 mg 2x/week + Ipamorelin 100-200 mcg nightly
Sustained IGF-1 + acute bedtime GH pulse
DAC Standalone
CJC-1295 DAC 2 mg 2x/week
Simplicity -- no daily injections needed
Stacking tips: Combining with another GHRH analog (sermorelin, no-DAC CJC) is generally described as redundant rather than synergistic — they share the same GHRH receptor, so a second analog adds little once one saturates the response. The documented synergy is GHRH + GHRP (e.g., ipamorelin), which acts on a different receptor. Monitor IGF-1 carefully when stacking. Combining with exogenous GH is not described in community protocols.
Side Effects & Safety
Injection site reactions -- most common in clinical trials (mild erythema, pain)
Flushing/warmth -- transient, 15-30 min post-injection
Water retention -- more pronounced than no-DAC due to sustained GH elevation
Numbness/tingling -- carpal tunnel-like symptoms at higher doses
Joint stiffness -- GH-mediated fluid retention
Insulin resistance -- monitor fasting glucose; sustained GH can impair glucose tolerance
No serious adverse events reported in published clinical trials
Contraindications -- active malignancy, diabetic retinopathy, pregnancy
Monitoring (community protocols): Community sources and trial safety protocols describe monitoring IGF-1 at baseline, week 4, and every 8 weeks, targeting 250-330 ng/mL. Fasting glucose is commonly tracked monthly; HbA1c at 3-month intervals when insulin resistance is a concern.
mg to Units Conversion
On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL). Once CJC-1295 DAC is reconstituted, the conversion from a target dose to syringe units depends on the chosen dilution.
The two reconstitution ratios most often described in community protocols are below.
Reconstitution A: 5 mg vial + 2.5 mL BAC water (2 mg/mL) — the standard dilution from the Quick Reference above.
1 mg
0.5 mL
50 units
2 mg
1 mL
100 units
Reconstitution B: 5 mg vial + 1 mL BAC water (5 mg/mL) — less BAC water for a lower total volume, so smaller draws and less fridge space.
0.2 mL
20 units
0.4 mL
40 units
These conversions reflect the dilutions documented in community reconstitution protocols. They report how the math is described, not a recommended dosing schedule.
Core Supplies for This Protocol
The three essentials for running any reconstituted injectable: cold storage, accurate syringes, and metabolic tracking.
Cooluli Classic 4L Mini Fridge
Compact thermoelectric mini-fridge with heat/cool toggle. The most-mentioned dedicated peptide-storage fridge in research community sources — fits ~20 vials and runs quietly.
BD Ultra-Fine 31G 0.3cc 5/16" Insulin Syringes (Box of 90)
0.3cc 31G syringes — each gradation marks 1 unit (vs 2 units on 1cc), making sub-50-unit peptide doses accurate. BD Ultra-Fine is the most widely-cited brand in peptide community sources.
CONTOUR NEXT GEN Glucose Meter All-In-One Kit
Ascensia's CONTOUR NEXT GEN — the most clinically-validated home glucose meter. Includes 20 test strips + lancing device. Tracks the blood-sugar response GLP-1 users care about, especially during dose escalation.
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