Tev-Tropin [somatropin (rDNA origin)] for Injection 5 mg and 10 mg

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C)-3 (l)-2 (e)4 (a)4 (n t)-2 (he)4 ( i)-2 (nj)-2 (e)-6 (c)4 (t)-2 (i)-2 (on s)-1 (i)-2 (t)-2 (e)4 ( w)2 (i)-2 (t)-2 (h a)4 (n a)4 (l)-2 (c)4 (ohol)-2 ( s)-1 (w)2 (a)4 (b, )]TJ 0 -1.15 TD [(us)-1 (i)-2 (ng)10 ( a)4 ( c)4 (i)-12 (r)3 (c)4 (ul)-2 (a)4 (r)3 ( p)-10 (a)4 (t)-2 (t)-2 (e)4 (r)3 (n, )-10 (a)-6 (nd w)2 (or)3 (k f)3 (r)3 (om)-2 ( t)-2 (he)4 ( i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (o)-10 (n s)-1 (i)-2 (t)-2 (e)4 ( out)-2 (w)2 (a)4 (r)3 (d a)4 (bout)-2 ( 2 i)-2 (n)-10 (c)4 (he)4 (s)-1 (. )]TJ T* [(A)2 (l)-2 (l)-2 (ow)2 ( t)-2 (he)4 ( a)4 (l)-2 (c)4 (ohol)-2 ( t)-2 (o dr)-17 (y )10 (be)4 (f)3 (or)3 (e )-6 (g)10 (i)-2 (vi)-2 (n)-10 (g)10 ( t)-2 (he)4 ( i)-2 (nj)-2 (e)-6 (c)4 (t)-2 (i)-2 (on. )]TJ EMC /LI_Label <>BDC 0 -2.3 TD [($)3 (3$)3 ( )]TJ EMC /LI_Title <>BDC [(C)-3 (he)4 (c)4 (k t)-2 (ha)4 (t)-2 ( t)-2 (he )-6 (c)4 (or)3 (r)-7 (e)4 (c)4 (t)-12 ( dos)-1 (e)4 ( i)-2 (s)-1 ( i)-2 (n t)-2 (he)4 ( s)-11 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e )-6 (a)4 (n)-10 (d r)3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( ne)-6 (e)4 (dl)-2 (e)4 ( c)-6 (a)4 (p. )-10 (H)2 (ol)-2 (d t)-2 (he )]TJ 0 -1.15 TD [(s)-11 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 ( t)-2 (h)-10 (e)4 ( w)2 (a)-16 (y y)20 (ou hol)-2 (d)-10 ( a)4 ( pe)4 (nc)4 (i)-2 (l)-2 (. )]TJ EMC /LI_Label <>BDC 0 -2.3 TD [($)3 (4$)3 ( )]TJ EMC /LI_Title <>BDC [(W)-6 (i)-2 (t)-2 (h )-10 (y)20 (our)3 ( f)-7 (r)3 (e)4 (e)4 ( h)-10 (a)4 (nd, )-10 (pi)-2 (nc)4 (h t)-2 (he)4 ( c)4 (l)-2 (e)4 (a)4 (ns)-11 (e)4 (d s)-1 (ki)-2 (n be)4 (t)-2 (w)2 (e)4 (e)4 (n )-20 (y)20 (our )-7 (f)3 (i)-2 (n)-10 (g)10 (e)4 (r)3 (s )-11 (a)4 (nd )-10 (qui)-2 (c)4 (kl)-12 (y )]TJ EMC ET /Figure <>BDC BT 12 0 0 12 116.7352 599.8181 Tm [(i)-2 (ns)-1 (e)4 (r)3 (t)-2 ( t)-2 (he)4 ( ne)4 (e)4 (dl)-2 (e)4 ( i)-2 (nt)-2 (o t)-2 (he )-6 (s)-1 (ki)-2 (n a)4 (t)-2 ( a)4 ( 45\260 -)-247 (90\260 a)4 (n)-10 (g)10 (l)-2 (e )-6 (w)2 (i)-2 (t)-2 (h a)4 ( qui)-2 (c)4 (k, f)3 (i)-2 (r)3 (m)-2 ( w)2 (r)3 (i)-2 (s)-1 (t )-12 (m)-2 (ot)-2 (i)-2 (on. )]TJ ET q /GS0 gs 152.2999829 0 0 -143.2999649 116.7951579 596.7580261 cm /Im0 Do Q EMC BT /LI_Label <>BDC 12 0 0 12 116.7352 428.9381 Tm [($)3 (5$)3 ( )]TJ EMC /LI_Title <>BDC [(H)2 (ol)-2 (di)-2 (ng)10 ( t)-2 (h)-10 (e)4 ( s)-21 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 ( i)-12 (n pl)-2 (a)4 (c)4 (e)4 (, pul)-2 (l)-2 ( ba)4 (c)4 (k )-10 (a)4 ( l)-2 (i)-2 (t)-2 (t)-2 (l)-2 (e)4 ( on t)-2 (he)4 ( pl)-2 (ung)10 (e)-6 (r)3 ( a)4 (nd c)4 (h)-10 (e)4 (c)4 (k)-10 ( t)-2 (o s)-1 (e)4 (e)4 ( i)-2 (f )]TJ 0 -1.15 TD [(a)4 (n)-10 (y)20 ( bl)-2 (ood )-10 (f)3 (l)-2 (ow)2 (s)-1 ( i)-2 (nt)-2 (o t)-2 (he)4 ( s)-11 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e )-6 ($)3 (ve)4 (s)-1 (s)-1 (e)4 (l )-12 (c)4 (he)4 (c)4 (k)-10 ($)3 (. )-10 (I)13 (f )-17 (y)20 (ou s)-1 (e)-6 (e)4 ( bl)-2 (ood i)-2 (n t)-2 (he)4 ( s)-11 (y)20 (r)3 (i)-12 (ng)10 (e)4 (, )]TJ T* [(r)3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( ne)-6 (e)4 (dl)-2 (e)4 ( a)4 (nd s)-21 (y)10 (r)3 (i)-2 (ng)10 (e )-6 (a)4 (nd di)-2 (s)-1 (c)4 (a)-6 (r)3 (d. Y)2 (ou w)-8 (i)-2 (l)-2 (l)-2 ( t)-2 (he)4 (n ne)4 (e)4 (d t)-2 (o pr)3 (e)4 (pa)-6 (r)3 (e)4 ( a )-6 (ne)4 (w )]TJ 0.002 Tc -0.002 Tw T* [(s)-9 (y)22 (r)5 (in)-8 (g)12 (e )-4 (f)5 (o)2 (r)5 ( in)2 (je)6 (c)6 (tio)2 (n)2 (. )]TJ EMC ET /Figure <>BDC q /GS0 gs 152.2999845 0 0 -137.299993 116.7951656 370.8080445 cm /Im1 Do Q EMC BT /LI_Label <>BDC -0.003 Tc 0.003 Tw 12 0 0 12 116.7352 208.9781 Tm [($6)-3 ($ )]TJ EMC /LI_Title <>BDC 1.42 0 Td [(I)10 (f,)-3 ( d)-3 (u)]TJ 0 Tc 0 Tw 2.16 0 Td [(r)3 (i)-2 (ng)10 ( t)-2 (h)-10 (e)4 ( ve)4 (s)-1 (s)-1 (e)4 (l)-2 ( c)-6 (he)4 (c)4 (k, )-20 (y)20 (ou s)-1 (e)4 (e )-6 (no bl)-2 (ood, t)-2 (he)4 (n s)-1 (l)-2 (ow)2 (l)-12 (y)20 ( pus)-1 (h dow)2 (n pl)-12 (ung)10 (e)-6 (r)3 ( unt)-2 (i)-2 (l )]TJ 0.002 Tc -0.002 Tw -3.58 -1.15 Td [(th)2 (e)6 ( s)-9 (y)22 (r)5 (in)-8 (g)2 (e)6 ( is)1 ( c)6 (o)2 (mp)2 (le)6 (te)6 (l)-20 (y)12 ( e)6 (mp)2 (t)-10 (y)22 (. )]TJ EMC /LI_Label <>BDC 0 Tc 0 Tw 0 -2.3 TD [($)3 (7$)3 ( )]TJ EMC /LI_Title <>BDC [(Q)2 (ui)-2 (c)4 (kl)-22 (y)20 ( r)3 (e)4 (m)-2 (ov)-10 (e)4 ( t)-2 (he)4 ( n)-10 (e)4 (e)4 (dl)-2 (e)4 ( f)-7 (r)3 (om)-2 ( t)-2 (he)4 ( s)-1 (ki)-2 (n a)4 (nd a)-6 (ppl)-12 (y)20 ( pr)3 (e)4 (s)-1 (s)-1 (u)-10 (r)3 (e)4 ( t)-2 (o t)-2 (he)4 ( i)-2 (nj)-2 (e)4 (c)-6 (t)-2 (i)-2 (on s)-1 (i)-2 (t)-2 (e )]TJ 0 -1.15 TD [(w)2 (i)-2 (t)-2 (h a)4 ( dr)-17 (y)20 ( s)-1 (t)-2 (e)4 (r)3 (i)-2 (l)-2 (e )-6 (g)10 (a)4 (uz)-6 (e)4 ( p)-10 (a)4 (d or)3 ( c)4 (ot)-2 (t)-2 (on ba)4 (l)-2 (l)-2 (. A)2 ( dr)3 (op )-10 (of)3 ( bl)-2 (ood m)-2 (a)-6 (y )10 (a)4 (ppe)4 (a)-6 (r)3 (. A)2 (p)-10 (pl)-12 (y)20 ( a)4 ( s)-1 (m)-2 (a)4 (l)-2 (l )]TJ -0.004 Tc 0.004 Tw T* [(b)-4 (an)-4 (d)-4 (a)-10 (g)6 (e i)-6 (f)-1 ( d)-14 (es)-5 (i)-6 (r)-1 (ed)-4 (. )]TJ EMC /LI_Label <>BDC 0 Tc 0 Tw 0 -2.3 TD [($)3 (8$)3 ( )]TJ EMC /LI_Title <>BDC [(D)2 (i)-2 (s)-1 (pos)-1 (e)4 ( of)3 ( n)-10 (e)4 (e)4 (dl)-2 (e )-6 (a)4 (n)-10 (d s)-11 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 ( i)-2 (n )-10 (a)4 ( pr)3 (ope)-6 (r)3 ( c)4 (on)-10 (t)-2 (a)4 (i)-2 (ne)4 (r)3 ( i)-2 (de)4 (nt)-2 (i)-2 (f)3 (i)-2 (e)4 (d b)-20 (y y)20 (our )-7 (ph)-10 (y)20 (s)-1 (i)-2 (c)4 (i)-2 (a)4 (n o)-10 (r )]TJ -0.004 Tc 0 -1.15 TD [(p)-4 (h)-4 (ar)-1 (m)-6 (aci)-6 (s)-5 (t)-6 (. )]TJ EMC /StyleSpan <>BDC 0 Tc 4.88 0 Td [(N)2 (e)4 (v)-10 (e)4 (r)3 ( di)-2 (s)-1 (pos)-11 (e)4 ( of)3 ( ne)4 (e)4 (dl)-12 (e)4 (s)-1 ( a)4 (nd s)-21 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 (s)-11 ( i)-2 (n )-10 (y)20 (our)3 ( hous)-1 (e)4 (hol)-2 (d t)-2 (r)-7 (a)4 (s)-1 (h)]TJ EMC /LI_Title <>BDC (. )Tj EMC /Artifact <>BDC 0 g /T1_0 1 Tf 10 0 0 10 44.7352 38.0981 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS1 gs /Fm0 Do Q EMC endstream endobj 529 0 obj <>>>/Resources 514 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 530 0 obj <> endobj 531 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 532 0 obj <> endobj 533 0 obj <>stream q 1 0 0 1 27.113281 13.187988 cm 0 0 595.32 841.92 re W n /Artifact <>BDC q 1 0 0 1 -27.113281 -13.187988 cm BT /CS0 cs 0.137 0.122 0.125 scn /TT0 1 Tf 3 Tr 12 0 0 12 231.4733 772.068 Tm [( )-1000 ( )-1670 ( )]TJ ET Q /CS0 cs 0.137 0.122 0.125 scn 90 756.36 152.4 1.2 re f* q 1 0 0 1 -27.113281 -13.187988 cm BT /TT1 1 Tf 3 Tr 12 0 0 12 131.1533 758.508 Tm ( )Tj /TT2 1 Tf 0.002 Tc -0.002 Tw 22.99 0 Td ( )Tj 0 Tc 0 Tw 3.03 0 Td ( )Tj -0.004 Tc 0.004 Tw 4.89 0 Td ( )Tj 0 Tc 0 Tw -8.25 -1.15 Td ( )Tj -23.83 -1.15 Td ( )Tj 0 -1.15 TD ( )Tj /CS1 cs 0 scn /TT0 1 Tf 10.26 -1.17 Td ( )Tj /CS0 cs 0.137 0.122 0.125 scn /TT2 1 Tf 3.51 -1.13 Td ( )Tj 6.89 0 Td ( )Tj 9.49 0 Td [( )-1230 ( )]TJ -23.52 -1.15 Td ( )Tj -0.004 Tc 0.004 Tw 20.27 0 Td ( )Tj 0.002 Tc -0.002 Tw -22.76 -1.15 Td ( )Tj 0 Tc 0 Tw 3.03 0 Td ( )Tj 25.79 0 Td ( )Tj -26.33 -1.15 Td [( )-1760 ( )]TJ -6.63 -1.15 Td ( )Tj 20.21 -1.15 Td [( )-2660 ( )]TJ 9.82 0 Td [( )-4120 ( )]TJ ET Q 335.52 605.4 31.92 0.599 re f q 1 0 0 1 -27.113281 -13.187988 cm BT /TT3 1 Tf 3 Tr 12 0 0 12 150.4733 606.708 Tm ( )Tj /TT2 1 Tf 14.35 0 Td [( )-3040 ( )]TJ 15.67 0 Td ( )Tj ET Q 280.2 591.6 15.36 0.6 re f q 1 0 0 1 -27.113281 -13.187988 cm BT /TT3 1 Tf 3 Tr 12 0 0 12 150.4733 592.908 Tm ( )Tj /TT2 1 Tf 0.002 Tc -0.002 Tw 3.42 0 Td ( )Tj 0 Tc 0 Tw 6.88 0 Td ( )Tj 6.72 0 Td ( )Tj 12.42 0 Td ( )Tj -19.87 -1.15 Td ( )Tj -12.35 -1.15 Td ( )Tj 12.69 -11.87 Td ( )Tj -12.69 -0.9 Td ( )Tj 5.81 -1.15 Td ( )Tj 10.63 0 Td ( )Tj 16.89 0 Td ( )Tj 0.002 Tc -0.002 Tw -13.95 -1.15 Td ( )Tj 15 0 Td ( )Tj -24.84 -2.3 Td [( )-840 ( )]TJ 0 Tc 0 Tw 23.06 0 Td ( )Tj -20.08 -1.15 Td ( )Tj 14.17 0 Td ( )Tj -26.69 -1.15 Td ( )Tj 0 -1.15 TD ( )Tj 0.002 Tc -0.002 Tw 5.66 -1.15 Td [( )-1490 ( )]TJ 8.15 0 Td ( )Tj 0 Tc 0 Tw 6.88 0 Td ( )Tj 8.71 0 Td [( )-3780 ( )]TJ -18.05 -1.15 Td ( )Tj 15.01 0 Td ( )Tj -11.95 -1.15 Td ( )Tj 14.57 0 Td ( )Tj -25.43 -1.15 Td ( )Tj -0.004 Tc 0.004 Tw 6.19 0 Td ( )Tj 9.91 0 Td ( )Tj 0 Tc 0 Tw 5.95 0 Td ( )Tj -25.6 -1.15 Td ( )Tj T* ( )Tj /TT0 1 Tf 5.56 -1.17 Td ( )Tj /TT2 1 Tf 7.82 -1.13 Td ( )Tj 15.49 0 Td [( )-3340 ( )]TJ -9.16 -1.15 Td ( )Tj 6.89 0 Td [( )-2970 ( )-3090 ( )]TJ -24.67 -1.15 Td ( )Tj 7.92 0 Td ( )Tj 12.8 0 Td ( )Tj 7.36 0 Td [( )-1340 ( )-1860 ( )]TJ -30.01 -1.15 Td ( )Tj 10.14 -1.15 Td ( )Tj 6.88 0 Td ( )Tj -0.004 Tc 0.004 Tw 10.72 0 Td [( )-2110 ( )]TJ -0.01 Tc 0.01 Tw 6.64 0 Td ( )Tj 0 Tc 0 Tw -1.03 -1.15 Td ( )Tj -11.97 -1.15 Td ( )Tj 6.88 0 Td [( )-1760 ( )]TJ -11.9 -1.15 Td ( )Tj 6.88 0 Td ( )Tj 9.94 0 Td ( )Tj -22.16 -1.15 Td ( )Tj ET Q EMC 1 0 0 1 -27.113281 -13.187988 cm BT /StyleSpan <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 12 0 0 12 117.1133 772.068 Tm [(P)7 (r)-10 (ep)-8 (a)-4 (ri)-6 (n)-8 (g)-4 ( T)-7 (ev)]TJ 0 Tc 0 Tw 6.19 0 Td [(-)3 (T)]TJ -0.004 Tc 0.004 Tw 1 0 Td [(ro)-4 (p)-8 (i)-6 (n )]TJ 0 Tc 0 Tw 2.59 0 Td (10 )Tj -0.013 Tc 0.013 Tw [(mg)-23 (: )]TJ EMC /Span <>BDC /TT2 1 Tf -0.003 Tc 0 Tw -9.78 -1.13 Td [($1)-3 ($ )]TJ EMC /Span <>BDC 0 Tc 1.5 0 Td [(R)-3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( s)-11 (y)20 (r)3 (i)-2 (n)-10 (ge)4 ( t)-2 (i)-2 (p c)-6 (a)4 (p f)3 (r)3 (om)-2 ( t)-2 (he)4 ( t)-2 (op of)3 ( t)-2 (he)4 ( p)-10 (r)3 (e)-6 (-)]TJ 0.002 Tc -0.002 Tw 20.55 0 Td [(f)5 (ille)6 (d )]TJ /TT3 1 Tf 0 Tc 0 Tw 2.36 0 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf -0.004 Tc 0.004 Tw 3.03 0 Td [(s)-15 (y)16 (r)-1 (i)-6 (n)-14 (g)-4 (e an)-14 (d )]TJ 0 Tc 0 Tw -27.44 -1.15 Td [(a)4 (t)-2 (t)-2 (a)4 (c)4 (h t)-2 (he)4 ( 25G)2 ( m)-2 (i)-2 (x)-10 (i)-2 (ng)10 ( ne)-6 (e)4 (dl)-2 (e)4 ( t)-2 (ha)4 (t)-2 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d i)-2 (n t)-2 (he)4 ( c)4 (a)4 (r)3 (t)-2 (on. )]TJ EMC /P <>BDC /CS1 cs 0 scn /TT0 1 Tf -0.002 Tc 0.002 Tw 0 -3.47 TD [(DI)-3 (L)-5 (UT)-5 (I)-3 (NG)6 ( T)]TJ -0.004 Tc 0.004 Tw 5.97 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)]TJ -0.004 Tc 0.004 Tw 1 0 Td [(ro)-4 (p)-8 (i)-16 (n )]TJ EMC /P <>BDC /CS0 cs 0.137 0.122 0.125 scn /TT2 1 Tf 0 Tc 0 Tw -7.91 -1.13 Td [(R)-3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( ha)4 (r)3 (d pl)-2 (a)4 (s)-1 (t)-2 (i)-2 (c)4 ( t)-12 (op of)3 ( t)-2 (he )-6 (g)10 (r)3 (ow)2 (t)-2 (h hor)3 (m)-2 (on)-10 (e )4 (vi)-2 (a)4 (l)-2 (. C)-3 (l)-2 (e)4 (a)4 (ns)-1 (e)4 ( t)-2 (he)4 ( t)-2 (op of )-7 (t)-2 (he )]TJ 0 -1.15 TD [(g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one )]TJ -0.004 Tc 0.004 Tw 6.88 0 Td [(v)-4 (i)-6 (al)-6 ( w)-2 (i)-6 (t)-16 (h)-4 ( an)-4 ( al)-6 (co)-4 (h)-4 (o)-4 (l)-6 ( s)-5 (w)-2 (ab)-4 (.)-4 ( R)-7 (em)-6 (o)-14 (v)-4 (e t)-6 (h)-4 (e n)-4 (eed)-4 (l)-16 (e cap )-14 (f)-1 (r)-1 (o)-4 (m)-6 ( t)-6 (h)-14 (e s)-15 (y)16 (r)-1 (i)-6 (n)-14 (g)-4 (e )]TJ 0.002 Tc -0.002 Tw -6.88 -1.15 Td [(f)5 (ille)6 (d)2 ( w)4 (ith )]TJ /TT3 1 Tf 0 Tc 0 Tw 4.39 0 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf 3.03 0 Td [(a)4 (nd i)-2 (ns)-1 (e)4 (r)3 (t)-2 ( t)-2 (he)4 ( ne)4 (e)4 (dl)-12 (e)4 ( i)-2 (nt)-2 (o t)-2 (he)4 ( c)4 (e)-6 (nt)-2 (e)4 (r)3 ( of)3 ( t)-2 (he)4 ( r)3 (ubb)-10 (e)4 (r)3 ( s)-1 (t)-2 (oppe)4 (r)-7 ( on t)-2 (he )]TJ -7.42 -1.15 Td [(g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one )]TJ 0.002 Tc -0.002 Tw 6.88 0 Td [(v)2 (ia)6 (l. )]TJ EMC /LI_Label <>BDC 0 Tc 0 Tw -6.88 -2.3 Td [($)3 (1$)3 ( )]TJ EMC /LI_Title <>BDC [(P)-4 (oi)-2 (nt)-2 ( t)-2 (he)4 ( ne)4 (e)4 (dl)-2 (e)4 ( t)-2 (ow)2 (a)-6 (r)3 (d t)-2 (he)4 ( s)-1 (i)-2 (de)4 ( of)3 ( t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( a)4 (nd )]TJ EMC /StyleSpan <>BDC -0.002 Tc 20.46 0 Td [(s)-3 (l)-4 (o)-2 (wl)-14 (y )]TJ EMC /LI_Title <>BDC 0 Tc 2.91 0 Td [(pus)-1 (h t)-2 (he)4 ( pl)-2 (un)-10 (g)10 (e)4 (r )-7 (s)-1 (o t)-2 (ha)4 (t)-2 ( t)-2 (he )]TJ /TT3 1 Tf -23.37 -1.15 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf 3.03 0 Td [(s)-1 (qui)-2 (r)3 (t)-2 (s)-1 ( ont)-2 (o t)-2 (he)4 ( s)-1 (i)8 (de)4 ( of)3 ( t)-2 (he)4 ( vi)-2 (a)4 (l)-2 (, )]TJ EMC /StyleSpan <>BDC (not )Tj EMC /LI_Title <>BDC 14.35 0 Td [(di)-2 (r)3 (e)-6 (c)4 (t)-2 (l)-2 (y )10 (ont)-2 (o t)-2 (he)4 ( pow)2 (d)-10 (e)4 (r)3 (. W)-6 (he)4 (n)-10 ( a)4 (l)-2 (l)-2 ( t)-2 (he )]TJ /TT3 1 Tf -17.38 -1.15 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf 0.002 Tc -0.002 Tw 3.03 0 Td [(is)1 ( in)2 ( th)2 (e )]TJ 0 Tc 0 Tw 3.42 0 Td [(g)10 (r)3 (ow)2 (t)-2 (h h)-10 (or)3 (m)-2 (one )4 (vi)-2 (a)4 (l)-2 (, r)3 (e)4 (m)-2 (ove)4 ( t)-2 (h)-10 (e )-6 (ne)4 (e)4 (dl)-2 (e)4 ( f)-7 (r)3 (om)-2 ( t)-2 (he)4 ( vi)-2 (a)4 (l)-2 (, r)3 (e)-6 (c)4 (a)-6 (p t)-2 (he )]TJ -6.45 -1.15 Td [(ne)4 (e)4 (dl)-2 (e)4 ( a)4 (nd di)-2 (s)-1 (c)-6 (a)4 (r)3 (d t)-2 (he)4 ( s)-21 (y)10 (r)3 (i)-2 (ng)10 (e)4 (. )]TJ EMC ET /Figure <>BDC q /GS0 gs 152.2999845 0 0 -139.5499712 117.1732786 562.3480832 cm /Im0 Do Q EMC BT /LI_Label <>BDC 12 0 0 12 117.1133 398.268 Tm [($)3 (2$)3 ( )]TJ EMC /LI_Title <>BDC [(T)1 (o m)-2 (i)-2 (x)-10 ( t)-2 (he )4 (g)10 (r)3 (ow)2 (t)-2 (h ho)-10 (r)3 (m)-2 (one)4 (, hol)-2 (d t)-2 (he )4 (vi)-2 (a)4 (l)-2 ( be)4 (t)-12 (w)2 (e)4 (e)4 (n )-20 (y)20 (our)3 ( h)-10 (a)4 (nds)-1 ( a)4 (nd )-10 (g)10 (e)4 (n)-10 (t)-2 (l)-12 (y)20 ( r)3 (ol)-2 (l)-2 ( i)-2 (t )]TJ 0.002 Tc -0.002 Tw T* [(u)2 (n)2 (til th)2 (e)6 ( mi)10 (x)-8 (tu)2 (r)5 (e)6 ( is)1 ( c)6 (le)6 (a)6 (r)5 (.)-8 ( N)4 (E)3 (V)4 (E)3 (R)-1 ( S)-2 (H)4 (A)4 (K)4 (E)3 ( T)3 (H)4 (E )-7 (V)-6 (I)15 (A)-6 (L)13 (!)5 ( S)-2 (o)2 (me)6 (time)6 (s)1 ( th)2 (e)6 ( v)2 (i)-10 (a)6 (l ma)-4 (y)22 ( n)-8 (e)6 (e)6 (d )]TJ -0.004 Tc 0.004 Tw T* [(t)-6 (o)-4 ( s)-5 (i)-6 (t)-6 ( a f)-1 (ew)-2 ( s)-5 (eco)-4 (n)-4 (d)-4 (s)-5 ( b)-14 (ef)-1 (o)-4 (r)-11 (e t)-6 (h)-4 (e m)-6 (i)-6 (x)-14 (t)-6 (u)-4 (r)-1 (e b)-4 (eco)-4 (m)-6 (es)-5 ( cl)-16 (ear)-1 (.)-4 ( D)-2 (o)-4 ( n)-4 (o)-4 (t)-6 ( u)-4 (s)-5 (e t)-6 (h)-14 (e m)-6 (i)-6 (x)-14 (t)-6 (u)6 (r)-1 (e i)-6 (n)-4 ( t)-6 (h)-4 (e )]TJ 0.002 Tc -0.002 Tw T* [(v)2 (ia)6 (l if)5 ( it r)5 (e)6 (ma)6 (in)2 (s)1 ( c)6 (lo)2 (u)2 (d)-8 (y )12 (o)2 (r )-5 (y)22 (o)2 (u)2 ( s)-9 (e)6 (e)6 ( p)2 (a)-4 (r)5 (tic)6 (le)6 (s)1 ( f)5 (l)]TJ 0 Tc 0 Tw [(oa)4 (t)-2 (i)-12 (ng)10 ( i)-2 (n t)-2 (he)4 ( m)-2 (i)-2 (x)-10 (t)-2 (ur)3 (e)4 (. )-10 (I)13 (f)3 ( a)4 (i)-2 (r)3 ( b)-10 (ubbl)-2 (e)4 (s )]TJ -0.004 Tc 0.004 Tw T* [(ap)-4 (p)-4 (ear)-1 (,)-4 ( l)-16 (et)-6 ( t)-6 (h)-4 (e )]TJ 0 Tc 0 Tw 5.89 0 Td [(g)10 (r)3 (ow)2 (t)-2 (h ho)-10 (r)3 (m)-2 (one )4 (s)-1 (i)-2 (t)-2 ( f)3 (or)3 ( a)4 ( w)2 (hi)-2 (l)-2 (e)4 ( unt)-2 (i)-12 (l)-2 ( t)-2 (he)-6 (y)20 ( di)-2 (s)-1 (a)4 (ppe)-6 (a)4 (r)3 (. )]TJ EMC /P <>BDC 0.002 Tc -0.002 Tw -5.89 -3.45 Td [(W)-4 (r)5 (ite)6 ( th)2 (e)6 ( d)2 (a)6 (te )-4 (y)22 (o)2 (u )-8 (r)5 (e)6 (c)-4 (o)2 (n)-8 (s)1 (titu)2 (te)6 ( th)2 (e )]TJ 0 Tc 0 Tw 14.06 0 Td [(g)10 (r)3 (ow)2 (t)-2 (h hor)3 (m)-2 (o)-10 (ne )4 (on t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( l)-2 (a)4 (be)4 (l)-2 (. T)1 (he )-6 (5 m)-2 (g)10 ( vi)-2 (a)4 (l )]TJ -14.06 -1.15 Td [(m)-2 (us)-1 (t)-2 ( be)4 ( us)-1 (e)4 (d w)2 (i)-2 (t)-2 (hi)-2 (n 14 da)-6 (y)20 (s )-11 (w)2 (he)4 (r)-7 (e)4 (a)4 (s)-1 ( t)-2 (he)4 ( 10 m)-12 (g)10 ( vi)-12 (a)4 (l)-2 ( m)-2 (us)-1 (t)-2 ( be)4 ( us)-1 (e)4 (d w)2 (i)-2 (t)-2 (hi)-2 (n 28 da)-6 (y)20 (s)-1 (. )]TJ T* [(S)-4 (t)-2 (or)3 (e)4 ( r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d )-10 (g)10 (r)3 (ow)2 (t)-12 (h hor)3 (m)-2 (one )4 (a)4 (l)-2 (on)-10 (g)10 ( w)2 (i)-2 (t)-2 (h a)4 (l)-2 (l)-2 ( unope)4 (ne)4 (d vi)-2 (a)4 (l)-2 (s)-1 ( of)3 ( t)-2 (he )-6 (g)10 (r)-7 (ow)2 (t)-2 (h )]TJ T* [(hor)3 (m)-2 (one )]TJ -0.004 Tc 0.004 Tw 3.8 0 Td [(i)-6 (n)-4 ( a s)-5 (af)-11 (e,)-4 ( cl)-6 (e)-10 (an )-14 (p)-4 (l)-6 (ace i)-6 (n)-4 ( t)-6 (h)-4 (e r)-11 (ef)-1 (r)-1 (i)-16 (g)6 (e)-10 (r)-1 (at)-6 (o)-4 (r)-1 (. )-14 (D)-2 (o)-4 ( n)-4 (o)-4 (t)-6 ( f)-1 (r)-1 (eez)-10 (e. )]TJ EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0 Tw -3.8 -3.47 Td [(I)-3 (NJ)-2 (E)-5 (CT)-5 (I)-3 (O)-4 (N )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 -1.13 TD [(T)1 (o pr)3 (e)4 (pa)4 (r)-7 (e)4 ( t)-2 (o )-10 (g)10 (i)-2 (ve)4 ( a)4 (n i)-2 (nj)-12 (e)4 (c)4 (t)-2 (i)-2 (on of )-7 (g)10 (r)3 (ow)2 (t)-2 (h hor)3 (m)-2 (on)-10 (e)4 (, be)-6 (g)10 (i)-2 (n b)-20 (y)20 ( t)-2 (hor)3 (ou)-10 (g)10 (hl)-12 (y )10 (w)-8 (a)4 (s)-1 (hi)-2 (ng )-10 (y)20 (o)]TJ -0.003 Tc 0.003 Tw [(u)-3 (r )]TJ 0 Tc 0 Tw 0 -1.15 TD [(ha)4 (nds)-1 ( w)2 (i)-2 (t)-2 (h s)-1 (oa)4 (p a)4 (nd w)2 (a)4 (t)-12 (e)4 (r)3 (. C)-3 (he)4 (c)4 (k t)-2 (ha)4 (t)-2 ( t)-2 (he)4 ( vi)-12 (a)4 (l)-2 ( of )-7 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one )-16 (y)20 (ou a)-6 (r)3 (e )-6 (us)-1 (i)-2 (ng)10 ( i)-2 (s )]TJ T* [(c)4 (l)-2 (e)4 (a)4 (r )-7 (a)4 (nd t)-2 (ha)4 (t)-2 ( t)-2 (he)4 ( da)4 (t)-2 (e)4 ( o)-10 (f )-7 (r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (i)-2 (on i)-2 (s)-1 ( w)2 (i)-2 (t)-2 (hi)-2 (n 1)10 (4 da)-6 (y)20 (s )-11 ($)3 (5 m)-2 (g$)3 ( or)3 ( 28 da)-16 (y)20 (s )-11 ($)3 (10 )]TJ -0.01 Tc 0.01 Tw [(m)-12 (g$)-7 (. )]TJ EMC /LI_Label <>BDC 0 Tc 0 Tw 0 -2.3 TD [($)3 (1$)3 ( )]TJ EMC /LI_Title <>BDC [(C)-3 (l)-2 (e)4 (a)4 (ns)-1 (e)4 ( t)-2 (he)4 ( t)-2 (op of)3 ( t)-2 (h)-10 (e )-6 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one )]TJ -0.004 Tc 0.004 Tw 17.27 0 Td [(v)-4 (i)-6 (al)-6 ( w)-2 (i)-6 (t)-16 (h)-4 ( an)-4 ( al)-6 (co)-4 (h)-4 (o)-4 (l)-6 ( s)-5 (w)-2 (ab)-4 (. )-14 (A)-2 (f)-1 (t)-6 (er )-11 (cl)-6 (ean)-4 (s)-5 (i)-6 (n)]TJ -0.01 Tc 0.01 Tw 16.37 0 Td (g, )Tj 0 Tc 0 Tw -33.64 -1.15 Td [(do not)-2 ( t)-2 (ouc)4 (h t)-2 (he)4 ( r)3 (ubbe)4 (r)3 ( s)-11 (t)-2 (oppe)4 (r)3 (. R)-3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( ne)-6 (e)4 (d)-10 (l)-2 (e)4 ( c)4 (a)4 (p f)-7 (r)3 (om)-2 ( t)-2 (he)4 ( s)-11 (y)20 (r)-7 (i)-2 (n)-10 (g)10 (e)4 ( a)-6 (nd i)-2 (ns)-1 (e)4 (r)3 (t )]TJ 0 -1.15 TD [(t)-2 (he)4 ( ne)4 (e)4 (dl)-2 (e)4 ( i)-2 (nt)-2 (o t)-2 (he)4 ( c)-6 (e)4 (nt)-2 (e)4 (r)-7 ( of)3 ( t)-2 (he)4 ( r)3 (ubbe)4 (r)3 ( s)-1 (t)-2 (opp)-10 (e)4 (r)3 ( on )-10 (t)-2 (he )4 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one )]TJ 0.002 Tc -0.002 Tw 28.51 0 Td [(v)2 (ia)6 (l. )]TJ -0.02 Tc 0.02 Tw 2.01 0 Td [(G)-18 (e)-16 (n)-20 (t)-22 (l)-32 (y )]TJ 0 Tc 0 Tw -30.52 -1.15 Td [(pul)-2 (l)-2 ( ba)4 (c)4 (k t)-2 (he)4 ( pl)-2 (unge)4 (r)3 ( unt)-12 (i)-2 (l)-2 ( t)-2 (he)4 ( a)4 (m)-2 (ount)-2 ( of )3 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one )4 (s)-1 (ol)-2 (ut)-2 (i)-2 (on )-10 (y)20 (our)3 ( do)-10 (c)4 (t)-2 (or)3 ( ha)4 (s )]TJ -0.004 Tc 0.004 Tw T* [(p)-4 (r)-1 (es)]TJ 0.002 Tc -0.002 Tw 1.66 0 Td [(c)6 (r)5 (ib)2 (e)6 (d)2 ( is)1 ( in)2 ( th)2 (e)6 ( s)-19 (y)22 (r)5 (in)-8 (g)12 (e)6 (. )]TJ EMC /Artifact <>BDC 0 g /T1_0 1 Tf 0 Tc 0 Tw 10 0 0 10 45.1133 31.188 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS1 gs /Fm0 Do Q EMC endstream endobj 534 0 obj <>>>/Resources 513 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 535 0 obj <> endobj 536 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 537 0 obj <> endobj 538 0 obj <>stream q 1 0 0 1 27.035126 13.197968 cm 0 0 595.32 841.92 re W n 1 0 0 1 -27.035126 -13.197968 cm BT /Artifact <>BDC /CS0 cs 0.137 0.122 0.125 scn /TT0 1 Tf 3 Tr 12 0 0 12 351.6351 772.318 Tm ( )Tj 15 0 Td ( )Tj -18.44 -1.15 Td ( )Tj 10.02 0 Td ( )Tj -13.44 -12.44 Td ( )Tj -12.69 -0.9 Td ( )Tj 0 -1.15 TD ( )Tj 1.16 -1.15 Td ( )Tj 10.14 0 Td ( )Tj /TT1 1 Tf 3.03 0 Td ( )Tj /TT0 1 Tf 11.82 0 Td ( )Tj 6.55 0 Td ( )Tj 0.002 Tc -0.002 Tw -12.71 -1.15 Td ( )Tj 0 Tc 0 Tw 9.73 0 Td ( )Tj -29.72 -1.15 Td ( )Tj 12.44 -12.81 Td ( )Tj -12.44 -0.9 Td ( )Tj 32.51 -1.15 Td ( )Tj 1.06 -1.15 Td ( )Tj -20 -1.15 Td ( )Tj 19.37 0 Td ( )Tj /TT1 1 Tf -30.16 -1.15 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw 29.48 0 Td ( )Tj 0.002 Tc -0.002 Tw -26.65 -1.15 Td ( )Tj 0 Tc 0 Tw 15.74 0 Td ( )Tj 10.99 0 Td ( )Tj -29.48 -1.15 Td ( )Tj -2.86 -1.15 Td ( )Tj 12.69 -12.31 Td ( )Tj -12.69 -0.9 Td ( )Tj T* ( )Tj T* ( )Tj EMC /P <>BDC 0 Tr 0 56.36 TD [(a)4 (nd pul)-2 (l)-2 ( ba)4 (c)4 (k on t)-2 (he)4 ( pl)-2 (un)-10 (g)10 (e)-6 (r)3 ( w)2 (i)-2 (t)-2 (h t)-2 (he)4 ( ot)-2 (he)4 (r)3 (, unt)-2 (i)-2 (l )-22 (y)10 (ou ha)4 (ve)4 ( dr)3 (a)-6 (w)2 (n up t)-2 (he)4 ( a)4 (m)-12 (ount)-2 ( of)3 ( a)4 (i)-2 (r )]TJ EMC ET /Figure <>BDC BT 12 0 0 12 117.0351 758.518 Tm [(t)-2 (ha)4 (t)-2 ( i)-2 (s)-1 ( t)-2 (he)4 ( s)-1 (a)4 (m)-2 (e)4 ( a)4 (s)-1 ( t)-2 (he)4 ( a)4 (m)-12 (ount)-2 ( of)3 ( di)-2 (l)-2 (ue)4 (nt )-12 (y)20 (our)3 ( do)-10 (c)4 (t)-2 (or)3 ( ha)4 (s)-1 ( or)3 (de)-6 (r)3 (e)4 (d. )]TJ ET q /GS0 gs 152.2999845 0 0 -146.2999723 117.0951159 755.4579778 cm /Im0 Do Q EMC BT /LI_Label <>BDC 12 0 0 12 117.0351 570.838 Tm [($)3 (3$ )]TJ EMC /LI_Title <>BDC 1.42 0 Td [(I)13 (ns)-1 (e)-6 (r)3 (t)-2 ( t)-2 (he)4 ( ne)4 (e)4 (dl)-2 (e)4 ( i)-2 (nt)-2 (o )-10 (t)-2 (he )]TJ /TT1 1 Tf 10.13 0 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT0 1 Tf 3.03 0 Td [(vi)-2 (a)4 (l)-2 ( t)-2 (hr)3 (oug)10 (h t)-12 (he)4 ( c)4 (e)4 (nt)-2 (e)-6 (r)3 ( of)3 ( t)-2 (he )-6 (c)4 (l)-2 (e)4 (a)4 (ns)-1 (e)4 (d )-10 (r)3 (ubbe)4 (r )]TJ -14.58 -1.15 Td [(s)-1 (t)-2 (oppe)4 (r)3 (. P)-4 (us)-1 (h dow)2 (n on t)-2 (he)4 ( pl)-2 (un)]TJ 0.002 Tc -0.002 Tw [(g)2 (e)6 (r)5 ( u)2 (n)2 (til a)6 (ll th)2 (e)6 ( a)6 (ir )-5 (is)1 ( r)5 (e)6 (le)6 (a)6 (s)1 (e)6 (d)2 ( in)2 (to)2 ( th)2 (e)6 ( v)2 (ia)6 (l. )]TJ EMC ET /Figure <>BDC /ClipSpan BMC q /Clip BMC 1 0 0 1 27.035126 13.197968 cm 90.06 526.96 149.299 -150.7 re W n EMC q /GS0 gs 149.299974 0 0 -150.7000051 90.0599823 526.960022 cm /Im1 Do Q EMC EMC Q BT /LI_Label <>BDC 0 Tc 0 Tw 12 0 0 12 117.0351 364.918 Tm [($)3 (4$)3 ( )]TJ EMC /LI_Title <>BDC [(H)2 (ol)-2 (di)-2 (ng)10 ( t)-2 (h)-10 (e)4 ( vi)-2 (a)4 (l)-2 ( w)2 (i)-2 (t)-2 (h one)4 ( ha)4 (nd, c)-6 (a)4 (r)3 (e)-6 (f)3 (ul)-2 (l)-12 (y)20 ( t)-2 (ur)3 (n i)-12 (t)-2 ( ups)-1 (i)-2 (de)4 ( dow)2 (n m)-2 (a)4 (ki)-2 (ng)10 ( s)-1 (u)-10 (r)3 (e)4 ( t)-2 (he )]TJ 0 -1.15 TD [(s)-11 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 ( n)-10 (e)4 (e)4 (dl)-2 (e)4 ( s)-1 (t)-2 (a)-16 (y)20 (s)-1 ( i)-2 (n t)-2 (h)-10 (e)4 ( vi)-2 (a)4 (l)-2 (. 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W)-6 (i)-2 (t)-2 (h )-10 (y)30 (our)3 ( ot)-12 (he)4 (r)3 ( ha)4 (nd, )-10 (g)10 (e)4 (nt)-2 (l)-22 (y)20 ( pul)-2 (l)-2 ( ba)4 (c)-6 (k t)-2 (he)4 ( pl)-2 (ung)10 (e)-6 (r)3 ( unt)-2 (i)-2 (l)-2 ( t)-2 (he)4 ( a)-6 (m)-2 (ount)-2 ( of )]TJ /TT1 1 Tf -4.25 -1.15 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT0 1 Tf -0.004 Tc 0.004 Tw 3.04 0 Td [(y)16 (o)-4 (u)-4 (r)-1 ( d)-4 (o)-4 (ct)-6 (o)-14 (r)-1 ( h)-4 (as)-5 ( p)-14 (r)-1 (es)-5 (cr)-1 (i)-6 (b)-4 (ed)-4 ( i)-6 (s)-5 ( i)-6 (n)-4 ( t)-6 (h)-4 (e s)-25 (y)16 (r)-1 (i)-6 (n)-14 (g)-4 (e.)-4 ( O)-2 (n)-4 (ce t)-6 (h)-14 (e s)-15 (y)16 (r)-11 (i)-6 (n)-14 (g)6 (e i)-6 (s)-5 ( co)-4 (r)-11 (r)-1 (ect)-6 (l)-26 (y )]TJ 0.002 Tc -0.002 Tw -3.04 -1.15 Td [(f)5 (ille)6 (d)2 ( w)4 (ith)2 ( th)2 (e )]TJ /TT1 1 Tf 0 Tc 0 Tw 5.86 0 Td [(di)-2 (l)-2 (ue)4 (nt)]TJ /TT0 1 Tf 2.78 0 Td [(, r)3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( s)-11 (y)20 (r)3 (i)-2 (n)-10 (ge)4 ( a)4 (nd n)-10 (e)4 (e)-6 (dl)-2 (e )4 (f)3 (r)3 (om)-2 ( t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( a)4 (nd r)-7 (e)4 (c)-6 (a)4 (p t)-2 (he )]TJ -0.004 Tc -8.64 -1.15 Td [(n)-4 (eed)-4 (l)-6 (e. )]TJ EMC ET /Figure <>BDC q /GS0 gs 152.2999845 0 0 -144.6999236 117.0951159 279.0580144 cm /Im2 Do Q EMC BT /Artifact <>BDC 0 g /T1_0 1 Tf 0 Tc 10 0 0 10 45.0351 31.198 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS1 gs /Fm0 Do Q EMC endstream endobj 539 0 obj <>>>/Resources 512 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 540 0 obj <> endobj 541 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 542 0 obj <> endobj 543 0 obj <>stream q 1 0 0 1 26.753113 12.802734 cm 0 0 595.32 841.92 re W n /Artifact <>BDC q 1 0 0 1 -26.753113 -12.802734 cm BT /CS0 cs 0.137 0.122 0.125 scn /TT0 1 Tf 3 Tr 14.04 0 0 14.04 452.6031 769.7627 Tm ( )Tj 12 0 0 12 384.7131 755.6027 Tm ( )Tj 6.67 0 Td ( )Tj 5.61 0 Td ( )Tj 9.96 0 0 9.96 534.5927 741.8027 Tm ( )Tj 12 0 0 12 116.7531 728.0027 Tm ( )Tj 0 -1.15 TD ( )Tj 14.04 0 0 14.04 362.3931 698.4827 Tm ( )Tj 12 0 0 12 320.2731 684.3227 Tm [( )-3230 ( )]TJ 9.09 0 Td ( )Tj -0.76 -1.15 Td ( )Tj 0.52 -1.15 Td ( )Tj /TT1 1 Tf 9 0 0 9 116.7531 645.8027 Tm ( )Tj 0 -1.147 TD ( )Tj /TT2 1 Tf 12 0 0 12 280.9131 622.4027 Tm ( )Tj 6.46 0 Td ( )Tj 10.64 0 Td ( )Tj -21.15 -1.15 Td [( )-1000 ( )]TJ 10.89 0 Td ( )Tj 11.05 0 Td [( )-1830 ( )]TJ -15.42 -1.15 Td ( )Tj 16.53 0 Td ( )Tj -17.39 -1.15 Td ( )Tj 8.14 0 Td [( )-3930 ( )]TJ -23.43 -1.15 Td ( )Tj /TT1 1 Tf 9 0 0 9 116.7531 556.0427 Tm ( )Tj /CS1 cs 0 scn /TT0 1 Tf 12 0 0 12 204.7132 542.8427 Tm ( )Tj /TT2 1 Tf 26.67 -1.13 Td ( )Tj 0.002 Tc -0.002 Tw -22.64 -1.15 Td ( )Tj 0 Tc 0 Tw 3.03 0 Td ( )Tj 17.83 0 Td ( )Tj -28.72 -1.15 Td ( )Tj 21.76 0 Td ( )Tj 8.67 0 Td ( )Tj -7.22 -1.15 Td ( )Tj ET Q /CS1 cs 0 scn 273.24 473.16 225.36 0.6 re f q 1 0 0 1 -26.753113 -12.802734 cm BT /TT2 1 Tf 3 Tr 12 0 0 12 217.9131 474.0827 Tm [( )-1840 ( )]TJ 11.58 0 Td ( )Tj 11.39 0 Td ( )Tj ET Q 90 459.36 214.8 0.6 re f q 1 0 0 1 -26.753113 -12.802734 cm BT /TT2 1 Tf 3 Tr 12 0 0 12 159.3531 460.2827 Tm ( )Tj 0.002 Tc -0.002 Tw 3.5 0 Td ( )Tj 7.46 0 Td ( )Tj 5.42 0 Td ( )Tj 0 Tc 0 Tw -9.6 -1.15 Td ( )Tj 10.76 0 Td ( )Tj 7.68 0 Td ( )Tj -28.77 -1.15 Td ( )Tj /CS0 cs 0.137 0.122 0.125 scn 2.32 -1.15 Td [( )-4980 ( )]TJ 31.79 0 Td ( )Tj -30.69 -1.15 Td ( )Tj -3.42 -1.15 Td ( )Tj 4.6 -1.15 Td ( )Tj 27.53 0 Td ( )Tj -20.19 -1.15 Td ( )Tj -11.94 -1.15 Td ( )Tj 4.6 -1.15 Td ( )Tj 19.44 0 Td ( )Tj /CS1 cs 0 scn 0.002 Tc 0.008 Tw 8.09 0 Td ( )Tj /CS0 cs 0.137 0.122 0.125 scn 0 Tc 0 Tw -15.83 -1.15 Td ( )Tj 7.22 0 Td [( )-500 ( )]TJ 0.002 Tc -0.002 Tw 9.74 0 Td ( )Tj 0 Tc 0 Tw -12.95 -1.15 Td ( )Tj /CS1 cs 0 scn -20.31 -1.15 Td ( )Tj /CS0 cs 0.137 0.122 0.125 scn 4.6 -1.15 Td ( )Tj 23.13 0 Td ( )Tj /CS1 cs 0 scn -0.004 Tc 0.004 Tw -23.88 -1.15 Td ( )Tj 20.52 0 Td ( )Tj /CS0 cs 0.137 0.122 0.125 scn 0 Tc 0 Tw 2.36 0 Td [( )-4630 ( )-2520 ( )]TJ 0.002 Tc -0.002 Tw -18.06 -1.15 Td ( )Tj 0 Tc 0 Tw 16.74 0 Td ( )Tj /CS1 cs 0 scn 2.33 0 Td ( )Tj -27.74 -1.15 Td ( )Tj /CS0 cs 0.137 0.122 0.125 scn 6.79 -1.15 Td ( )Tj 22.78 0 Td ( )Tj -12.3 -1.15 Td ( )Tj -17.27 -1.15 Td ( )Tj /TT0 1 Tf 9.53 -1.17 Td [( )-2420 ( )]TJ ET Q /CS0 cs 0.137 0.122 0.125 scn 90 168.72 146.4 1.2 re f* q 1 0 0 1 -26.753113 -12.802734 cm BT /TT2 1 Tf 3 Tr 12 0 0 12 362.6331 170.4827 Tm ( )Tj /TT3 1 Tf 3.03 0 Td ( )Tj /TT2 1 Tf 2.99 0 Td ( )Tj -19.36 -1.15 Td ( )Tj 12.47 0 Td ( )Tj 6.08 0 Td ( )Tj -18.27 -1.15 Td [( )-4260 ( )]TJ 26.95 0 Td ( )Tj -34.38 -1.15 Td ( )Tj 5.18 -1.15 Td [( )-4470 ( )]TJ 19.07 0 Td ( )Tj 8.42 0 Td ( )Tj -19.35 -1.15 Td ( )Tj ET Q EMC 1 0 0 1 -26.753113 -12.802734 cm BT /P <>BDC /TT0 1 Tf 14.04 0 0 14.04 456.2331 769.7627 Tm (T)Tj 0.001 Tc -0.001 Tw [(e)1 (v)]TJ 0 Tc 0 Tw 1.615 0 Td (-T)Tj 0.004 Tc -0.004 Tw 0.991 0 Td [(r)4 (op)13 (in)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 9 0 0 9 525.4731 776.2427 Tm (\256 )Tj EMC /P <>BDC 12 0 0 12 322.0731 755.6027 Tm [([)3 (s)-1 (o)-10 (m)13 (at)3 (r)4 (op)-4 (i)-2 (n )]TJ -0.002 Tc 0.002 Tw 5.47 0 Td [($)1 (r)2 (DN)-10 (A )]TJ 0 Tc 0 Tw [(or)4 (i)-12 (gi)-2 (n)-4 ($)3 (] )]TJ -0.004 Tc 0.004 Tw 6.67 0 Td [(f)-11 (o)-4 (r )]TJ 0 Tc 0 Tw (I)Tj -0.004 Tc 0.004 Tw 1.92 0 Td [(n)-8 (j)-1 (ect)-1 (i)-6 (o)-4 (n )]TJ 0 Tc 0 Tw -2.47 -1.15 Td [(5 m)13 (g )-10 (&)3 ( 10 )-10 (m)]TJ -0.006 Tw 9.96 0 0 9.96 527.0331 741.8027 Tm (g )Tj EMC /P <>BDC 0 Tw 14.04 0 0 14.04 286.4331 698.4827 Tm (T)Tj 0.001 Tc -0.001 Tw [(e)1 (v)]TJ 0 Tc 0 Tw 1.615 0 Td (-T)Tj 0.004 Tc -0.004 Tw 0.991 0 Td [(r)4 (op)13 (in)]TJ EMC /StyleSpan <>BDC 0 Tc 0 Tw 9 0 0 9 355.6731 704.9627 Tm (\256)Tj /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT0 1 Tf 12 0 0 12 219.3531 684.3227 Tm ([)Tj -0.013 Tc 0.013 Tw 0.33 0 Td [(s)-14 (o)-23 (ma)-13 (t)]TJ 0.004 Tc -0.004 Tw 2.55 0 Td [(r)8 (o)4 (pi)2 (n )]TJ -0.004 Tc 0.004 Tw [($)-1 (rD)-2 (N)-12 (A )]TJ 0 Tc 0 Tw 5.78 0 Td [(or)4 (i)-12 (gi)-2 (n)-4 ($)3 (] )]TJ -0.004 Tc 0.004 Tw 3.48 0 Td [(f)-11 (o)-4 (r )]TJ 0 Tc 0 Tw (I)Tj -0.004 Tc 0.004 Tw 1.92 0 Td [(n)-8 (j)-1 (ect)-1 (i)-6 (o)-4 (n)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -13.29 -1.15 Td [(I)-5 (n)-8 (f)-11 (o)-4 (rm)9 (a)-4 (t)-1 (i)-6 (o)-4 (n)-8 ( f)-11 (o)-4 (r t)-1 (h)-8 (e P)7 (a)-14 (t)-11 (i)-6 (en)-8 (t)-1 ( o)-4 (r )-10 (P)7 (a)-4 (ren)-8 (t)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -0.53 -1.15 Td [(R)-2 (ea)-4 (d)-8 ( a)-4 (l)-6 (l)-6 ( i)-6 (n)-8 (s)-5 (t)-1 (ru)-8 (ct)-1 (i)-6 (o)-4 (n)-8 (s)-5 ( b)-8 (e)10 (f)-11 (o)-4 (re p)-8 (ro)-4 (ceed)-8 (i)-6 (n)-8 (g)-4 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT2 1 Tf 0 Tc 0 Tw -8.79 -2.86 Td [(D)2 (o not)-2 ( m)-2 (i)-2 (x)-10 ( $)3 (r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 ($)3 ( t)-2 (he)4 ( dr)3 (ug or)3 ( i)-2 (nj)-2 (e)4 (c)4 (t)-2 ( i)-2 (t)-2 ( unt)-2 (i)-2 (l )-12 (y)20 (ou ha)4 (v)-10 (e)4 ( be)-6 (e)4 (n t)-2 (hor)3 (ou)-10 (g)10 (hl)-2 (y )10 (t)-2 (r)3 (a)4 (i)-2 (n)-10 (e)4 (d )]TJ 0 -1.15 TD [(i)-2 (n t)-2 (he)4 ( pr)3 (ope)4 (r)3 ( t)-2 (e)-6 (c)4 (hni)-2 (que)4 (s )-11 (b)-10 (y y)20 (our)3 ( do)-10 (c)4 (t)-2 (or)3 (. U)2 (s)-1 (e)4 ( s)-1 (t)-2 (e)-6 (r)3 (i)-2 (l)-2 (e )4 (t)-2 (e)4 (c)4 (hni)-2 (que)4 (s)-1 ( a)4 (s)-1 ( i)-2 (ns)-1 (t)-2 (r)3 (u)-10 (c)4 (t)-2 (e)-6 (d b)-10 (y y)20 (our )]TJ T* [(doc)4 (t)-2 (or)3 (. T)1 (he)4 ( f)3 (i)-2 (r)3 (s)-1 (t)-2 ( i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on)-10 ( of)3 ( T)]TJ -0.004 Tc 0.004 Tw 12.16 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n s)-1 (houl)-2 (d be)-6 ( g)10 (i)-2 (ve)4 (n und)-10 (e)4 (r)3 ( t)-2 (he)4 ( s)-1 (upe)-6 (r)3 (vi)-2 (s)-1 (i)-2 (on of )]TJ -13.1 -1.15 Td [(y)20 (o)-10 (ur)3 ( do)-10 (c)4 (t)-2 (or)3 (. P)-4 (r)3 (ope)4 (r)3 (l)-22 (y)20 ( di)-2 (s)-11 (c)4 (a)4 (r)3 (d s)-21 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 (s )-11 (a)4 (nd/)-2 (or)3 ( ne)-6 (e)-6 (dl)-2 (e)4 (s)-1 ( a)4 (f)3 (t)-2 (e)4 (r )-7 (e)4 (a)4 (c)4 (h us)-11 (e)4 (. )]TJ EMC /P <>BDC /CS1 cs 0 scn /TT0 1 Tf -0.002 Tc 0 -3.18 TD [(P)9 (RE)-15 (P)9 (A)-10 (RAT)-5 (I)-3 (O)-4 (N )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 -1.13 TD [(Y)2 (our)3 ( G)2 (R)-3 (O)2 (W)-6 (T)1 (H)2 ( H)2 (O)2 (R)-3 (M)-1 (O)2 (N)2 (E)1 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d i)-2 (n a)4 ( pow)2 (de)4 (r)3 ( f)3 (o)-10 (r)3 (m)-2 ( t)-2 (ha)4 (t)-2 ( m)-2 (us)-1 (t)-2 ( be)4 ( pr)3 (e)4 (pa)4 (r)-7 (e)4 (d f)3 (or )]TJ 0.002 Tc -0.002 Tw 0 -1.15 TD [(in)2 (je)6 (c)6 (tio)2 (n)2 ( b)-8 (y)22 ( mix)-8 (in)2 (g)12 ( it w)4 (ith)2 ( a )]TJ /TT3 1 Tf 0 Tc 0 Tw 11.61 0 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf 3.03 0 Td [($)3 (a)4 ( l)-2 (i)-2 (qui)-2 (d, e)4 (i)-2 (t)-2 (he)4 (r)3 ( B)-3 (a)4 (c)4 (t)-2 (e)-6 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( 0.9%)3 ( S)-4 (odi)-2 (um )]TJ -14.64 -1.15 Td [(C)-3 (hl)-2 (or)3 (i)-2 (de )-6 (I)23 (nj)-2 (e)-6 (c)4 (t)-2 (i)-2 (on, U)2 (S)-4 (P)-4 ( [)3 (5 m)-2 (g)10 ( vi)-2 (a)4 (l)-2 (])-7 ( or)3 ( B)7 (a)-6 (c)4 (t)-2 (e)4 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-12 (i)-2 (c)4 ( W)-6 (a)4 (t)-2 (e)4 (r)3 ( f)3 (or )-7 (I)13 (nj)-12 (e)4 (c)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h 0.33% )]TJ T* [(M)-1 (e)4 (t)-2 (a)4 (c)4 (r)-7 (e)4 (s)-1 (ol)-2 ( [)-7 (10 m)-2 (g)10 ( vi)-2 (a)4 (l)-2 (])-7 ($)3 ( pr)3 (i)-2 (or)3 ( t)-2 (o us)-1 (e)4 (. )]TJ EMC /StyleSpan <>BDC -0.004 Tc 0.004 Tw [(O)-2 (n)-4 (l)-26 (y)16 ( u)-4 (s)-5 (e t)-6 (h)-4 (e)-10 ( s)-5 (p)-4 (eci)-6 (f)-1 (i)-6 (c )]TJ /TT3 1 Tf 0 Tc 0 Tw [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf 26.96 0 Td [(t)-2 (ha)4 (t)-2 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d i)-2 (n )]TJ -26.96 -1.15 Td [(t)-2 (he)4 ( c)4 (a)4 (r)3 (t)-2 (on c)4 (ont)-12 (a)4 (i)-2 (ni)-2 (ng )-10 (y)20 (ou)-10 (r )3 (gr)3 (ow)2 (t)-2 (h hor)3 (m)-2 (one)4 (.)]TJ EMC /P <>BDC [( O)2 (n)-10 (c)4 (e )-6 (y)20 (o)-10 (u ha)4 (v)-10 (e)4 ( r)3 (e)-6 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d )-10 (y)10 (our )3 (gr)3 (ow)2 (t)-2 (h )]TJ T* [(hor)3 (m)-2 (one )]TJ 0.002 Tc -0.002 Tw 3.8 0 Td [(w)4 (ith)2 ( th)2 (e )]TJ /TT3 1 Tf 0 Tc 0 Tw 3.5 0 Td [(di)-2 (l)-2 (ue)4 (nt)]TJ /TT2 1 Tf 0.002 Tc -0.002 Tw 2.78 0 Td [(,)2 ( it is)1 ( r)5 (e)6 (a)6 (d)-8 (y )12 (f)5 (o)2 (r)5 ( in)2 (je)6 (c)6 (tio)2 (n)2 (. )-8 (Y)4 (o)2 (u)2 (r)5 ( d)2 (o)2 (c)6 (to)2 (r)5 ( w)4 (ill p)2 (r)5 (e)6 (s)-9 (c)6 (r)5 (ib)-8 (e)6 ( th)2 (e)6 ( e)6 (x)-8 (a)6 (c)6 (t )]TJ 0 Tc 0 Tw -10.08 -1.15 Td [(a)4 (m)-2 (ount)-2 ( of)3 ( di)-2 (l)-2 (ue)4 (nt)-2 ( a)4 (nd t)-2 (e)4 (l)-2 (l )-12 (y)20 (ou t)-2 (he)4 ( s)-1 (i)-2 (z)-6 (e)4 ( of)3 ( t)-2 (he)4 ( s)-21 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e )-6 (a)4 (nd ne)-6 (e)4 (dl)-2 (e)4 ( t)-2 (o us)-1 (e)4 (. )]TJ EMC /P <>BDC /CS0 cs 0.137 0.122 0.125 scn /TT0 1 Tf -0.004 Tc 0.004 Tw 0 -2.3 TD [(N)-2 (o)-4 (t)-1 (e: )]TJ /TT2 1 Tf 2.57 0 Td [(T)-3 (h)-14 (e )]TJ /TT3 1 Tf 0 Tc 0 Tw [(di)-2 (l)-2 (ue)4 (nt)-2 (s )]TJ /TT2 1 Tf 5.23 0 Td [(a)4 (r)3 (e)4 ( di)-12 (f)3 (f)3 (e)4 (r)-7 (e)4 (nt)-2 ( f)3 (or)3 ( t)-2 (he)4 ( 5 m)-12 (g)10 ( a)4 (nd )-10 (10 m)-2 (g)10 ( vi)-2 (a)4 (l)-2 (s)-1 (. D)2 (o not)-2 ( i)-2 (nt)-2 (e)4 (r)-7 (c)4 (ha)4 (n)-10 (g)10 (e)4 ( t)-2 (he )]TJ /TT3 1 Tf -7.8 -1.15 Td [(di)-2 (l)-2 (ue)4 (nt)-2 (s)]TJ /TT2 1 Tf 3.17 0 Td (. )Tj EMC /P <>BDC -3.17 -2.3 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n s)-1 (houl)-2 (d be)4 ( ke)-6 (pt)-2 ( r)3 (e)4 (f)3 (r)3 (i)-12 (g)10 (e)-6 (r)3 (a)4 (t)-2 (e)4 (d $)3 (36\260 t)-2 (o 46)-10 (\260F)6 ( [)-7 (2\260t)-2 (o 8\260C)-3 (])-7 ($)3 ( be)4 (f)3 (or)3 (e)4 ( a)4 (nd)-10 ( a)4 (f)3 (t)-2 (e)4 (r )]TJ -1.55 -1.15 Td [(r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (i)-2 (on. D)2 (o not)-2 ( f)3 (r)3 (e)-6 (e)4 (z)-6 (e)4 (. )]TJ EMC /P <>BDC T* (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n 5 m)-12 (g)10 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d w)2 (i)-2 (t)-2 (h a)4 ( vi)-2 (a)4 (l)-2 ( of)3 ( l)-2 (i)-2 (qui)-2 (d c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng )]TJ /CS1 cs 0 scn 0.002 Tc 0.008 Tw 22.74 0 Td [(B)-1 (a)6 (c)6 (te)-4 (r)5 (io)2 (s)1 (ta)6 (tic)6 ( 0)2 (.)2 (9)2 (% )]TJ 0 Tc 0 Tw -24.29 -1.15 Td [(S)-4 (odi)-2 (um)-2 ( C)-3 (hl)-2 (or)3 (i)-2 (de)4 ( I)23 (nj)-12 (e)4 (c)4 (t)-2 (i)-2 (o)-10 (n, U)2 (S)-4 (P)-4 ( $)3 (5 m)-12 (L)21 ($)3 (. )]TJ /CS0 cs 0.137 0.122 0.125 scn -0.003 Tc 0.003 Tw [(A)-1 (ft)-15 (e)1 (r T)]TJ 0.006 Tc -0.006 Tw 19.52 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n 5 )]TJ 0.002 Tc -0.002 Tw [(mg)12 ( v)2 (ia)6 (l is)1 ( mi)-10 (x)-8 (e)6 (d)2 ( w)4 (ith )]TJ -0.004 Tc 0.004 Tw -20.47 -1.15 Td [(t)-6 (h)-4 (e )]TJ /TT3 1 Tf 0 Tc 0 Tw [(di)-2 (l)-2 (ue)4 (nt)]TJ /TT2 1 Tf 4.25 0 Td [(, t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( s)-1 (houl)-2 (d be)4 ( us)-1 (e)4 (d w)2 (i)-2 (t)-2 (hi)-2 (n 14 da)-16 (y)20 (s)-1 (. )]TJ EMC /P <>BDC -4.25 -2.3 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n 10 m)-12 (g)10 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d w)2 (i)-2 (t)-2 (h a)4 ( s)-11 (y)20 (r)3 (i)-2 (n)-10 (ge)4 ( of)3 ( l)-2 (i)-2 (qui)-2 (d c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng)10 ( vi)-2 (a)4 (l )]TJ /CS1 cs 0 scn -0.007 Tc 0.007 Tw 26.44 0 Td (Ba)Tj -0.004 Tc 0.004 Tw 1.1 0 Td [(ct)-16 (er)-1 (i)-6 (o)-4 (s)-5 (t)-6 (at)-6 (i)-6 (c )]TJ -29.09 -1.15 Td [(W)-10 (at)-6 (er)-1 ( f)-1 (o)-4 (r )-11 (I)9 (n)-4 (j)-6 (e)-10 (ct)-6 (i)-6 (o)-4 (n)-4 ( w)-2 (i)-6 (t)-6 (h)-4 ( 0)-4 (.)-4 (3)-4 (3)-4 (%)-1 ( M)-5 (et)-6 (acr)-11 (es)-5 (o)-4 (l)-6 ( as)-5 ( a p)-14 (r)-11 (es)-5 (er)-1 (v)-4 (at)-6 (i)-6 (v)-4 (e. )-14 (A)-2 (f)-1 (t)-6 (er )]TJ /CS0 cs 0.137 0.122 0.125 scn 0 Tc 0 Tw 26.98 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.62 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)-9 (r)-7 (opi)-2 (n 10 m)-2 (g )]TJ 0.002 Tc -0.002 Tw -28.54 -1.15 Td [(v)2 (ia)6 (l is)1 ( mi)10 (x)-8 (e)6 (d)2 ( w)4 (ith)2 ( th)2 (e )]TJ /TT3 1 Tf 0 Tc 0 Tw 8.92 0 Td [(di)-2 (l)8 (ue)4 (nt)]TJ /TT2 1 Tf 2.77 0 Td [(, t)-2 (he)4 ( vi)-2 (a)4 (l)-2 ( s)-1 (houl)-2 (d be)4 ( us)-1 (e)4 (d w)2 (i)-2 (t)-2 (hi)-2 (n 28 )]TJ -0.02 Tc 0.02 Tw [(d)-20 (a)-26 (ys)-21 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -11.69 -2.3 Td [(B)7 (e)4 (f)3 (o)-10 (r)3 (e)4 ( pr)-7 (e)4 (pa)4 (r)3 (i)-2 (n)-10 (g )-10 (y)20 (ou)-10 (r)3 ( m)-2 (e)4 (di)-2 (c)4 (a)4 (t)-2 (i)-2 (on, be)4 ( s)-1 (ur)-7 (e)4 ( t)-2 (o w)2 (a)4 (s)-11 (h )-10 (y)20 (our)3 ( h)-10 (a)4 (nds)-1 ( t)-2 (hor)3 (ou)-10 (g)10 (hl)-22 (y )10 (w)2 (i)-2 (t)-2 (h s)-1 (oa)4 (p )]TJ 0 -1.15 TD [(a)4 (nd w)2 (a)4 (t)-2 (e)4 (r)3 (. )-10 (T)1 (hi)-2 (s)-1 ( w)2 (i)-2 (l)-2 (l)-2 ( he)4 (l)-2 (p pr)3 (e)4 (ve)4 (nt)-2 ( i)-2 (nf)3 (e)-6 (c)4 (t)-2 (i)-2 (on. )]TJ EMC /StyleSpan <>BDC /TT0 1 Tf -0.004 Tc 0.004 Tw 0 -2.32 TD [(P)7 (r)-10 (ep)-8 (a)-4 (ri)-6 (n)-8 (g)-4 ( T)-7 (ev)]TJ 0 Tc 0 Tw 6.19 0 Td [(-)3 (T)]TJ -0.004 Tc 0.004 Tw 1 0 Td [(ro)-4 (p)-8 (i)-6 (n )]TJ -0.013 Tc 0.013 Tw 2.59 0 Td [(5)-13 ( mg)-23 (: )]TJ EMC /LI_Label <>BDC /TT2 1 Tf 0 Tc 0 Tw -9.78 -1.13 Td [($)3 (1$)3 ( )]TJ EMC /LI_Title <>BDC [(R)-3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( ha)-6 (r)3 (d pl)-2 (a)4 (s)-11 (t)-2 (i)-2 (c)4 ( c)4 (a)4 (p f)3 (r)3 (om)-2 ( t)-2 (he)4 ( t)-2 (op of)3 ( t)-2 (h)-10 (e )]TJ /TT3 1 Tf 20.74 0 Td [(di)-2 (l)-2 (ue)4 (nt )]TJ /TT2 1 Tf 3.03 0 Td [(vi)-2 (a)4 (l)-2 ( b)-10 (y )10 (ge)4 (nt)-2 (l)-12 (y)20 ( p)-10 (us)-1 (hi)-2 (ng)10 ( up )]TJ -23.77 -1.15 Td [(on t)-2 (he)4 ( e)4 (d)-10 (g)10 (e)4 ( of)3 ( t)-2 (he )-6 (c)4 (a)4 (p. D)-8 (o not)-2 ( r)3 (e)4 (m)-2 (ove)4 ( t)-2 (he)4 ( r)3 (ubb)-10 (e)4 (r )-7 (s)-1 (t)-2 (oppe)4 (r)3 (. U)2 (s)-1 (i)-2 (ng a)4 (n a)4 (l)-2 (c)4 (ohol)-12 ( s)-1 (w)2 (a)4 (b, )]TJ 0 -1.15 TD [(w)2 (i)-2 (pe)4 ( of)3 (f)3 ( t)-2 (he)4 ( t)-2 (op of )]TJ -0.004 Tc 0.004 Tw 7.68 0 Td [(t)-6 (h)-4 (e )]TJ /TT3 1 Tf 0 Tc 0 Tw [(di)-2 (l)-12 (ue)4 (nt )]TJ /TT2 1 Tf 4.51 0 Td [(bot)-2 (t)-2 (l)-2 (e)4 (. A)2 (f)3 (t)-2 (e)4 (r)3 ( c)4 (l)-12 (e)4 (a)4 (ns)-1 (i)-12 (ng)10 (, do not)-2 ( t)-2 (ouc)4 (h t)-2 (he)4 ( r)3 (ubb)-10 (e)4 (r)3 ( s)-1 (t)-2 (oppe)4 (r)3 (. )]TJ EMC /LI_Label <>BDC -12.19 -2.3 Td [($)3 (2$)3 ( )]TJ EMC /LI_Title <>BDC [(C)-3 (a)4 (r)3 (e)-6 (f)3 (ul)-2 (l)-12 (y )10 (r)3 (e)4 (m)-2 (ove)4 ( t)-2 (he )-6 (ne)4 (e)4 (dl)-2 (e)4 ( c)-6 (a)4 (p f)3 (r)3 (om)-2 ( t)-2 (he)4 ( s)-21 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 (, t)-12 (a)4 (ki)-2 (ng c)4 (a)4 (r)-7 (e)4 ( not)-2 ( t)-2 (o t)-2 (ouc)4 (h t)-2 (he )]TJ T* [(ne)4 (e)4 (dl)-2 (e)4 (. D)2 (o not)-2 ( di)-2 (s)-1 (c)4 (a)-6 (r)3 (d t)-2 (h)-10 (e)4 ( ne)4 (e)4 (dl)-2 (e )-6 (c)4 (a)4 (p. H)2 (ol)-2 (d t)-2 (he)4 ( b)-10 (a)-6 (r)3 (r)3 (e)4 (l)-2 ( of)3 ( t)-2 (he)4 ( s)-21 (y)20 (r)3 (i)-2 (n)-10 (ge)4 ( w)2 (i)-2 (t)-2 (h one)4 ( ha)4 (nd )]TJ EMC /Artifact <>BDC 0 g /T1_1 1 Tf 10 0 0 10 44.7531 30.8027 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 544 0 obj <>>>/Resources 511 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 545 0 obj <> endobj 546 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 547 0 obj <> endobj 548 0 obj <>stream q 1 0 0 1 26.633453 13.198059 cm 0 0 595.32 841.92 re W n /Artifact <>BDC q 1 0 0 1 -26.633453 -13.198059 cm BT /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 171.8335 772.3181 Tm [( )-550 ( )]TJ 0.05 Tw 5.29 0 Td ( )Tj 0 Tw 22.84 0 Td ( )Tj -0.004 Tc 0.434 Tw -17.77 -1.15 Td ( )Tj 0.004 Tw 4.59 0 Td ( )Tj 0 Tc 0 Tw 9.48 0 0 9.48 414.7135 758.5181 Tm ( )Tj 12 0 0 12 434.3935 758.5181 Tm ( )Tj 0.43 Tw 6.49 0 Td [( )-960 ( )]TJ 0.05 Tw -13.64 -1.15 Td [( )-3200 ( )]TJ -0.004 Tc 0.054 Tw 15.28 0 Td ( )Tj 0 Tc 0 Tw -32.36 -1.15 Td ( )Tj 6.5 0 Td ( )Tj 16.44 0 Td ( )Tj -25.19 -1.15 Td ( )Tj /TT1 1 Tf 13.01 -1.17 Td ( )Tj /TT0 1 Tf -4.21 -1.13 Td ( )Tj ET Q /CS0 cs 0 scn 90 674.4 105.6 0.6 re f q 1 0 0 1 -26.633453 -13.198059 cm BT /TT0 1 Tf 0.002 Tc 0.058 Tw 3 Tr 12 0 0 12 155.6334 675.7181 Tm ( )Tj 0 Tc 0 Tw 8.04 0 0 8.04 214.6735 681.2381 Tm ( )Tj 0.06 Tw 12 0 0 12 287.3934 675.7181 Tm ( )Tj 0.002 Tc -0.002 Tw 20.38 0 Td ( )Tj 0 Tc 0.16 Tw -14.53 -1.15 Td ( )Tj 0 Tw -17.5 -1.15 Td ( )Tj -2.58 -1.15 Td ( )Tj 8.19 -1.15 Td ( )Tj ET Q 90 605.4 98.28 0.599 re f q 1 0 0 1 -26.633453 -13.198059 cm BT /TT0 1 Tf 3 Tr 12 0 0 12 171.8335 606.7181 Tm [( )-640 ( )-2470 ( )]TJ 0.002 Tc 0.138 Tw 30.01 0 Td ( )Tj 0 Tc 0.01 Tw 0 -1.15 TD ( )Tj 0 Tw -13.65 -1.15 Td ( )Tj -20.96 -1.15 Td ( )Tj T* ( )Tj 8.04 0 0 8.04 171.8335 543.2381 Tm ( )Tj 12 0 0 12 185.9935 537.7181 Tm ( )Tj 0.02 Tw 28.83 0 Td ( )Tj 0 Tw -1.79 -1.15 Td ( )Tj -0.004 Tc 0.004 Tw 1.79 0 Td ( )Tj 0 Tc 0.15 Tw -25.19 -1.15 Td ( )Tj 25.19 0 Td ( )Tj 0 Tw -31.14 -1.15 Td ( )Tj -3.47 -1.15 Td ( )Tj /TT1 1 Tf 7.75 -1.17 Td ( )Tj /TT0 1 Tf -3.15 -1.13 Td ( )Tj 11.71 0 Td ( )Tj 16.77 0 Td ( )Tj -16.27 -1.15 Td ( )Tj -16.81 -1.15 Td ( )Tj 4.6 -1.15 Td ( )Tj 0.04 Tw 13.44 0 Td ( )Tj 0 Tw 4.91 0 Td ( )Tj 0.04 Tw 11.66 0 Td ( )Tj 0 Tw -29.4 -1.15 Td ( )Tj 0.13 Tw 29.4 0 Td ( )Tj 0 Tw -13.31 -1.15 Td ( )Tj -21.3 -1.15 Td ( )Tj 4.6 -1.15 Td ( )Tj 0.22 Tw 3.21 0 Td ( )Tj 0 Tw 17.03 0 Td [( )-1550 ( )]TJ 9.77 0 Td ( )Tj -26.47 -1.15 Td ( )Tj 0.002 Tc -0.002 Tw 1.63 0 Td ( )Tj 14.31 0 Td ( )Tj 0 Tc 0 Tw 2.03 0 Td [( )-2580 ( )-4330 ( )]TJ -0.004 Tc 0.004 Tw 8.5 0 Td ( )Tj 0 Tc 0 Tw -29.39 -1.15 Td ( )Tj 26.52 0 Td ( )Tj -31.74 -1.15 Td ( )Tj T* ( )Tj /TT1 1 Tf 3.56 -1.17 Td ( )Tj /TT2 1 Tf -3.56 -1.13 Td ( )Tj /TT0 1 Tf 17.3 -1.15 Td ( )Tj 0.002 Tc -0.002 Tw 1.49 -1.15 Td ( )Tj -0.02 Tc 0.02 Tw 1.52 0 Td ( )Tj 0 Tc 0 Tw 0.26 0 Td ( )Tj -11.97 -1.15 Td ( )Tj -0.47 -1.15 Td ( )Tj /TT2 1 Tf -8.13 -1.15 Td ( )Tj /TT0 1 Tf 34.61 -1.15 Td ( )Tj T* ( )Tj /TT2 1 Tf T* ( )Tj ET Q EMC 1 0 0 1 -26.633453 -13.198059 cm BT /P <>BDC /TT0 1 Tf 12 0 0 12 116.6335 772.3181 Tm (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-50 (5 )]TJ -0.01 Tc 0.01 Tw 4.15 0 Td [(m)-12 (g )]TJ 0 Tc 0.05 Tw 1.57 0 Td [(c)4 (a)4 (n be )-6 (a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d us)-1 (i)-2 (ng)10 ( a)4 ( s)-1 (t)-2 (a)4 (nda)4 (r)3 (d s)-1 (t)-2 (e)4 (r)3 (i)-2 (l)-2 (e)4 ( di)-2 (s)-1 (pos)-1 (a)4 (bl)-2 (e)4 ( s)-1 (y)20 (r)-7 (i)-2 (n)-10 (g)10 (e )]TJ -0.003 Tc 0.003 Tw 25.76 0 Td [(o)-3 (r )]TJ 0.006 Tc -0.006 Tw 1.13 0 Td (a )Tj -0.004 Tc 0.434 Tw -34.16 -1.15 Td [(T)-3 (j)-6 (et)-6 ( N)-2 (eed)-4 (l)-16 (e)]TJ 0 Tc 0 Tw [(-)-7 (F)]TJ -0.004 Tc 0.434 Tw 6.01 0 Td [(r)-1 (e)-10 (e i)-6 (n)-4 (j)-6 (ect)-16 (i)-6 (o)-4 (n)-4 ( d)-4 (ev)-4 (i)-6 (ce. )]TJ 0 Tw 9.63 0 Td [(H)-2 (o)-4 (w)-2 (ev)-14 (er)-1 (, )]TJ 0 Tc 4.6 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-380 (10 )]TJ 0.43 Tw 5.37 0 Td [(m)-2 (g c)-6 (a)-6 (n onl)-12 (y )10 (be )]TJ 0.05 Tw -27.16 -1.15 Td [(a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d us)-1 (i)-2 (ng a)4 ( s)-1 (t)-2 (a)-6 (nda)4 (r)3 (d s)-1 (t)-2 (e)4 (r)3 (i)-2 (l)-2 (e)4 ( di)-2 (s)-1 (pos)-1 (a)4 (bl)-12 (e )-6 (s)-11 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 (. )]TJ -0.004 Tc 0.054 Tw 23.43 0 Td [(F)2 (o)-14 (r)-1 ( p)-4 (r)-1 (o)-4 (p)-14 (er)-1 ( u)-4 (s)-5 (e,)-14 ( p)-4 (l)-6 (eas)-5 (e r)-11 (ef)-11 (er )]TJ 0 Tc 0 Tw -23.43 -1.15 Td [(t)-2 (o t)-2 (he )]TJ /TT1 1 Tf -0.004 Tc 0.004 Tw 2.5 0 Td [(U)-2 (s)-5 (er')-6 (s)-5 ( Ma)-4 (n)-8 (u)-8 (a)-4 (l )]TJ /TT0 1 Tf 0 Tc 0 Tw 6.5 0 Td [(pr)3 (ovi)-2 (de)4 (d w)2 (i)-2 (t)-2 (h t)-2 (he)4 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on de)4 (vi)-2 (c)4 (e)4 (. )]TJ EMC /P <>BDC /TT1 1 Tf -0.002 Tc 0.002 Tw -9 -2.32 Td [(S)-6 (T)-5 (AB)-5 (I)-3 (L)-5 (I)7 (T)-5 (Y AND S)-6 (T)-5 (O)-4 (RAG)6 (E )]TJ EMC /StyleSpan <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 0 -1.13 TD [(B)9 (e)6 (f)5 (o)-8 (r)5 (e)6 ( R)-1 (e)-4 (c)6 (o)2 (n)2 (s)1 (titu)2 (tio)2 (n )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.15 TD (V)Tj 0.002 Tc 0.058 Tw 0.72 0 Td [(ia)6 (ls)1 ( o)2 (f )]TJ 0 Tc 0 Tw 2.84 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.06 Tw 3.28 0 Td [($)3 (5 )-10 (a)-6 (nd 10 m)-2 (g$ )3 (a)-6 (r)3 (e)4 ( s)-1 (t)-2 (a)4 (bl)-12 (e)4 ( w)2 (h)-10 (e)4 (n r)3 (e)-6 (f)3 (r)3 (i)-12 (g)10 (e)4 (r)-7 (a)4 (t)-2 (e)4 (d )-10 (a)4 (t)-2 ( 36\260 t)-2 (o )-10 (46\260F)6 ( $)3 (2\260 )]TJ 0.002 Tc -0.002 Tw (to )Tj 0 Tc 0 Tw -8.4 -1.15 Td [(8\260C)-3 ($)3 (. )]TJ 0.16 Tw 2.56 0 Td [(A)2 (voi)-2 (d f)3 (r)-7 (e)4 (e)4 (z)-6 (i)-2 (ng t)-2 (h)-10 (e)4 ( a)-6 (c)4 (c)4 (om)-2 (pa)4 (n)-20 (y)20 (i)-2 (n)-10 (g)10 ( di)-2 (l)-2 (ue)4 (nt)-2 (. )]TJ -0.004 Tc 0.164 Tw 17.93 0 Td [(E)-3 (x)-14 (p)-4 (i)-6 (r)-1 (at)-6 (i)-6 (o)-4 (n)-4 ( d)-4 (at)-6 (es)-5 ( ar)-11 (e s)-5 (t)-16 (at)-6 (ed)-4 ( o)-4 (n)-4 ( t)-6 (h)-14 (e )]TJ 0 Tw -20.49 -1.15 Td [(l)-6 (ab)-4 (el)-6 (s)-5 (. )]TJ EMC /StyleSpan <>BDC 0.002 Tc -0.002 Tw 0 -2.3 TD [(A)4 (f)5 (te)6 (r)5 ( R)-1 (e)6 (c)6 (o)2 (n)2 (s)1 (titu)2 (tio)2 (n )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -1.15 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-140 (5 )]TJ -0.01 Tc 0.01 Tw 4.33 0 Td [(m)-12 (g )]TJ 0.002 Tc -0.002 Tw 1.66 0 Td (is )Tj 0 Tc 0.14 Tw 1.06 0 Td [(s)-1 (t)-2 (a)4 (bl)-2 (e)4 ( f)3 (or)3 ( up t)-2 (o 14)10 ( da)-6 (y)30 (s)-1 ( w)2 (h)-10 (e)4 (n r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (u)]TJ 0.002 Tc 0.138 Tw [(te)6 (d)2 ( w)4 (ith)2 ( b)2 (a)6 (c)6 (te)6 (r)5 (io)2 (s)1 (ta)6 (tic )]TJ 0 Tc 0.01 Tw -8.6 -1.15 Td [(0.9%)3 ( s)-1 (odi)-2 (um)-2 ( c)4 (hl)-2 (or)3 (i)-2 (de)4 ( $)3 (nor)3 (m)-2 (a)4 (l)-2 ( s)-1 (a)4 (l)-2 (i)-2 (ne)4 ($)3 (, U)2 (S)-4 (P)-4 (, a)4 (nd s)-1 (t)-2 (or)3 (e)4 (d i)-2 (n a)4 ( r)3 (e)4 (f)-7 (r)3 (i)-2 (ge)4 (r)3 (a)4 (t)-2 (o)-10 (r)3 ( a)4 (t)-2 ( 36\260 t)-2 (o 46\260F )]TJ 0 Tw T* [($)3 (2\260 t)-2 (o 8\260C)-3 ($)3 (. D)2 (o not)-2 ( f)3 (r)3 (e)-6 (e)4 (z)-6 (e)4 ( t)-2 (he)4 ( r)3 (e)-6 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d s)-1 (ol)-2 (ut)-2 (i)8 (on. )]TJ EMC /P <>BDC 0 -3.45 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )70 (10 )]TJ 0.02 Tw 4.5 0 Td [(m)-12 (g)10 ( i)-2 (s)-1 ( s)-1 (t)-2 (a)4 (bl)-2 (e)4 ( f)3 (or)3 ( up t)-2 (o 28 da)-6 (y)30 (s)-1 ( w)2 (he)-6 (n r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d w)2 (i)-2 (t)-2 (h 1 )10 (m)8 (L)11 ( s)-21 (y)20 (r)3 (i)-2 (n)-10 (g)10 (e)4 ( of )]TJ -0.004 Tc 0.004 Tw -6.05 -1.15 Td [(b)-4 (ac)]TJ 0.094 Tw [(t)-6 (er)-1 (i)-6 (o)-4 (s)-5 (t)-6 (at)-6 (i)-6 (c w)-12 (at)-6 (er)-1 ( f)-1 (o)-14 (r)-1 ( i)-16 (n)-4 (j)-6 (ect)-6 (i)-6 (o)-4 (n)-4 ( co)-4 (n)-4 (t)-6 (ai)-6 (n)-4 (i)-6 (n)-4 (g)6 ( 0)-4 (.)-4 (3)-4 (3)-14 (%)-1 ( m)-6 (et)-6 (acr)-11 (es)-5 (o)-4 (l)-6 ( as)-5 ( a p)-4 (r)-11 (es)-5 (e)-10 (r)-1 (v)-4 (at)-6 (i)-6 (v)-4 (e)]TJ 0 Tc 0 Tw (, )Tj -0.004 Tc 0.004 Tw 33.16 0 Td [(an)-4 (d )]TJ 0 Tc 0.15 Tw -33.16 -1.15 Td [(s)-1 (t)-2 (or)3 (e)4 (d i)-2 (n a)-6 ( r)3 (e)-6 (f)3 (r)3 (i)-12 (g)10 (e)4 (r)-7 (a)4 (t)-2 (or )-7 (a)4 (t)-2 ( 36\260 t)-2 (o 46\260)-10 (F)6 ( $)3 (2\260 t)-2 (o)-10 ( 8\260)-10 (C)-3 ($)3 (. D)2 (o not)-2 ( f)-7 (r)3 (e)4 (e)4 (z)-6 (e)4 ( t)-2 (h)-10 (e)4 ( r)-7 (e)-6 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d )]TJ 0 Tw 0 -1.15 TD [(s)-1 (ol)-2 (ut)-2 (i)-2 (on. )]TJ EMC /P <>BDC /TT1 1 Tf 0.002 Tc -0.002 Tw 0 -2.32 TD [(HOW)2 ( S)-2 (U)4 (P)3 (P)13 (L)-1 (I)1 (E)-1 (D )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 0 -1.13 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-80 ([)-7 (s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )-80 ($)]TJ -0.002 Tc 0.082 Tw 8.88 0 Td [(r)1 (DNA o)-2 (r)1 (i)-14 (g)8 (i)-4 (n)]TJ -0.003 Tc 0.003 Tw 5.21 0 Td [($] )-90 (fo)-3 (r )]TJ 0 Tc 0 Tw 2.5 0 Td (I)Tj 0.08 Tw 0.32 0 Td [(nj)-2 (e)4 (c)-6 (t)-2 (i)-2 (on i)-2 (s)-1 ( s)-1 (upp)10 (l)-2 (i)-2 (e)4 (d )]TJ -0.01 Tc 0.09 Tw [(a)-6 (s)-11 ( 5)-10 ( m)-12 (g )]TJ 0 Tc 0 Tw 11.85 0 Td [(a)4 (nd )-80 (10 m)-2 (g )]TJ -30.31 -1.15 Td [(of)3 ( l)-12 (y)20 (ophi)-2 (l)-2 (i)-2 (z)-6 (e)4 (d, s)-1 (t)-2 (e)4 (r)3 (i)-2 (l)-2 (e)4 ( s)-1 (o)-10 (m)-2 (a)4 (t)-2 (r)3 (opi)-2 (n pe)4 (r)3 ( vi)-2 (a)4 (l)-2 (. )]TJ EMC /P <>BDC 0 -2.3 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.04 Tw 3.34 0 Td [(5)-10 ( m)-2 (g c)4 (a)-6 (r)3 (t)-2 (on )-10 (c)4 (ont)-2 (a)4 (i)-2 (ns)-1 ( one)4 ( vi)-2 (a)4 (l)-12 ( of )]TJ 0 Tw 13.44 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.62 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)-7 (T)1 (r)3 (opi)-2 (n )]TJ 0.04 Tw 3.35 0 Td [($)3 (5 m)-12 (g)10 ( p)-10 (e)4 (r)3 ( vi)-2 (a)4 (l)-12 ($)3 ( a)-6 (nd one)4 ( vi)-2 (a)4 (l )]TJ 0.13 Tw -23.24 -1.15 Td [(of)3 ( di)-2 (l)-2 (ue)4 (nt)-2 ( [)-7 (5 m)-2 (L)21 ( o)-10 (f)3 ( ba)4 (c)4 (t)-12 (e)4 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( 0.9%)3 ( s)-1 (odi)-2 (um)-2 ( c)4 (hl)-2 (or)3 (i)-2 (de)4 ( f)3 (or)3 ( i)-2 (nj)-2 (e)-6 (c)4 (t)-2 (i)-2 (on, U)2 (S)-4 (P)-4 ( $)3 (be)4 (nz)-16 (y)20 (l )]TJ 0 Tw 0 -1.15 TD [(a)4 (l)-2 (c)4 (ohol)-2 ( pr)3 (e)4 (s)-1 (e)-6 (r)3 (ve)4 (d$)3 (])-7 (, a)4 (nd i)-12 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d i)-2 (n s)-1 (i)-2 (ng)10 (l)-2 (e)4 ( c)4 (a)-6 (r)3 (t)-2 (ons)-1 (. )]TJ EMC /P <>BDC 0 -2.3 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.22 Tw 3.52 0 Td [(10 m)-2 (g c)4 (a)4 (r)3 (t)-12 (on c)4 (ont)-2 (a)4 (i)-2 (ns)-1 ( one)4 ( vi)-2 (a)4 (l)-2 ( of)3 ( T)]TJ -0.004 Tc 0.004 Tw 15.78 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -0.003 Tc 0.003 Tw 3.52 0 Td [($1)-3 (0 )]TJ 0 Tc 0.22 Tw 1.8 0 Td [(m)-12 (g)10 ( pe)-6 (r)3 ( vi)-2 (a)4 (l)-2 ($)3 (, )]TJ 0 Tw (one )Tj 0.002 Tc -0.002 Tw -27.11 -1.15 Td [(s)-9 (y)22 (r)5 (in)-8 (g)12 (e)6 ( o)-8 (f)5 ( d)2 (ilu)2 (e)6 (n)2 (t [)-5 (1 )2 (m)-10 (L )13 (o)2 (f)5 ( b)2 (a)6 (c)6 (te)-4 (r)5 (io)2 (s)1 (ta)6 (tic)6 ( w)4 (a)6 (te)-4 (r)5 ( f)5 (o)-8 (r)5 ( in)2 (je)6 (c)6 (tio)2 (n )2 (w)4 (ith )]TJ 0 Tc 0 Tw 26.36 0 Td (0.33% )Tj -0.004 Tc 0.004 Tw 2.83 0 Td [(m)-6 (et)-6 (acr)-11 (es)-5 (o)-4 (l )-6 (as )]TJ -29.19 -1.15 Td [(p)-4 (r)-1 (es)-5 (er)-1 (v)-14 (at)-6 (i)-6 (v)-4 (e)]TJ 0 Tc 0 Tw [(] )-7 (a)4 (nd a)4 ( 25G)2 ( r)-7 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (i)-2 (on ne)4 (e)4 (dl)-2 (e)4 (, a)4 (nd )-10 (i)-2 (s)-1 ( s)-1 (upp)]TJ 0.002 Tc -0.002 Tw [(lie)6 (d)2 ( in)2 ( s)1 (in)2 (g)12 (le)6 ( c)6 (a)6 (r)5 (to)-8 (n)2 (s)]TJ 0 Tc 0 Tw 31.49 0 Td (. )Tj EMC /P <>BDC /TT1 1 Tf -31.49 -3.47 Td [(R)2 (x on)-4 (l)-2 (y. )]TJ EMC /P <>BDC /TT0 1 Tf 0.002 Tc -0.002 Tw 14.29 -3.43 Td [(D)4 (is)1 (tr)5 (ib)2 (u)2 (te)6 (d )]TJ 0 Tc 0 Tw 4.75 0 Td (b)Tj -0.02 Tc 0.02 Tw 0.51 0 Td (y:)Tj /T1_0 1 Tf (\002 )Tj /TT1 1 Tf -0.004 Tc 0.004 Tw -10.69 -1.15 Td [(T)-7 (ev)-4 (a)-4 ( S)-8 (el)-6 (ect)-1 ( B)-7 (ra)-4 (n)-8 (d)-8 (s)]TJ /TT0 1 Tf 0 Tc 0 Tw 8.22 0 Td [(, H)2 (or)3 (s)-1 (ha)4 (m)-2 (, P)-4 (A)2 ( 19044)]TJ /T1_0 1 Tf (\002 )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw -8.69 -1.15 Td [(D)-2 (i)-6 (v)-4 (i)-6 (s)-5 (i)-6 (o)-4 (n)-4 ( o)-4 (f)-1 ( T)-3 (ev)-4 (a P)-8 (h)-4 (ar)-1 (m)-6 (a)-10 (ceu)-4 (t)-6 (i)-6 (cal)-6 (s)-5 ( U)-2 (S)]TJ -0.013 Tc 0.023 Tw 15.1 0 Td [(A)-11 (,)-13 ( In)-23 (c)-9 (.)]TJ /T1_0 1 Tf (\002 )Tj EMC /P <>BDC /TT0 1 Tf 0 Tc 0 Tw 5.73 -2.3 Td [(R)-3 (e)4 (v. )]TJ /TT2 1 Tf (07)Tj /TT0 1 Tf [(/)-2 (2014 )]TJ -2.05 -1.15 Td [(6805-)3 (03 /)-2 ( 6810-)3 (03 )]TJ EMC /Artifact <>BDC 0 g /T1_1 1 Tf 10 0 0 10 44.6335 31.1981 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 549 0 obj <>>>/Resources 510 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 550 0 obj <> endobj 551 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 552 0 obj <> endobj 553 0 obj <>stream q 1 0 0 1 26.633423 13.198059 cm 0 0 595.32 841.92 re W n 1 0 0 1 -26.633423 -13.198059 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf -0.004 Tc 0.264 Tw 3 Tr 12 0 0 12 351.1138 772.3181 Tm ( )Tj 15.07 0 Td ( )Tj 0 Tc 0.01 Tw -28.14 -1.15 Td ( )Tj 0 Tw 8.04 0 0 8.04 347.2734 764.0381 Tm ( )Tj -0.004 Tc 0.014 Tw 12 0 0 12 459.9543 758.5181 Tm ( )Tj 6 0 Td ( )Tj 0 Tc 0 Tw -23.29 -1.15 Td ( )Tj 21.67 0 Td ( )Tj -32.99 -1.15 Td ( )Tj 0.002 Tc 0.078 Tw 26.95 -1.15 Td [( )-4170 ( )-2830 ( )]TJ 0 Tc 0.21 Tw -7.28 -1.15 Td ( )Tj 14.94 0 Td ( )Tj 0.32 Tw -20.09 -1.15 Td ( )Tj 20.09 0 Td ( )Tj 0 Tw -10.72 -1.15 Td ( )Tj -23.89 -1.15 Td ( )Tj 21.6 -1.15 Td ( )Tj -21.6 -1.15 Td ( )Tj /TT1 1 Tf 7.11 -1.17 Td ( )Tj /TT0 1 Tf 0.05 Tw 27.5 -1.13 Td ( )Tj 0.09 Tw -26.59 -1.15 Td ( )Tj 0 Tw 26.59 0 Td ( )Tj -0.004 Tc 0.144 Tw -23.59 -1.15 Td ( )Tj 0.004 Tw 4.1 0 Td ( )Tj 0 Tc 0.11 Tw -6.76 -1.15 Td ( )Tj 0 Tw 6.29 0 Td ( )Tj 0.11 Tw 1.2 0 Td ( )Tj 7.22 0 Td ( )Tj 0 Tw -14.89 -1.15 Td ( )Tj 12.98 0 Td ( )Tj -21.16 -1.15 Td ( )Tj /TT1 1 Tf 16.01 -1.17 Td ( )Tj /TT0 1 Tf -8.36 -1.13 Td ( )Tj 0.14 Tw 26.96 0 Td ( )Tj 0 Tw -14.53 -1.15 Td ( )Tj -20.08 -1.15 Td ( )Tj 8.04 0 0 8.04 171.8334 474.2381 Tm ( )Tj 12 0 0 12 180.7134 468.7181 Tm ( )Tj 15.09 0 Td ( )Tj 0.07 Tw 14.18 0 Td ( )Tj 0 Tw -11.13 -1.15 Td ( )Tj 11.13 0 Td ( )Tj -34.11 -1.15 Td ( )Tj 0.002 Tc 0.028 Tw 3.69 0 Td ( )Tj 0 Tc 0 Tw 13.23 0 Td ( )Tj -0.004 Tc 0.284 Tw -14.6 -1.15 Td [( )-4310 ( )]TJ 31.79 0 Td ( )Tj 0 Tc 0.08 Tw -19.42 -1.15 Td ( )Tj 0 Tw 8.04 0 0 8.04 512.7534 419.0381 Tm ( )Tj -0.002 Tc 0.562 Tw 12 0 0 12 531.9538 399.7181 Tm ( )Tj 0 Tc 0 Tw -26.91 -1.15 Td ( )Tj -7.7 -1.15 Td ( )Tj 8.04 0 0 8.04 171.8334 363.8381 Tm ( )Tj 12 0 0 12 186.8334 358.3181 Tm ( )Tj 0.002 Tc 0.088 Tw 28.76 0 Td ( )Tj 0 Tc 0 Tw -17.8 -1.15 Td ( )Tj 17.8 0 Td ( )Tj -33.61 -1.15 Td ( )Tj 0.002 Tc -0.002 Tw 3.66 0 Td ( )Tj 0 Tc 0 Tw 13.94 0 Td [( )-3000 ( )]TJ 9.12 0 Td ( )Tj -27.72 -1.15 Td ( )Tj 0.11 Tw 34.61 -1.15 Td ( )Tj 0.002 Tc 0.348 Tw 0 -1.15 TD ( )Tj 0 Tc 0.01 Tw -30.18 -1.15 Td ( )Tj 0 Tw 10.73 0 Td ( )Tj -0.002 Tc 0.012 Tw 3.37 0 Td ( )Tj 10.36 0 Td ( )Tj 0 Tc 0 Tw 8.04 0 0 8.04 521.7534 281.0381 Tm ( )Tj 0.18 Tw 12 0 0 12 531.9522 261.7181 Tm ( )Tj 0.002 Tc 0.108 Tw T* ( )Tj 0 Tc 0 Tw -30 -1.15 Td ( )Tj 29.76 -1.15 Td [( )510 ( )]TJ -0.004 Tc 0.074 Tw -28.91 -1.15 Td ( )Tj 0 Tc 0.07 Tw 29.15 0 Td ( )Tj 0.35 Tw -29.29 -1.15 Td ( )Tj 29.29 0 Td ( )Tj 0 Tw -4.77 -1.15 Td [( )-3290 ( )]TJ -29.84 -1.15 Td ( )Tj 0.23 Tw 19.27 -1.15 Td ( )Tj 0.02 Tw -15.23 -1.15 Td ( )Tj 25.68 0 Td [( )-4620 ( )]TJ -0.004 Tc 0.004 Tw -19.08 -1.15 Td ( )Tj 0 Tc 0 Tw ( )Tj -10.64 -1.15 Td ( )Tj EMC /P <>BDC 0.26 Tw 0 Tr 0 55.2 TD [(N)2 (one)4 ( of)3 ( t)-2 (he)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h a)4 (nt)-2 (i)]TJ 0 Tw 13.15 0 Td (-)Tj -0.004 Tc 0.264 Tw 0.33 0 Td [(G)-2 (H)-2 ( an)-4 (t)-6 (i)-6 (b)-4 (o)-4 (d)-4 (i)-6 (es )5 (i)-6 (n)-4 ( t)-6 (h)-4 (e cl)-6 (i)-6 (n)-4 (i)-6 (cal)-6 ( s)-5 (t)-6 (u)-4 (d)6 (i)-6 (es)-5 ( ex)-14 (p)-4 (er)-1 (i)-6 (en)-4 (ced )]TJ 0 Tc 0.01 Tw -13.48 -1.15 Td [(de)4 (c)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 (d l)-2 (i)-2 (ne)4 (a)-6 (r )-7 (g)10 (r)3 (ow)2 (t)-2 (h r)-7 (e)4 (s)-1 (pons)-1 (e)4 ( t)-2 (o )]TJ 0 Tw (T)Tj -0.004 Tc 0.004 Tw 15.23 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -0.004 Tc 0.014 Tw 3.23 0 Td [(o)-4 (r)-11 ( an)-14 (y)16 ( o)-4 (t)-6 (h)-4 (e)-10 (r)-1 ( as)-5 (s)-5 (o)-4 (ci)-6 (at)-6 (ed )-14 (ad)-4 (v)-14 (er)-1 (s)-5 (e ev)-14 (en)-4 (t)-6 (. )]TJ 0.002 Tc -0.002 Tw -19.4 -1.15 Td [(I)15 (n)2 (je)-4 (c)6 (tio)2 (n)2 ( s)1 (ite)6 ( r)5 (e)6 (a)-4 (c)6 (tio)2 (n)2 (s)1 ( $)5 (e)-4 (.)2 (g)12 (.)]TJ 0 Tc 0 Tw 11.07 0 Td [(, pa)4 (i)-2 (n, b)-10 (r)3 (ui)-2 (s)-1 (e)4 ($)3 ( oc)-6 (c)4 (ur)3 (r)-7 (e)-6 (d i)-2 (n 8 of)3 ( t)-2 (he)4 ( 164 t)-2 (r)3 (e)4 (a)4 (t)-2 (e)4 (d )-10 (pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (. )]TJ EMC /P <>BDC -0.004 Tc 0.084 Tw -11.07 -2.3 Td [(L)7 (eu)-4 (k)-14 (em)-6 (i)-6 (a h)-4 (as)-5 ( b)-4 (e)-10 (en)-4 ( r)-11 (ep)-4 (o)]TJ 0.002 Tc 0.078 Tw 9.99 0 Td [(r)5 (te)6 (d)2 ( in)2 ( a)6 ( s)1 (ma)6 (ll n)2 (u)2 (mb)2 (e)6 (r)5 ( o)-8 (f)5 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( tr)5 (e)6 (a)6 (te)6 (d )-8 (w)4 (ith)2 ( o)2 (th)2 (e)6 (r )-5 (g)12 (r)5 (o)2 (w)4 (th )]TJ 0 Tc 0.21 Tw -9.99 -1.15 Td [(hor)3 (m)-2 (one)4 ( pr)3 (oduc)4 (t)-2 (s)-1 (. )-10 (I)13 (t)-2 ( i)-2 (s)-11 ( unc)4 (e)4 (r)3 (t)-2 (a)4 (i)-2 (n w)2 (h)-10 (e)4 (t)-2 (he)4 (r)3 ( t)-2 (hi)-2 (s )-11 (r)3 (i)-2 (s)-1 (k i)-2 (s)-1 ( r)3 (e)4 (l)-2 (a)4 (t)-2 (e)4 (d t)-2 (o t)-2 (he)4 ( pa)-6 (t)-2 (hol)-2 (og)-10 (y)20 ( of )]TJ 0.32 Tw 0 -1.15 TD [(g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one)-6 ( de)4 (f)3 (i)-12 (c)4 (i)-2 (e)4 (nc)-16 (y)20 ( i)-2 (t)-2 (s)-1 (e)4 (l)-2 (f)3 (, )-20 (g)10 (r)3 (ow)2 (t)-2 (h)-10 ( hor)-7 (m)-2 (one)4 ( t)-2 (he)4 (r)-7 (a)4 (p)-20 (y)20 (, or)-7 ( ot)-2 (he)4 (r)-7 ( a)4 (s)-1 (s)-1 (oc)4 (i)-2 (a)4 (t)-2 (e)-6 (d )]TJ -0.004 Tc 0.004 Tw T* [(t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 (s)-5 ( s)-5 (u)-4 (ch)-4 ( as)-5 ( r)-11 (ad)-4 (i)-6 (at)-6 (i)-16 (o)-4 (n)-4 ( t)-6 (h)-4 (er)-1 (a)]TJ 0.002 Tc -0.002 Tw [(p)-18 (y)22 ( f)5 (o)2 (r)-5 ( in)2 (tr)5 (a)6 (c)6 (r)-5 (a)6 (n)2 (ia)-4 (l tu)2 (mo)2 (r)5 (s)1 (. )]TJ EMC /P <>BDC -0.004 Tc 0.004 Tw 0 -2.3 TD [(N)-2 (ew)]TJ 0 Tc 0 Tw 1.88 0 Td [(-)3 (ons)-1 (e)4 (t)-2 ( t)-22 (y)20 (pe)4 ( 2 di)-12 (a)4 (be)4 (t)-2 (e)-6 (s)-1 ( m)-2 (e)4 (l)-2 (l)-2 (i)-2 (t)-2 (us)-1 ( ha)4 (s)-1 ( be)4 (e)4 (n r)3 (e)4 (por)3 (t)-12 (e)4 (d. )]TJ EMC /P <>BDC /TT1 1 Tf -0.002 Tc -1.88 -2.32 Td [(O)-4 (VE)-5 (RDO)-4 (S)-6 (AG)6 (E )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0.05 Tw 0 -1.13 TD [(T)1 (he)4 ( r)3 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nd)-10 (e)4 (d dos)-1 (a)-6 (ge)4 ( of)3 ( up t)-2 (o 0.1 m)-2 (g)10 (/)-2 (kg)10 ( $)3 (0.3 )-10 (I)23 (U)2 (/)-2 (k)-10 (g)10 ($)3 ( of)3 ( bod)-20 (y)20 ( w)2 (e)4 (i)-12 (g)10 (ht)-2 ( 3 t)-2 (i)-2 (m)-2 (e)4 (s)-1 ( pe)4 (r )]TJ 0.09 Tw 0 -1.15 TD [(w)2 (e)4 (e)4 (k s)-1 (houl)-2 (d not)-2 ( be )]TJ -0.004 Tc 0.094 Tw 8.36 0 Td [(ex)-14 (ce)-10 (ed)-4 (ed)-4 (.)-4 ( A)-12 (cu)-4 (t)-6 (e o)-4 (v)-4 (e)-10 (r)-1 (d)-4 (o)-4 (s)-5 (e co)-14 (u)-4 (l)-6 (d)-4 ( cau)-4 (s)-5 (e i)-6 (n)-4 (i)-6 (t)-6 (i)-6 (al)-6 ( h)-24 (y)16 (p)-4 (o)-14 (g)6 (l)-26 (y)6 (cem)-6 (i)-6 (a an)-4 (d )]TJ 0.144 Tw -8.36 -1.15 Td [(s)-5 (u)-4 (b)-4 (s)-5 (eq)-4 (u)-4 (en)-4 (t)-6 ( h)-14 (y)16 (p)-14 (er)-11 (g)6 (l)-26 (y)16 (cem)-16 (i)-6 (a. )]TJ 0.004 Tw 11.41 0 Td [(R)-7 (ep)-4 (eat)-6 (ed )]TJ 0 Tc 0.14 Tw 4.1 0 Td [(us)-1 (e)4 ( of)3 ( dos)-11 (e)4 (s)-1 ( i)-2 (n e)4 (x)-10 (c)4 (e)4 (s)-1 (s)-1 ( of)3 ( t)-2 (hos)-1 (e)4 ( r)3 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nde)4 (d )]TJ 0.11 Tw -15.51 -1.15 Td [(c)4 (oul)-2 (d r)3 (e)4 (s)-1 (ul)-2 (t)-2 ( i)-2 (n s)-1 (i)-12 (g)10 (ns )-11 (a)4 (nd)-10 ( s)-11 (y)20 (m)-2 (pt)-2 (om)-2 (s )-1 (of )-17 (g)10 (i)-2 (ga)4 (nt)-2 (i)-2 (s)-1 (m)-2 ( a)4 (nd/)-2 (or )-7 (a)4 (c)4 (r)3 (om)-12 (e)-6 (g)10 (a)4 (l)-22 (y)20 ( c)4 (ons)-11 (i)-2 (s)-1 (t)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-2 (h )]TJ 0 Tw T* [(t)-2 (he)4 ( know)2 (n e)4 (f)3 (f)-7 (e)4 (c)4 (t)-2 (s)-1 ( of )-7 (e)4 (x)-10 (c)4 (e)4 (s)-1 (s)-1 ( hum)-2 (a)4 (n gr)3 (ow)2 (t)-2 (h hor)3 (m)-2 (o)-10 (ne)4 (. )]TJ EMC /P <>BDC /TT1 1 Tf -0.002 Tc 0.002 Tw 0 -2.32 TD [(DO)-4 (S)-6 (AG)6 (E)-5 ( AND AD)-10 (M)2 (I)-13 (NI)-3 (S)-6 (T)-5 (RAT)-5 (I)-3 (O)-4 (N )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0.14 Tw 0 -1.13 TD [(A)2 ( dos)-1 (a)4 (g)10 (e)4 ( of)3 ( up t)-2 (o 0.1 )10 (m)-2 (g)10 (/)-2 (k)-10 (g)10 ( $)3 (0.3 )-10 (I)13 (U)2 (/)-2 (kg$)3 ( of)3 ( bod)-10 (y)20 ( w)2 (e)4 (i)-12 (g)10 (ht)-2 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d 3 t)-2 (i)-2 (m)-2 (e)4 (s)-1 ( pe)4 (r )]TJ 0 Tw 0 -1.15 TD [(w)2 (e)4 (e)4 (k b)-20 (y)20 ( s)-1 (ubc)4 (ut)-12 (a)4 (ne)4 (ous)-1 ( i)-2 (n)-10 (j)-2 (e)4 (c)4 (t)-2 (i)-2 (on i)-2 (s)-1 ( r)3 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nde)4 (d. )]TJ EMC /P <>BDC 0 -2.3 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )10 (5 )]TJ -0.01 Tc 0.01 Tw 4.11 0 Td [(m)-12 (g )]TJ 0 Tc 0 Tw 1.59 0 Td (s)Tj 0.07 Tw 0.39 0 Td [(houl)-2 (d)-10 ( be)4 ( r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d w)2 (i)-2 (t)-2 (h 1)]TJ 0 Tw [(-)-7 (5 )]TJ 0.07 Tw 13.11 0 Td [(m)-12 (L)21 ( of)3 ( b)-10 (a)4 (c)4 (t)-2 (e)4 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( 0.)-10 (9%)3 ( s)-1 (odi)-2 (um )]TJ 0.26 Tw -20.75 -1.15 Td [(c)4 (hl)-2 (or)3 (i)-2 (de)4 ( f)3 (or)3 ( i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on, )-10 (U)2 (S)-4 (P)-4 ( $)3 (be)4 (nz)-16 (y)30 (l)-2 ( a)4 (l)-2 (c)4 (ohol)-2 ( pr)-7 (e)4 (s)-1 (e)4 (r)3 (ve)4 (d)-10 ($)3 (. )]TJ -0.004 Tc 0.004 Tw [(R)-7 (eco)-4 (n)-4 (s)]TJ 0.002 Tc 0.258 Tw 26.93 0 Td [(titu)2 (te)6 (d)2 ( T)]TJ -0.004 Tc 0.004 Tw 3.68 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -31.55 -1.15 Td (5 )Tj 0.002 Tc 0.028 Tw [(mg)12 ( v)2 (ia)6 (ls )]TJ 0 Tc 0.03 Tw 4.47 0 Td [(s)-1 (houl)-2 (d not)-2 ( be)4 ( us)-1 (e)4 (d i)-2 (f)3 ( t)-2 (he)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt )-2 (ha)4 (s)-1 ( a)4 ( know)2 (n s)-1 (e)4 (ns)-1 (i)-2 (t)-2 (i)-2 (vi)-2 (t)-12 (y)30 ( t)-2 (o be)4 (n)-10 (z)]TJ 0 Tw 25.91 0 Td (y)Tj 0.03 Tw 0.47 0 Td [(l)-2 ( a)4 (l)-12 (c)4 (ohol)-2 (. )]TJ -0.004 Tc 0.284 Tw -30.85 -1.15 Td [(B)3 (en)-4 (z)-20 (y)16 (l )-16 (al)-6 (co)-4 (h)-4 (o)-4 (l)-6 ( as )-15 (a p)-4 (r)-11 (es)-5 (er)-1 (v)-4 (at)-6 (i)-6 (v)-4 (e i)-6 (n)-4 ( b)-14 (act)-6 (e)-10 (r)-1 (i)-6 (o)-4 (s)-5 (t)-6 (at)-6 (i)-6 (c n)-4 (o)-4 (r)-1 (m)-6 (al)-6 ( s)-5 (al)-6 (i)-6 (n)-4 (e,)-4 ( U)-2 (S)-8 (P)-8 (,)-4 ( h)-4 (as)-5 ( b)-4 (ee)-10 (n )]TJ 0 Tc 0.08 Tw 0 -1.15 TD [(a)4 (s)-1 (s)-1 (oc)4 (i)-2 (a)4 (t)-2 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h t)-2 (ox)-10 (i)-2 (c)4 (i)-2 (t)-12 (y)30 ( i)-12 (n ne)4 (w)2 (bor)3 (ns)-1 (. )]TJ -0.002 Tc 0.082 Tw 15.52 0 Td [(W)-8 (HE)-1 (N AD)-10 (M)-13 (I)21 (N)-20 (I)21 (S)-6 (T)-11 (E)-1 (R)-15 (I)11 (NG T)-11 (E)-1 (V)]TJ 0 Tc 0 Tw (-)Tj -0.023 Tc 0.023 Tw 13.88 0 Td [(T)-32 (R)-26 (O)-21 (P)-37 (IN )]TJ 0 Tc 0 Tw 3.86 0 Td (T)Tj 0.008 Tc -0.008 Tw 0.62 0 Td (O )Tj -0.002 Tc 0.562 Tw -33.88 -1.15 Td [(NE)-1 (W)-8 (B)5 (OR)-5 (NS)-6 (,)-2 ( R)-5 (E)-1 (C)-5 (ONS)-6 (T)-11 (I)21 (T)-1 (UT)-11 (E)-1 ( W)-18 (I)21 (T)-11 (H S)-6 (T)-1 (E)-1 (R)-15 (I)11 (L)9 (E)-1 ( N)-10 (OR)-5 (M)-3 (A)-10 (L)9 ( S)-6 (A)-10 (L)-1 (I)11 (N)-10 (E)-1 ( F)4 (OR )]TJ 0.002 Tw T* [(I)11 (NJ)-13 (E)-1 (C)-5 (T)-11 (I)11 (ON,)-2 ( US)-6 (P)-6 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw 0 -2.3 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n 10 )]TJ 0.002 Tc 0.088 Tw 4.64 0 Td [(m)-10 (g)12 ( s)1 (h)2 (o)2 (u)2 (ld)2 ( b)2 (e)6 ( r)5 (e)6 (c)6 (o)2 (n)2 (s)1 (titu)2 (te)6 (d)2 ( w)4 (ith)2 ( 1)12 ( mL)23 ( s)-19 (y)22 (r)5 (in)-8 (g)2 (e)6 ( o)2 (f)5 ( b)2 (a)6 (c)6 (te)6 (r)5 (io)2 (s)-9 (ta)6 (tic)6 ( w)4 (a)6 (te)6 (r )]TJ 0 Tc 0 Tw -6.19 -1.15 Td [(f)3 (or)3 ( i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on )-10 (c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (n)-10 (g)10 ( 0)-10 (.33%)3 ( m)-2 (e)4 (t)-2 (a)4 (c)-6 (r)3 (e)4 (s)-1 (ol )-12 (a)4 (s)-1 ( a)-6 ( pr)3 (e)-6 (s)-1 (e)4 (r)3 (va)4 (t)-2 (i)-2 (ve)4 (. )]TJ 0.01 Tw [(R)-3 (e)-6 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d T)]TJ -0.004 Tc 0.004 Tw 30.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -31.55 -1.15 Td (10 )Tj 0.002 Tc -0.002 Tw [(mg)12 ( v)2 (ia)6 (ls )]TJ 0.001 Tc -0.001 Tw 4.91 0 Td (sh)Tj 0 Tc 0 Tw 0.89 0 Td [(oul)-2 (d not)-2 ( be)4 ( us)-1 (e)4 (d i)-2 (f)3 ( t)-2 (he)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 ( i)-2 (s )]TJ -0.004 Tc 0.004 Tw 13.05 0 Td [(al)-6 (l)-16 (er)-11 (g)6 (i)-6 (c t)-6 (o)-4 ( m)-6 (et)-6 (ac)-10 (r)-1 (es)-5 (o)]TJ 0.002 Tc -0.002 Tw 8.33 0 Td (l. )Tj EMC /P <>BDC 0 Tc 0.11 Tw -27.18 -2.3 Td [(T)1 (he)4 ( s)-1 (t)-2 (r)3 (e)4 (a)4 (m)-2 ( of)3 ( nor)3 (m)-2 (a)4 (l)-2 ( s)-1 (a)4 (l)-2 (i)-2 (ne)4 ( s)-1 (houl)-2 (d be)4 ( a)4 (i)-2 (m)-2 (e)4 (d a)4 (g)10 (a)4 (i)-2 (ns)-1 (t)-2 ( t)-2 (he)4 ( s)-1 (i)-2 (de)4 ( of)3 ( t)-2 (he)4 ( v)10 (i)-2 (a)4 (l)-2 ( t)-2 (o pr)3 (e)4 (ve)4 (nt )]TJ 0.002 Tc 0.348 Tw 0 -1.15 TD [(f)5 (o)2 (a)6 (min)2 (g)12 (.)2 ( S)-2 (w)4 (ir)5 (l th)2 (e)6 ( v)2 (ia)-4 (l w)4 (ith)2 ( a)6 ( G)4 (E)3 (N)4 (T)-7 (L)13 (E)3 ( r)5 (o)2 (t)-10 (a)6 (r)-15 (y)22 ( mo)2 (tio)2 (n)2 ( u)2 (n)2 (til th)2 (e)6 ( c)6 (o)2 (n)2 (te)6 (n)2 (ts)1 ( a)6 (r)5 (e )]TJ 0 Tc 0.01 Tw T* [(c)4 (om)-2 (pl)-2 (e)4 (t)-2 (e)4 (l)-12 (y )10 (di)-2 (s)-1 (s)-1 (ol)-2 (ve)4 (d a)4 (nd)-10 ( t)-2 (he)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on )]TJ -0.002 Tc 0.012 Tw [(i)-4 (s)-3 ( c)2 (l)-4 (e)2 (a)2 (r)1 (. )-12 (DO)-10 ( NOT)-1 ( S)-6 (HAKE)-1 (.)-2 ( S)-6 (i)-4 (n)-2 (c)-8 (e )]TJ 0 Tc 0 Tw 29.15 0 Td (T)Tj 0.006 Tc -0.006 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.001 Tc -0.001 Tw 3.23 0 Td [(i)-1 (s )]TJ 0 Tc 0.18 Tw -33.94 -1.15 Td [(a)4 ( pr)3 (ot)-2 (e)4 (i)-2 (n, s)-1 (ha)4 (ki)-2 (n)-10 (g)10 ( or)3 ( vi)-2 (g)10 (or)3 (ous)-1 ( m)-2 (i)-2 (x)-10 (i)-2 (ng)10 ( w)2 (i)-2 (l)-2 (l)-2 ( c)4 (a)4 (us)-11 (e)4 ( t)-2 (he)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on t)-2 (o be)4 ( c)4 (l)-2 (oud)-10 (y)20 (. )-10 (I)13 (f)3 ( t)-2 (h)-10 (e )]TJ 0.002 Tc 0.108 Tw T* [(r)5 (e)6 (s)1 (u)2 (ltin)2 (g)12 ( s)1 (o)2 (lu)2 (tio)2 (n)2 ( is)1 ( c)6 (lo)2 (u)12 (d)-8 (y)22 ( o)2 (r)5 ( c)6 (o)2 (n)2 (ta)6 (in)2 (s)1 ( p)2 (a)6 (r)5 (tic)6 (u)2 (la)6 (t)-10 (e)6 ( ma)6 (tte)6 (r)5 (,)2 ( th)2 (e)6 ( c)6 (o)2 (n)2 (te)6 (n)2 (ts)1 ( M)1 (U)4 (S)-2 (T)3 ( N)4 (O)4 (T )]TJ -0.004 Tc 0.004 Tw T* [(b)-4 (e i)-6 (n)-4 (j)-6 (ect)-6 (ed)-4 (. )]TJ EMC /P <>BDC 0.074 Tw 0 -2.3 TD [(O)-2 (ccas)-5 (i)-6 (o)-4 (n)-4 (al)-6 (l)-26 (y)16 (, )-14 (af)-1 (t)-6 (er)-11 ( r)-1 (e)-10 (f)-1 (r)-1 (i)-16 (g)-4 (er)-1 (at)]TJ 0 Tc 0.07 Tw 11.66 0 Td [(i)-2 (on, s)-1 (om)-2 (e)4 ( c)4 (l)-2 (oudi)-2 (ne)4 (s)-1 (s)-11 ( m)-2 (a)-6 (y)20 ( o)-10 (c)4 (c)4 (u)-10 (r)3 (. T)1 (hi)-2 (s)-1 ( i)-2 (s)-1 ( not)-2 ( unus)-1 (ua)4 (l)-2 ( f)3 (or )]TJ 0.35 Tw -11.66 -1.15 Td [(pr)3 (ot)-2 (e)4 (i)-2 (ns)-1 ( l)-2 (i)-2 (ke )]TJ 0 Tw 5.92 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)-9 (r)3 (opi)-2 (n)]TJ 0.35 Tw [(. A)2 (l)-2 (l)-2 (ow)2 ( t)-2 (he)4 ( pr)3 (oduc)4 (t)-2 ( t)-12 (o w)2 (a)4 (r)3 (m)-2 ( t)-2 (o r)3 (oom)-2 ( t)-2 (e)4 (m)-2 (p)-10 (e)4 (r)3 (a)4 (t)-2 (ur)-7 (e)4 (. )-10 (I)3 (f )]TJ 0 Tw -7.47 -1.15 Td [(c)4 (l)-2 (oudi)-2 (ne)4 (s)-1 (s)-1 ( pe)4 (r)3 (s)-1 (i)-2 (s)-1 (t)-2 (s)-1 ( or)3 ( pa)4 (r)-7 (t)-2 (i)-2 (c)4 (ul)-2 (a)4 (t)-2 (e)4 ( m)-2 (a)4 (t)-2 (t)-2 (e)4 (r)3 ( i)-2 (s)-1 ( not)-2 (e)4 (d, t)-2 (he)4 ( c)4 (ont)-2 (e)4 (nt)-2 (s)-1 ( M)-1 (U)2 (S)-4 (T)1 ( N)2 (O)2 (T )-9 (be)4 ( us)-1 (e)4 (d. )]TJ EMC /P <>BDC -0.004 Tc 0.234 Tw T* [(B)3 (ef)-1 (o)-14 (r)-1 (e )-10 (an)-4 (d)-4 ( af)-1 (t)-16 (er)-1 ( i)-6 (n)-4 (j)-6 (ect)-6 (i)-16 (o)-4 (n)-4 (,)-4 ( t)-6 (h)-4 (e s)-5 (ep)-4 (t)-6 (u)-4 (m)-6 ( o)]TJ 0 Tc 0.23 Tw 17.24 0 Td [(f)3 ( t)-2 (he )-6 (vi)-2 (a)4 (l)-2 ( s)-1 (houl)-2 (d be)4 ( w)2 (i)-2 (pe)4 (d w)-8 (i)-2 (t)-2 (h r)3 (ubbi)-2 (ng )]TJ 0.02 Tw -17.24 -1.15 Td [(a)4 (l)-2 (c)4 (ohol)-2 ( or )-7 (a)4 (n )-10 (a)4 (l)-2 (c)4 (ohol)-2 (i)-2 (c)4 ( a)-6 (nt)-2 (i)-2 (s)-1 (e)4 (pt)-2 (i)-2 (c)4 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on t)-2 (o pr)3 (e)4 (v)-10 (e)4 (nt)-2 ( c)4 (ont)-2 (a)4 (m)-2 (i)-2 (na)4 (t)-2 (i)-2 (on of)-7 ( t)-2 (he )-6 (c)4 (ont)-2 (e)4 (nt)-2 (s)-1 ( b)-20 (y )]TJ -0.004 Tc 0.004 Tw 0 -1.15 TD [(r)-1 (ep)-4 (eat)-16 (ed)-4 ( n)-4 (eed)-4 (l)-16 (e i)-6 (n)-4 (s)-5 (er)-1 (t)-6 (i)-6 (o)-4 (n)-14 (s)-5 (. )]TJ EMC /Artifact <>BDC 0 g /T1_0 1 Tf 0 Tc 0 Tw 10 0 0 10 44.6334 31.1981 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 554 0 obj <>>>/Resources 509 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 555 0 obj <> endobj 556 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 557 0 obj <> endobj 558 0 obj <>stream q 1 0 0 1 26.632782 13.197998 cm 0 0 595.32 841.92 re W n 1 0 0 1 -26.632782 -13.197998 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 0.08 Tw 3 Tr 12 0 0 12 335.8729 772.318 Tm [( )-3560 ( )]TJ 0 Tw -13.33 -1.15 Td ( )Tj 0.08 Tw 29.67 0 Td ( )Tj 0 Tw -27.79 -1.15 Td ( )Tj 7.37 0 Td ( )Tj -14.19 -1.15 Td ( )Tj 0.002 Tc 0.318 Tw 29.31 -1.15 Td [( )-4730 ( )]TJ 0 Tc 0 Tw -27.25 -1.15 Td ( )Tj 0.002 Tc 0.428 Tw 32.55 0 Td ( )Tj 0 Tc 0 Tw -30.11 -1.15 Td ( )Tj 0.35 Tw 8.67 0 Td ( )Tj 21.44 0 Td ( )Tj 0.15 Tw -12.73 -2.3 Td [( )-3780 ( )]TJ 12.73 0 Td ( )Tj 0.002 Tc 0.158 Tw -28.26 -1.15 Td ( )Tj 0 Tc 0.16 Tw 25.11 0 Td ( )Tj 0 Tw -25.63 -1.15 Td ( )Tj /TT1 1 Tf -5.83 -1.15 Td ( )Tj /TT2 1 Tf 0.002 Tc -0.002 Tw 19.02 -1.17 Td ( )Tj 0 Tc 0 Tw 3.75 0 Td ( )Tj /TT0 1 Tf -17.91 -2.28 Td ( )Tj -4.86 -1.15 Td ( )Tj /TT2 1 Tf 4.56 -1.17 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.154 Tw 5.03 -1.13 Td ( )Tj 0 Tc 0 Tw 25.02 0 Td ( )Tj 0.002 Tc 0.198 Tw -29.76 -1.15 Td [( )-1730 ( )]TJ -0.004 Tc 0.004 Tw 4.25 0 Td ( )Tj 0 Tc 0.2 Tw 8.58 0 Td ( )Tj 0 Tw 5.07 0 Td ( )Tj -0.004 Tc 0.204 Tw 1.83 0 Td [( )-4460 ( )-4670 ( )]TJ 0 Tc 0 Tw 8.04 0 0 8.04 531.9528 515.638 Tm ( )Tj 12 0 0 12 320.7528 496.318 Tm ( )Tj -0.004 Tc 0.004 Tw 0.86 0 Td ( )Tj 0 Tc 0 Tw 6.32 0 Td ( )Tj /TT1 1 Tf -24.19 -1.15 Td ( )Tj /TT2 1 Tf 7.31 -1.17 Td ( )Tj /TT0 1 Tf 0.03 Tw 25.79 -1.13 Td ( )Tj 0 Tw 1.51 0 Td ( )Tj -0.004 Tc 0.544 Tw -6.86 -1.15 Td ( )Tj 0 Tc 0 Tw 5.4 0 Td ( )Tj -19.57 -1.15 Td ( )Tj /TT2 1 Tf -13.58 -1.17 Td ( )Tj 5.75 -1.15 Td ( )Tj /TT0 1 Tf -0.004 Tc 0.004 Tw -1.57 -1.13 Td ( )Tj 0 Tc 0 Tw 29.74 0 Td ( )Tj 0.002 Tc -0.002 Tw -14.07 -1.15 Td ( )Tj 0 Tc 0 Tw 13.53 0 Td ( )Tj -23.78 -1.15 Td ( )Tj 16.7 0 Td ( )Tj /TT1 1 Tf -26.3 -1.15 Td ( )Tj /TT0 1 Tf 0 -1.15 TD ( )Tj /TT2 1 Tf 10.98 -1.17 Td ( )Tj /TT0 1 Tf 0.33 Tw -4.97 -1.13 Td ( )Tj 28.6 0 Td ( )Tj 0.03 Tw T* ( )Tj 0 Tw -24.39 -1.15 Td ( )Tj 5.86 0 Td [( )-3090 ( )]TJ -16.08 -1.15 Td ( )Tj -0.004 Tc 0.064 Tw 34.61 -1.15 Td ( )Tj 0 Tc 0.17 Tw T* ( )Tj 0 Tw -14.05 -2.3 Td ( )Tj 0.06 Tw 14.05 0 Td ( )Tj 0 Tw -14.97 -1.15 Td ( )Tj 9.64 0 Td ( )Tj 5.33 0 Td ( )Tj 0.04 Tw T* ( )Tj 0 Tw -28.91 -1.15 Td ( )Tj 0.07 Tw 8.95 0 Td ( )Tj 19.96 0 Td ( )Tj 0.05 Tw T* ( )Tj 0.3 Tw T* ( )Tj 0 Tw -12.43 -1.15 Td ( )Tj -22.18 -1.15 Td ( )Tj EMC /P <>BDC 0.08 Tw 0 Tr 0 55.2 TD [(g)10 (l)-2 (uc)4 (o)-10 (c)4 (or)3 (t)-2 (i)-2 (c)4 (oi)-2 (d r)-7 (e)4 (pl)-2 (a)4 (c)-6 (e)4 (m)-2 (e)-6 (nt)-2 ( dos)-1 (i)-2 (ng)10 ( s)-1 (houl)-2 (d)-10 ( be )-6 (c)4 (a)4 (r)-7 (e)-6 (f)3 (ul)-2 (l)-12 (y )10 (a)4 (dj)-2 (us)-1 (t)-2 (e)4 (d i)-2 (n )-10 (c)4 (hi)-2 (l)-2 (dr)3 (e)-6 (n r)3 (e)-6 (c)4 (e)4 (i)-2 (vi)-2 (ng )]TJ 0 Tw 0 -1.15 TD [(c)4 (onc)4 (om)-2 (i)-2 (t)-2 (a)4 (nt )]TJ 0.08 Tw 5.27 0 Td [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n a)4 (nd g)10 (l)-2 (uc)4 (o)-10 (c)4 (or)3 (t)-2 (i)-2 (c)4 (oi)-2 (d t)-2 (r)3 (e)4 (a)4 (t)-12 (m)-2 (e)4 (nt)-2 (s)-1 ( t)-2 (o a)4 (voi)-2 (d bot)-2 (h)10 ( h)-10 (y)20 (p)-10 (oa)4 (dr)3 (e)4 (na)4 (l)-2 (i)-2 (s)-1 (m )]TJ 0 Tw -5.27 -1.15 Td [(a)4 (nd a)4 (n i)-2 (nhi)-2 (bi)-2 (t)-2 (or)-7 (y )10 (e)4 (f)3 (f)-7 (e)4 (c)4 (t)-2 ( o)-10 (n g)10 (r)3 (o)-10 (w)2 (t)-2 (h. )]TJ EMC /P <>BDC 0.002 Tc 0.318 Tw 0 -2.3 TD [(L)13 (imite)6 (d)2 ( p)2 (u)2 (b)2 (lis)1 (h)2 (e)6 (d)2 ( d)2 (a)6 (ta)-4 ( in)2 (d)2 (ic)6 (a)6 (te)6 ( th)2 (a)6 (t s)1 (o)2 (ma)6 (tr)5 (o)2 (p)-8 (in)2 ( tr)5 (e)6 (a)6 (tme)6 (n)2 (t in)2 (c)6 (r)5 (e)-4 (a)6 (s)1 (e)6 (s )-9 (c)-4 (y)22 (to)-8 (c)6 (h)2 (r)5 (o)2 (me )]TJ 0 Tc 0 Tw 0 -1.15 TD [(P)-4 (450 )]TJ -0.004 Tc 0.434 Tw [($)-1 (C)-7 (P)-8 (4)-4 (5)-4 (0)-4 ($)-1 ( m)-6 (ed)-4 (i)-6 (at)-6 (ed)-4 ( an)-4 (t)-6 (i)-6 (p)-14 (y)16 (r)-1 (i)-6 (n)-4 (e )-10 (cl)-6 (ea)-10 (r)-1 (an)-4 (c)-10 (e i)-16 (n)-4 ( m)-6 (an)-4 (.)-4 ( T)-3 (h)-4 (es)-5 (e d)-4 (at)-6 (a s)-5 (u)-14 (g)-4 (g)6 (es)]TJ 0.002 Tc 0.428 Tw 32.14 0 Td [(t th)2 (a)6 (t )]TJ 0 Tc 0 Tw -32.14 -1.15 Td [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )]TJ 0.35 Tw 5.1 0 Td [(a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)8 (on m)-2 (a)-6 (y )20 (a)4 (l)-2 (t)-2 (e)4 (r)3 ( t)-2 (he)4 ( c)4 (l)-2 (e)4 (a)4 (r)-7 (a)4 (nc)4 (e)4 ( of)3 ( c)4 (om)-2 (pounds)-1 ( know)2 (n t)-2 (o be )]TJ 0.73 Tw -5.1 -1.15 Td [(m)-2 (e)4 (t)-2 (a)4 (bol)-2 (i)-2 (z)-6 (e)4 (d b)-10 (y)30 ( C)-3 (P)-4 (450 l)-2 (i)-2 (ve)4 (r)3 ( e)4 (nz)-16 (y)30 (m)-2 (e)4 (s)-1 ( $)-7 (e)4 (.)-10 (g)10 (., c)4 (or)3 (t)-2 (i)-2 (c)4 (os)-1 (t)-2 (e)-6 (r)3 (oi)-2 (ds)-1 (, s)-1 (e)4 (x)-10 ( s)9 (t)-2 (e)4 (r)3 (oi)-2 (ds)-1 (, )]TJ 0.15 Tw T* [(a)4 (nt)-2 (i)-2 (c)4 (onvul)-2 (s)-1 (a)4 (nt)-2 (s)-1 (, c)-16 (y)20 (c)4 (l)-2 (os)-1 (p)-10 (or)3 (i)-2 (ne)4 ($)3 (. C)-3 (a)-6 (r)3 (e)4 (f)3 (ul)-2 ( m)-2 (oni)-2 (t)-2 (or)3 (i)-12 (ng)10 ( i)-2 (s )-11 (a)4 (dvi)-2 (s)-1 (a)4 (bl)-2 (e )-6 (w)2 (he)4 (n s)-1 (o)-10 (m)-2 (a)4 (t)-2 (r)3 (opi)-2 (n i)-2 (s )]TJ 0.002 Tc 0.158 Tw T* [(a)6 (d)2 (min)2 (is)1 (te)6 (r)5 (e)6 (d)2 ( in )-8 (c)6 (o)]TJ 0 Tc 0.16 Tw 7.71 0 Td [(m)-2 (bi)-2 (na)-6 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h ot)-2 (he)4 (r)3 ( dr)3 (u)-10 (g)10 (s)-11 ( k)-10 (now)2 (n t)-2 (o be)-6 ( m)-2 (e)4 (t)-2 (a)4 (bol)-2 (i)-2 (z)-6 (e)4 (d b)-10 (y )10 (C)-3 (P)-4 (450 )]TJ -0.004 Tc 0.004 Tw -7.71 -1.15 Td [(l)-6 (i)-6 (v)-4 (er)-1 ( en)-4 (z)-20 (y)16 (m)-6 (es)-5 (. )]TJ EMC /P <>BDC /TT2 1 Tf 0 -2.32 TD [(C)-2 (a)-4 (rci)-6 (n)-8 (o)-4 (g)-4 (en)-8 (es)-5 (i)-6 (s)-5 (,)-4 ( Mu)-8 (t)-1 (a)-4 (g)]TJ 0.002 Tc -0.002 Tw 9.77 0 Td [(e)-4 (n)-2 (e)6 (s)1 (is)1 (,)2 ( I)1 (m)15 (p)-2 (a)2 (ir)-4 (m)15 (e)6 (n)-2 (t)5 ( o)2 (f )-15 (F)13 (e)-4 (r)6 (t)5 (ilit)5 (y )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0.09 Tw -9.77 -1.13 Td [(C)-3 (a)4 (r)3 (c)4 (i)-2 (no)-10 (g)10 (e)4 (ne)4 (s)-1 (i)-2 (s)-1 (, m)-2 (ut)-2 (a)-6 (g)10 (e)4 (n)-10 (e)4 (s)-1 (i)-2 (s)-1 ( a)4 (nd r)3 (e)4 (pr)3 (oduc)4 (t)-2 (i)-2 (on s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( ha)4 (ve)4 ( not)-2 ( be)4 (e)4 (n c)4 (ond)-10 (uc)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h )]TJ 0 Tw 0 -1.15 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n. )]TJ EMC /P <>BDC /TT2 1 Tf -0.004 Tc -1.55 -2.32 Td [(P)7 (r)-10 (eg)-4 (n)-8 (a)-4 (n)-8 (cy )]TJ EMC /P <>BDC /TT0 1 Tf 0.154 Tw 0 -1.13 TD [(P)-8 (r)-1 (eg)6 (n)-14 (an)-4 (c)-20 (y)16 ( C)-7 (at)-6 (e)-10 (g)6 (o)-4 (r)-21 (y)16 ( C)-7 (. )]TJ 0 Tc 0.15 Tw 10 0 Td [(A)2 (ni)-2 (m)-2 (a)4 (l)-2 ( r)3 (e)4 (pr)3 (oduc)4 (t)-2 (i)-2 (on s)-1 (t)-2 (udi)-2 (e)4 (s)-1 ( ha)4 (ve)4 ( not)-2 ( be)4 (e)4 (n c)4 (ond)-10 (uc)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h )]TJ 0 Tw -10 -1.15 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n)]TJ 0.002 Tc 0.198 Tw [(. )-8 (I)15 (t is )]TJ -0.004 Tc 0.004 Tw 5.94 0 Td [(al)-6 (s)-5 (o )]TJ 0 Tc 0.2 Tw 2.06 0 Td [(n)-10 (ot)-2 ( know)2 (n w)2 (he)4 (t)-2 (he)-6 (r )]TJ 0 Tw 8.58 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)-7 (T)1 (r)3 (opi)-2 (n )]TJ -0.004 Tc 0.204 Tw 3.51 0 Td [(can )-14 (cau)-4 (s)-5 (e)-10 ( f)-1 (et)-16 (al )-16 (h)-4 (ar)-1 (m)-6 ( w)-2 (h)-4 (en )]TJ 0 Tc 0.15 Tw -23.2 -1.15 Td [(a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (o )-10 (a)4 ( pr)-7 (e)-6 (g)10 (n)-10 (a)4 (nt)-2 ( w)2 (om)-2 (a)4 (n o)-10 (r)3 ( c)-6 (a)4 (n )-10 (a)4 (f)3 (f)-7 (e)4 (c)-6 (t)-2 ( r)3 (e)4 (pr)3 (odu)-10 (c)4 (t)-2 (i)-2 (ve)4 ( c)-6 (a)4 (pa)-6 (c)4 (i)-2 (t)-12 (y)20 (. )]TJ 0 Tw 30 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -31.55 -1.15 Td [(s)-1 (houl)-2 (d be)4 ( g)10 (i)-2 (ve)4 (n t)-2 (o a)4 ( p)-10 (r)3 (e)-6 (gna)4 (nt)-2 ( w)2 (om)-2 (a)4 (n onl)-12 (y )]TJ -0.004 Tc 0.004 Tw 17.26 0 Td [(i)-6 (f )-11 (cl)-6 (ea)-10 (r)-11 (l)-16 (y)16 ( n)-4 (e)-10 (ed)-4 (ed)-4 (. )]TJ EMC /P <>BDC /TT2 1 Tf -17.26 -2.32 Td [(N)-2 (u)-8 (rs)-5 (i)-6 (n)-8 (g)-4 ( Mo)-4 (t)-1 (h)-8 (ers )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0.03 Tw T* [(I)13 (t)-2 ( i)-2 (s)-1 ( not)-2 ( know)2 (n w)2 (he)4 (t)-2 (h)-10 (e)4 (r)3 ( t)-12 (hi)-2 (s)-1 ( dr)3 (ug)10 ( i)-2 (s)-1 ( e)4 (x)-10 (c)4 (r)3 (e)4 (t)-2 (e)4 (d i)-2 (n hu)-10 (m)-2 (a)4 (n m)-2 (i)-2 (l)-2 (k. B)7 (e)4 (c)4 (a)4 (us)-11 (e)4 ( m)-2 (a)4 (n)-20 (y)10 ( dr)3 (ug)10 (s )-11 (a)4 (r)3 (e )]TJ 0.54 Tw 0 -1.15 TD [(e)4 (x)-10 (c)4 (r)3 (e)4 (t)-2 (e)4 (d i)-2 (n hum)-2 (a)4 (n m)8 (i)-2 (l)-2 (k, c)4 (a)4 (ut)-2 (i)-2 (on s)-1 (houl)-2 (d b)]TJ -0.004 Tc 0.544 Tw [(e)10 ( ex)-14 (er)-1 (ci)-6 (s)-5 (ed)-4 ( w)-2 (h)-4 (en )]TJ 0 Tc 0 Tw 28.54 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)-7 (T)1 (r)3 (opi)-2 (n )]TJ 0.001 Tc -0.001 Tw 3.85 0 Td [(i)-1 (s )]TJ 0 Tc 0 Tw -33.94 -1.15 Td [(a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d t)-2 (o a)4 ( nur)3 (s)-1 (i)-2 (n)-10 (g w)2 (om)-2 (a)4 (n. )]TJ EMC /P <>BDC /TT2 1 Tf -0.004 Tc 0.004 Tw 0 -2.32 TD [(G)4 (e)-10 (ri)-6 (a)-4 (t)-1 (ri)-6 (c U)-2 (s)-15 (e )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.13 TD [(T)-3 (h)-4 (e s)-5 (af)-1 (et)-26 (y )6 (an)-4 (d)-4 ( e)]TJ 0 Tc 0 Tw [(f)-7 (f)3 (e)4 (c)4 (t)-2 (i)-2 (ve)4 (n)-10 (e)4 (s)-1 (s)-1 ( of)3 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( a)4 (ge)4 (d 65 a)4 (nd ov)-10 (e)4 (r)3 ( ha)-6 (s)-1 ( not)-2 ( be)4 (e)4 (n )]TJ 0.002 Tc -0.002 Tw 0 -1.15 TD [(e)6 (v)2 (a)6 (lu)2 (a)6 (te)6 (d)2 ( in)2 ( c)6 (lin)2 (ic)6 (a)6 (l s)1 (tu)2 (d)-8 (ie)6 (s)1 (.)2 ( E)3 (ld)2 (e)6 (r)5 (l)-10 (y)22 ( p)-8 (a)6 (tie)6 (n)2 (ts)1 ( ma)-14 (y )12 (b)2 (e)6 ( mo)2 (r)5 (e)6 ( s)1 (e)6 (n)2 (s)1 (itiv)2 (e)6 ( to)2 ( th)2 (e)6 ( a)-4 (c)6 (tio)2 (n)2 ( o)2 (f )]TJ 0 Tc 0 Tw T* [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n, a)4 (nd m)-2 (a)-16 (y)20 ( be )-6 (m)-2 (or)3 (e)4 ( pr)3 (one)4 ( t)-2 (o de)4 (v)-10 (e)4 (l)-2 (op a)4 (d)-10 (ve)4 (r)3 (s)-1 (e)4 ( r)-7 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 (. )]TJ EMC /P <>BDC /TT2 1 Tf -0.002 Tc 0.002 Tw 0 -3.47 TD [(ADVE)-5 (RS)-6 (E)-5 ( RE)-5 (ACT)-5 (I)-3 (O)-4 (NS )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0.33 Tw 0 -1.13 TD [(T)1 (he)4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng a)4 (dve)4 (r)3 (s)-11 (e)4 ( r)3 (e)4 (a)4 (c)4 (t)-2 (i)-2 (ons)-1 ( ha)4 (v)-10 (e)4 ( be)4 (e)4 (n ob)-10 (s)-1 (e)4 (r)3 (ve)4 (d dur)3 (i)-2 (n)-10 (g)10 ( a)4 (pp)-10 (r)3 (opr)3 (i)-2 (a)-6 (t)-2 (e)4 ( us)-1 (e)4 ( of )]TJ 0.03 Tw 0 -1.15 TD [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n:)-2 ( he)4 (a)4 (da)4 (c)4 (he)4 (s)-1 ( $)3 (c)-6 (hi)-2 (l)-2 (dr)3 (e)4 (n a)4 (nd a)4 (dul)-2 (t)-2 (s)-1 ($)3 (, g)-10 (y)20 (ne)-6 (c)4 (om)-2 (a)4 (s)-1 (t)-2 (i)-2 (a)4 ( $)3 (c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n$)3 ( a)4 (nd )-10 (pa)4 (nc)4 (r)3 (e)-6 (a)4 (t)-2 (i)-2 (t)-2 (i)-2 (s )]TJ 0 Tw T* [($)3 (c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n a)4 (nd )-10 (a)4 (dul)-2 (t)-2 (s)-1 ($)3 (. S)-4 (e)4 (e )]TJ /TT2 1 Tf -0.002 Tc 10.47 0 Td [(W)-2 (ARNI)-3 (N)-10 (G)6 (S )]TJ /TT0 1 Tf -0.004 Tc 5.86 0 Td [(s)-5 (ect)-6 (i)-6 (o)-4 (n)-4 (. )]TJ EMC /P <>BDC 0.002 Tc 0.058 Tw -16.33 -2.3 Td [(A)4 (s)1 ( w)4 (ith)2 ( a)6 (ll th)2 (e)-4 (r)5 (a)6 (p)2 (e)6 (u)2 (tic)-4 ( p)-8 (r)5 (o)2 (te)6 (in)2 (s)1 (,)2 ( th)2 (e)6 (r)5 (e)-4 ( is)1 ( p)2 (o)2 (te)6 (n)2 (tia)6 (l)-10 ( f)5 (o)2 (r)5 ( immu)2 (n)]TJ -0.004 Tc 0.064 Tw 24.79 0 Td [(o)-14 (g)6 (en)-4 (i)-6 (ci)-6 (t)-26 (y)16 (.)-4 ( T)-3 (h)-14 (e d)-4 (et)-6 (e)-10 (ct)-6 (i)-6 (o)-4 (n )]TJ 0 Tc 0.17 Tw -24.79 -1.15 Td [(of)3 ( a)4 (nt)-2 (i)-2 (bod)-10 (y)20 ( f)3 (or)3 (m)-2 (a)4 (t)-2 (i)-2 (on i)-2 (s)-1 ( hi)-2 (g)10 (hl)-12 (y)20 ( de)4 (p)-10 (e)4 (nde)4 (nt)-2 ( on t)-2 (he)4 ( s)-1 (e)4 (ns)-1 (i)-2 (t)-2 (i)-2 (vi)-2 (t)-12 (y)30 ( a)4 (nd s)-1 (pe)-6 (c)4 (i)-2 (f)3 (i)-12 (c)4 (i)-2 (t)-12 (y)20 ( of)3 ( t)-2 (he )]TJ 0.31 Tw T* [(a)4 (s)-1 (s)-1 (a)-16 (y)20 (. A)2 (ddi)-2 (t)-2 (i)-2 (ona)4 (l)-2 (l)-12 (y)30 (, t)-2 (h)-10 (e)4 ( obs)-1 (e)4 (r)3 (ve)4 (d i)-2 (nc)4 (i)-2 (de)4 (nc)-6 (e)4 ( of)3 ( a)4 (nt)-2 (i)-2 (bod)-10 (y)20 ( $)3 (i)-2 (nc)4 (l)-2 (udi)-2 (n)-10 (g)10 ( ne)4 (ut)-2 (r)3 (a)4 (l)-2 (i)-2 (z)-6 (i)-2 (ng )]TJ 0.06 Tw T* [(a)4 (nt)-2 (i)-2 (bod)-10 (y)20 ($)3 ( pos)-1 (i)-2 (t)-2 (i)-2 (vi)-2 (t)-12 (y)20 ( i)-2 (n )-10 (a)-6 (n a)4 (s)-1 (s)-1 (a)-16 (y)20 ( m)-2 (a)-16 (y)20 ( be)4 ( i)-2 (n)-10 (f)3 (l)-2 (ue)4 (nc)-6 (e)]TJ 0 Tw 20.06 0 Td (d )Tj -0.004 Tc 0.064 Tw 0.81 0 Td [(b)-14 (y)16 ( s)-15 (ev)-4 (e)-10 (r)-1 (al)-6 ( f)-1 (a)-10 (ct)]TJ 0 Tc 0.06 Tw 5.95 0 Td [(or)3 (s)-1 ( i)-2 (nc)-6 (l)-2 (udi)-2 (ng)10 ( a)4 (s)-1 (s)-1 (a)-16 (y )]TJ 0 Tw -26.82 -1.15 Td [(m)-2 (e)4 (t)-2 (hodol)-2 (og)-10 (y)20 (, s)-1 (a)4 (m)-2 (pl)-2 (e)4 ( h)-10 (a)-6 (ndl)-2 (i)-2 (ng)10 (, t)-2 (i)-2 (m)-2 (i)-2 (ng)10 ( of)3 ( s)-11 (a)4 (m)-2 (pl)-2 (e )-6 (c)4 (ol)-2 (l)-2 (e)4 (c)4 (t)-2 (i)-2 (on, c)4 (onc)4 (om)-2 (i)-2 (t)-2 (a)4 (nt )-12 (m)-2 (e)4 (di)-2 (c)4 (a)4 (t)-2 (i)-2 (ons)-1 (, )]TJ 0.04 Tw T* [(a)4 (nd unde)4 (r)3 (l)-22 (y)20 (i)-2 (n)-10 (g)10 ( di)-2 (s)-1 (e)-6 (a)4 (s)-1 (e)4 (. )-10 (F)6 (or)3 ( t)-2 (he)4 (s)-11 (e)4 ( r)-7 (e)4 (a)4 (s)-1 (ons)-1 (, c)4 (om)-2 (p)-10 (a)4 (r)3 (i)-2 (s)-1 (on of)3 ( t)-2 (he)-6 ( i)-2 (nc)4 (i)-2 (de)4 (nc)-6 (e)4 ( o)-10 (f)3 ( a)4 (nt)-2 (i)-2 (bodi)-2 (e)4 (s )]TJ 0.07 Tw T* [(t)-2 (o T)]TJ -0.004 Tc 0.004 Tw 1.71 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.07 Tw 3.37 0 Td [(w)2 (i)-2 (t)-2 (h t)-2 (he)-6 ( i)-2 (nc)4 (i)-2 (de)4 (nc)4 (e)-6 ( of )-7 (a)4 (nt)-2 (i)-2 (bodi)-2 (e)4 (s)-1 ( t)-2 (o ot)-2 (he)4 (r)3 ( pr)3 (odu)-10 (c)4 (t)-2 (s)-1 ( m)-2 (a)-16 (y)20 ( be)-6 ( m)-2 (i)-2 (s)-1 (l)-2 (e)4 (a)4 (di)-2 (ng. )]TJ 0.05 Tw -6.02 -1.15 Td [(W)-6 (i)-2 (t)-2 (h r)3 (e)4 (s)-1 (pe)4 (c)4 (t)-2 ( t)-2 (o g)10 (r)3 (ow)2 (t)-2 (h h)-10 (or)3 (m)-2 (one)4 (, a)4 (nt)-2 (i)-2 (bod)-10 (y)20 ( bi)-2 (ndi)-2 (n)-10 (g)10 ( c)-6 (a)4 (pa)4 (c)4 (i)-2 (t)-2 (i)-2 (e)4 (s)-1 ( be)4 (l)-2 (ow)2 ( 2 m)-12 (g)10 (/)-12 (L)11 ( ha)4 (v)-10 (e)4 ( not )]TJ 0.3 Tw T* [(be)4 (e)4 (n a)4 (s)-1 (s)-1 (oc)4 (i)-2 (a)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h gr)3 (ow)2 (t)-2 (h a)4 (t)-2 (t)-2 (e)4 (nua)4 (t)-2 (i)-2 (on. )-10 (I)23 (n s)-1 (om)-2 (e)4 ( c)4 (a)4 (s)-1 (e)4 (s)-1 (, w)2 (he)4 (n bi)-2 (ndi)-2 (ng)10 ( c)4 (a)4 (p)-10 (a)4 (c)4 (i)-2 (t)-22 (y )]TJ 0 Tw T* [(e)4 (x)-10 (c)4 (e)4 (e)4 (ds)-1 ( 2 m)-2 (g)10 (/)-12 (L)11 (, )-10 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h a)4 (t)-2 (t)-2 (e)4 (nua)4 (t)-2 (i)-2 (on ha)4 (s)-1 ( be)4 (e)4 (n obs)-11 (e)4 (r)3 (ve)4 (d. )]TJ EMC /Artifact <>BDC 0 g /T1_0 1 Tf 10 0 0 10 44.6328 31.198 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 559 0 obj <>>>/Resources 508 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 560 0 obj <> endobj 561 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 562 0 obj <> endobj 563 0 obj <>stream q 1 0 0 1 26.573029 13.197937 cm 0 0 595.32 841.92 re W n 1 0 0 1 -26.573029 -13.197937 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 0.06 Tw 3 Tr 12 0 0 12 418.8528 772.3179 Tm ( )Tj 0 Tw 9.42 0 Td ( )Tj 0.002 Tc 0.068 Tw -26.14 -1.15 Td ( )Tj 26.14 0 Td ( )Tj 0 Tc 0 Tw -8.24 -1.15 Td ( )Tj -26.37 -1.15 Td ( )Tj 0.43 Tw 9.16 -1.15 Td ( )Tj 25.45 0 Td ( )Tj 0 Tw -30.62 -1.15 Td ( )Tj 0.03 Tw 18.37 0 Td ( )Tj 12.25 0 Td ( )Tj 0 Tw -29.73 -1.15 Td ( )Tj -0.004 Tc 0.044 Tw 24.04 0 Td ( )Tj -0.003 Tc 0.043 Tw 5.69 0 Td ( )Tj 0 Tc 0 Tw -31.53 -1.15 Td ( )Tj -3.08 -1.15 Td ( )Tj 0.07 Tw 34.61 -1.15 Td ( )Tj 0 Tw -33.78 -1.15 Td ( )Tj 0.002 Tc 0.068 Tw 8.31 0 Td ( )Tj 9.9 0 Td ( )Tj 15.57 0 Td ( )Tj 0 Tc 0 Tw -32.33 -1.15 Td ( )Tj -0.004 Tc 0.254 Tw 8.15 0 Td ( )Tj 0 Tc 0 Tw 24.18 0 Td ( )Tj 0 -1.15 TD ( )Tj 0.002 Tc -0.002 Tw -19.82 -1.15 Td ( )Tj 0 Tc 0 Tw 3.25 0 Td ( )Tj 6.59 0 Td ( )Tj -24.63 -1.15 Td ( )Tj /TT1 1 Tf 10.44 -1.17 Td ( )Tj /TT0 1 Tf 0.002 Tc 0.178 Tw 0.75 -1.13 Td ( )Tj 0 Tc 0 Tw 5.03 0 Td ( )Tj -0.004 Tc 0.184 Tw 9.8 0 Td ( )Tj 0 Tc 0.18 Tw 8.59 0 Td ( )Tj 0.002 Tc 0.278 Tw -20.93 -1.15 Td ( )Tj 0 Tc 0 Tw 13.94 0 Td ( )Tj -0.004 Tc 0.284 Tw 6.99 0 Td ( )Tj 0 Tc 0 Tw -8.47 -1.15 Td ( )Tj 0.002 Tc 0.178 Tw 8.47 0 Td ( )Tj 0 Tc 0.09 Tw -4.36 -1.15 Td [( )-4020 ( )]TJ 0 Tw -20.34 -1.15 Td ( )Tj 11.26 0 Td ( )Tj -21.17 -1.15 Td ( )Tj 22.33 -1.15 Td ( )Tj 6.04 0 Td [( )-4560 ( )]TJ -5.93 -1.15 Td ( )Tj 11.13 0 Td ( )Tj -23.89 -2.3 Td ( )Tj 22.52 0 Td ( )Tj -1.16 -1.15 Td ( )Tj -18.61 -1.15 Td ( )Tj -0.004 Tc 0.004 Tw 1.69 0 Td ( )Tj 0 Tc 0 Tw 12.23 0 Td ( )Tj -26.35 -1.15 Td ( )Tj /TT1 1 Tf 7.42 -1.17 Td ( )Tj /TT0 1 Tf 21.18 -1.13 Td ( )Tj 5.51 0 Td ( )Tj -24.03 -1.15 Td ( )Tj -10.08 -1.15 Td ( )Tj /TT1 1 Tf 7.64 -1.17 Td ( )Tj /C2_0 1 Tf 17.34 -1.13 Td [<0003>-1900 <0003>]TJ /TT0 1 Tf -0.003 Tc 0.183 Tw 9.63 0 Td ( )Tj 0 Tc 0 Tw -21.1 -2.3 Td ( )Tj /C2_0 1 Tf 9.89 0 Td <0003>Tj /TT0 1 Tf 0.19 Tw 11.21 0 Td ( )Tj /C2_0 1 Tf -0.004 Tc 0 Tw -17.49 -1.15 Td <0003>Tj 9.74 0 Td [<0003>-924 <0003>]TJ /TT0 1 Tf 0 Tc 0.14 Tw 7.75 0 Td ( )Tj 0.002 Tc 0.288 Tw -28.38 -1.15 Td ( )Tj 18.48 0 Td ( )Tj 9.9 0 Td ( )Tj 0 Tc 0.08 Tw T* ( )Tj 0.83 Tw -25.76 -1.15 Td ( )Tj 16.07 0 Td ( )Tj 9.69 0 Td ( )Tj 0.15 Tw T* ( )Tj 0.17 Tw T* ( )Tj -0.004 Tc 0.004 Tw T* ( )Tj 0.002 Tc 0.088 Tw -12.51 -1.15 Td ( )Tj 12.51 0 Td ( )Tj 0 Tc 0.06 Tw T* ( )Tj 0 Tw -5.15 -1.15 Td ( )Tj -29.46 -1.15 Td ( )Tj -0.004 Tc 0.084 Tw 15.43 -1.15 Td ( )Tj 19.18 0 Td ( )Tj 0.004 Tw T* ( )Tj EMC /P <>BDC 0 Tc 0.06 Tw 0 Tr -34.61 56.35 Td [(P)-4 (r)3 (og)10 (r)-7 (e)4 (s)-1 (s)-1 (i)-2 (on of)3 ( s)-1 (c)4 (ol)-2 (i)-2 (os)-1 (i)-2 (s)-1 ( c)4 (a)4 (n oc)-6 (c)4 (ur)3 ( i)-2 (n c)4 (hi)-2 (l)-2 (dr)-7 (e)4 (n w)2 (h)-10 (o e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)4 (nc)4 (e )-6 (r)3 (a)4 (pi)-2 (d )-10 (g)10 (r)3 (ow)2 (t)-12 (h. B)7 (e)-6 (c)4 (a)4 (us)-11 (e )]TJ 0.002 Tc 0.068 Tw T* [(s)1 (o)2 (ma)6 (tr)5 (o)2 (p)2 (in)2 ( in)2 (c)6 (r)5 (e)6 (a)6 (s)1 (e)6 (s )-9 (g)12 (r)5 (o)-8 (w)4 (th)2 ( r)5 (a)6 (te)6 (,)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( a)6 ( h)2 (is)1 (to)2 (r)-5 (y)22 ( o)2 (f)5 ( s)1 (c)6 (o)2 (lio)2 (s)1 (is)1 ( w)4 (h)2 (o)2 ( a)6 (r)5 (e)6 ( tr)5 (e)-4 (a)6 (te)6 (d )]TJ 0 Tc 0 Tw T* [(w)2 (i)-2 (t)-2 (h s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n s)-1 (houl)-2 (d be)4 ( m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d f)3 (or)3 ( pr)3 (o)-10 (gr)3 (e)4 (s)-1 (s)-1 (i)-12 (on of)3 ( s)-1 (c)4 (ol)-2 (i)-2 (os)-1 (i)-2 (s)-1 (. )]TJ EMC /P <>BDC 0.43 Tw 0 -2.3 TD [(B)7 (one)-6 ( a)-6 (g)10 (e)-6 ( s)-1 (houl)-2 (d be )-16 (m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d pe)4 (r)3 (i)-2 (odi)-2 (c)-6 (a)4 (l)-2 (l)-12 (y)10 ( dur)3 (i)-2 (n)-10 (g)10 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )-10 (a)4 (d)-10 (m)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on, )]TJ -0.004 Tc 0.004 Tw 0 -1.15 TD [(es)-5 (p)-4 (eci)-6 (al)-6 (l)-26 (y )]TJ 0 Tc 0.03 Tw 4.27 0 Td [(i)-2 (n p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (h)-10 (o a)4 (r)-7 (e)4 ( pube)-6 (r)3 (t)-2 (a)4 (l)-2 ( a)4 (nd/)-2 (or)-7 ( r)-7 (e)4 (c)-6 (e)4 (i)-2 (vi)-2 (ng c)4 (onc)4 (om)-2 (i)-2 (t)-2 (a)4 (nt)-2 ( t)-2 (h)-20 (y)20 (r)3 (o)-10 (i)-2 (d hor)3 (m)-2 (one )]TJ -0.004 Tc 0.004 Tw -4.27 -1.15 Td [(r)-1 (ep)-4 (l)-6 (ac)-10 (em)-6 (en)-4 (t )]TJ 0.044 Tw 5.17 0 Td [(t)-6 (h)-4 (er)-1 (ap)-24 (y)16 (.)-4 ( U)-2 (n)-14 (d)-4 (er)-1 ( t)-6 (h)-4 (es)-5 (e ci)-6 (r)-1 (cu)-4 (m)-6 (s)-5 (t)-6 (an)-14 (ces)-5 (,)-4 ( ep)-4 (i)-6 (p)-4 (h)-14 (y)16 (s)-5 (e)-10 (al)-6 ( m)-6 (at)-6 (u)-4 (r)-1 (at)-6 (i)-6 (o)-4 (n )]TJ -0.003 Tc 0.043 Tw 24.04 0 Td [(m)-5 (a)-9 (y)17 ( p)-3 (ro)-13 (g)-3 (re)1 (s)-4 (s )]TJ 0 Tc 0 Tw -29.21 -1.15 Td [(r)3 (a)4 (pi)-2 (dl)-12 (y)20 (. )]TJ EMC /P <>BDC 0.07 Tw 0 -2.3 TD [(W)-6 (he)4 (n s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n i)-2 (s)9 ( a)4 (dm)8 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d s)-1 (ubc)4 (ut)-2 (a)4 (ne)4 (ous)-1 (l)-12 (y)10 ( a)4 (t)-2 ( t)-2 (he)4 ( s)-1 (a)4 (m)-2 (e)4 ( s)-1 (i)8 (t)-2 (e)4 ( ove)4 (r)3 ( a)4 ( l)8 (ong)10 ( pe)4 (r)3 (i)-2 (o)-10 (d )]TJ 0 Tw 0 -1.15 TD (of )Tj 0.002 Tc 0.068 Tw 1.15 0 Td [(time)6 (,)2 ( tis)1 (s)1 (u)2 (e)6 ( a)6 (tr)5 (o)2 (p)2 (h)-8 (y )12 (ma)-4 (y)22 ( r)-5 (e)6 (s)1 (u)2 (lt.)2 ( T)3 (h)2 (is)1 ( c)6 (a)6 (n)2 ( b)2 (e )-4 (a)6 (v)2 (o)2 (id)2 (e)6 (d)2 ( b)-18 (y)22 ( r)5 (o)2 (ta)6 (tin)-8 (g)12 ( th)2 (e)6 ( i)-10 (n)2 (je)6 (c)6 (tio)2 (n)2 ( s)1 (ite)6 (. )]TJ -0.002 Tc 0.252 Tw -1.15 -1.15 Td [(As)-3 ( i)-4 (s )]TJ -0.004 Tc 0.254 Tw 2.78 0 Td [(t)-6 (h)-4 (e cas)-5 (e )-10 (w)-2 (i)-6 (t)-6 (h)-4 ( an)-14 (y )6 (p)-4 (r)-1 (o)-4 (t)-16 (ei)-6 (n)-4 (,)-4 ( l)-6 (o)-4 (cal)-6 ( o)-4 (r)-1 ( s)-25 (y)16 (s)-5 (t)-16 (em)-6 (i)-6 (c al)-6 (l)-6 (er)-11 (g)6 (i)-6 (c )-10 (r)-1 (ea)-10 (ct)-6 (i)-6 (o)-4 (n)-4 (s)-5 ( m)-6 (a)-10 (y)16 ( o)-14 (ccu)-4 (r)-1 (. )]TJ 0 Tc 0.12 Tw -2.78 -1.15 Td [(P)-4 (a)4 (r)3 (e)4 (nt)-2 (s)-1 (/)-2 (P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 ( s)-1 (houl)-2 (d be)4 ( i)-2 (nf)3 (or)3 (m)-2 (e)4 (d t)-2 (ha)4 (t)-2 ( s)-1 (uc)4 (h r)-7 (e)4 (a)-6 (c)4 (t)-2 (i)-2 (ons)-1 ( a)4 (r)3 (e)4 ( pos)-1 (s)-1 (i)-2 (bl)-2 (e)4 ( a)4 (nd t)-12 (ha)4 (t)-2 ( pr)3 (om)-2 (pt )]TJ 0.002 Tc -0.002 Tw T* [(me)6 (d)2 (ic)6 (a)6 (l a)6 (tte)6 (n)2 (tio)2 (n)2 ( s)1 (h)2 (o)2 (u)2 (ld)2 ( b)2 (e)6 ( s)1 (o)2 (u)2 (g)12 (h)2 (t if )-5 (a)6 (lle)6 (r)-5 (g)12 (ic )]TJ -0.004 Tc 0.004 Tw 18.29 0 Td [(r)-11 (ea)-10 (ct)-6 (i)-6 (o)-4 (n)-4 (s)-5 ( o)-4 (ccu)-4 (r)-1 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw -18.29 -2.32 Td [(I)-1 (n)-4 (f)-7 (or)4 (m)13 (at)3 (i)-2 (on)-4 ( f)-7 (or)4 ( P)11 (at)3 (i)-12 (e)4 (n)-4 (t)3 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0.002 Tc 0.178 Tw 0 -1.13 TD [(P)-2 (a)6 (tie)6 (n)2 (ts)1 ( b)2 (e)6 (in)2 (g)2 ( tr)5 (e)-4 (a)6 (te)6 (d)2 ( w)-6 (ith )]TJ 0 Tc 0 Tw 11.62 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -0.004 Tc 0.184 Tw 3.49 0 Td [(an)-4 (d)-4 (/)-6 (o)-4 (r)-1 ( t)-16 (h)-4 (ei)-6 (r)-1 ( c)-10 (ar)-1 (e)-10 (g)6 (i)-6 (v)-14 (er)-1 (s )]TJ 0 Tc 0.18 Tw 9.79 0 Td [(s)-1 (houl)-2 (d b)-10 (e)4 ( i)-2 (nf)3 (or)3 (m)-2 (e)-6 (d )]TJ 0.002 Tc 0.278 Tw -26.45 -1.15 Td [(a)6 (b)2 (o)2 (u)2 (t th)2 (e)6 ( p)2 (o)2 (te)6 (n)2 (tia)6 (l b)-8 (e)6 (n)-8 (e)6 (f)5 (its)1 ( a)6 (n)2 (d )-8 (r)5 (is)1 (k)2 (s)1 ( a)6 (s)1 (s)1 (o)2 (c)6 (ia)6 (t)-10 (e)6 (d)2 ( w)4 (ith)2 ( tr)5 (e)-4 (a)6 (tme)6 (n)2 (t. )]TJ -0.004 Tc 0.284 Tw 28.15 0 Td [(S)-8 (ee)-10 ( t)-6 (h)-4 (e p)-4 (at)-6 (i)-6 (en)-4 (t )]TJ 0 Tc 0.18 Tw -28.15 -1.15 Td [(i)-2 (nf)3 (or)3 (m)-2 (a)4 (t)-2 (i)-2 (on i)-2 (nc)4 (l)-2 (ude)4 (d w)2 (i)-12 (t)-2 (h t)-2 (he)4 ( pr)3 (oduc)4 (t)-2 ( a)4 (nd/)-2 (or)3 ( i)-2 (n)-10 (j)-2 (e)4 (c)4 (t)-2 (i)-2 (on de)4 (vi)-2 (c)4 (e)4 (. )]TJ 0.002 Tc 0.178 Tw [(T)3 (h)2 (is)1 ( in)2 (f)-5 (o)2 (r)5 (ma)6 (tio)2 (n)2 ( is )]TJ 0 Tc 0.09 Tw 0 -1.15 TD [(i)-2 (nt)-2 (e)4 (nde)4 (d t)-2 (o a)4 (i)-2 (d i)-2 (n t)-2 (he)4 ( s)-1 (a)4 (f)3 (e)4 ( a)4 (nd e)-6 (f)3 (f)3 (e)-6 (c)4 (t)-2 (i)-2 (ve)4 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on of)3 ( t)-2 (he)4 ( m)-2 (e)4 (di)-2 (c)4 (a)4 (t)-2 (i)-2 (on. )-20 (I)23 (t)-2 ( i)-2 (s)-1 ( not)-2 ( a )]TJ 0 Tw T* [(di)-2 (s)-1 (c)4 (l)-2 (os)-1 (ur)3 (e)4 ( of)3 ( a)4 (l)-2 (l)-2 ( pos)-1 (s)-1 (i)-2 (bl)-2 (e )-6 (a)4 (dve)4 (r)3 (s)-1 (e)4 ( o)-10 (r)3 ( i)-2 (nt)-2 (e)4 (nde)4 (d e)-6 (f)3 (f)3 (e)-6 (c)-6 (t)-2 (s)-1 (. )]TJ EMC /P <>BDC 0.002 Tc -0.002 Tw 0 -2.3 TD [(P)-2 (a)6 (tie)6 (n)2 (ts)1 ( a)6 (n)2 (d)2 ( c)6 (a)6 (r)-5 (e)-4 (g)12 (iv)2 (e)6 (r)5 (s)1 ( w)-6 (h)2 (o)2 ( w)4 (ill a)6 (d)2 (min)2 (is)1 (te)6 (r)5 ( T)]TJ -0.004 Tc 0.004 Tw 18.33 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)-9 (r)3 (opi)-2 (n s)-1 (houl)-2 (d r)3 (e)4 (c)4 (e)4 (i)-2 (ve )-6 (a)4 (ppr)-7 (opr)3 (i)-2 (a)4 (t)-2 (e )]TJ -19.27 -1.15 Td [(t)-2 (r)3 (a)4 (i)-2 (ni)-2 (ng)10 ( a)4 (nd i)-2 (ns)-1 (t)-2 (r)3 (u)-10 (c)4 (t)-2 (i)-2 (on on t)-2 (he)4 ( pr)3 (ope)4 (r)3 ( us)-11 (e)4 ( of)3 ( T)]TJ -0.004 Tc 0.004 Tw 18.43 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)-7 (T)1 (r)3 (opi)-2 (n f)3 (r)3 (om)-2 ( t)-2 (he)4 ( ph)-20 (y)20 (s)-1 (i)-2 (c)4 (i)-2 (a)-6 (n or)3 ( ot)-2 (he)4 (r )]TJ 0.002 Tc -0.002 Tw -19.38 -1.15 Td [(s)1 (u)2 (ita)6 (b)2 (le)6 ( q)2 (u)2 (a)6 (lif)5 (i)]TJ 0 Tc 0 Tw [(e)4 (d he)4 (a)4 (l)-2 (t)-2 (h )-10 (c)4 (a)4 (r)3 (e)4 ( p)-10 (r)3 (of)3 (e)4 (s)-1 (s)-1 (i)-2 (ona)4 (l)-2 (. )-10 (A)2 ( punc)-6 (t)-2 (ur)3 (e)4 (-)]TJ -0.004 Tc 0.004 Tw 21.96 0 Td [(r)-1 (es)-5 (i)-6 (s)-5 (t)-6 (an)-4 (t)-6 ( co)-4 (n)-4 (t)-16 (ai)-6 (n)-4 (er)-1 ( f)-11 (o)-4 (r)-1 ( t)-6 (h)-4 (e )]TJ 0 Tc 0 Tw -21.96 -1.15 Td [(di)-2 (s)-1 (pos)-1 (a)4 (l)-2 ( of)3 ( us)-1 (e)4 (d ne)4 (e)4 (dl)-2 (e)4 (s )-11 (a)4 (nd s)-11 (y)20 (r)3 (i)-2 (n)-10 (ge)4 (s)-1 ( s)-1 (houl)-2 (d be)4 ( s)-1 (t)-12 (r)3 (ong)10 (l)-22 (y)20 ( r)-7 (e)4 (c)4 (om)-2 (m)-2 (e)4 (nd)-10 (e)4 (d. P)-4 (a)-6 (t)-2 (i)-2 (e)4 (nt)-2 (s )]TJ 0 -1.15 TD [(a)4 (nd/)-2 (or)3 ( c)4 (a)-6 (r)3 (e)-6 (g)10 (i)-2 (ve)4 (r)3 (s)-1 ( s)-1 (houl)-2 (d )-10 (be)4 ( t)-2 (hor)3 (ou)-10 (g)10 (hl)-12 (y)20 ( i)-2 (ns)-1 (t)-2 (r)3 (uc)4 (t)-12 (e)4 (d )-10 (i)-2 (n t)-2 (he)4 ( i)-2 (m)-2 (por)3 (t)-2 (a)4 (nc)4 (e)4 ( of)3 ( pr)3 (op)-10 (e)4 (r )]TJ T* [(di)-2 (s)-1 (pos)-1 (a)4 (l)-2 (, a)4 (nd c)4 (a)4 (ut)-2 (i)-2 (one)4 (d a)-6 (g)10 (a)4 (i)-2 (ns)-1 (t )]TJ -0.004 Tc 0.004 Tw 12.68 0 Td [(an)-24 (y )6 (r)-1 (eu)-4 (s)-5 (e o)-14 (f)-1 ( n)-4 (eed)-4 (l)-16 (es)-5 ( an)-4 (d)-4 ( s)-25 (y)16 (r)-1 (i)-6 (n)-14 (g)6 (es)-5 (. )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw -12.68 -2.32 Td [(L)-3 (ab)-4 (or)4 (at)3 (or)4 (y T)-3 (e)4 (s)-1 (t)3 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0 -1.13 TD [(S)-4 (e)4 (r)3 (um)-2 ( l)-2 (e)4 (ve)4 (l)-2 (s)-1 ( of)3 ( i)-2 (nor)-7 (g)10 (a)4 (ni)-12 (c)4 ( phos)-1 (phor)3 (us)-1 (, a)4 (l)-2 (ka)4 (l)-2 (i)-2 (ne)4 ( ph)-10 (os)-1 (pha)4 (t)-2 (a)4 (s)-1 (e)4 (, a)4 (nd )-20 (I)13 (G)2 (F)-4 (-)3 (1 )]TJ -0.004 Tc 0.014 Tw [(m)-6 (a)-10 (y)16 ( i)-6 (n)-4 (cr)-11 (eas)-15 (e )]TJ 0 Tc 0 Tw 0 -1.15 TD [(a)4 (f)3 (t)-2 (e)4 (r)3 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (he)-6 (r)3 (a)4 (p)-20 (y)20 (. )]TJ EMC /P <>BDC /TT1 1 Tf -0.004 Tc 0.004 Tw 0 -2.32 TD [(D)-2 (ru)-8 (g)-4 ( I)-5 (n)-8 (t)-1 (era)-4 (c)-10 (t)-1 (i)-6 (o)-4 (n)-8 (s )]TJ EMC /P <>BDC /TT0 1 Tf 0.184 Tw 0 -1.13 TD [(T)-3 (h)-4 (e m)-6 (i)-6 (cr)-1 (o)-4 (s)-5 (o)-4 (m)-6 (al)-6 ( en)-4 (z)-20 (y)16 (m)-16 (e 1)-4 (1)]TJ /C2_0 1 Tf 0 Tc 0 Tw 11.67 0 Td <0215>Tj /TT0 1 Tf 0.51 0 Td (-)Tj /C2_0 1 Tf 0.33 0 Td [<004B>-10 <005C>20 <0047>-10 <0055>3 <0052005B>-20 <005C>20 <0056>-1 <0057>-2 <0048>4 <0055>3 <0052004C>-2 <00470003>-180 <00470048>-6 <004B>-10 <005C>20 <00470055>3 <0052>-10 <004A0048>4 <00510044>4 <0056>-1 <00480003>-176 <0057>-22 <005C>20 <005300480003>-176 <00140003>-190 <000B>3 <00140014>-10 <0215>-1 <002B>2 <0036>-4 <0027>]TJ /TT0 1 Tf 19.84 0 Td (-)Tj -0.003 Tc 0.183 Tw 0.33 0 Td [(1)-3 (\) i)-5 (s )]TJ 0 Tc 0.11 Tw -32.68 -1.15 Td [(r)3 (e)4 (qui)-2 (r)3 (e)4 (d f)3 (o)-10 (r)3 ( c)4 (onve)4 (r)3 (s)-1 (i)-2 (on )-10 (of)3 ( c)4 (or)3 (t)-2 (i)-2 (s)-1 (one)4 ( t)-2 (o i)-2 (t)-2 (s)-1 ( a)4 (c)4 (t)-2 (i)-2 (ve)4 ( m)-2 (e)4 (t)-2 (a)4 (bol)-2 (i)-2 (t)-2 (e)4 (, c)4 (or)3 (t)-2 (i)-2 (s)-1 (ol)-2 (, i)-2 (n )10 (he)4 (pa)4 (t)-2 (i)-2 (c)4 ( a)4 (nd )]TJ 0.19 Tw 0 -1.15 TD [(a)4 (di)-2 (pos)-1 (e)4 ( t)-2 (i)-2 (s)-1 (s)-1 (ue)4 (. )]TJ 0.2 Tw [(G)2 (r)3 (ow)2 (t)-2 (h hor)3 (m)-2 (one )]TJ /C2_0 1 Tf 0 Tw 13.95 0 Td [<0044>4 <005100470003>-190 <0056>-1 <00520050>-2 <0044>4 <0057>-2 <0055>3 <00520053004C>-12 <00510003>-190 <004C>-2 <0051004B004C>-2 <0045004C>-2 <00570003>-192 <001400140215>-1 <002B>2 <0036>-4 <0027>]TJ /TT0 1 Tf 13.4 0 Td (-)Tj 0.19 Tw 0.33 0 Td [(1. C)-3 (o)10 (ns)-1 (e)4 (que)4 (nt)-2 (l)-12 (y)20 (, )]TJ 0.002 Tc 0.138 Tw -27.68 -1.15 Td [(in)2 (d)2 (iv)2 (id)2 (u)2 (a)6 (ls)1 ( w)4 (ith)2 ( u)2 (n)2 (tr)5 (e)6 (a)6 (te)-4 (d)2 ( G)4 (H)4 ( d)-8 (e)6 (f)5 (ic)6 (ie)6 (n)]TJ /C2_0 1 Tf -0.004 Tc 0.004 Tw 16.18 0 Td [<0046>-20 <005C0003>-128 <004B>-14 <00440059>-4 <00480003>-154 <0055>-11 <0048004F>-6 <00440057>-6 <004C>-6 <0059>-4 <00480003>-144 <004C>-6 <0051>-4 <00460055>-11 <004800440056>-15 <004800560003>-149 <004C>-6 <00510003>-148 <0014>-4 <0014>-4 <0215>-15 <002B>-2 <0036>-8 <0027>]TJ /TT0 1 Tf 0 Tc 0 Tw 15.76 0 Td (-)Tj 0.14 Tw 0.33 0 Td [(1 a)4 (nd )]TJ 0.002 Tc 0.288 Tw -32.27 -1.15 Td [(s)1 (e)6 (r)5 (u)2 (m c)6 (o)2 (r)5 (tis)1 (o)2 (l. )-8 (I)15 (n)2 (tr)5 (o)2 (d)2 (u)-8 (c)-4 (tio)2 (n)2 ( o)2 (f)5 ( s)1 (o)2 (ma)6 (tr)5 (o)2 (p)2 (in)2 ( tr)5 (e)6 (a)-4 (tme)6 (n)2 (t ma)-4 (y )12 (r)5 (e)6 (s)1 (u)2 (lt in)2 ( in)-8 (h)2 (ib)2 (itio)2 (n)2 ( o)2 (f )]TJ /C2_0 1 Tf 0 Tc 0 Tw T* [<001400140215>-1 <002B>2 <0036>-4 <0027>]TJ /TT0 1 Tf 3.51 0 Td (-)Tj 0.08 Tw 0.33 0 Td [(1 a)4 (nd )-10 (r)3 (e)4 (duc)-6 (e)4 (d )-10 (s)-1 (e)4 (r)3 (um)-2 ( c)4 (or)3 (t)-2 (i)-2 (s)-1 (ol)-2 ( c)4 (on)-10 (c)4 (e)4 (nt)-2 (r)-7 (a)-6 (t)-2 (i)-2 (ons)-1 (. A)2 (s)-1 ( a)4 ( c)4 (ons)-11 (e)4 (que)4 (nc)-6 (e)4 (,)-10 ( pr)3 (e)4 (vi)-2 (ous)-1 (l)-22 (y )]TJ 0.83 Tw -3.84 -1.15 Td [(undi)-2 (a)4 (g)10 (nos)-11 (e)4 (d c)4 (e)4 (nt)-2 (r)-7 (a)4 (l )-12 ($)3 (s)-1 (e)4 (c)4 (onda)-6 (r)-17 (y)20 ($)3 ( h)-20 (y)20 (poa)4 (d)-10 (r)3 (e)4 (n)-10 (a)4 (l)-2 (i)-2 (s)-1 (m)-2 ( m)-2 (a)-6 (y )20 (be)4 ( unm)-12 (a)4 (s)-1 (ke)4 (d a)4 (nd )]TJ 0.15 Tw T* [(g)10 (l)-2 (uc)4 (o)-10 (c)4 (or)3 (t)-2 (i)-2 (c)4 (oi)-2 (d r)3 (e)4 (pl)-2 (a)-6 (c)4 (e)4 (m)-12 (e)4 (nt)-2 ( m)-2 (a)-6 (y)20 ( be)4 ( r)-7 (e)4 (qui)-2 (r)3 (e)4 (d i)-2 (n )-10 (pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n. )-10 (I)23 (n )]TJ 0.17 Tw T* [(a)4 (ddi)-2 (t)-2 (i)-2 (on, pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (e)4 (d)-10 ( w)2 (i)-2 (t)-2 (h g)10 (l)-2 (uc)4 (o)-10 (c)4 (or)3 (t)-2 (i)-2 (c)4 (oi)-2 (d r)3 (e)4 (p)-10 (l)-2 (a)4 (c)4 (e)4 (m)-2 (e)4 (nt)-2 ( f)3 (o)-10 (r)3 ( pr)3 (e)4 (vi)-2 (ous)-1 (l)-22 (y)10 ( di)-2 (a)4 (g)10 (nos)-11 (e)4 (d )]TJ 0.4 Tw T* [(h)-10 (y)20 (poa)4 (d)-10 (r)3 (e)4 (na)4 (l)-2 (i)-2 (s)-1 (m)-2 ( m)-2 (a)-16 (y)20 ( r)-7 (e)-6 (qui)-2 (r)3 (e)4 ( a)4 (n i)-2 (nc)-6 (r)3 (e)4 (a)4 (s)-11 (e)4 ( i)-2 (n t)-2 (he)4 (i)-2 (r)3 ( m)-2 (a)4 (i)-2 (nt)-2 (e)4 (na)4 (nc)-6 (e)4 ( or)3 ( s)-1 (t)-12 (r)3 (e)4 (s)-1 (s)-1 ( dos)]TJ -0.004 Tc 0.004 Tw 33.77 0 Td (es )Tj 0.002 Tc 0.088 Tw -33.77 -1.15 Td [(f)5 (o)2 (llo)2 (w)4 (in)2 (g)12 ( in)2 (itia)6 (tio)2 (n)2 ( o)2 (f)-5 ( s)1 (o)2 (ma)6 (tr)5 (o)2 (p)2 (in)2 ( tr)5 (e)6 (a)6 (tme)6 (n)2 (t; th)2 (i)-10 (s)1 ( ma)-4 (y )12 (b)2 (e)-4 ( e)6 (s)1 (p)2 (e)-4 (c)6 (ia)6 (ll)-20 (y)22 ( tr)5 (u)2 (e)-4 ( f)5 (o)2 (r)5 ( p)-8 (a)6 (tie)6 (n)2 (ts )]TJ 0 Tc 0.06 Tw T* [(t)-2 (r)3 (e)4 (a)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h c)4 (or)3 (t)-2 (i)-2 (s)-1 (one)4 ( a)4 (c)-6 (e)4 (t)-2 (a)4 (t)-2 (e)4 ( a)4 (nd pr)3 (e)4 (dni)-2 (s)-1 (one)4 ( s)-1 (i)-2 (n)-10 (c)4 (e)4 ( c)4 (onve)-6 (r)3 (s)-1 (i)-2 (on of)3 ( t)-2 (he)4 (s)-1 (e)4 ( dr)3 (ug)10 (s)-1 ( t)-2 (o t)-2 (he)4 (i)-2 (r )]TJ /C2_0 1 Tf 0 Tw T* [<0045004C>-2 <0052004F>-2 <0052004A>10 <004C>-2 <0046>4 <0044>4 <004F>-2 <004F>-22 <005C>20 <00030044>-6 <0046>4 <0057>-2 <004C>-2 <00590048>4 <00030050>-2 <0048>4 <0057>-2 <0044>4 <0045>-10 <0052004F>-2 <004C>-2 <0057>-2 <0048>4 <0056>-1 <0003004C>-2 <0056>-1 <000300470048>4 <00530048>4 <005100470048>4 <00510057>-2 <00030052005100030057>-2 <004B0048>-6 <00030044>4 <0046>4 <0057>-2 <004C>-2 <0059004C>-2 <0057>-12 <005C>20 <000300520049>3 <0003001400140215>-1 <002B>2 <0036>-4 <0027>]TJ /TT0 1 Tf 28.36 0 Td [(-)-7 (1. )]TJ EMC /P <>BDC -0.004 Tc 0.004 Tw -28.36 -2.3 Td [(P)-8 (h)-4 (ar)]TJ 0.084 Tw 1.83 0 Td [(m)-6 (aco)-4 (l)-6 (o)-14 (g)6 (i)-6 (c )-10 (g)6 (l)-6 (u)-4 (c)-10 (o)-4 (co)-4 (r)-1 (t)-16 (i)-6 (co)-4 (i)-6 (d)-4 ( t)-6 (h)-4 (er)-1 (ap)-24 (y )6 (an)-4 (d)-14 ( s)-5 (u)-4 (p)-4 (r)-1 (ap)-14 (h)-14 (y)16 (s)-5 (i)-6 (o)-4 (l)-6 (o)-14 (g)6 (i)-6 (c )-10 (g)6 (l)-6 (u)-4 (co)-14 (co)-4 (r)-1 (t)-6 (i)-6 (co)-4 (i)-16 (d)-4 ( t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t )]TJ 0 Tc 0.21 Tw -1.83 -1.15 Td [(m)-2 (a)-6 (y)20 ( a)4 (t)-2 (t)-2 (e)4 (nu)-10 (a)4 (t)-2 (e)4 ( t)-2 (he)4 ( gr)3 (ow)-8 (t)-2 (h pr)3 (om)-2 (ot)-2 (i)-2 (ng)10 ( e)4 (f)3 (f)3 (e)-6 (c)4 (t)-2 (s)-1 ( of)3 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n i)-2 (n c)4 (hi)-2 (l)-2 (dr)3 (e)]TJ -0.01 Tc 0.01 Tw 29.22 0 Td [(n)-10 (. )]TJ -0.004 Tc 0 Tw 1.2 0 Td [(T)-3 (h)-4 (er)-1 (ef)-1 (o)-4 (r)-11 (e, )]TJ EMC /P <>BDC 0 g /T1_0 1 Tf 0 Tc 10 0 0 10 44.573 31.1979 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 564 0 obj <>>>/Resources 507 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 565 0 obj <> endobj 566 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 567 0 obj <> endobj 568 0 obj <>stream q 1 0 0 1 26.632751 13.197876 cm 0 0 595.32 841.92 re W n 1 0 0 1 -26.632751 -13.197876 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf -0.004 Tc 0.114 Tw 3 Tr 12 0 0 12 200.1532 772.3179 Tm ( )Tj 27.65 0 Td ( )Tj 0 Tc 0.17 Tw -7.76 -1.15 Td [( )-3390 ( )-3530 ( )]TJ 0.002 Tc 0.088 Tw -5.33 -1.15 Td ( )Tj 13.09 0 Td ( )Tj 0 Tc 0 Tw -21.31 -1.15 Td ( )Tj 16.07 0 Td [( )-4480 ( )]TJ -29.37 -1.15 Td ( )Tj 0.13 Tw 16.4 -1.15 Td ( )Tj 9.65 0 Td ( )Tj 0 Tw 3.46 0 Td ( )Tj -13.79 -1.15 Td ( )Tj -15.72 -1.15 Td ( )Tj 0.002 Tc 0.198 Tw 13.46 -1.15 Td ( )Tj 16.95 0 Td [( )-3750 ( )]TJ 0 Tc 0.14 Tw 4.2 -1.15 Td ( )Tj 0.09 Tw 0 -2.3 TD ( )Tj 0 Tw -17.92 -2.3 Td ( )Tj 0.19 Tw 17.92 0 Td ( )Tj 0.002 Tc 0.038 Tw 0 -1.15 TD ( )Tj 0 Tc 0.13 Tw T* ( )Tj 0.03 Tw T* ( )Tj 0.002 Tc 0.338 Tw T* ( )Tj 0 Tc 0 Tw -31 -1.15 Td ( )Tj -3.61 -1.15 Td ( )Tj 34.61 -1.15 Td ( )Tj T* ( )Tj 0.56 Tw -5.63 -1.15 Td [( )-4820 ( )]TJ 0.11 Tw 5.63 -1.15 Td ( )Tj 0.01 Tw -8.42 -1.15 Td ( )Tj 0.2 Tw 8.42 -1.15 Td ( )Tj 0.32 Tw -17.42 -1.15 Td ( )Tj 0 Tw 17.42 -1.15 Td ( )Tj 0.15 Tw T* ( )Tj 0 Tw -24.68 -1.15 Td ( )Tj 10.17 0 Td ( )Tj -20.1 -1.15 Td ( )Tj 0.02 Tw 17.64 -1.15 Td ( )Tj 0 Tw 16.97 0 Td ( )Tj 0.12 Tw T* ( )Tj 0 Tw -4.57 -1.15 Td [( )-4090 ( )]TJ -30.04 -1.15 Td ( )Tj -0.004 Tc 0.214 Tw 34.61 -1.15 Td ( )Tj 0.002 Tc 0.068 Tw -5.26 -1.15 Td [( )-4940 ( )]TJ 0.168 Tw 0.77 -2.3 Td [( )-4070 ( )]TJ 0 Tc 0.13 Tw 4.49 -1.15 Td ( )Tj 0.6 Tw -31.79 -1.15 Td ( )Tj 7.64 0 Td ( )Tj 24.15 0 Td ( )Tj -0.004 Tc 0.094 Tw 0 -2.3 TD ( )Tj 0 Tc 0.22 Tw -25.26 -1.15 Td ( )Tj 12.05 0 Td ( )Tj 8.23 0 Td ( )Tj 0.33 Tw -11.31 -1.15 Td ( )Tj 0.002 Tc 0.328 Tw 13.41 0 Td ( )Tj 0 Tc 0 Tw 2.88 0 Td ( )Tj -0.004 Tc 0.254 Tw -1.89 -1.15 Td ( )Tj 0 Tc 0 Tw -14.22 -1.15 Td ( )Tj -18.5 -1.15 Td ( )Tj EMC /P <>BDC -0.004 Tc 0.114 Tw 0 Tr 0 54.05 TD [(B)3 (ec)-10 (au)-4 (s)-5 (e )-10 (ch)-4 (i)-6 (l)-6 (d)-4 (r)-1 (en )-14 (w)-2 (i)-6 (t)-6 (h)-4 ( c)-10 (er)-1 (t)-6 (ai)-6 (n)-4 ( r)-11 (ar)-1 (e )-10 (g)-4 (en)-4 (et)-6 (i)-6 (c )-10 (cau)-4 (s)-15 (e)-10 (s)-5 ( o)-4 (f)-1 ( s)-5 (h)-4 (o)-4 (r)-1 (t)-6 ( s)-5 (t)-6 (at)-6 (u)-4 (r)-1 (e)-10 ( h)-4 (av)-4 (e)-10 ( a)-10 (n)-4 ( i)-6 (n)-4 (cr)-1 (eas)-15 (ed )]TJ 0 Tc 0.17 Tw 0 -1.15 TD [(r)3 (i)-2 (s)-1 (k of)3 ( de)4 (ve)4 (l)-2 (opi)-2 (ng)10 ( m)-2 (a)4 (l)-2 (i)-12 (g)10 (na)4 (n)-10 (c)4 (i)-2 (e)4 (s)-1 (, pr)3 (a)-6 (c)4 (t)-2 (i)-2 (t)-2 (i)-2 (one)4 (r)3 (s)-1 ( s)-1 (houl)-2 (d t)-2 (hor)3 (oug)10 (hl)-12 (y )10 (c)4 (ons)-1 (i)-2 (de)4 (r )3 (t)-2 (he)4 ( r)3 (i)-2 (s)-1 (ks )]TJ 0.002 Tc 0.088 Tw T* [(a)6 (n)2 (d)2 ( b)2 (e)6 (n)2 (e)-4 (f)5 (its)1 ( o)2 (f)5 ( s)1 (ta)6 (r)5 (tin)2 (g)2 ( s)1 (o)2 (ma)6 (tr)5 (o)2 (p)2 (in)2 ( in)2 ( th)2 (e)6 (s)1 (e)6 ( p)2 (a)6 (tie)-4 (n)2 (ts)1 (. )-8 (I)25 (f)5 ( t)-10 (r)5 (e)6 (a)6 (tme)6 (n)2 (t w)4 (ith)2 ( s)1 (o)-8 (ma)6 (tr)5 (o)2 (p)2 (in)2 ( is )]TJ 0 Tc 0 Tw T* [(i)-2 (ni)-2 (t)-2 (i)-2 (a)4 (t)-2 (e)4 (d, t)-2 (he)4 (s)-1 (e)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( s)-1 (houl)-2 (d be )4 (c)4 (a)4 (r)-7 (e)4 (f)3 (ul)-2 (l)-22 (y)20 ( m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d f)3 (or)3 ( d)-10 (e)4 (ve)4 (l)-2 (opm)-2 (e)4 (nt)-2 ( of )-7 (ne)4 (opl)-2 (a)4 (s)]TJ 0.001 Tc -0.001 Tw 32.68 0 Td [(m)-1 (s. )]TJ EMC /P <>BDC 0 Tc 0.13 Tw -32.68 -2.3 Td [(M)-1 (oni)-2 (t)-2 (or)3 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( on s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (c)4 (a)4 (r)-7 (e)4 (f)3 (ul)-2 (l)-22 (y)10 ( f)3 (or)3 ( i)-2 (nc)4 (r)-7 (e)4 (a)4 (s)-1 (e)4 (d )-20 (g)10 (r)3 (ow)2 (t)-2 (h, )]TJ 0.002 Tc 0.128 Tw [(o)-8 (r)5 ( p)2 (o)2 (te)6 (n)2 (tia)6 (l )]TJ -0.004 Tc 0.004 Tw T* [(m)-6 (al)-6 (i)-6 (g)6 (n)-4 (an)-4 (t)-6 ( ch)-14 (an)-14 (g)6 (es)-5 (,)-4 ( o)-4 (r)-1 ( p)-14 (r)-11 (eex)-14 (i)-6 (s)-5 (t)-6 (i)-6 (n)-4 (g)6 ( n)-4 (ev)-4 (i)-6 (. )]TJ EMC /P <>BDC 0.002 Tc 0.198 Tw 0 -2.3 TD [(T)3 (r)5 (e)6 (a)6 (tme)6 (n)2 (t )-10 (w)4 (ith)2 ( s)1 (o)2 (ma)6 (tr)5 (o)-8 (p)2 (in)2 ( ma)-4 (y )12 (d)2 (e)-4 (c)6 (r)5 (e)-4 (a)6 (s)1 (e)6 ( in)2 (s)1 (u)2 (li)-10 (n)2 ( s)1 (e)6 (n)2 (s)1 (itiv)2 (it)-10 (y)22 (,)2 ( p)2 (a)-4 (r)5 (tic)6 (u)2 (la)6 (r)5 (l)-10 (y )12 (a)-4 (t h)2 (i)-10 (g)12 (h)2 (e)-4 (r )]TJ 0 Tc 0.14 Tw 0 -1.15 TD [(dos)-1 (e)4 (s)-1 ( i)-2 (n s)-1 (us)-1 (c)4 (e)4 (pt)-2 (i)-2 (bl)-2 (e)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (. A)2 (s)-1 ( a)4 ( r)3 (e)4 (s)-1 (ul)-2 (t)-2 (, pr)3 (e)4 (vi)-2 (o)-10 (us)-1 (l)-12 (y)20 ( undi)-2 (a)-6 (g)10 (nos)-1 (e)4 (d i)-2 (m)-2 (pa)4 (i)-2 (r)-7 (e)4 (d g)10 (l)-2 (u)-10 (c)4 (os)-1 (e )]TJ -0.004 Tc 0.064 Tw T* [(t)-6 (o)-4 (l)-6 (er)-1 (an)-4 (ce )-10 (an)-4 (d)-4 ( o)-4 (v)-4 (er)-1 (t)-6 ( d)-4 (i)-6 (ab)-14 (et)-6 (es)-5 ( m)-6 (el)-6 (l)-6 (i)]TJ 0 Tc 0.06 Tw 13.73 0 Td [(t)-2 (us)-1 ( m)-2 (a)-6 (y)20 ( be)4 ( un)-10 (m)-2 (a)4 (s)-1 (ke)4 (d dur)3 (i)-2 (n)-10 (g)10 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (op)-10 (i)-2 (n t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 (. )]TJ -0.004 Tc 0.004 Tw -13.73 -1.15 Td [(N)-2 (ew)]TJ 0 Tc 0 Tw 1.88 0 Td (-)Tj 0.08 Tw 0.33 0 Td [(ons)-1 (e)4 (t)-2 ( t)-22 (y)20 (pe)4 ( 2 di)-2 (a)4 (b)-10 (e)4 (t)-12 (e)4 (s)-1 ( m)-2 (e)4 (l)-2 (l)-2 (i)-2 (t)-2 (us)-1 ( ha)4 (s)-1 ( be)4 (e)4 (n r)3 (e)4 (p)-10 (or)3 (t)-2 (e)4 (d i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (. )]TJ 0.09 Tw [(T)1 (he)4 (r)3 (e)-6 (f)-7 (or)3 (e)4 (, g)10 (l)-2 (uc)4 (os)-1 (e )]TJ 0.31 Tw -2.21 -1.15 Td [(l)-2 (e)4 (ve)4 (l)-2 (s)-1 ( s)-1 (houl)-2 (d be)-6 ( m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d p)-10 (e)4 (r)3 (i)-2 (odi)-2 (c)4 (a)4 (l)-2 (l)-22 (y)20 ( i)-2 (n )-10 (a)4 (l)-2 (l)-2 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h )-10 (s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n, )]TJ 0.002 Tc 0.188 Tw T* [(e)6 (s)1 (p)2 (e)6 (c)6 (ia)6 (ll)-20 (y)22 ( in)2 ( th)2 (o)2 (s)1 (e)6 ( w)4 (ith)-8 ( r)5 (is)1 (k)2 ( f)5 (a)6 (c)6 (to)2 (r)5 (s)1 ( f)-5 (o)2 (r )]TJ 0 Tc 0.19 Tw 17.13 0 Td [(di)-2 (a)4 (be)4 (t)-12 (e)-6 (s)-1 ( m)-2 (e)4 (l)-2 (l)-2 (i)-2 (t)-2 (us)-1 (, s)-1 (uc)4 (h a)4 (s)-1 ( obe)4 (s)-1 (i)-2 (t)-12 (y)20 (, T)1 (ur)3 (ne)-6 (r )]TJ 0.002 Tc 0.038 Tw -17.13 -1.15 Td [(s)-9 (y)22 (n)2 (d)2 (r)5 (o)2 (me)6 (,)2 ( o)2 (r)5 ( a)6 ( f)-5 (a)6 (mil)-10 (y)22 ( h)2 (i)-10 (s)1 (to)2 (r)-5 (y)22 ( o)2 (f)5 ( d)2 (ia)6 (b)2 (e)6 (te)6 (s)1 ( me)6 (llitu)2 (s)1 (.)2 ( P)-2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)12 ( p)2 (r)5 (e)6 (e)6 (x)-8 (is)1 (tin)12 (g)12 ( t)-10 (y)22 (p)-8 (e)6 ( 1)2 ( o)2 (r )]TJ 0 Tc 0.13 Tw T* [(t)-12 (y)20 (pe)-6 ( 2 di)-2 (a)4 (b)-10 (e)4 (t)-2 (e)4 (s)-1 ( m)-2 (e)4 (l)-2 (l)-2 (i)-2 (t)-2 (us)-1 ( or)3 ( i)-2 (m)-2 (pa)4 (i)-2 (r)-7 (e)4 (d )-10 (g)10 (l)-2 (uc)4 (os)-11 (e)4 ( t)-2 (ol)-12 (e)4 (r)3 (a)4 (nc)-6 (e)4 ( s)-1 (houl)-2 (d b)-10 (e)4 ( m)-2 (oni)-2 (t)-2 (o)-10 (r)3 (e)4 (d )-10 (c)4 (l)-2 (os)-1 (e)4 (l)-12 (y )]TJ 0.03 Tw T* [(dur)3 (i)-2 (ng)10 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (he)4 (r)-7 (a)4 (p)-10 (y)20 (.)-10 ( T)1 (he)4 ( dos)-1 (e)4 (s)-1 ( o)-10 (f)3 ( a)4 (nt)-2 (i)-2 (h)-10 (y)20 (p)-10 (e)-6 (r)3 (g)10 (l)-22 (y)20 (c)-6 (e)4 (m)-2 (i)-2 (c)4 ( dr)3 (u)-10 (g)10 (s)-1 ( $)3 (i)-2 (.e)4 (., i)-2 (ns)-11 (ul)-2 (i)-2 (n or)3 ( or)3 (a)4 (l )]TJ 0.002 Tc 0.338 Tw T* [(a)6 (g)2 (e)6 (n)2 (ts)1 ($)5 ( ma)-14 (y)22 ( r)-5 (e)6 (q)2 (u)2 (ir)5 (e)6 ( a)6 (d)-8 (ju)2 (s)1 (tme)6 (n)2 (t w)4 (h)2 (e)6 (n)2 ( s)1 (o)2 (ma)6 (tr)5 (o)2 (p)2 (in)2 ( th)2 (e)6 (r)5 (a)6 (p)-18 (y)22 ( is)1 ( in)2 (s)1 (titu)2 (te)16 (d)2 ( in)2 ( th)2 (e)6 (s)1 (e )]TJ 0 Tc 0 Tw T* [(pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (. )]TJ EMC /P <>BDC 0.09 Tw 0 -2.3 TD [(I)13 (n)-10 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h )-10 (h)-20 (y)20 (popi)-2 (t)-2 (ui)-2 (t)-2 (a)4 (r)3 (i)-2 (s)-1 (m)-2 ( $)3 (m)-2 (ul)-2 (t)-2 (i)-2 (pl)-2 (e)4 ( hor)3 (m)-2 (one)4 ( de)-6 (f)3 (i)-2 (c)4 (i)-2 (e)4 (nc)4 (i)-2 (e)4 (s)-11 ($)3 (, s)-1 (t)-2 (a)4 (nd)-10 (a)-6 (r)3 (d hor)3 (m)-2 (ona)4 (l )]TJ 0.4 Tw 0 -1.15 TD [(r)3 (e)4 (pl)-2 (a)4 (c)-6 (e)4 (m)-2 (e)4 (nt)-2 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( s)-1 (h)-10 (oul)-2 (d be)4 ( m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d c)4 (l)-2 (os)-1 (e)4 (l)-12 (y)20 ( w)2 (h)-10 (e)4 (n s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( i)-2 (s )]TJ 0.56 Tw T* [(a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (e)4 (d. U)2 (ndi)-2 (a)-6 (g)10 (no)-10 (s)-1 (e)4 (d/)-2 (unt)-2 (r)3 (e)4 (a)4 (t)-2 (e)4 (d h)-20 (y)20 (pot)-2 (h)-20 (y)20 (r)-7 (oi)-2 (di)-2 (s)-1 (m)-2 ( m)-2 (a)-6 (y)20 ( pr)3 (e)4 (v)-10 (e)4 (nt )-12 (a)4 (n opt)-2 (i)-2 (m)-2 (a)4 (l )]TJ 0.11 Tw T* [(r)3 (e)4 (s)-1 (pons)-1 (e)4 ( t)-2 (o s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n, i)-2 (n pa)4 (r)3 (t)-2 (i)-2 (c)4 (ul)-2 (a)4 (r)3 (, t)-2 (he)4 ( g)10 (r)3 (o)-10 (w)2 (t)-2 (h r)3 (e)4 (s)-1 (pons)-1 (e)4 ( i)-2 (n c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n. P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h )]TJ 0.01 Tw T* [(T)1 (ur)3 (ne)4 (r)3 ( s)-21 (y)20 (nd)-10 (r)3 (om)-2 (e)4 ( ha)4 (v)-10 (e)4 ( a)-6 (n i)-2 (nhe)4 (r)3 (e)4 (nt)-2 (l)-22 (y)20 ( i)-2 (nc)4 (r)-7 (e)4 (a)4 (s)-1 (e)4 (d)-10 ( r)3 (i)-2 (s)-11 (k of)3 ( de)4 (ve)4 (l)-2 (opi)-2 (n)-10 (g a)4 (ut)-2 (oi)-2 (m)-2 (m)-2 (une)4 ( t)-2 (h)-10 (y)20 (r)-7 (oi)-2 (d )]TJ 0.2 Tw T* [(di)-2 (s)-1 (e)4 (a)4 (s)-1 (e)4 ( a)4 (nd pr)3 (i)-2 (m)-2 (a)4 (r)-17 (y)30 ( h)-20 (y)10 (pot)-2 (h)-10 (y)20 (r)3 (oi)-2 (di)-2 (s)-1 (m)-2 (. )-10 (I)23 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-12 (s)-1 ( w)2 (i)-2 (t)-2 (h g)10 (r)3 (ow)2 (t)-2 (h hor)3 (m)-2 (one)4 ( de)4 (f)3 (i)-2 (c)4 (i)-2 (e)4 (nc)-16 (y)20 (, )]TJ 0.32 Tw T* [(c)4 (e)4 (nt)-2 (r)3 (a)4 (l)-2 ( $)3 (s)-11 (e)4 (c)4 (onda)-6 (r)-17 (y)20 ($)3 ( h)-20 (y)20 (p)-10 (ot)-2 (h)-10 (y)20 (r)3 (oi)-2 (di)-2 (s)-1 (m)-2 ( m)-2 (a)-6 (y )10 (f)3 (i)-2 (r)3 (s)-1 (t)-2 ( be)4 (c)4 (om)-2 (e)4 ( e)4 (vi)-2 (de)4 (nt)-2 ( or)3 ( w)2 (o)-10 (r)-7 (s)-1 (e)4 (n dur)3 (i)-2 (ng )]TJ 0.4 Tw T* [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 (. )-10 (T)1 (he)4 (r)3 (e)4 (f)3 (o)-10 (r)3 (e)4 (,)-10 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( t)-2 (r)3 (e)-6 (a)-6 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n s)-11 (houl)-2 (d )]TJ 0 Tw [(ha)4 (ve )]TJ 0.15 Tw T* [(pe)4 (r)3 (i)-2 (odi)-2 (c)4 ( t)-2 (h)-10 (y)20 (r)3 (oi)-2 (d f)3 (unc)4 (t)-2 (i)-2 (o)-10 (n t)-2 (e)4 (s)-1 (t)-2 (s)-1 ( a)4 (nd t)-2 (h)-10 (y)30 (r)3 (oi)-2 (d hor)3 (m)-2 (one)4 ( r)3 (e)4 (pl)-2 (a)4 (c)4 (e)4 (m)-12 (e)4 (nt)-2 ( t)-2 (he)4 (r)3 (a)-6 (p)-10 (y)20 ( s)-1 (houl)-2 (d be )]TJ 0 Tw T* [(i)-2 (ni)-2 (t)-2 (i)-2 (a)4 (t)-2 (e)4 (d or)3 ( a)4 (ppr)3 (opr)3 (i)-2 (a)4 (t)-2 (e)4 (l)-22 (y )10 (a)4 (dj)-2 (us)-1 (t)-2 (e)4 (d w)2 (he)4 (n i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (e)4 (d. )]TJ EMC /P <>BDC 0.02 Tw 0 -2.3 TD [(P)-4 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h e)4 (ndoc)4 (r)3 (i)-2 (ne)4 ( di)-2 (s)-1 (or)3 (de)4 (r)3 (s)-1 (, i)-2 (nc)4 (l)-2 (udi)-2 (ng g)10 (r)3 (ow)2 (t)-12 (h hor)3 (m)-2 (one)4 ( de)4 (f)3 (i)-2 (c)4 (i)-2 (e)4 (nc)-16 (y)20 (, m)-12 (a)-6 (y)20 ( h)-10 (a)4 (ve)4 ( a)4 (n )]TJ -0.004 Tc 0.124 Tw 0 -1.15 TD [(i)-6 (n)-4 (cr)-1 (eas)-15 (ed)-4 ( i)-6 (n)-4 (ci)-6 (d)-4 (en)-4 (ce o)-4 (f)-1 ( s)-5 (l)-16 (i)-6 (p)-4 (p)-4 (ed)-4 ( c)]TJ 0 Tc 0.12 Tw [(a)4 (pi)-2 (t)-2 (a)4 (l)-2 ( f)3 (e)4 (m)-2 (or)3 (a)4 (l)-2 ( e)4 (p)-10 (i)-2 (ph)-10 (y)20 (s)-1 (i)-2 (s)-1 (. A)2 (n)-10 (y)20 ( c)4 (hi)-2 (l)-2 (d w)2 (ho )-10 (de)4 (ve)4 (l)-2 (ops)-1 ( a )]TJ 0 Tw T* [(l)-2 (i)-2 (m)-2 (p or)3 ( c)4 (om)-2 (pl)-2 (a)4 (i)-2 (ns)-1 ( of)3 ( hi)-2 (p or)3 ( kne)4 (e)4 ( pa)4 (i)-2 (n du)-10 (r)3 (i)-2 (ng)10 ( s)-1 (om)-2 (a)-6 (t)-2 (r)3 (opi)-2 (n t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( s)-1 (houl)-2 (d be )-6 (e)4 (va)4 (l)-2 (ua)4 (t)-2 (e)4 (d. )]TJ EMC /P <>BDC -0.004 Tc 0.214 Tw 0 -2.3 TD [(I)9 (n)-4 (t)-6 (r)-11 (acr)-11 (an)-4 (i)-6 (al)-6 ( h)-14 (y)16 (p)-14 (er)-1 (t)-6 (en)-4 (s)-5 (i)-6 (o)-4 (n)-14 ( $)-11 (I)19 (H)-12 ($)-1 ( w)-2 (i)-6 (t)-6 (h)-4 ( p)-4 (ap)-4 (i)-6 (l)-6 (l)-6 (ed)-4 (em)-6 (a,)-14 ( v)-4 (i)-6 (s)-5 (u)-4 (al)-6 ( ch)-4 (an)-4 (g)6 (es)-5 (,)-4 ( h)-4 (e)-10 (ad)-4 (ac)-10 (h)-4 (e,)-4 ( n)-4 (au)-4 (s)-5 (ea )]TJ 0 Tc 0.07 Tw 0 -1.15 TD [(a)4 (nd/)-2 (or)3 ( vom)-2 (i)-2 (t)-2 (i)-2 (ng)10 ( ha)4 (s)-1 ( b)-10 (e)4 (e)-6 (n r)3 (e)4 (por)3 (t)-2 (e)4 (d i)-2 (n )]TJ 0.002 Tc 0.068 Tw 15.42 0 Td [(a)6 ( s)1 (ma)6 (ll n)2 (u)-8 (mb)2 (e)6 (r)5 ( o)2 (f)5 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( tr)-5 (e)6 (a)6 (te)6 (d )-8 (w)4 (ith)2 ( g)12 (r)5 (o)2 (w)4 (th )]TJ 0 Tc 0.07 Tw -15.42 -1.15 Td [(hor)3 (m)-2 (one)4 ( pr)3 (oduc)4 (t)-2 (s)-1 (. )-10 (I)13 (H)2 ( h)-10 (a)-6 (s)-1 ( be)4 (e)4 (n r)3 (e)4 (po)-10 (r)3 (t)-2 (e)4 (d m)-2 (or)3 (e)4 ( f)-7 (r)3 (e)-6 (que)4 (nt)-2 (l)-12 (y)20 ( a)-6 (f)3 (t)-2 (e)4 (r)3 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-2 (h )-10 (I)23 (G)-8 (F)]TJ 0 Tw 33.52 0 Td [(-)3 (1)]TJ 0.01 Tc -0.01 Tw (. )Tj 0.002 Tc 0.168 Tw -33.52 -1.15 Td [(S)-12 (y)32 (mp)2 (to)2 (ms)1 ( u)2 (s)1 (u)2 (a)6 (ll)-20 (y)32 ( o)-8 (c)6 (c)6 (u)2 (r)-5 ( w)4 (ith)2 (in)2 ( th)2 (e)6 ( f)5 (ir)5 (s)1 (t e)6 (ig)12 (h)2 (t w)4 (e)6 (e)6 (k)2 (s)1 ( a)6 (f)5 (te)-4 (r)5 ( th)2 (e)6 ( in)2 (itia)6 (tio)2 (n )12 (o)2 (f)5 ( g)12 (r)5 (o)-8 (w)4 (th )]TJ 0 Tc 0.13 Tw T* [(hor)3 (m)-2 (one)4 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. )-10 (I)13 (n )-10 (a)4 (l)-2 (l)-2 ( r)3 (e)4 (por)3 (t)-2 (e)4 (d c)-6 (a)4 (s)-1 (e)4 (s)-1 (, )-10 (I)13 (H)]TJ 0 Tw 17.65 0 Td (-)Tj 0.13 Tw 0.33 0 Td [(a)4 (s)-1 (s)-1 (oc)-6 (i)-2 (a)4 (t)-2 (e)4 (d s)-1 (i)-2 (g)10 (ns)-1 ( a)4 (nd s)-21 (y)20 (m)-2 (pt)-2 (om)-2 (s)-1 ( r)3 (e)4 (s)-1 (ol)-2 (ve)4 (d )]TJ 0.6 Tw -17.98 -1.15 Td [(r)3 (a)4 (pi)-2 (dl)-12 (y )10 (a)4 (f)3 (t)-2 (e)-6 (r)3 ( t)-2 (e)4 (m)-2 (por)3 (a)-6 (r)-7 (y )10 (s)-1 (us)-1 (pe)4 (ns)-1 (i)-2 (on o)-10 (r)3 ( t)-2 (e)4 (r)3 (m)-12 (i)-2 (na)4 (t)-2 (i)-2 (on of)3 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. )-10 (F)-4 (undus)-1 (c)4 (opi)-2 (c )]TJ 0.57 Tw T* [(e)4 (x)-10 (a)4 (m)-2 (i)-2 (na)4 (t)-2 (i)-2 (on s)-1 (houl)-2 (d be)14 ( pe)4 (r)3 (f)3 (or)3 (m)-12 (e)4 (d r)3 (out)-2 (i)-2 (ne)4 (l)-22 (y)10 ( be)4 (f)3 (or)3 (e)4 ( i)-2 (ni)-2 (t)-2 (i)-2 (a)4 (t)-2 (i)-2 (n)-10 (g)10 ( t)-2 (r)3 (e)4 (a)-6 (t)-2 (m)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-2 (h )]TJ 0.09 Tw T* [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (o e)4 (x)-10 (c)4 (l)-2 (ude)4 ( pr)3 (e)4 (e)4 (x)-10 (i)-2 (s)-1 (t)-2 (i)-2 (ng)10 ( pa)4 (pi)-2 (l)-2 (l)-2 (e)4 (de)4 (m)-2 (a)4 ( a)-6 (nd pe)4 (r)3 (i)-2 (odi)-2 (c)4 (a)4 (l)-2 (l)-22 (y)20 ( dur)3 (i)-2 (n)]TJ -0.004 Tc 0.094 Tw 28.43 0 Td [(g)6 ( t)-6 (h)-4 (e co)-4 (u)-4 (r)-1 (s)-5 (e o)-14 (f )]TJ 0 Tc 0.22 Tw -28.43 -1.15 Td [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 (. )-20 (I)13 (f )-7 (pa)4 (pi)-2 (l)-2 (l)-2 (e)4 (de)4 (m)-2 (a)4 ( i)-2 (s)-1 ( obs)-1 (e)-6 (r)3 (ve)4 (d)-10 ( b)-10 (y )10 (f)3 (undus)-1 (c)4 (op)-20 (y)20 ( du)-10 (r)3 (i)-2 (n)-10 (g s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )]TJ 0.33 Tw T* [(t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 (, t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( s)-1 (h)-10 (oul)-2 (d be)4 ( s)-1 (t)-2 (oppe)4 (d. )-10 (I)23 (f )3 (s)-1 (o)-10 (m)-2 (a)4 (t)-2 (r)3 (opi)-2 (n i)-2 (nduc)4 (e)4 (d )]TJ 0.002 Tc 0.328 Tw [(id)2 (io)2 (p)2 (a)6 (th)2 (ic )-4 (I)15 (H)4 ( is )]TJ 0 Tc 0 Tw T* [(di)-2 (a)4 (g)10 (nos)-1 (e)-6 (d)]TJ -0.004 Tc 0.254 Tw [(,)-4 ( t)-6 (r)-1 (eat)-6 (m)-6 (en)-4 (t)-6 ( w)-2 (i)-16 (t)-6 (h)-4 ( s)-5 (o)-4 (m)-6 (at)-6 (r)-1 (o)-4 (p)-4 (i)-6 (n)-4 ( can)-4 ( b)-4 (e r)-11 (es)-5 (t)-6 (ar)-1 (t)-6 (ed)-4 ( at)-6 ( a l)-6 (o)-4 (w)-2 (e)-10 (r)-1 ( d)-4 (o)-4 (s)-15 (e af)-1 (t)-6 (er )]TJ 0 Tw 33.24 0 Td [(I)9 (H)]TJ 0 Tc 1.04 0 Td (-)Tj -0.004 Tc 0.004 Tw -34.28 -1.15 Td [(as)-5 (s)]TJ 0 Tc 0 Tw 1.22 0 Td [(oc)4 (i)-2 (a)4 (t)-2 (e)4 (d s)-1 (i)-12 (g)10 (ns)-1 ( a)4 (nd s)-21 (y)20 (m)-12 (pt)-2 (om)-2 (s)-1 ( ha)4 (ve)4 ( r)3 (e)4 (s)-1 (ol)-2 (ve)4 (d. )]TJ EMC /Artifact <>BDC 0 g /T1_0 1 Tf 10 0 0 10 44.6328 31.1979 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 569 0 obj <>>>/Resources 506 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 570 0 obj <> endobj 571 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 572 0 obj <> endobj 573 0 obj <>stream q 1 0 0 1 26.632935 13.198059 cm 0 0 595.32 841.92 re W n 1 0 0 1 -26.632935 -13.198059 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 187.3129 772.3181 Tm ( )Tj 0.002 Tc 0.088 Tw 5.11 0 Td ( )Tj 0 Tc 0 Tw 10.21 0 Td ( )Tj 0.09 Tw 8.54 0 Td [( )-4520 ( )]TJ 0.21 Tw -26.19 -1.15 Td ( )Tj 25.9 0 Td [( )-4690 ( )]TJ 0.002 Tc -0.002 Tw 5.15 -1.15 Td ( )Tj 0 Tc 0.12 Tw -9.43 -1.15 Td ( )Tj 9.43 0 Td ( )Tj 0 Tw -26.53 -1.15 Td ( )Tj -0.004 Tc 0.134 Tw 26.53 0 Td ( )Tj 0 Tc 0 Tw -29.6 -1.15 Td ( )Tj 27.08 0 Td ( )Tj 0.04 Tw 2.52 0 Td ( )Tj 0 Tw -16.17 -2.3 Td ( )Tj -0.004 Tc 0.284 Tw 16.17 -2.32 Td ( )Tj 0 Tc 0.31 Tw -10.58 -1.15 Td ( )Tj 0.3 Tw 0.26 -1.15 Td ( )Tj 10.32 0 Td ( )Tj -0.004 Tc 0.104 Tw -5.02 -1.15 Td [( )-4670 ( )]TJ 0 Tc 0.3 Tw -1.06 -1.15 Td [( )-450 ( )]TJ 0 Tw -24.98 -1.15 Td ( )Tj 13.83 0 Td ( )Tj 0.05 Tw -5.58 -2.33 Td ( )Tj 0 Tw 8.17 0 Td [( )-1260 ( )-4650 ( )]TJ 0.17 Tw -6.96 -1.17 Td ( )Tj 21.85 0 Td ( )Tj 0.38 Tw -0.25 -1.17 Td ( )Tj 0.18 Tw -23.22 -1.16 Td ( )Tj 23.22 0 Td ( )Tj 0.15 Tw 0 -1.17 TD ( )Tj 0.29 Tw T* ( )Tj 0.39 Tw -15.3 -1.16 Td ( )Tj -0.004 Tc 0.004 Tw 15.3 0 Td ( )Tj 0 Tc 0.17 Tw T* ( )Tj 0.13 Tw -16.07 -2.33 Td ( )Tj 0 Tw 3.76 -1.17 Td ( )Tj -22.3 -1.65 Td ( )Tj 0.13 Tw 8.26 -1.15 Td ( )Tj 0 Tw 8.04 0 0 8.04 275.6329 382.7981 Tm ( )Tj 12 0 0 12 285.1129 377.2781 Tm ( )Tj 0.13 Tw 20.57 0 Td ( )Tj -0.002 Tc 0.092 Tw -4.69 -1.15 Td [( )-4350 ( )]TJ 0 Tc 0 Tw 0.17 -1.15 Td ( )Tj -25.51 -1.14 Td ( )Tj -4.58 -1.15 Td ( )Tj /TT1 1 Tf 7.28 -1.17 Td ( )Tj -3.84 -1.15 Td ( )Tj /TT0 1 Tf 1.16 -1.13 Td ( )Tj 0.11 Tw 19.85 0 Td ( )Tj 0 Tw 10.16 0 Td ( )Tj -5.12 -1.15 Td [( )-4870 ( )]TJ -21.27 -1.15 Td ( )Tj 26.14 -1.15 Td ( )Tj -22.11 -1.15 Td ( )Tj -0.002 Tc 0.112 Tw 4.38 0 Td ( )Tj 0.002 Tc 0.108 Tw 11.86 0 Td ( )Tj -0.004 Tc 0.114 Tw 6.12 0 Td ( )Tj 0 Tc 0 Tw -32.78 -1.15 Td ( )Tj 6.46 0 Td ( )Tj 5.93 -1.15 Td ( )Tj 7.4 0 Td ( )Tj -0.004 Tc 0.144 Tw 4 0 Td ( )Tj 0.004 Tw 8.99 0 Td ( )Tj 0 Tc 0.46 Tw -6.23 -1.15 Td ( )Tj -0.004 Tc 0.464 Tw 6.23 0 Td ( )Tj 0 Tc 0 Tw -23.13 -1.15 Td ( )Tj 0.33 Tw 23.13 0 Td ( )Tj 0 Tw -16.24 -1.15 Td ( )Tj 13.11 0 Td ( )Tj -19.77 -1.15 Td ( )Tj 0.18 Tw 22.9 -1.15 Td ( )Tj 0 Tw -24.95 -1.15 Td ( )Tj -9.66 -1.15 Td ( )Tj EMC /Span <>BDC 0.002 Tc 0.088 Tw 0 Tr 0 55.91 TD [(tr)5 (e)6 (a)6 (tme)6 (n)2 (t w)4 (ith )]TJ 0 Tc 0 Tw 6.23 0 Td [(s)-1 (om)-2 (a)4 (t)-12 (r)3 (op)-10 (i)-2 (n)]TJ 0.002 Tc 0.088 Tw [(. )-8 (I)15 (f)5 ( d)2 (u)-8 (r)5 (in)2 (g)2 ( tr)5 (e)-4 (a)6 (tme)6 (n)2 (t w)-6 (ith )]TJ 0 Tc 0 Tw 15.32 0 Td [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n)]TJ 0.09 Tw [(, pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s )-11 (s)-1 (how)2 ( s)-1 (i)-2 (g)10 (ns )]TJ 0.21 Tw -21.55 -1.15 Td [(of)3 ( uppe)4 (r )3 (a)4 (i)-12 (r)3 (w)2 (a)-16 (y)20 ( obs)-1 (t)-2 (r)3 (u)-10 (c)-6 (t)-2 (i)-2 (on $)3 (i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 ( ons)-1 (e)4 (t)-2 ( of)-7 ( or)3 ( i)-2 (nc)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 (d s)-1 (nor)3 (i)-2 (n)-10 (g)10 ($ )-7 (a)-6 (nd/)-2 (or)3 ( ne)4 (w )]TJ 0.22 Tw 0 -1.15 TD [(ons)-1 (e)4 (t)-2 ( s)-1 (l)-2 (e)4 (e)4 (p a)4 (pne)4 (a)4 (, t)-2 (r)3 (e)-6 (a)4 (t)-12 (m)-2 (e)4 (nt)-2 ( s)-1 (houl)-2 (d be)4 ( i)-2 (nt)-2 (e)4 (r)3 (r)3 (upt)-2 (e)4 (d. A)2 (l)-2 (l)-2 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h )10 (P)6 (r)3 (a)4 (de)4 (r)]TJ 0 Tw 32.22 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(W)-4 (illi )]TJ 0 Tc 0.12 Tw -32.55 -1.15 Td [(s)-11 (y)20 (ndr)3 (om)-2 (e)4 ( t)-2 (r)-7 (e)4 (a)4 (t)-2 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h )]TJ 0 Tw [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )]TJ 0.12 Tw 14.42 0 Td [(s)-1 (houl)-2 (d a)4 (l)-2 (s)-1 (o ha)4 (ve)4 ( e)4 (f)-7 (f)3 (e)4 (c)4 (t)-2 (i)-2 (ve )-6 (w)2 (e)4 (i)-12 (g)10 (ht)-2 ( c)4 (on)-10 (t)-2 (r)3 (ol)-2 ( a)4 (nd be )]TJ 0.13 Tw -14.42 -1.15 Td [(m)-2 (oni)-2 (t)-2 (or)3 (e)4 (d f)3 (or)3 ( s)-1 (i)-2 (g)10 (ns )-1 (of)3 ( r)-7 (e)4 (s)-1 (pi)-2 (r)3 (a)4 (t)-2 (or)-17 (y)20 ( i)-2 (nf)3 (e)-6 (c)4 (t)-2 (i)-2 (on, w)2 (hi)-2 (c)4 (h s)-1 (houl)-2 (d be)4 ( di)-2 (a)4 (g)10 (nos)-1 (e)4 (d )]TJ -0.004 Tc 0.134 Tw 30.19 0 Td [(as)-5 ( ear)-1 (l)-26 (y)16 ( as )]TJ 0 Tc 0.04 Tw -30.19 -1.15 Td [(pos)-1 (s)-1 (i)-2 (bl)-2 (e)4 ( a)4 (n)]TJ 0 Tw (d )Tj -0.004 Tc 0.044 Tw 5.3 0 Td [(t)-6 (r)-1 (eat)-6 (ed)-4 ( a)-10 (g)-4 (g)-4 (r)-11 (es)-5 (s)-5 (i)-6 (v)-4 (el)-16 (y)16 ( $)-1 (s)-15 (ee )]TJ /TT1 1 Tf -0.002 Tc 0 Tw [(CO)-4 (NT)-5 (RAI)-13 (NDI)-3 (CAT)-5 (I)-3 (O)-4 (NS)]TJ /TT0 1 Tf -0.003 Tc 0.043 Tw 21.31 0 Td [($.)-3 ( T)]TJ -0.004 Tc 0.004 Tw 1.48 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)-7 (opi)-2 (n )]TJ 0.04 Tw 3.35 0 Td [(i)-2 (s)-1 ( not )]TJ 0.26 Tw -32.38 -1.15 Td [(i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (e)4 (d f)3 (or)3 ( t)-2 (he)4 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of)3 ( pe)4 (di)-2 (a)4 (t)-2 (r)3 (i)-2 (c)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (ho ha)4 (ve)4 ( g)10 (r)3 (ow)2 (t)-2 (h f)3 (a)4 (i)-2 (l)-12 (ur)3 (e)4 ( due)4 ( t)-2 (o )]TJ -0.004 Tc 0.004 Tw T* [(g)6 (en)-14 (et)-6 (i)-6 (cal)-6 (l)-26 (y)16 ( co)-4 (n)-4 (f)-1 (i)-6 (r)-1 (m)-16 (ed)-4 ( P)-8 (r)-11 (ad)-4 (er)]TJ 0 Tc 0 Tw 11.6 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(W)-4 (ill)]TJ 0 Tc 0 Tw [(i)-2 ( s)-11 (y)20 (ndr)3 (om)-2 (e)4 (. )]TJ EMC /P <>BDC -0.004 Tc 0.284 Tw -11.93 -2.32 Td [(C)-7 (as)-5 (es)-5 ( o)-4 (f)-1 ( p)-4 (an)-4 (cr)-1 (e)-10 (at)-6 (i)-6 (t)-6 (i)-6 (s)-5 ( h)6 (av)-4 (e b)-4 (een)-4 ( r)-11 (ep)-4 (o)-4 (r)-1 (t)-6 (ed)-4 ( r)-1 (a)-10 (r)-1 (el)-16 (y)16 ( i)-6 (n)-4 ( ch)-4 (i)-6 (l)-6 (d)-4 (r)-11 (en)-4 ( an)-4 (d)-4 ( ad)-4 (u)-4 (l)-6 (t)-6 (s)-5 ( r)-1 (ecei)-6 (v)-4 (i)-6 (n)-14 (g )]TJ 0 Tc 0.31 Tw T* [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 (, w)2 (i)-2 (t)-2 (h s)-1 (om)-2 (e)4 ( e)4 (vi)-2 (de)4 (nc)4 (e)4 ( s)-1 (u)-10 (ppor)3 (t)-2 (i)-2 (ng)10 ( a )-6 (g)10 (r)-7 (e)4 (a)4 (t)-2 (e)-6 (r)3 ( r)3 (i)-2 (s)-1 (k)-10 ( i)-2 (n c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n )]TJ 0.3 Tw T* [(c)4 (om)-2 (pa)4 (r)3 (e)4 (d)-10 ( w)2 (i)-2 (t)-2 (h a)4 (dul)-2 (t)-2 (s)-1 (. )-10 (P)-4 (ubl)-2 (i)-2 (s)-1 (he)4 (d l)-2 (i)-2 (t)-2 (e)4 (r)3 (a)4 (t)-2 (ur)3 (e)4 ( i)-2 (ndi)-12 (c)4 (a)4 (t)-2 (e)4 (s)-1 ( t)-2 (ha)4 (t )-22 (g)10 (i)-2 (r)3 (l)-2 (s)-1 ( w)2 (ho h)-10 (a)-6 (ve)4 ( T)1 (ur)3 (n)-10 (e)4 (r )]TJ -0.02 Tc 0.02 Tw T* [(s)-31 (yn)-20 (d)]TJ 0 Tc 0.1 Tw 1.88 0 Td [(r)3 (om)-2 (e)4 ( m)-2 (a)-16 (y)20 ( b)-10 (e)4 ( a)4 (t)-2 ( gr)3 (e)-6 (a)4 (t)-2 (e)4 (r)3 ( r)3 (i)-2 (s)-1 (k t)-2 (ha)4 (n ot)-2 (he)4 (r)3 ( s)-1 (om)-12 (a)4 (t)-2 (r)3 (opi)-2 (n)]TJ 0 Tw (-)Tj -0.004 Tc 0.104 Tw 21.12 0 Td [(t)-6 (r)-1 (eat)-16 (ed)-4 ( ch)-4 (i)-6 (l)-6 (d)-4 (r)-1 (en)-4 (. )-14 (P)-8 (an)-4 (cr)-1 (eat)-6 (i)-6 (t)-6 (i)-6 (s )]TJ 0 Tc 0.3 Tw -23 -1.15 Td [(s)-1 (houl)-2 (d be)4 ( c)4 (ons)-1 (i)-2 (de)4 (r)3 (e)4 (d)-10 ( i)-2 (n a)4 (n)-10 (y)20 ( s)-1 (om)-12 (a)4 (t)-2 (r)3 (opi)-2 (n)]TJ 0 Tw (-)Tj 0.3 Tw 17.74 0 Td [(t)-2 (r)3 (e)-6 (a)4 (t)-2 (e)-6 (d pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (, e)4 (s)-1 (pe)4 (c)4 (i)-12 (a)4 (l)-2 (l)-12 (y )10 (a )-6 (c)4 (hi)-2 (l)-2 (d, w)2 (ho )]TJ 0 Tw -17.74 -1.15 Td [(de)4 (ve)4 (l)-2 (ops )]TJ -0.004 Tc 0.004 Tw 3.8 0 Td [(p)-4 (er)-1 (s)-5 (i)-6 (s)-5 (t)-6 (en)-4 (t)-6 (,)-4 ( s)-5 (ev)-4 (e)-10 (r)-1 (e )]TJ 0 Tc 0 Tw [(a)4 (bdom)-2 (i)-2 (na)4 (l)-2 ( pa)4 (i)-2 (n. )]TJ EMC /P <>BDC 0.05 Tw -3.8 -2.33 Td [(B)7 (e)4 (nz)-16 (y)20 (l)-2 ( a)4 (l)-2 (c)4 (ohol)-2 (, a)4 ( c)4 (om)-2 (po)-10 (ne)4 (nt )-2 (us)-1 (e)4 (d t)-2 (o r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e )]TJ 0.002 Tc -0.002 Tw 20.26 0 Td (th)Tj 0 Tc 0 Tw 0.78 0 Td [(e )-46 (T)]TJ -0.004 Tc 0.004 Tw 1.35 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.05 Tw 3.35 0 Td [(5 m)-2 (g)10 ( vi)-2 (a)4 (l)-2 (, ha)4 (s)-1 ( be)4 (e)4 (n )]TJ 0.17 Tw -26.68 -1.17 Td [(a)4 (s)-1 (s)-1 (oc)4 (i)-2 (a)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h s)-1 (e)4 (r)3 (i)-2 (ous)-1 ( a)4 (dve)4 (r)3 (s)-1 (e )-6 (e)4 (ve)4 (nt)-2 (s)-1 ( a)4 (nd de)4 (a)4 (t)-12 (h, pa)4 (r)3 (t)-2 (i)-2 (c)4 (ul)-2 (a)4 (r)3 (l)-22 (y)30 ( i)-2 (n pe)4 (di)-12 (a)4 (t)-2 (r)-7 (i)-2 (c)4 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 (. )]TJ 0.38 Tw 0 -1.17 TD [(T)1 (he)4 ( \223)4 (ga)4 (s)-1 (pi)-2 (n)-10 (g)10 ( s)-11 (y)20 (ndr)3 (om)-12 (e)4 (,\224)4 ( $)3 (c)4 (ha)-6 (r)3 (a)-6 (c)4 (t)-2 (e)4 (r)3 (i)-2 (z)-6 (e)4 (d b)-10 (y)20 ( c)-6 (e)4 (nt)-2 (r)3 (a)4 (l)-2 ( ne)4 (r)3 (vous)-1 ( s)-11 (y)20 (s)-1 (t)-12 (e)4 (m)-2 ( de)4 (pr)3 (e)4 (s)-1 (s)-1 (i)-2 (on, )]TJ 0.18 Tw 0 -1.16 TD [(m)-2 (e)4 (t)-2 (a)4 (bol)-2 (i)-2 (c)4 ( a)-6 (c)4 (i)-2 (dos)-1 (i)-2 (s)-1 (, ga)4 (s)-1 (p)-10 (i)-2 (ng r)3 (e)]TJ 0 Tw 12.6 0 Td (s)Tj 0.18 Tw 0.39 0 Td [(pi)-2 (r)3 (a)4 (t)-2 (i)-2 (ons)-1 (, )-10 (a)4 (nd hi)-12 (gh l)-2 (e)4 (ve)4 (l)-2 (s)-1 ( o)-10 (f)3 ( be)4 (nz)-26 (y)20 (l)-2 ( a)4 (l)-12 (c)4 (o)-10 (hol)-2 ( a)4 (nd i)-2 (t)-2 (s )]TJ 0.15 Tw -12.99 -1.17 Td [(m)-2 (e)4 (t)-2 (a)4 (bol)-2 (i)-2 (t)-2 (e)4 (s)-1 ( f)3 (ound i)-2 (n t)-2 (he)-6 ( bl)-2 (ood a)4 (nd u)-10 (r)3 (i)-2 (ne)4 ($)3 ( h)-10 (a)4 (s)-1 ( b)-10 (e)4 (e)4 (n )-10 (a)4 (s)-1 (s)-1 (oc)4 (i)-2 (a)4 (t)-2 (e)4 (d )-10 (w)2 (i)-2 (t)-2 (h be)4 (n)-10 (z)-16 (y)30 (l)-12 ( a)4 (l)-2 (c)4 (ohol )]TJ 0.29 Tw 0 -1.17 TD [(dos)-1 (a)4 (ge)4 (s)-1 ( >)4 (99 m)-12 (g)10 (/)-2 (k)-10 (g)10 (/)-2 (da)-16 (y)10 ( i)-2 (n ne)4 (ona)4 (t)-2 (e)4 (s)-1 ( a)4 (nd)-10 ( l)-2 (ow)]TJ 0 Tw 19.47 0 Td (-)Tj 0.29 Tw 0.33 0 Td [(b)-10 (i)-2 (r)3 (t)-2 (h w)2 (e)4 (i)-2 (g)10 (ht)-2 ( n)-10 (e)4 (ona)4 (t)-2 (e)4 (s)-1 (. )-10 (A)2 (ddi)-2 (t)-2 (i)-2 (ona)4 (l )]TJ 0.39 Tw -19.8 -1.16 Td [(s)-11 (y)20 (m)-2 (pt)-2 (om)-2 (s)-1 ( m)-2 (a)-6 (y)20 ( i)-2 (nc)4 (l)-2 (ude)-6 ( g)10 (r)3 (a)4 (du)-10 (a)4 (l)-2 ( ne)4 (ur)3 (ol)-2 (o)-10 (g)10 (i)-2 (c)4 (a)4 (l )-12 (de)4 (t)-2 (e)4 (r)3 (i)-2 (or)3 (a)4 (t)-2 (i)-2 (on, s)-1 (e)4 (i)-2 (z)-6 (ur)3 (e)4 (s)-1 (, i)-2 (nt)-2 (r)3 (a)]TJ -0.004 Tc 0.004 Tw 31.89 0 Td [(cr)-1 (an)-4 (i)-16 (al )]TJ 0 Tc 0.17 Tw -31.89 -1.17 Td [(he)4 (m)-2 (or)3 (r)3 (ha)-6 (ge)4 (, he)4 (m)-12 (a)4 (t)-2 (ol)-2 (og)10 (i)-12 (c)4 ( a)4 (bno)-10 (r)3 (m)-2 (a)4 (l)-2 (i)-2 (t)-2 (i)-2 (e)4 (s)-1 (, s)-1 (ki)-2 (n br)-7 (e)4 (a)4 (kdow)2 (n,)-10 ( he)4 (pa)4 (t)-2 (i)-2 (c)-6 ( a)4 (nd)-10 ( r)-7 (e)4 (na)4 (l)-2 ( f)-7 (a)4 (i)-2 (l)-2 (ur)3 (e)4 (, )]TJ 0.2 Tw T* [(h)-10 (y)20 (pot)-2 (e)4 (ns)-1 (i)-2 (on, br)-7 (a)4 (d)-20 (y)20 (c)4 (a)-6 (r)3 (di)-2 (a)4 (, a)4 (nd c)4 (a)-6 (r)3 (di)-2 (ova)4 (s)-1 (c)4 (ul)-2 (a)-6 (r)3 ( c)-6 (ol)-2 (l)-2 (a)4 (ps)-1 (e)4 (. P)-4 (r)3 (a)4 (c)4 (t)-2 (i)-2 (t)-2 (i)-2 (one)4 (r)3 (s)-1 ( a)-6 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (i)-2 (ng )]TJ 0.13 Tw 0 -1.16 TD [(t)-2 (hi)-2 (s)-1 ( a)4 (nd ot)-2 (he)4 (r)3 ( m)-2 (e)4 (di)-2 (c)4 (a)4 (t)-2 (i)-2 (ons)-1 ( c)4 (ont)-2 (a)4 (i)-2 (ni)-2 (ng)10 ( be)4 (nz)-26 (y)30 (l )-12 (a)4 (l)-2 (c)-6 (ohol)-2 ( s)-1 (houl)-2 (d c)4 (ons)-1 (i)-2 (de)4 (r)3 ( t)-2 (he)4 ( c)4 (om)-2 (bi)-2 (ne)4 (d )]TJ 0 Tw 0 -1.17 TD [(da)4 (i)-2 (l)-12 (y)20 ( m)-2 (e)4 (t)-2 (a)4 (bol)-2 (i)-2 (c)4 ( l)-2 (oa)4 (d o)-10 (f)3 ( b)-10 (e)4 (nz)-16 (y)20 (l)-2 ( a)4 (l)-2 (c)4 (ohol)-2 ( f)-7 (r)3 (om)-2 ( a)4 (l)-2 (l)-2 ( s)-1 (our)3 (c)4 (e)4 (s)-1 (. )]TJ EMC /P <>BDC 0.13 Tw 0 -2.8 TD [(W)-6 (he)4 (n a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (e)4 (r)3 (i)-2 (ng )]TJ 0 Tw 8.64 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-40 (5 )]TJ -0.01 Tc 0.01 Tw 4.22 0 Td [(m)-22 (g )]TJ 0 Tc 0.13 Tw 1.66 0 Td [(t)-2 (o ne)4 (w)2 (bor)-7 (ns)-1 (, r)3 (e)4 (c)4 (ons)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 ( w)2 (i)-2 (t)-2 (h s)-1 (t)-2 (e)4 (r)3 (i)-2 (l)-2 (e)4 ( nor)3 (m)-2 (a)4 (l )]TJ -0.002 Tc 0.092 Tw -16.08 -1.15 Td [(s)-3 (a)2 (l)-4 (i)-4 (n)-2 (e)2 ( f)1 (o)-2 (r)1 ( i)-4 (n)-2 (j)-4 (e)2 (c)2 (t)-4 (i)-4 (o)-2 (n)-2 (,)-2 ( US)-6 (P)-6 (.)-2 ( W)-8 (HE)-1 (N R)-5 (E)-1 (C)-5 (ONS)-6 (T)-11 (I)21 (T)-1 (U)-10 (T)-11 (I)11 (NG W)-18 (I)11 (T)-1 (H S)-6 (T)-1 (E)-1 (R)-15 (I)1 (L)9 (E )-11 (NOR)-5 (M)-3 (A)-20 (L )]TJ 0.222 Tw 0 -1.15 TD [(S)-6 (A)-10 (L)9 (I)11 (N)-10 (E)-1 (,)-2 ( US)-6 (E)-1 ( ON)-10 (L)9 (Y )-10 (ONE)-1 ( DOS)-6 (E)-1 ( P)-6 (E)-1 (R)-5 ( V)-10 (I)11 (A)-10 (L)9 ( AN)-10 (D D)-10 (I)11 (S)-6 (C)-5 (AR)-5 (D T)-1 (H)-10 (E )]TJ 0.002 Tw 30.56 0 Td [(UNUS)-6 (E)-1 (D )]TJ 0 Tw -30.56 -1.14 Td [(P)-6 (OR)-5 (T)-11 (I)21 (ON. )]TJ EMC /P <>BDC /TT1 1 Tf 0 -2.32 TD [(P)9 (RE)-5 (CA)-10 (UT)-5 (I)-3 (O)-4 (NS )]TJ -0.004 Tc 0 -1.15 TD [(G)4 (en)-8 (e)-10 (ra)-4 (l )]TJ EMC /P <>BDC /TT0 1 Tf 0 Tc 0 -1.13 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.11 Tw 3.41 0 Td [(t)-2 (he)4 (r)-7 (a)4 (p)-20 (y)30 ( s)-1 (hou)-10 (l)-2 (d be)4 ( c)4 (a)4 (r)3 (r)3 (i)-2 (e)4 (d out)-2 ( unde)4 (r)3 ( t)-12 (he)4 ( r)3 (e)-6 (g)10 (ul)-2 (a)4 (r )-7 (g)10 (ui)-2 (da)4 (n)-10 (c)4 (e)4 ( of)3 ( a)-6 ( ph)-10 (y)20 (s)-1 (i)-2 (c)4 (i)-2 (a)4 (n )]TJ 0 Tw -4.96 -1.15 Td [(w)2 (ho i)-2 (s)-1 ( e)4 (x)-10 (pe)4 (r)3 (i)-2 (e)4 (nc)4 (e)4 (d i)-2 (n t)-2 (he)-6 ( di)-2 (a)4 (g)10 (nos)-1 (i)-2 (s)-1 ( a)4 (nd m)-12 (a)4 (na)-6 (g)10 (e)4 (m)-12 (e)4 (nt)-2 ( of)3 ( pe)4 (di)-2 (a)4 (t)-2 (r)3 (i)-2 (c)4 ( p)-10 (a)4 (t)-2 (i)-2 (e)4 (nt)-2 (s )-11 (w)2 (i)-2 (t)-2 (h g)10 (r)3 (ow)2 (t)-2 (h )]TJ 0 -1.15 TD [(hor)3 (m)-2 (one)4 ( de)4 (f)3 (i)-2 (c)4 (i)-12 (e)4 (nc)-16 (y)20 (. )]TJ EMC /P <>BDC 0 -2.3 TD (I)Tj 0.11 Tw 0.32 0 Td [(n )-10 (c)4 (hi)-2 (l)-2 (dhood c)4 (a)4 (n)-10 (c)4 (e)-6 (r)3 ( s)-1 (ur)-7 (vi)-2 (vor)3 (s )]TJ -0.002 Tc 0.112 Tw 12.29 0 Td [(wh)-2 (o)-2 ( we)-8 (r)1 (e )]TJ 0.002 Tc 0.108 Tw 4.38 0 Td [(tr)-5 (e)6 (a)6 (te)6 (d)-8 ( w)4 (ith)2 ( r)5 (a)6 (d)2 (ia)6 (tio)2 (n)2 ( to)2 ( th)2 (e )]TJ 0 Tc 0 Tw 11.86 0 Td [(br)-7 (a)4 (i)-2 (n/)]TJ -0.004 Tc 0.114 Tw 2.34 0 Td [(h)-4 (ead)-4 ( f)-1 (o)-14 (r )]TJ 0.002 Tc -0.002 Tw -31.19 -1.15 Td [(th)2 (e)6 (ir )]TJ 0 Tc 0.26 Tw 2.34 0 Td [(f)3 (i)-2 (r)3 (s)-1 (t)-2 ( ne)4 (opl)-2 (a)4 (s)-1 (m )-2 (a)4 (nd w)2 (ho de)4 (ve)4 (l)-2 (ope)4 (d s)-1 (ubs)-1 (e)4 (que)4 (nt)-2 ( G)2 (H)2 (D)2 ( a)4 (nd w)2 (e)4 (r)3 (e)4 ( t)-12 (r)3 (e)4 (a)4 (t)-2 (e)4 (d w)2 (i)-2 (t)-2 (h )]TJ 0.14 Tw -2.34 -1.15 Td [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n, a)4 (n i)-2 (n)-10 (c)4 (r)3 (e)-6 (a)4 (s)-1 (e)-6 (d r)3 (i)-2 (s)-1 (k of)-7 ( a )]TJ -0.004 Tc 0.144 Tw 14.61 0 Td [(s)-5 (eco)-4 (n)-4 (d)-14 ( n)-4 (eo)-4 (p)-14 (l)-6 (as)-5 (m )-6 (h)-4 (as)-5 ( b)-14 (een )-14 (r)-1 (ep)-4 (o)-4 (r)-1 (t)-16 (ed)]TJ 0.01 Tc -0.01 Tw 14.74 0 Td (. )Tj -0.004 Tc 0.004 Tw 0.66 0 Td [(I)9 (n)-4 (t)-6 (r)-1 (a)-10 (cr)-1 (an)-4 (i)-16 (al )]TJ 0.002 Tc 0.458 Tw -30.01 -1.15 Td [(tu)2 (mo)2 (r)5 (s)1 (,)2 ( in)2 ( p)2 (a)6 (r)5 (tic)6 (u)2 (la)6 (r)5 ( me)6 (n)2 (in)2 (g)12 (io)2 (ma)6 (s)1 (,)2 ( w)4 (e)6 (r)-5 (e)6 ( th)]TJ 0 Tc 0.46 Tw 19.53 0 Td [(e)-6 ( m)-2 (os)-1 (t)-2 ( c)4 (om)-2 (m)-2 (on)10 ( of )]TJ -0.004 Tc 0.464 Tw 9.56 0 Td [(t)-6 (h)6 (es)-5 (e s)-5 (eco)-4 (n)-4 (d )]TJ 0 Tc 0 Tw -29.09 -1.15 Td [(ne)4 (opl)-2 (a)4 (s)-1 (m)-2 (s)-1 (. )]TJ 0.002 Tc 0.328 Tw 5.06 0 Td [(I)25 (n)2 ( a)6 (d)2 (u)2 (lts)1 (,)2 ( it is )]TJ 0 Tc 0.33 Tw 7 0 Td [(unknow)2 (n w)2 (he)4 (t)-2 (he)4 (r)3 ( t)8 (he)4 (r)3 (e)4 ( i)-2 (s)-1 ( a)4 (n)-10 (y)20 ( r)-7 (e)4 (l)-2 (a)4 (t)-2 (i)-2 (ons)-1 (hi)-2 (p be)4 (t)-2 (w)2 (e)4 (e)4 (n )]TJ -0.004 Tc 1.274 Tw -12.06 -1.15 Td [(s)-5 (o)-4 (m)-6 (at)-6 (r)-1 (o)-4 (p)-4 (i)-6 (n)-4 ( r)-1 (ep)-4 (l)-6 (acem)-16 (e)-10 (n)-4 (t)-6 ( t)-6 (h)-4 (er)-1 (ap)-14 (y)16 ( an)-4 (d )]TJ -0.003 Tc 1.273 Tw 19.9 0 Td [(C)-6 (N)-1 (S)-7 ( t)-5 (u)-3 (m)-5 (o)-3 (r re)1 (c)1 (u)-3 (rre)-9 (n)-3 (c)1 (e )]TJ -0.004 Tc 0.004 Tw 13.1 0 Td [([)-11 (s)-5 (ee )]TJ /TT1 1 Tf -0.002 Tc 0 Tw -33 -1.15 Td [(CO)-4 (NT)-5 (RAI)-3 (NDI)-3 (CAT)-5 (I)-3 (O)-14 (NS)]TJ /TT0 1 Tf 0 Tc 11.12 0 Td [(])-7 (. )]TJ 0.02 Tw 0.86 0 Td [(M)-1 (oni)-2 (t)-2 (or)3 ( a)4 (l)-2 (l)-2 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)9 ( w)2 (i)-2 (t)-2 (h a)4 ( hi)-2 (s)-1 (t)-2 (or)-7 (y)20 ( of)3 ( G)2 (H)-8 (D)2 ( s)-11 (e)4 (c)4 (onda)4 (r)-17 (y)20 ( t)-2 (o )]TJ -0.004 Tc 0.184 Tw -11.98 -1.15 Td [(an)-4 ( i)-6 (n)-4 (t)-6 (r)-1 (acr)-11 (a)]TJ 0 Tc 0.18 Tw [(ni)-2 (a)4 (l)-2 ( ne)4 (opl)-2 (a)4 (s)-1 (m)-12 ( r)3 (out)-2 (i)-2 (ne)4 (l)-12 (y)20 ( w)2 (hi)-2 (l)-2 (e)4 ( on s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( f)3 (or)3 ( p)-10 (r)3 (o)-10 (gr)3 (e)4 (s)-1 (s)-1 (i)-2 (on or )]TJ 0 Tw 0 -1.15 TD [(r)3 (e)4 (c)4 (ur)-7 (r)3 (e)4 (nc)-6 (e)4 ( of)3 ( t)-2 (he)4 ( t)-2 (um)-2 (or)3 (. )]TJ EMC /Artifact <>BDC 0 g /T1_0 1 Tf 10 0 0 10 44.6329 31.1981 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 574 0 obj <>>>/Resources 505 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 575 0 obj <> endobj 576 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 577 0 obj <> endobj 578 0 obj <>stream q 1 0 0 1 26.615143 13.187988 cm 0 0 595.32 841.92 re W n 1 0 0 1 -26.615143 -13.187988 cm BT /Artifact <>BDC /CS0 cs 0 scn /TT0 1 Tf -0.002 Tc 0.002 Tw 3 Tr 12 0 0 12 250.0553 772.068 Tm ( )Tj 0 Tc 0 Tw ( )Tj /TT1 1 Tf 8.04 0 0 8.04 171.8151 764.028 Tm ( )Tj /TT2 1 Tf 12 0 0 12 181.0551 758.508 Tm ( )Tj 11.52 0 0 11.52 200.2551 758.508 Tm ( )Tj 0.073 Tw 28.786 0 Td ( )Tj 0.083 Tw -23.302 -1.167 Td ( )Tj 23.296 0 Td ( )Tj 0 Tw -21.837 -1.146 Td [( )-1604 ( )]TJ 8.535 0 Td ( )Tj -22.739 -1.146 Td ( )Tj 12 0 0 12 171.8151 704.988 Tm [( )-1230 ( )]TJ 0.002 Tc 0.238 Tw 8.91 0 Td ( )Tj 0.228 Tw 21.1 0 Td ( )Tj 0 Tc 0 Tw -27.45 -1.15 Td ( )Tj 5.64 0 Td ( )Tj 17.41 0 Td ( )Tj 11.52 0 0 11.52 116.6151 677.748 Tm ( )Tj 0.156 Tw 30.922 -1.146 Td [( )-4718 ( )]TJ 0 Tw -26.484 -1.146 Td ( )Tj -4.438 -1.146 Td ( )Tj 13.646 -2.302 Td ( )Tj -13.646 -1.146 Td ( )Tj 0.24 Tw 25.57 -1.146 Td ( )Tj 0.003 Tc 0.08 Tw -8.398 -1.146 Td [( )-1438 ( )]TJ 13.395 0 Td ( )Tj 0 Tc 0.25 Tw -10.278 -1.146 Td ( )Tj 15.76 0 Td ( )Tj 0.031 Tw -32.435 -1.156 Td ( )Tj 32.432 0 Td ( )Tj 0 Tw -0.003 -1.146 Td ( )Tj 0.073 Tw 0.007 -1.146 Td ( )Tj 0 Tw -7.627 -1.146 Td [( )-2625 ( )]TJ -28.423 -1.146 Td ( )Tj 0.003 Tc 0.299 Tw 11.862 -2.302 Td ( )Tj 0 Tc 0.302 Tw 24.186 0 Td ( )Tj 0.292 Tw -27.789 -1.146 Td ( )Tj 12.186 0 Td ( )Tj 9.821 0 Td ( )Tj 0 Tw 3.416 0 Td ( )Tj 0.01 Tw -20.738 -1.146 Td ( )Tj 13.509 0 Td ( )Tj 9.59 0 Td ( )Tj 0.115 Tw -31.845 -1.146 Td [( )-4155 ( )]TJ 18.499 0 Td [( )-4217 ( )]TJ 13.352 0 Td ( )Tj 0.063 Tw -25.449 -1.156 Td ( )Tj 11.263 0 Td [( )-2550 ( )-1239 ( )-1582 ( )-3322 ( )-3926 ( )]TJ 0 Tw -9.552 -1.146 Td ( )Tj 6.678 0 Td ( )Tj -18.989 -1.146 Td ( )Tj 0.003 Tc 0.122 Tw 5.707 -1.146 Td ( )Tj 0 Tc 0.125 Tw 30.343 0 Td ( )Tj 0.281 Tw -14.776 -1.146 Td ( )Tj 0 Tw 6.715 0 Td ( )Tj 7.56 0 0 7.56 498.2151 369.468 Tm ( )Tj 0.281 Tw 11.52 0 0 11.52 531.9217 360.468 Tm ( )Tj 0.375 Tw -10.177 -1.156 Td ( )Tj 10.176 0 Td ( )Tj 0 Tw 12 0 0 12 328.6551 333.948 Tm ( )Tj /TT0 1 Tf -17.67 -1.15 Td ( )Tj 5.61 -1.15 Td ( )Tj /TT2 1 Tf 0.002 Tc 0.368 Tw 3.89 -1.13 Td ( )Tj 25.11 0 Td ( )Tj 0 Tc 0.17 Tw -14.21 -1.15 Td ( )Tj 14.21 0 Td ( )Tj -0.004 Tc 0.524 Tw -9.72 -1.15 Td ( )Tj 0.002 Tc 0.518 Tw 9.72 0 Td ( )Tj 0 Tc 0.13 Tw -18 -1.15 Td ( )Tj -0.003 Tc 0.003 Tw 12.08 0 Td ( )Tj -0.004 Tc 0.134 Tw 5.92 0 Td ( )Tj 0 Tc 0 Tw -30.34 -1.15 Td ( )Tj -0.004 Tc 0.024 Tw 24.89 0 Td ( )Tj 5.45 0 Td ( )Tj 0 Tc 0.06 Tw -25.07 -2.3 Td ( )Tj 0.002 Tc 0.058 Tw 25.07 0 Td ( )Tj 0 Tc 0 Tw -29.46 -1.15 Td ( )Tj 0.002 Tc -0.002 Tw 2.36 0 Td ( )Tj 14.42 0 Td ( )Tj 0 Tc 0 Tw 10.32 0 Td ( )Tj -32.25 -1.15 Td ( )Tj -0.004 Tc 0.294 Tw 28.25 -1.15 Td ( )Tj 0 Tc 0 Tw -20.43 -2.3 Td ( )Tj 0.13 Tw 10.56 0 Td ( )Tj 16.23 0 Td ( )Tj 0 Tw -4.96 -1.15 Td [( )-4710 ( )]TJ -0.004 Tc 0.304 Tw -27.44 -1.15 Td [( )-2780 ( )]TJ 0 Tc 0.3 Tw 32.4 0 Td ( )Tj 0.12 Tw 0 -1.15 TD ( )Tj EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0 Tw 0 Tr -34.61 56.04 Td [(CO)-4 (NT)-5 (RAI)-3 (NDI)-3 (CAT)-5 (I)-3 (O)-14 (NS )]TJ EMC /P <>BDC /TT2 1 Tf 0 Tc 0 -1.13 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-20 (5 )]TJ 0.002 Tc -0.002 Tw 4.15 0 Td (mg )Tj 0 Tc 0.073 Tw 11.52 0 0 11.52 204.0913 758.508 Tm [(re)-4 (c)-4 (ons)4 (t)-3 (i)-3 (t)-3 (ut)7 (e)-4 (d )-10 (w)3 (i)-3 (t)-3 (h ba)-4 (c)7 (t)-3 (e)-4 (r)10 (i)-3 (os)4 (t)-3 (a)7 (t)-3 (i)7 (c)-4 ( 0.9% )-10 (s)4 (odi)-3 (um)-3 ( c)-4 (hl)-3 (or)10 (i)-3 (de)-4 ( i)-3 (nj)7 (e)-4 (c)-4 (t)7 (i)-3 (on, )-10 (U)3 (S)4 (P )]TJ 0.083 Tw -7.594 -1.167 Td [($norm)-3 (a)7 (l)-3 ( s)4 (a)7 (l)-3 (i)-3 (ne)7 ($ $b)10 (e)-4 (nz)-4 (y)21 (l)-3 ( a)-4 (l)7 (c)-4 (ohol )7 (pre)-4 (s)4 (e)-4 (rv)10 (e)-4 (d$ s)4 (hou)11 (l)-3 (d n)10 (ot)-3 ( be)7 ( a)-4 (d)10 (m)-3 (i)-3 (n)11 (i)-3 (s)4 (t)-3 (e)-4 (r)10 (e)-4 (d )10 (t)-3 (o p)10 (a)-4 (t)-3 (i)7 (e)-4 (nt)-3 (s)4 ( w)3 (i)7 (t)-3 (h )10 (a )]TJ 0 Tw 0 -1.146 TD [(know)3 (n s)4 (e)-4 (ns)4 (i)-3 (t)-3 (i)-3 (v)11 (i)-3 (t)-3 (y)21 ( t)-3 (o be)-4 (nz)7 (y)11 (l)-3 ( a)-4 (l)-3 (c)-4 (ohol )7 ($s)4 (e)-4 (e )]TJ /TT0 1 Tf -0.003 Tc 16.308 0 Td [(W)-3 (ARNI)1 (NG)-6 (S)]TJ /TT2 1 Tf 0 Tc 5.598 0 Td ($. )Tj EMC /P <>BDC 12 0 0 12 116.6151 704.988 Tm (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-230 (10 )]TJ 0.002 Tc 0.238 Tw 5.01 0 Td [(m)-10 (g)12 ( r)5 (e)-4 (c)6 (o)-8 (n)2 (s)1 (titu)2 (te)6 (d )]TJ 0.228 Tw 7.43 0 Td [(w)4 (ith)2 ( b)2 (a)6 (c)6 (te)6 (r)5 (io)2 (s)1 (ta)6 (tic)6 ( w)4 (a)6 (te)-4 (r)5 ( f)5 (o)-8 (r)5 ( in)2 (je)6 (c)6 (tio)2 (n)-8 ( c)6 (o)2 (n)2 (ta)6 (in)2 (in)2 (g )]TJ 0 Tc 0 Tw -13.99 -1.15 Td [(0.33%)3 ( m)-2 (e)4 (t)-2 (a)4 (c)4 (r)-7 (e)4 (s)-1 (ol )-2 (s)-1 (houl)-2 (d not)-2 ( be )]TJ -0.004 Tc 0.004 Tw 13.05 0 Td [(u)-4 (s)-5 (ed)-4 ( i)-6 (f)-1 ( t)-6 (h)-4 (e p)-4 (at)-6 (i)-6 (en)-4 (t)-16 ( i)-6 (s)-5 ( al)-6 (l)-6 (er)-1 (g)6 (i)-16 (c t)-6 (o)-4 ( m)-6 (et)-6 (acr)-11 (es)-5 (o)-4 (l)]TJ 0 Tc 0 Tw 16.91 0 Td (. )Tj EMC /P <>BDC 0.156 Tw 11.52 0 0 11.52 116.6151 664.5461 Tm [(S)4 (om)-3 (a)-4 (t)-3 (rop)10 (i)-3 (n s)4 (houl)-3 (d)10 ( not)7 ( b)10 (e)-4 ( us)4 (e)-4 (d f)10 (or g)10 (row)3 (t)-3 (h pro)10 (m)-3 (o)10 (t)-3 (i)-3 (on )10 (i)-3 (n p)10 (e)-4 (di)-3 (a)7 (t)-3 (ri)7 (c)-4 ( p)11 (a)-4 (t)-3 (i)7 (e)-4 (nt)-3 (s )14 (w)3 (i)-3 (t)-3 (h c)7 (l)-3 (os)4 (e)-4 (d )]TJ 0 Tw T* [(e)-4 (pi)-3 (phy)21 (s)4 (e)-4 (s)4 (. )]TJ EMC /P <>BDC 0.385 Tw 0 -2.292 TD [(S)4 (om)-3 (a)-4 (t)-3 (rop)10 (i)-3 (n i)-3 (s)4 ( c)-4 (ont)-3 (r)10 (a)-4 (i)-3 (nd)10 (i)7 (c)-4 (a)-4 (t)5 (e)-4 (d i)-3 (n pa)7 (t)-3 (i)-3 (e)-4 (n)10 (t)-3 (s)4 ( w)3 (i)-3 (t)-3 (h a)-4 (c)-4 (t)7 (i)-3 (v)10 (e)-4 ( prol)-3 (i)-3 (f)10 (e)-4 (ra)-4 (t)7 (i)-3 (v)10 (e)-4 ( or s)-7 (e)-4 (v)10 (e)-4 (re)-4 ( non)]TJ 0 Tw (-)Tj 0 -1.156 TD [(prol)-3 (i)-3 (f)10 (e)-4 (ra)-4 (t)7 (i)-3 (v)10 (e)-4 ( di)-3 (a)-4 (b)10 (e)-4 (t)7 (i)-3 (c)-4 ( r)10 (e)-4 (t)-3 (i)-3 (n)10 (opa)-4 (t)-3 (hy)21 (. )]TJ EMC /P <>BDC 0.24 Tw 0 -2.292 TD [(I)10 (n )-10 (g)10 (e)-4 (ne)-4 (ra)-4 (l)-3 (, s)4 (om)7 (a)-4 (t)-3 (rop)11 (i)-3 (n i)-3 (s)14 ( c)-4 (ont)-3 (ra)7 (i)-3 (ndi)7 (c)-4 (a)7 (t)-3 (e)-4 (d )1 (i)7 (n )1 (t)-3 (he)-4 ( p)10 (re)-4 (s)4 (e)-4 (nc)7 (e)-4 ( of )11 (a)-4 (c)-4 (t)-3 (i)-3 (v)10 (e)-4 ( m)7 (a)-4 (l)7 (i)-3 (g)10 (na)-4 (nc)-4 (y)21 (. A)3 (n)-10 (y )]TJ 0.003 Tc 0.08 Tw 0 -1.146 TD [(p)3 (r)3 (e)-1 (e)-1 (x)14 (is)7 (tin)3 (g)14 ( m)10 (a)-1 (lig)13 (n)3 (a)-1 (n)3 (c)-1 (y)24 ( s)7 (h)3 (o)3 (u)3 (ld)3 ( b)13 (e)-1 ( in)14 (a)-1 (c)10 (tiv)13 (e )9 (a)-1 (n)3 (d )13 (its)7 ( t)10 (r)13 (e)-1 (a)-1 (t)10 (me)-1 (n)13 (t )10 (c)-1 (o)3 (mp)13 (le)-1 (t)10 (e)-1 ( p)3 (r)13 (io)3 (r )13 (to)13 ( i)]TJ 0 Tc 0 Tw [(ns)4 (t)-3 (i)7 (t)-3 (ut)7 (i)-3 (ng )]TJ 0.25 Tw T* [(t)-3 (he)-4 (ra)7 (py)10 ( w)3 (i)-3 (t)-3 (h s)4 (om)-3 (a)-4 (t)-3 (ropi)7 (n.)10 ( S)4 (om)-3 (a)-4 (t)-3 (ropi)7 (n s)4 (houl)-3 (d be )6 (di)-3 (s)4 (c)-4 (ont)7 (i)-3 (nue)-4 (d i)-3 (f)10 ( t)-3 (he)-4 (r)10 (e)-4 ( i)-3 (s)4 ( e)-4 (v)10 (i)-3 (de)-4 (nc)-4 (e)-4 ( of )]TJ 0.031 Tw 0 -1.156 TD [(re)-4 (c)-4 (urr)10 (e)-4 (nt )7 (a)-4 (c)7 (t)-3 (i)-3 (v)10 (i)-3 (t)-3 (y)21 (. S)4 (i)-3 (nc)-4 (e)-4 ( grow)3 (t)-3 (h horm)-3 (on)10 (e)-4 ( de)-4 (f)10 (i)-3 (c)7 (i)-3 (e)-4 (n)10 (c)-4 (y)10 ( m)-3 (a)-4 (y)21 ( be)-4 ( a)-4 (n e)-4 (a)-4 (r)10 (l)-3 (y)21 ( s)4 (i)-14 (g)10 (n o)-10 (f)10 ( t)-3 (he)-4 ( pre)-4 (s)4 (e)-4 (n)10 (c)-4 (e )]TJ 0 Tw 0 -1.146 TD [(of)10 ( a)-4 ( pi)-3 (t)-3 (ui)-3 (t)-3 (a)-4 (ry)21 ( t)-3 (um)-3 (or $or, ra)-4 (re)-4 (l)-3 (y)21 (, ot)-3 (he)-4 (r bra)-4 (i)-3 (n t)-3 (um)-3 (ors)4 ($, t)7 (he)-4 ( pre)-4 (s)4 (e)-4 (nc)7 (e)-4 ( of)10 ( s)4 (uc)-4 (h t)-3 (um)-3 (ors)4 ( s)4 (houl)-3 (d be )]TJ 0.073 Tw T* [(rul)-3 (e)-4 (d ou)10 (t)-3 ( pri)-3 (or )11 (t)-3 (o i)-3 (ni)7 (t)-3 (i)7 (a)-4 (t)-3 (i)-3 (o)10 (n of)10 ( t)-3 (re)-4 (a)-4 (t)-3 (m)7 (e)-4 (nt)-3 (. S)4 (om)7 (a)-4 (t)-3 (ro)10 (pi)7 (n s)4 (houl)-3 (d not)-3 ( be)-4 ( us)14 (e)-4 (d i)-3 (n p)10 (a)-4 (t)-3 (i)7 (e)-4 (nt)-3 (s)4 ( w)3 (i)-3 (t)7 (h )]TJ 0 Tw T* [(a)-4 (ny)21 ( e)-14 (v)10 (i)-3 (de)-4 (nc)-4 (e)-4 ( of)10 ( prog)11 (re)-4 (s)4 (s)4 (i)-3 (on or re)-4 (c)-4 (u)11 (rre)-4 (n)10 (c)-4 (e)-4 ( of)10 ( a)-4 (n und)10 (e)-4 (rl)-3 (y)21 (i)-3 (ng)10 ( i)-3 (nt)-3 (ra)-4 (c)-4 (ra)-4 (ni)7 (a)-4 (l )7 (t)-3 (um)-3 (or. )]TJ EMC /P <>BDC 0.052 Tw 0 -2.302 TD [(T)-4 (re)-4 (a)7 (t)-3 (m)7 (e)-4 (nt)-3 ( w)3 (i)-3 (t)-3 (h ph)10 (a)-4 (rm)7 (a)-4 (c)-4 (o)10 (l)-3 (og)10 (i)-3 (c)-4 ( a)-4 (m)-3 (ount)-3 (s)4 ( of)10 ( s)4 (om)-3 (a)-4 (t)-3 (ro)10 (pi)-3 (n i)-3 (s)4 ( c)-4 (ont)-3 (ra)7 (i)-3 (ndi)]TJ 0.003 Tc 0.049 Tw 27.375 0 Td [(c)-1 (a)10 (te)-1 (d)3 ( in)3 ( p)13 (a)-1 (ti)10 (e)-1 (n)3 (ts)7 ( w)6 (it)]TJ -0.01 Tc 0.01 Tw (h )Tj 0.003 Tc 0.299 Tw -27.375 -1.146 Td [(a)-1 (c)-1 (u)3 (t)10 (e)-1 ( c)-1 (r)13 (iti)10 (c)-1 (a)10 (l il)10 (ln)3 (e)-1 (s)7 (s)7 ( d)3 (u)3 (e)10 ( to )]TJ 0 Tc 0.302 Tw 12.414 0 Td [(c)-4 (om)-3 (p)10 (l)-3 (i)7 (c)-4 (a)-4 (t)7 (i)-3 (ons)4 ( f)10 (ol)-3 (l)-3 (ow)3 (i)-3 (ng)10 ( ope)-4 (n he)-4 (a)-4 (r)10 (t)-3 ( s)4 (urg)10 (e)-4 (r)-11 (y)21 (,)-10 ( a)-4 (bdom)-3 (i)7 (na)7 (l )]TJ 0.292 Tw -12.414 -1.146 Td [(s)4 (urg)11 (e)-4 (r)-11 (y)10 ( or m)-3 (ul)-3 (t)-3 (i)-3 (pl)-3 (e )7 (a)-4 (c)-4 (c)7 (i)7 (de)-4 (nt)-3 (a)7 (l)-3 ( t)-3 (ra)-4 (u)10 (m)-3 (a)-4 (, or t)-3 (hos)4 (e )7 (w)3 (i)-3 (t)-3 (h a)-4 (c)-4 (u)11 (t)-3 (e)-4 ( re)-4 (s)4 (pi)-3 (r)10 (a)-4 (t)-3 (ory )11 (f)10 (a)-4 (i)-3 (l)-3 (ure)-4 (. )]TJ -0.01 Tc 0.01 Tw 34.229 0 Td [(T)-14 (w)-7 (o )]TJ 0 Tc 0 Tw -34.229 -1.146 Td [(pl)-3 (a)-4 (c)7 (e)-4 (bo-)]TJ 0.01 Tw 3.438 0 Td [(c)-4 (ont)-3 (ro)10 (l)-3 (l)-3 (e)7 (d c)7 (l)-3 (i)-3 (ni)7 (c)-4 (a)7 (l)-3 ( t)-3 (ri)7 (a)-4 (l)-3 (s )14 (i)-3 (n non)]TJ 0 Tw (-)Tj 0.01 Tw [(g)10 (row)3 (t)-3 (h hor)10 (m)-3 (one)-4 ( d)10 (e)-4 (f)10 (i)-3 (c)-4 (i)7 (e)-4 (nt )7 (a)-4 (dul)7 (t)-3 ( p)10 (a)-4 (t)-3 (i)7 (e)7 (nt)-3 (s)4 ( $n =)2 ( 522)11 ($ )]TJ 0.115 Tw -3.438 -1.146 Td [(w)3 (i)-3 (t)-3 (h t)-3 (h)10 (e)-4 (s)4 (e )7 (c)-4 (ondi)7 (t)-3 (i)-3 (ons )15 (i)-3 (n i)7 (nt)-3 (e)-4 (ns)4 (i)-3 (v)10 (e)-4 ( c)7 (a)-4 (re)7 ( uni)7 (t)-3 (s)4 ( re)-4 (v)10 (e)-4 (a)-4 (l)7 (e)-4 (d a )8 (s)4 (i)-3 (g)10 (ni)-3 (f)10 (i)-3 (c)-4 (a)-4 (nt )8 (i)-3 (nc)-4 (r)10 (e)-4 (a)-4 (s)4 (e)7 ( i)7 (n m)-3 (ort)7 (a)-4 (l)7 (i)-3 (t)-3 (y )]TJ 0.063 Tw 0 -1.156 TD [($41.9% )1 (v)11 (s)4 (. )1 (19.3%$ )1 (a)7 (m)-3 (ong )11 (s)4 (om)-3 (a)-4 (t)7 (ropi)-3 (n)]TJ 0 Tw (-)Tj 0.063 Tw 15.74 0 Td [(t)-3 (re)7 (a)-4 (t)-3 (e)7 (d pa)7 (t)-3 (i)7 (e)-4 (n)10 (t)-3 (s )5 ($dos)4 (e)-4 (s )5 (5.3 )11 (t)-3 (o )1 (8 )11 (m)-3 (g)10 (/)-3 (da)-4 (y)21 ($ )-10 (c)-4 (om)-3 (p)10 (a)-4 (re)7 (d )]TJ 0 Tw -15.74 -1.146 Td [(t)-3 (o t)-3 (hos)4 (e)-4 ( r)10 (e)-4 (c)7 (e)-4 (i)-3 (v)10 (i)-3 (ng)10 ( pl)-3 (a)-4 (c)7 (e)-4 (bo)10 ( $s)4 (e)-4 (e )]TJ /TT0 1 Tf -0.003 Tc 12.561 0 Td [(W)-3 (ARNI)1 (NG)-6 (S)]TJ /TT2 1 Tf 0 Tc ($. )Tj EMC /P <>BDC -12.561 -2.292 Td [(S)4 (om)-3 (a)-4 (t)-3 (rop)]TJ 0.003 Tc 0.122 Tw 3.885 0 Td [(in)3 ( is )17 (c)-1 (o)3 (n)3 (tr)13 (a)-1 (in)3 (d)13 (ic)10 (a)-1 (te)-1 (d)14 ( in)3 ( p)14 (a)-1 (t)10 (ie)-1 (n)3 (ts)7 ( w)17 (ith)3 ( P)7 (r)3 (a)10 (d)13 (e)-1 (r)]TJ 0 Tc 0 Tw 18.094 0 Td (-)Tj 0.125 Tw [(W)17 (i)-3 (l)-3 (l)-3 (i)-3 ( s)4 (y)21 (ndrom)-3 (e)-4 ( w)3 (ho a)6 (re)-4 ( s)4 (e)-4 (v)10 (e)-4 (re)-4 (l)-3 (y )]TJ 0.281 Tw -21.979 -1.146 Td [(obe)-4 (s)4 (e)-4 ( or ha)-4 (v)10 (e)-4 ( s)4 (e)-4 (v)11 (e)-4 (re)-4 ( re)7 (s)4 (pi)-3 (ra)-4 (t)-3 (ory)21 ( i)-3 (m)-3 (pa)-4 (i)-3 (rm)7 (e)-4 (nt)-3 ( $s)4 (e)7 (e )]TJ /TT0 1 Tf -0.003 Tc 0 Tw 21.805 0 Td [(W)-3 (ARNI)1 (NG)-6 (S)]TJ /TT2 1 Tf 0 Tc 5.601 0 Td [($. )-282 (T)]TJ 0.004 Tc -0.004 Tw 1.73 0 Td (ev)Tj 0 Tc 0 Tw 0.938 0 Td [(-T)-4 (ropi)-3 (n )]TJ 0.281 Tw 3.499 0.002 Td [(i)-3 (s)4 ( not )]TJ 0.375 Tw -33.573 -1.156 Td [(i)-3 (ndi)-3 (c)7 (a)-4 (t)7 (e)-4 (d f)10 (or t)-3 (he)-4 ( t)-3 (re)-4 (a)-4 (t)7 (m)7 (e)-4 (nt)-3 ( of)10 ( pe)-4 (di)-3 (a)-4 (t)-3 (ri)7 (c)-4 ( pa)-4 (t)7 (i)-3 (e)-4 (n)10 (t)-3 (s)4 ( w)3 (ho ha)-4 (v)10 (e )-14 (g)10 (row)3 (t)-3 (h )-10 (f)10 (a)-4 (i)-3 (l)-3 (ure)-4 ( due)-4 ( t)-3 (o )]TJ 0.003 Tc -0.003 Tw 0 -1.146 TD [(g)13 (e)-1 (n)3 (e)-1 (tic)10 (a)-1 (lly)24 ( c)-1 (o)3 (n)3 (f)13 (ir)3 (m)]TJ 0 Tc 0 Tw [(e)-4 (d P)4 (ra)7 (de)-4 (r-)]TJ 0.003 Tc -0.003 Tw [(W)20 (illi s)7 (y)24 (n)3 (d)3 (r)3 (o)3 (me)-1 (. )]TJ EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0 Tw 12 0 0 12 116.6151 306.348 Tm [(W)-2 (ARNI)-3 (N)-10 (G)6 (S )]TJ EMC /P <>BDC /TT2 1 Tf 0.002 Tc 0.368 Tw 0 -1.13 TD [(I)15 (n)-8 (c)6 (r)5 (e)-4 (a)6 (s)1 (e)6 (d)2 ( mo)2 (r)5 (ta)6 (lit)-10 (y)22 ( in )-8 (p)2 (a)6 (tie)6 (n)2 (ts)1 ( w)4 (ith)2 ( a)6 (c)6 (u)2 (te)6 ( c)6 (r)5 (itic)6 (a)6 (l illn)2 (e)6 (s)1 (s)1 ( d)2 (u)2 (e)6 ( to)2 ( c)6 (o)12 (mp)2 (lic)6 (a)6 (tio)2 (n)2 (s )]TJ 0 Tc 0.17 Tw 0 -1.15 TD [(f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( op)-10 (e)4 (n he)-6 (a)4 (r)3 (t)-2 ( s)-1 (u)-10 (r)3 (ge)4 (r)-17 (y)20 (, )-10 (a)4 (bdom)-2 (i)-2 (na)4 (l)-2 ( s)-1 (ur)-7 (g)10 (e)-6 (r)-7 (y )10 (o)-10 (r)3 ( m)-2 (ul)-2 (t)-2 (i)-2 (pl)-2 (e)4 ( a)4 (c)-6 (c)4 (i)-2 (de)4 (nt)-2 (a)4 (l)-12 ( t)-2 (r)3 (a)4 (um)-2 (a)4 (, o)-10 (r )]TJ -0.004 Tc 0.524 Tw T* [(t)-6 (h)-4 (o)-4 (s)-5 (e w)-2 (i)-6 (t)-6 (h)-4 ( acu)-4 (t)-16 (e r)-11 (es)-5 (p)-4 (i)-6 (r)-1 (at)-6 (o)-4 (r)-21 (y)16 ( f)-11 (ai)-6 (l)-6 (u)-4 (r)-1 (e h)-14 (as)-5 ( b)-4 (e)-10 (en)-4 ( r)-1 (ep)-4 (o)-14 (r)-1 (t)-6 (ed )-14 (af)]TJ 0.002 Tc 0.518 Tw 26.44 0 Td [(te)6 (r)-5 ( tr)5 (e)-4 (a)6 (tme)6 (n)2 (t w)4 (ith )]TJ 0 Tc 0.13 Tw -26.44 -1.15 Td [(pha)4 (r)3 (m)-2 (a)4 (c)4 (ol)-2 (o)-10 (g)10 (i)-2 (c)4 ( dos)-1 (e)4 (s)-1 ( o)-10 (f)3 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n $)3 (s)-1 (e)4 (e )]TJ /TT0 1 Tf 0 Tw 16.99 0 Td (C)Tj -0.002 Tc 0.002 Tw 0.72 0 Td [(O)-4 (NT)-15 (RAI)-3 (NDI)-3 (CAT)-5 (I)-3 (O)-4 (NS)]TJ /TT2 1 Tf -0.003 Tc 0.003 Tw 10.4 0 Td ($. )Tj -0.004 Tc 0.134 Tw 0.96 0 Td [(T)-13 (h)-4 (e s)-5 (af)-1 (et)-26 (y)16 ( o)-4 (f )]TJ 0 Tc 0 Tw -29.07 -1.15 Td [(c)4 (ont)-2 (i)-2 (nui)-2 (ng )-10 (s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )]TJ -0.004 Tc 0.024 Tw 9.31 0 Td [(t)-6 (r)-11 (eat)-6 (m)-6 (en)-4 (t)-6 ( i)-6 (n)-4 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( r)-11 (ec)-10 (ei)-6 (v)-4 (i)-6 (n)-4 (g)6 ( r)-11 (ep)-4 (l)-6 (ac)-10 (em)-6 (en)-4 (t)-6 ( d)-4 (o)-4 (s)-5 (es )-15 (f)-11 (o)-4 (r)-1 ( ap)-4 (p)-4 (r)-1 (o)-4 (v)-14 (ed )]TJ 0 Tc 0.38 Tw -9.31 -1.15 Td [(i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (i)-2 (ons)-1 ( w)2 (ho c)4 (onc)4 (ur)-7 (r)3 (e)4 (nt)-2 (l)-12 (y)20 ( de)4 (v)-10 (e)4 (l)-2 (op t)-2 (he)4 (s)-1 (e)4 ( i)-2 (l)-2 (l)-2 (ne)4 (s)-1 (s)-1 (e)4 (s)-1 ( ha)4 (s)-1 ( not)-2 ( be)4 (e)4 (n e)4 (s)-1 (t)-2 (a)4 (bl)-2 (i)-2 (s)-1 (he)4 (d. )]TJ 0.06 Tw T* [(T)1 (he)4 (r)3 (e)4 (f)3 (o)-10 (r)3 (e)4 (,)-10 ( t)-2 (he)4 ( pot)-2 (e)4 (nt)-2 (i)-2 (a)4 (l )-22 (be)4 (ne)4 (f)3 (i)-2 (t)-2 ( of)-7 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( c)4 (ont)-12 (i)-2 (nua)4 (t)-2 (i)-2 (on w)2 (i)-2 (t)-2 (h )]TJ 0 Tw [(s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )]TJ 0.002 Tc 0.058 Tw 30.4 0 Td [(in)2 ( p)2 (a)6 (tie)6 (n)2 (ts )]TJ -0.004 Tc 0.004 Tw -30.4 -1.15 Td [(ex)-14 (p)-4 (er)-1 (i)-6 (en)-4 (ci)-6 (n)-4 (g )]TJ 0.002 Tc -0.002 Tw 5.41 0 Td [(a)6 (c)6 (u)2 (te )-4 (c)6 (r)5 (itic)-4 (a)6 (l illn)2 (e)6 (s)1 (s)1 (e)6 (s)1 ( s)1 (h)2 (o)2 (u)2 (ld)2 ( b)2 (e)6 ( w)4 (e)6 (i)-10 (g)12 (h)2 (e)6 (d )-8 (a)-4 (g)12 (a)6 (in)2 (s)1 (t th)2 (e)6 ( p)2 (o)2 (te)6 (n)2 (tia)-4 (l r)5 (is)1 (k)2 (. )]TJ EMC /Span <>BDC -0.004 Tc 0.294 Tw -5.41 -2.3 Td [(T)-3 (h)-4 (er)-1 (e h)-14 (av)-4 (e b)-14 (een)-4 ( r)-11 (ep)-4 (o)-4 (r)-1 (t)-16 (s)-5 ( o)-4 (f)-1 ( f)-1 (at)-6 (al)-6 (i)-6 (t)-6 (i)-6 (es)-5 ( a)-10 (f)-1 (t)-6 (er)-1 ( i)-6 (n)-4 (i)-6 (t)-16 (i)-6 (at)-6 (i)-6 (n)-4 (g)6 ( t)-6 (h)-4 (er)-11 (ap)-24 (y)16 ( w)-2 (i)-6 (t)-6 (h )]TJ 0 Tc 0 Tw 28.79 0 Td [(s)-1 (o)-10 (m)-2 (a)4 (t)-2 (r)3 (opi)-2 (n )]TJ -0.01 Tc 0.01 Tw 5.05 0 Td [(i)-12 (n )]TJ 0 Tc 0 Tw -33.84 -1.15 Td (pe)Tj 0.002 Tc -0.002 Tw 0.94 0 Td [(d)2 (ia)6 (tr)5 (i)]TJ -0.004 Tc 0.074 Tw [(c p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-2 (i)-6 (t)-6 (h)-4 ( P)-8 (r)-1 (ad)-4 (er)]TJ 0 Tc 0 Tw 11.01 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(W)-4 (illi )]TJ -0.03 Tc 0.03 Tw 2.39 0 Td [(s)-41 (yn)]TJ 0 Tc 0.07 Tw 1.37 0 Td [(dr)3 (om)-12 (e)4 ( w)-8 (ho ha)4 (d one)4 ( or)3 ( m)-2 (or)-7 (e)4 ( of)3 ( t)-12 (he)4 ( f)3 (ol)-2 (l)-2 (ow)2 (i)-2 (ng )]TJ -0.004 Tc 0.134 Tw -16.04 -1.15 Td [(r)-1 (i)-6 (s)-5 (k)-4 ( f)-1 (a)-10 (ct)-6 (o)-4 (r)-1 (s)-5 (:)-6 ( s)-5 (ev)-14 (er)]TJ 0 Tc 0 Tw 7.37 0 Td (e )Tj 0.13 Tw 0.83 0 Td [(obe)4 (s)-11 (i)-2 (t)-12 (y)20 (, hi)-2 (s)-1 (t)-2 (or)-17 (y)20 ( o)-10 (f)3 ( upp)-10 (e)4 (r )-7 (a)4 (i)-2 (r)-7 (w)2 (a)-16 (y)20 ( obs)-1 (t)-2 (r)3 (u)-10 (c)4 (t)-2 (i)-2 (ons)-1 ( or)3 ( s)-1 (l)-2 (e)-6 (e)-6 (p a)4 (pne)-6 (a)4 (, or )]TJ 0 Tw -8.2 -1.15 Td [(uni)-2 (de)4 (nt)-2 (i)-2 (f)3 (i)-2 (e)4 (d r)3 (e)4 (s)-1 (pi)-2 (r)-7 (a)4 (t)-2 (or)-17 (y)20 ( i)-12 (nf)3 (e)4 (c)4 (t)-2 (i)-2 (on. M)-1 (a)4 (l)-2 (e)-6 ( pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)-8 (i)-2 (t)-2 (h one)4 ( or)3 ( m)-2 (or)-7 (e)4 ( of)-7 ( t)-2 (he)4 (s)-1 (e )-6 (f)-7 (a)4 (c)4 (t)-2 (or)3 (s)-1 ( m)-2 (a)-16 (y )]TJ T* (b)Tj -0.004 Tc 0.304 Tw [(e at )-16 (g)-4 (r)-1 (eat)-16 (er )-11 (r)-1 (i)-6 (s)-5 (k)-4 ( t)-6 (h)-4 (an)-14 ( f)-1 (em)-6 (al)-6 (es)-5 (.)-14 ( P)-8 (at)-6 (i)-6 (en)-4 (t)-6 (s)-5 ( w)-2 (i)-6 (t)-6 (h)-14 ( P)-8 (r)-1 (ad)-4 (er)]TJ 0 Tc 0 Tw 23.01 0 Td (-)Tj 0.3 Tw 0.33 0 Td [(W)-6 (i)-2 (l)-2 (l)-2 (i)-2 ( s)-11 (y)30 (nd)-10 (r)3 (om)-2 (e)-6 ( s)-1 (houl)-2 (d be )]TJ 0.12 Tw -23.34 -1.15 Td [(e)4 (va)4 (l)-2 (ua)4 (t)-2 (e)4 (d f)3 (or)3 ( s)-1 (i)-12 (g)10 (ns)-1 ( of)3 ( uppe)4 (r)3 ( a)4 (i)-2 (r)3 (w)2 (a)-16 (y)20 ( obs)-1 (t)-2 (r)3 (uc)4 (t)-2 (i)-2 (on )-10 (a)4 (nd s)-1 (l)-2 (e)4 (e)4 (p a)4 (pne)4 (a)4 ( be)-6 (f)3 (or)3 (e)4 ( i)-12 (ni)-2 (t)-2 (i)-2 (a)4 (t)-2 (i)-2 (on of )]TJ EMC /Artifact <>BDC 0 g /T1_0 1 Tf 0 Tw 10 0 0 10 44.6151 31.188 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 579 0 obj <>>>/Resources 504 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 580 0 obj <> endobj 581 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda endstream endobj 582 0 obj <> endobj 583 0 obj <>stream q 1 0 0 1 26.621002 13.198059 cm 0 0 595.32 841.92 re W n /Artifact <>BDC q 1 0 0 1 -26.621002 -13.198059 cm BT /CS0 cs 0 scn /TT0 1 Tf 3 Tr 12 0 0 12 179.621 772.3181 Tm ( )Tj /TT1 1 Tf -0.004 Tc 0.104 Tw 6.57 0 Td ( )Tj 22.79 0 Td ( )Tj ET Q /CS0 cs 0 scn 168 757.2 60.84 0.6 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf 0.03 Tw 3 Tr 12 0 0 12 531.9409 758.5181 Tm ( )Tj 0.02 Tw 0 -1.15 TD ( )Tj 0 Tw -7.12 -1.15 Td [( )-2090 ( )]TJ /TT0 1 Tf -22.24 -1.15 Td ( )Tj /TT1 1 Tf 0.06 Tw 29.36 0 Td ( )Tj ET Q 168 702 70.2 0.6 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf 3 Tr 12 0 0 12 339.221 703.3181 Tm ( )Tj -14.05 -1.15 Td ( )Tj /TT2 1 Tf -2.14 -1.15 Td ( )Tj /TT3 1 Tf 10.11 0 Td ( )Tj ET Q 144 660.6 95.64 0.6 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf 0.002 Tc 0.008 Tw 3 Tr 12 0 0 12 201.8209 661.9181 Tm [( )-3770 ( )]TJ 16.97 0 Td ( )Tj 10.54 0 Td ( )Tj 0 Tc 0 Tw -7.76 -1.15 Td ( )Tj 0.52 Tw 7.76 0 Td ( )Tj 0 Tw -0.09 -1.15 Td ( )Tj -34.52 -1.15 Td ( )Tj /TT2 1 Tf 2.42 -1.15 Td ( )Tj /TT3 1 Tf 12.66 0 Td ( )Tj ET Q 144 591.6 126.96 0.6 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf 0.002 Tc -0.002 Tw 3 Tr 12 0 0 12 531.9401 592.9181 Tm ( )Tj 0 Tc 0 Tw 0 -1.15 TD ( )Tj -0.004 Tc 0.004 Tw -25.54 -1.15 Td ( )Tj 0 Tc 0 Tw 7.48 0 Td ( )Tj -16.55 -1.15 Td ( )Tj /TT2 1 Tf 2.47 -1.15 Td ( )Tj /TT3 1 Tf 9.11 0 Td ( )Tj ET Q 144 522.6 84.96 0.599 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf -0.004 Tc 0.524 Tw 3 Tr 12 0 0 12 531.9415 523.9181 Tm ( )Tj 0 Tc 0 Tw -20.59 -1.15 Td ( )Tj 17.16 0 Td [( )-2320 ( )]TJ -31.18 -1.15 Td ( )Tj /TT2 1 Tf 2.36 -1.15 Td ( )Tj /TT3 1 Tf 10.33 0 Td ( )Tj ET Q 144 467.4 98.28 0.6 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf 3 Tr 12 0 0 12 266.141 468.7181 Tm ( )Tj 0.03 Tw 8.61 0 Td ( )Tj 13.54 0 Td ( )Tj 0.13 Tw -22.02 -2.3 Td ( )Tj 5.59 0 Td ( )Tj 0 Tw 8.04 0 0 8.04 420.821 446.6381 Tm ( )Tj 0.13 Tw 12 0 0 12 531.9411 441.1181 Tm ( )Tj 0.002 Tc 0.028 Tw 0 -1.15 TD ( )Tj 0 Tc 0 Tw -22.01 -1.15 Td [( )-4860 ( )]TJ -12.6 -1.15 Td ( )Tj /TT2 1 Tf 2.36 -1.15 Td ( )Tj /TT3 1 Tf 14.42 0 Td ( )Tj ET Q 144 370.8 147.36 0.6 re f q 1 0 0 1 -26.621002 -13.198059 cm BT /TT1 1 Tf 0.05 Tw 3 Tr 12 0 0 12 358.4211 372.1181 Tm ( )Tj 7.88 0 Td ( )Tj 6.58 0 Td ( )Tj 0 Tw -22.71 -1.15 Td ( )Tj 11.74 0 Td ( )Tj -23.64 -1.15 Td ( )Tj /TT4 1 Tf 10.89 -1.17 Td ( )Tj /TT1 1 Tf 0.19 Tw 11.76 -1.13 Td ( )Tj 0.002 Tc 0.188 Tw 6.96 0 Td [( )-4560 ( )]TJ 0 Tc 0.24 Tw -24.36 -1.15 Td ( )Tj 14.26 0 Td ( )Tj 15.1 0 Td ( )Tj 0 Tw -7.52 -1.15 Td ( )Tj -27.09 -1.15 Td ( )Tj 21.67 -1.15 Td ( )Tj 10.38 0 Td ( )Tj 0.03 Tw 2.56 0 Td ( )Tj -0.004 Tc 0.264 Tw -21.43 -1.15 Td ( )Tj 0 Tc 0 Tw 5.96 0 Td ( )Tj 0.26 Tw 15.47 0 Td ( )Tj 0.11 Tw -24.99 -1.15 Td ( )Tj 16.48 0 Td ( )Tj 0.002 Tc -0.002 Tw 8.51 0 Td ( )Tj 0 Tc 0.09 Tw -26.95 -1.15 Td ( )Tj 26.95 0 Td ( )Tj 0 Tw -2.35 -1.15 Td ( )Tj -32.26 -1.15 Td ( )Tj /TT4 1 Tf 12.34 -1.17 Td ( )Tj /TT1 1 Tf -7.74 -1.13 Td ( )Tj 0.07 Tw 21.07 0 Td ( )Tj 0 Tw -7.1 -1.15 Td ( )Tj 7.16 0 Td ( )Tj -25.73 -1.15 Td ( )Tj ET Q EMC 1 0 0 1 -26.621002 -13.198059 cm BT /LI_Label <>BDC /TT1 1 Tf 12 0 0 12 170.621 772.3181 Tm (2.)Tj /T1_0 1 Tf (\003 )Tj EMC /StyleSpan <>BDC /TT1 1 Tf 2 0 Td (C)Tj 0.002 Tc 0.098 Tw 0.67 0 Td [(e)6 (ll G)4 (r)5 (o)2 (w)4 (th)]TJ EMC /LI_Title <>BDC -0.004 Tc 0.104 Tw 4.4 0 Td [(. )-14 (I)19 (t)-6 ( h)-4 (as)-5 ( b)-4 (een)-14 ( s)-5 (h)-4 (o)-4 (w)-2 (n)-4 ( t)-6 (h)-4 (at)-6 ( t)-6 (h)-4 (er)-1 (e ar)-1 (e f)-1 (e)-10 (w)-2 (er)-1 ( s)-5 (k)-4 (el)-6 (et)-6 (al)-6 ( m)-6 (u)-4 (s)-5 (cl)-6 (e )]TJ 0 Tc 0.03 Tw -5.07 -1.15 Td [(c)4 (e)4 (l)-2 (l)-2 (s)-1 ( i)-2 (n s)-1 (hor)3 (t)-2 ( s)-1 (t)-2 (a)4 (t)-2 (ur)3 (e)4 (d c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n w)2 (ho l)-2 (a)4 (c)4 (k e)4 (ndo)-10 (ge)4 (no)-10 (us)-1 ( g)10 (r)3 (ow)2 (t)-2 (h hor)3 (m)-2 (one )]TJ 0.02 Tw 0 -1.15 TD [(a)4 (s)-1 ( c)4 (om)-2 (pa)-6 (r)3 (e)4 (d)-10 ( w)2 (i)-2 (t)-2 (h nor)3 (m)-2 (a)4 (l)-12 ( c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n.)-10 ( T)1 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-12 (h s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n r)-7 (e)4 (s)-1 (ul)-2 (t)-2 (s )]TJ 0 Tw T* [(i)-2 (n a)4 (n i)-2 (nc)4 (r)3 (e)4 (a)4 (s)-11 (e)4 ( i)-2 (n bot)-2 (h t)-2 (he)-6 ( num)-2 (be)4 (r)3 ( a)4 (nd s)-1 (i)-2 (z)-6 (e)4 ( of)3 ( m)-2 (us)-1 (c)4 (l)-2 (e )]TJ -0.004 Tc 0.004 Tw 21.24 0 Td [(cel)-6 (l)-6 (s)-5 (. )]TJ EMC /LI_Label <>BDC 0 Tc 0 Tw -23.24 -1.15 Td (3.)Tj /T1_0 1 Tf (\003 )Tj EMC /StyleSpan <>BDC /TT1 1 Tf -0.002 Tc 0.062 Tw 2 0 Td [(Or)-9 (g)8 (a)2 (n)-2 ( Gr)1 (o)-2 (wt)-4 (h)]TJ EMC /LI_Title <>BDC 0 Tc 0.06 Tw 5.85 0 Td [(. S)-4 (om)-2 (a)4 (t)-2 (r)3 (o)-10 (pi)-2 (n i)-2 (nf)3 (l)-2 (ue)4 (nc)4 (e)4 (s)-1 ( t)-2 (he)4 ( s)-1 (i)-2 (z)-6 (e)4 ( of)13 ( i)-2 (nt)-2 (e)4 (r)3 (na)4 (l)-2 ( or)3 (g)10 (a)4 (ns)-1 ( a)4 (nd )]TJ -0.004 Tc 0.004 Tw -5.85 -1.15 Td [(i)-6 (t)-6 ( al)-6 (s)-5 (o)-4 ( i)-6 (n)-4 (cr)-1 (eas)-5 (es)-5 ( r)-11 (ed)-4 ( c)-10 (el)-6 (l)-6 ( m)-6 (as)-5 (s)-5 (. )]TJ EMC /Span <>BDC /TT3 1 Tf -0.001 Tc 0 Tw -5 -2.3 Td (B. )Tj EMC /StyleSpan <>BDC 0 Tc 3 0 Td [(P)1 (r)-1 (ot)-2 (e)4 (i)-2 (n M)3 (e)4 (t)-2 (abol)-2 (i)-2 (s)-1 (m )]TJ EMC /P <>BDC /TT1 1 Tf 0.002 Tc 0.008 Tw T* [(L)13 (in)2 (e)-4 (a)6 (r )-5 (g)2 (r)5 (o)2 (w)4 (th)2 ( is )-9 (f)5 (a)6 (c)6 (ilita)6 (t)-10 (e)6 (d)2 (,)2 ( in)2 ( p)2 (a)-4 (r)5 (t,)2 ( b)-18 (y)22 ( in)-8 (c)6 (r)5 (e)-4 (a)6 (s)1 (e)6 (d )-18 (c)6 (e)6 (llu)2 (la)6 (r)5 ( p)-8 (r)5 (o)2 (te)6 (in)2 ( s)-19 (y)22 (n)2 (th)2 (e)6 (s)1 (is)-9 (. )]TJ 0 Tc 0.52 Tw T* [(N)2 (i)-2 (t)-2 (r)3 (og)10 (e)4 (n r)-7 (e)4 (t)-2 (e)4 (nt)-2 (i)-2 (on, a)4 (s)-11 ( de)4 (m)-2 (ons)-1 (t)-2 (r)3 (a)4 (t)-2 (e)4 (d b)-10 (y)20 ( de)-6 (c)-6 (r)3 (e)4 (a)4 (s)-1 (e)4 (d ur)3 (i)-2 (n)-10 (a)4 (r)-17 (y)20 ( ni)-2 (t)-2 (r)3 (oge)-6 (n )]TJ 0 Tw T* [(e)4 (x)-10 (c)4 (r)3 (e)4 (t)-2 (i)-2 (on a)4 (nd s)-1 (e)4 (r)3 (um)-2 ( ur)-7 (e)4 (a)-6 ( ni)-2 (t)-2 (r)3 (og)10 (e)4 (n, )-10 (r)3 (e)4 (s)-1 (ul)-2 (t)-2 (s)-1 ( f)3 (r)3 (om)-2 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-2 (h s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n. )]TJ EMC /Span <>BDC /TT3 1 Tf 0.003 Tc -3 -2.3 Td (C. )Tj EMC /StyleSpan <>BDC 0 Tc 3 0 Td [(C)-3 (ar)-1 (bohy)4 (dr)-1 (at)-2 (e)4 ( M)3 (e)4 (t)-2 (abol)-2 (i)-2 (s)-1 (m )]TJ EMC /P <>BDC /TT1 1 Tf 0.002 Tc -0.002 Tw T* [(C)-1 (h)2 (ild)2 (r)5 (e)6 (n)2 ( w)4 (ith)2 ( h)-8 (y)22 (p)2 (o)2 (p)2 (itu)2 (ita)6 (r)5 (is)1 (m s)1 (o)2 (me)6 (time)6 (s)1 ( e)6 (x)-8 (p)2 (e)6 (r)5 (ie)6 (n)2 (c)6 (e)6 ( f)-5 (a)6 (s)1 (tin)2 (g)12 ( h)-18 (y)22 (p)2 (o)-8 (g)12 (l)-20 (y)22 (c)-4 (e)6 (mia )]TJ 0 Tc 0.04 Tw T* [(t)-2 (ha)4 (t)-2 ( i)-2 (s)-1 ( i)-2 (m)-2 (pr)3 (ove)4 (d b)-20 (y)20 ( t)-2 (r)3 (e)-6 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( w)2 (i)-2 (t)-2 (h s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n. )-10 (L)11 (a)4 (r)-7 (g)10 (e)4 ( dos)-11 (e)4 (s)-1 ( of)3 ( s)-1 (om)-2 (a)]TJ 0 Tw 27.7 0 Td [(t)-2 (r)3 (opi)-2 (n )]TJ -0.004 Tc 0.004 Tw -27.7 -1.15 Td [(m)-6 (a)-10 (y)16 ( i)-6 (m)-6 (p)-4 (ai)-6 (r )-11 (g)6 (l)-6 (u)-4 (co)-4 (s)-15 (e t)-6 (o)-4 (l)-6 (er)-11 (an)-4 (ce. )]TJ EMC /Span <>BDC /TT3 1 Tf -0.002 Tc 0 Tw -3 -2.3 Td (D. )Tj EMC /StyleSpan <>BDC 0 Tc 3 0 Td [(L)-4 (i)-2 (pi)-2 (d M)3 (e)4 (t)-2 (abol)-2 (i)-2 (s)-1 (m )]TJ EMC /P <>BDC /TT1 1 Tf 0.52 Tw T* [(A)2 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on of)3 ( s)-1 (om)8 (a)4 (t)-2 (r)3 (opi)-2 (n t)-2 (o g)10 (r)3 (ow)2 (t)-2 (h hor)-7 (m)-2 (one)]TJ 0 Tw 22.39 0 Td (-)Tj -0.004 Tc 0.524 Tw 0.33 0 Td [(d)-4 (ef)-1 (i)-6 (ci)-16 (en)-4 (t)-6 ( p)-4 (at)-6 (i)-6 (en)-4 (t)-6 (s )]TJ 0 Tc 0 Tw -22.72 -1.15 Td [(m)-2 (obi)-2 (l)-2 (i)-2 (z)-6 (e)4 (s)-1 ( l)8 (i)-2 (pi)-2 (d, r)3 (e)4 (duc)4 (e)4 (s )-11 (bod)-10 (y)20 ( f)-7 (a)4 (t)-2 ( s)-1 (t)-2 (or)3 (e)4 (s)-1 (, a)4 (nd i)-2 (nc)-6 (r)3 (e)-6 (a)4 (s)-1 (e)4 (s)-1 ( pl)-2 (a)4 (s)-1 (m)-2 (a)4 ( f)-7 (a)4 (t)-2 (t)-12 (y )10 (a)4 (c)4 (i)-2 (ds)-1 (. )]TJ EMC /Span <>BDC /TT3 1 Tf -0.001 Tc -3 -2.3 Td (E. )Tj EMC /StyleSpan <>BDC 0 Tc 3 0 Td [(M)3 (i)-2 (ne)4 (r)-1 (al)-2 ( M)3 (e)4 (t)-2 (abol)-2 (i)-2 (s)-1 (m )]TJ EMC /P <>BDC /TT1 1 Tf 0.03 Tw T* [(S)-4 (odi)-2 (um)-2 (, pot)-2 (a)4 (s)-1 (s)-1 (i)-2 (um)]TJ 0 Tw 7.71 0 Td (, )Tj 0.03 Tw 0.53 0 Td [(a)4 (nd phos)-1 (phor)3 (ous)-1 ( a)4 (r)3 (e )-6 (c)4 (ons)-1 (e)-6 (r)3 (v)-10 (e)4 (d b)-20 (y)20 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n. S)-4 (e)4 (r)3 (um )]TJ 0.12 Tw -8.24 -1.15 Td [(c)4 (onc)4 (e)4 (nt)-2 (r)-7 (a)4 (t)-2 (i)-2 (ons)-1 ( of)3 ( i)-2 (nor)3 (ga)-6 (ni)-2 (c)4 ( phos)-1 (pha)4 (t)-2 (e)4 (s)-1 ( i)-2 (nc)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 (d)-10 ( i)-2 (n pa)4 (t)-2 (i)-2 (e)4 (nt)-2 (s)-1 ( w)2 (i)-2 (t)-2 (h g)10 (r)3 (ow)2 (t)-2 (h )]TJ 0.13 Tw T* [(hor)3 (m)-2 (one)4 ( de)4 (f)3 (i)-12 (c)4 (i)-2 (e)4 (nc)-16 (y )10 (a)4 (f)3 (t)-2 (e)-6 (r)3 ( t)-2 (he)4 (r)3 (a)4 (p)-20 (y )10 (w)2 (i)-2 (t)-2 (h )]TJ 0 Tw (T)Tj -0.004 Tc 0.004 Tw 16.84 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)]TJ -0.003 Tc 0.003 Tw 0.94 0 Td [(ro)-3 (p)-13 (i)-5 (n )]TJ 0 Tc 0.13 Tw 2.42 0 Td [(or)3 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n. S)-4 (e)4 (r)3 (um )]TJ 0.002 Tc 0.028 Tw -21.15 -1.15 Td [(c)6 (a)6 (lc)6 (iu)2 (m c)6 (o)2 (n)2 (c)-4 (e)6 (n)2 (tr)5 (a)6 (tio)2 (n)2 (s)1 ( a)-4 (r)5 (e)6 ( n)2 (o)2 (t s)1 (ig)12 (n)2 (if)5 (ic)-4 (a)6 (n)2 (tl)-10 (y)22 ( a)6 (lte)-4 (r)5 (e)-4 (d)2 ( in)2 ( p)2 (a)6 (tie)6 (n)2 (ts)1 ( tr)5 (e)6 (a)6 (te)6 (d)2 ( w)4 (ith )]TJ -0.002 Tw T* [(e)6 (ith)]TJ 0 Tc 0 Tw 1.5 0 Td [(e)4 (r)3 ( s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n or )3 (T)]TJ -0.004 Tc 0.004 Tw 7.46 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n. )]TJ EMC /Span <>BDC /TT3 1 Tf -0.001 Tc -12.91 -2.3 Td (F. )Tj EMC /StyleSpan <>BDC -0.004 Tc 0.004 Tw 3 0 Td [(C)-7 (o)-4 (n)-4 (n)-4 (ect)-6 (i)-6 (ve T)-8 (i)-6 (s)-5 (s)-5 (u)-4 (e M)-1 (et)-6 (a)-4 (b)-14 (o)-4 (l)-6 (i)-6 (s)-5 (m )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0.05 Tw T* [(S)-4 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n s)-1 (t)-2 (i)-2 (m)-2 (ul)-2 (a)4 (t)-2 (e)4 (s)-1 ( t)-2 (he)4 ( s)-21 (y)20 (nt)-2 (he)4 (s)-1 (i)-2 (s)-1 ( of )-7 (c)4 (hondr)3 (oi)-2 (t)-2 (i)-2 (n s)-1 (ul)-2 (f)3 (a)4 (t)-2 (e )-6 (a)4 (nd c)4 (ol)-2 (l)-2 (a)-6 (ge)4 (n a)4 (s )]TJ 0 Tw T* [(w)2 (e)4 (l)-2 (l)-2 ( a)4 (s)-1 ( t)-2 (he)4 ( ur)3 (i)-2 (na)4 (r)-17 (y )10 (e)4 (x)-10 (c)4 (r)3 (e)4 (t)-12 (i)-2 (on of)3 ( h)-10 (y)20 (dr)3 (ox)-20 (y)20 (p)-10 (r)3 (ol)-2 (i)-2 (ne)4 (. )]TJ EMC /P <>BDC /TT4 1 Tf -0.002 Tc 0.002 Tw -4.5 -2.32 Td [(P)9 (H)-4 (AR)-10 (M)2 (ACO)-14 (K)6 (I)-3 (NE)-5 (T)-5 (I)-3 (CS )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0.19 Tw 0 -1.13 TD [(F)6 (ol)-2 (l)-2 (ow)2 (i)-2 (ng)10 ( i)-2 (nt)-2 (r)3 (a)4 (v)-10 (e)4 (nous)-1 ( a)-6 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on of)3 ( 0.1 m)-2 (g)10 (/)-2 (kg)10 ( of )]TJ 0 Tw 23.09 0 Td [(T)1 (e)4 (v)-10 (-)3 (T)1 (r)3 (opi)-2 (n)]TJ 0.002 Tc 0.188 Tw [(,)2 ( th)2 (e )-4 (e)6 (limin)2 (a)6 (tio)2 (n )]TJ -0.004 Tc 0.004 Tw -23.09 -1.15 Td [(h)-4 (al)-6 (f)]TJ 0 Tc 0 Tw 1.55 0 Td (-)Tj 0.24 Tw 0.33 0 Td [(l)-2 (i)-2 (f)3 (e)4 ( w)2 (a)4 (s )-11 (a)4 (bout)-2 ( 0.42 hour)3 (s)-1 ( $)3 (a)4 (ppr)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y )10 (25 m)-2 (i)-2 (nut)-2 (e)4 (s)-1 ($)3 ( a)4 (nd t)-2 (he)4 ( m)-2 (e)4 (a)4 (n pl)-2 (a)4 (s)-1 (m)-2 (a )]TJ -0.004 Tc 0.004 Tw -1.88 -1.15 Td [(cl)-6 (ear)-11 (an)-4 (ce )-10 ($)-1 (\261)-5 (S)-8 (D)-2 ($)-1 ( w)-2 (as)-5 ( 1)-4 (3)-4 (3)-14 ( $)-1 (\261)-5 (1)-4 (6)-4 ($)-1 ( m)-16 (L)17 (/)-6 (m)-6 (i)-6 (n)-4 ( i)-6 (n)-4 ( h)-4 (eal)-6 (t)-6 (h)-24 (y)6 ( m)-6 (al)-6 (e v)-4 (o)-4 (l)-6 (u)-4 (n)-4 (t)-6 (eer)-1 (s)-5 (. )]TJ EMC /P <>BDC 0 Tc 0.03 Tw 0 -2.3 TD [(I)13 (n)-10 ( t)-2 (he)4 ( s)-1 (a)4 (m)-2 (e)-6 ( vol)-2 (unt)-2 (e)4 (e)4 (r)3 (s)-1 (,)-10 ( a)-6 (f)3 (t)-2 (e)4 (r)3 ( a)-6 ( s)-1 (ubc)4 (ut)-2 (a)4 (n)-10 (e)4 (ous)-1 ( i)-2 (nj)-2 (e)4 (c)-6 (t)-2 (i)-2 (on of)3 ( 0.1 m)-2 (g)10 (/)-2 (k)-10 (g T)]TJ -0.004 Tc 0.004 Tw 28.04 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)-9 (r)-7 (opi)-2 (n )]TJ 0.03 Tw 3.35 0 Td [(t)-2 (o t)-2 (he )]TJ -0.004 Tc 0.264 Tw -32.33 -1.15 Td [(f)-1 (o)-4 (r)-1 (ea)-10 (r)-1 (m)-6 (,)-4 ( t)-6 (h)-4 (e)-10 ( m)-6 (ean)-14 ( p)-4 (eak)-14 ( s)-5 (er)-1 (u)-4 (m )-16 (co)-4 (n)-4 (cen)-4 (t)-16 (r)-1 (at)-6 (i)-6 (o)-4 (n )]TJ 0 Tc 0.26 Tw 19.65 0 Td [($)-7 (\261)-1 (S)-4 (D)2 ($)3 ( w)2 (a)4 (s)-1 ( 80)-10 ( $)3 (\261)-1 (50$)-7 ( n)-10 (g/)-2 (m)-12 (L)21 ( w)2 (hi)-12 (c)4 (h )]TJ 0.11 Tw -19.65 -1.15 Td [(oc)4 (c)4 (ur)3 (r)-7 (e)4 (d a)4 (ppr)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y )10 (7 hour)3 (s)-1 ( pos)-1 (t)]TJ 0 Tw 15.1 0 Td (-)Tj 0.11 Tw 0.33 0 Td [(i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on a)4 (nd t)-2 (he)4 ( a)4 (ppa)4 (r)3 (e)4 (nt )-12 (e)4 (l)-2 (i)-2 (m)-2 (i)-2 (na)4 (t)-2 (i)-2 (on ha)4 (l)-2 (f)]TJ 0 Tw 17.51 0 Td (-)Tj 0.002 Tc -0.002 Tw 0.33 0 Td [(lif)5 (e )]TJ 0 Tc 0.09 Tw -33.27 -1.15 Td [(w)2 (a)4 (s)-1 ( a)4 (ppr)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y )10 (2.7 h)-10 (our)3 (s)-1 (. C)-3 (om)-2 (pa)4 (r)3 (e)4 (d t)-2 (o i)-2 (nt)-2 (r)-7 (a)-6 (ve)4 (nous)-1 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on, t)-2 (he)4 ( e)4 (x)-10 (t)-2 (e)4 (nt)-2 ( of )]TJ -0.004 Tc 0.004 Tw 0 -1.15 TD [(s)-15 (y)16 (s)-5 (t)-6 (em)-6 (i)-6 (c av)-14 (ai)-6 (l)]TJ 0 Tc 0 Tw 5.69 0 Td [(a)4 (bi)-2 (l)-2 (i)-2 (t)-12 (y)20 ( f)3 (r)3 (o)-10 (m)-2 ( s)-1 (ubc)4 (ut)-2 (a)4 (ne)4 (ous)-1 ( a)4 (dm)-2 (i)-2 (ni)-2 (s)-1 (t)-2 (r)3 (a)4 (t)-2 (i)-2 (on w)2 (a)4 (s)-1 ( a)4 (pp)-10 (r)3 (ox)-10 (i)-2 (m)-2 (a)4 (t)-2 (e)4 (l)-12 (y)20 ( 70%)3 (. )]TJ EMC /P <>BDC /TT4 1 Tf -0.002 Tc 0.002 Tw -5.69 -2.32 Td [(I)-3 (NDI)-3 (CAT)-5 (I)-3 (O)-4 (N AND US)-16 (AG)6 (E )]TJ EMC /P <>BDC /TT1 1 Tf 0 Tc 0 Tw 0 -1.13 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.07 Tw 3.37 0 Td [(i)-2 (s)-1 ( i)-2 (ndi)-2 (c)4 (a)4 (t)-2 (e)4 (d f)-7 (or)3 ( t)-2 (he)4 ( t)-2 (r)3 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( of)3 ( c)4 (hi)-2 (l)-2 (dr)3 (e)4 (n w)2 (ho ha)4 (ve )-6 (g)10 (r)3 (ow)2 (t)-2 (h f)-7 (a)4 (i)-2 (l)-2 (ur)3 (e)4 ( due)4 ( t)-2 (o )]TJ 0 Tw -4.92 -1.15 Td [(a)4 (n i)-2 (na)4 (de)4 (qua)4 (t)-12 (e)4 ( s)-1 (e)4 (c)-6 (r)3 (e)4 (t)-2 (i)-2 (on o)-10 (f)3 ( nor)3 (m)-2 (a)4 (l)-2 ( e)4 (ndo)-10 (g)10 (e)4 (nous )-11 (gr)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one)4 (. )]TJ EMC /Artifact <>BDC 0 g /T1_1 1 Tf 10 0 0 10 44.621 31.1981 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 584 0 obj <>>>/Resources 503 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 585 0 obj <> endobj 586 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. 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I)23 (t )]TJ 0.05 Tw 4.35 0 Td [(ha)4 (s)-11 ( a)4 (n )-10 (a)4 (m)-2 (i)-2 (no )-10 (a)4 (c)4 (i)-2 (d s)-1 (e)4 (qu)-10 (e)4 (nc)4 (e)-6 ( i)-2 (de)4 (nt)-2 (i)-2 (c)4 (a)4 (l)-12 ( t)-2 (o t)-2 (ha)4 (t)-2 ( of )-7 (hum)-2 (a)4 (n )-10 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h )-10 (hor)3 (m)-2 (one)4 ( of )]TJ 0.01 Tw -4.35 -1.15 Td [(pi)-2 (t)-2 (ui)-2 (t)-2 (a)4 (r)-7 (y)20 ( or)3 (i)-12 (g)10 (i)-2 (n. )]TJ 0 Tw (T)Tj -0.004 Tc 0.004 Tw 7.15 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)]TJ -0.003 Tc 0.003 Tw 0.95 0 Td [(ro)-13 (p)-3 (i)-5 (n )]TJ 0.002 Tc 0.008 Tw 2.38 0 Td [(is)1 ( a)6 ( s)1 (tr)5 (a)6 (in)2 ( o)2 (f )]TJ /TT3 1 Tf -0.004 Tc 0.014 Tw 5.2 0 Td [(E)-3 (s)-5 (ch)-4 (er)-5 (i)-6 (ch)-4 (i)-6 (a)-4 ( co)-4 (l)-6 (i )]TJ /TT1 1 Tf 0 Tc 0.01 Tw 6.79 0 Td [(m)-2 (odi)-2 (f)3 (i)-2 (e)4 (d b)-10 (y)20 ( i)-2 (ns)-11 (e)4 (r)3 (t)-2 (i)-2 (on of)3 ( t)-2 (he )]TJ 0 Tw -23.41 -1.15 Td [(hum)-2 (a)4 (n g)10 (r)-7 (ow)2 (t)-2 (h hor)3 (m)-2 (one )-6 (g)10 (e)4 (n)-10 (e)4 (. )]TJ EMC /P <>BDC 0 -2.3 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.41 Tw 3.71 0 Td [(i)-2 (s)-11 ( a)4 ( s)-1 (t)-2 (e)-6 (r)3 (i)-2 (l)-2 (e)-6 (, w)2 (hi)-2 (t)-2 (e)4 (, l)-22 (y)20 (ophi)-2 (l)-2 (i)-2 (z)-6 (e)4 (d pow)2 (de)4 (r)3 (, i)-2 (nt)-2 (e)4 (nd)-10 (e)4 (d f)3 (o)-10 (r )]TJ 0 Tw 23.95 0 Td [(s)-1 (u)-10 (bc)4 (ut)-2 (a)4 (ne)4 (ous )]TJ 0.002 Tc -0.002 Tw -29.21 -1.15 Td [(a)6 (d)2 (min)2 (is)1 (tr)5 (a)6 (tio)2 (n)2 (,)2 ( a)6 (f)5 (te)6 (r)5 ( r)-5 (e)6 (c)6 (o)-8 (n)2 (s)1 (titu)2 (tio)2 (n)2 ( w)4 (ith )]TJ -0.004 Tc 0.004 Tw 16.14 0 Td [(t)-6 (h)-4 (e acco)-4 (m)-16 (p)-4 (an)-14 (y)16 (i)-6 (n)-14 (g)6 ( d)-4 (i)-6 (l)-6 (u)-4 (en)-4 (t)-6 (. )]TJ EMC /P <>BDC 0 Tc 0 Tw -16.14 -2.3 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.15 Tw 3.37 0 Td [(5 m)-12 (g)10 ( vi)-2 (a)4 (l )-12 (c)-6 (ont)-2 (a)4 (i)-2 (ns)-1 ( r)3 (e)4 (c)4 (om)-2 (bi)-2 (na)4 (nt )-2 (s)-1 (o)-10 (m)-2 (a)4 (t)-2 (r)3 (opi)-2 (n 5 m)-2 (g a)4 (nd m)-2 (a)4 (n)-10 (ni)-2 (t)-2 (ol)-2 ( 30 )]TJ -0.01 Tc 0.01 Tw 28.17 0 Td [(m)-12 (g. )]TJ 0 Tc 0.04 Tw -33.09 -1.15 Td [(T)1 (he)4 ( 5 m)-2 (g)10 ( vi)-2 (a)4 (l)-2 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d i)-2 (n a )4 (c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on pa)4 (c)4 (ka)-6 (g)10 (e )]TJ -0.004 Tc 0.044 Tw 21.26 0 Td [(w)-2 (i)-6 (t)-6 (h)-4 ( an)-4 ( a)-10 (cco)-4 (m)-6 (p)-4 (an)-24 (y)16 (i)-6 (n)-14 (g)6 ( 5 )]TJ 0.002 Tc 0.038 Tw 10.17 0 Td [(m)-10 (L)13 ( v)2 (ia)6 (l )]TJ 0 Tc 0.4 Tw -31.43 -1.15 Td [(of)3 ( di)-2 (l)-2 (ut)-2 (i)-2 (ng)10 ( s)-1 (ol)-2 (ut)-2 (i)-2 (on. T)-9 (he)4 ( di)-2 (l)-2 (ue)4 (nt)-2 ( c)4 (ont)-12 (a)4 (i)-2 (ns)-1 ( ba)-6 (c)4 (t)-2 (e)4 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-2 (i)-2 (c)4 ( 0.9%)-7 ( s)-1 (odi)-2 (u)-10 (m)-2 ( c)4 (hl)-2 (or)3 (i)-2 (de )]TJ 0.06 Tw 0 -1.15 TD [(i)-2 (nj)-2 (e)4 (c)4 (t)-2 (i)-2 (on, U)2 (S)-4 (P)-4 (, $)3 (nor)3 (m)-2 (a)4 (l )-12 (s)-1 (a)4 (l)-2 (i)-2 (ne)4 ($)3 (, 0.9%)-7 ( be)4 (nz)-16 (y)20 (l )-12 (a)4 (l)-2 (c)-6 (ohol)-2 ( a)4 (s)-1 ( a)4 ( p)-10 (r)3 (e)4 (s)-1 (e)-6 (r)3 (va)4 (t)-2 (i)-2 (ve)4 (, )-10 (a)-6 (nd w)2 (a)4 (t)-2 (e)4 (r)-7 ( f)3 (or )]TJ 0.002 Tc 0 Tw T* [(in)2 (je)6 (c)6 (tio)2 (n)2 (. )]TJ EMC /P <>BDC 0 Tc 0 -2.3 TD (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )-110 (10 )]TJ 0.19 Tw 4.85 0 Td [(m)-12 (g)10 ( vi)-2 (a)4 (l )-12 (c)4 (ont)-2 (a)4 (i)-2 (ns)-1 ( r)3 (e)-6 (c)4 (om)-2 (bi)-2 (na)4 (nt )-2 (s)-1 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n 10 m)-2 (g)10 (,)-10 ( m)-2 (a)4 (nni)-12 (t)-2 (ol)-2 ( 1)]TJ -0.01 Tc 0.2 Tw [(0)-10 ( m)-12 (g, )]TJ 0 Tc 0.34 Tw -6.4 -1.15 Td [(di)-2 (s)-1 (odi)-2 (um)-2 ( phos)-1 (pha)4 (t)-2 (e)4 ( dode)4 (c)4 (a)4 (h)-20 (y)20 (dr)-7 (a)4 (t)-2 (e)4 ( 3.57 m)-12 (g)10 (, )-10 (a)4 (nd s)-1 (odi)-2 (um)-2 ( di)-2 (h)-10 (y)20 (dr)3 (o)-10 (ge)4 (n)-10 ( phos)-1 (pha)4 (t)-2 (e )]TJ 0.16 Tw 0 -1.15 TD [(de)4 (h)-10 (y)20 (d)-10 (r)3 (a)4 (t)-2 (e)-6 ( 0.79 m)-12 (g)10 (. T)1 (he)-6 ( 10 m)-2 (g vi)-2 (a)4 (l)-2 ( i)-2 (s)-1 ( s)-1 (uppl)-2 (i)-2 (e)4 (d)-10 ( i)-2 (n a )4 (c)4 (om)-2 (bi)-2 (na)4 (t)-2 (i)-2 (on p)-10 (a)4 (c)4 (k)-10 (a)-6 (g)10 (e )]TJ 0.002 Tc 0.158 Tw 31.47 0 Td [(w)4 (ith)2 ( a)6 (n )]TJ 0 Tc 0.1 Tw -31.47 -1.15 Td [(a)4 (c)4 (c)4 (om)-2 (pa)4 (n)-20 (y)20 (i)-2 (n)-10 (g)10 ( 1)-10 ( m)-12 (L)11 ( s)-21 (y)20 (r)-7 (i)-2 (ng)10 (e)-6 ( of)3 ( di)-2 (l)-2 (ut)-2 (i)-2 (ng s)-1 (ol)-2 (ut)-2 (i)-2 (on. T)1 (he)4 ( di)-2 (l)-2 (ue)4 (nt )-12 (c)4 (ont)-2 (a)4 (i)-2 (ns)-1 ( ba)-6 (c)4 (t)-2 (e)4 (r)3 (i)-2 (os)-1 (t)-2 (a)4 (t)-2 (i)-2 (c )]TJ 0.002 Tc -0.002 Tw T* [(w)4 (a)6 (te)6 (r)5 ( f)5 (o)-8 (r)5 ( in)2 (je)6 (c)6 (tio)2 (n)2 ( w)4 (ith)2 ( 0)2 (.)2 (3)2 (3)2 (%)5 ( me)6 (ta)]TJ -0.004 Tc 0.004 Tw 14.43 0 Td [(cr)-11 (es)-5 (o)-4 (l)-6 ( as)-5 ( a p)-4 (r)-11 (e)-10 (s)-5 (er)-1 (v)-4 (at)-6 (i)-6 (v)-4 (e. )]TJ EMC /P <>BDC 0 Tc 0 Tw -14.43 -2.3 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.06 Tw 3.36 0 Td [(i)-2 (s)-1 ( a)4 ( hi)-2 (g)10 (hl)-12 (y)]TJ 0 Tw 4.27 0 Td (-)Tj 0.06 Tw 0.34 0 Td [(p)-10 (ur)3 (i)-2 (f)3 (i)-2 (e)4 (d pr)3 (e)4 (pa)-6 (r)3 (a)4 (t)-2 (i)-2 (on. R)-3 (e)4 (c)4 (o)-10 (ns)-1 (t)-2 (i)-2 (t)-2 (ut)-2 (e)4 (d s)-1 (ol)-2 (ut)8 (i)-2 (ons)-1 ( ha)4 (ve )14 (a)4 ( pH)2 ( i)-2 (n t)-2 (he )]TJ 0 Tw -9.52 -1.15 Td [(r)3 (a)4 (n)-10 (g)10 (e)4 ( of)3 ( 7.0 t)-2 (o 9.0. )]TJ EMC /P <>BDC /TT0 1 Tf -0.002 Tc 0.002 Tw 0 -2.32 TD [(CL)-5 (I)-3 (NI)-3 (CAL)-5 ( P)9 (H)-4 (AR)-10 (M)2 (A)-10 (CO)-4 (L)-5 (O)-4 (G)6 (Y )]TJ EMC /P <>BDC /TT1 1 Tf 0.002 Tc 0.258 Tw 0 -1.13 TD [(C)-1 (lin)2 (ic)6 (a)6 (l tr)5 (ia)6 (ls )]TJ 0 Tc 0.26 Tw 6.19 0 Td [(ha)4 (ve)4 ( de)4 (m)-2 (ons)-1 (t)-2 (r)3 (a)4 (t)-2 (e)4 (d t)-2 (ha)4 (t)-2 ( T)]TJ -0.004 Tc 0.004 Tw 10.9 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)-7 (opi)-2 (n )]TJ 0.002 Tc 0.258 Tw 3.57 0 Td [(is)1 ( e)6 (q)2 (u)2 (iv)2 (a)6 (le)6 (n)2 (t in)12 ( it)10 (s)1 ( th)2 (e)6 (r)5 (a)6 (p)2 (e)6 (u)2 (tic )]TJ -0.004 Tc 0.024 Tw -21.6 -1.15 Td [(ef)-1 (f)-1 (e)-10 (ct)-6 (i)-6 (v)-4 (en)-4 (es)-5 (s)-5 ( an)]TJ 0 Tc 0.02 Tw 6.42 0 Td [(d i)-2 (n i)-2 (t)-2 (s)-1 ( pha)4 (r)3 (m)-2 (a)4 (c)4 (oki)-2 (ne)4 (t)-2 (i)-2 (c)4 ( p)-10 (r)3 (of)3 (i)-2 (l)-2 (e)4 ( t)-2 (o)-10 ( t)-2 (hos)-1 (e)4 ( of)3 ( hum)-2 (a)4 (n gr)3 (ow)2 (t)-2 (h hor)3 (m)-2 (one)4 ( of )]TJ 0.18 Tw -6.42 -1.15 Td [(pi)-2 (t)-2 (ui)-2 (t)-2 (a)4 (r)-7 (y)20 ( or)3 (i)-12 (g)10 (i)-2 (n $)3 (s)-1 (om)-2 (a)4 (t)-2 (r)3 (o)-10 (pi)-2 (n$)3 (. )]TJ 0 Tw (T)Tj -0.004 Tc 0.004 Tw 13.09 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.002 Tc 0.178 Tw 3.48 0 Td [(s)1 (timu)2 (la)6 (te)6 (s)1 ( lin)2 (e)6 (a)6 (r )-5 (g)12 (r)5 (o)-8 (w)4 (th)2 ( in)2 ( c)6 (h)2 (ild)2 (r)5 (e)6 (n)2 ( w)4 (h)2 (o )]TJ 0 Tc 0.06 Tw -17.51 -1.15 Td [(l)-2 (a)4 (c)4 (k a)4 (d)-10 (e)4 (qua)4 (t)-2 (e)-6 ( l)-2 (e)4 (ve)4 (l)-2 (s)-11 ( of )-7 (e)-6 (ndog)10 (e)4 (nous )-21 (g)10 (r)3 (ow)2 (t)-2 (h)-10 ( hor)3 (m)-12 (one)4 (. T)1 (r)-7 (e)4 (a)4 (t)-2 (m)-2 (e)4 (nt)-2 ( o)-10 (f )-7 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one)]TJ 0 Tw 34.27 0 Td (-)Tj 0.002 Tc 0.358 Tw -34.27 -1.15 Td [(d)2 (e)6 (f)5 (ic)6 (ie)6 (n)2 (t c)6 (h)2 (ild)2 (r)5 (e)6 (n)2 ( w)4 (ith )]TJ 0 Tc 0 Tw 10.37 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ -0.004 Tc 0.364 Tw 3.66 0 Td [(p)-4 (r)-1 (o)-4 (d)-4 (u)-4 (ces )-15 (i)-6 (n)-4 (cr)-1 (eas)-15 (ed)-4 ( g)6 (r)-1 (o)-14 (w)-2 (t)-6 (h)-4 ( r)-1 (at)-6 (es)-15 ( an)-4 (d )-14 (I)19 (G)-12 (F)]TJ 0 Tc 0 Tw 18.19 0 Td (-)Tj 0.01 Tc -0.01 Tw 0.33 0 Td (1 )Tj 0 Tc 0 Tw -34.1 -1.15 Td [($)-7 (I)13 (ns)-1 (ul)-2 (i)-2 (n-)]TJ -0.004 Tc 0.224 Tw 3.45 0 Td [(L)17 (i)-6 (k)-14 (e G)-12 (r)-1 (o)-4 (w)-2 (t)-6 (h)-4 ( F)-8 (act)-6 (o)-4 (r)]TJ 0 Tc 0 Tw 8.37 0 Td [(-)3 (1)]TJ -0.004 Tc 0.224 Tw [($)-11 ( co)-4 (n)-14 (cen)-4 (t)-6 (r)-1 (at)-6 (i)-6 (o)-4 (n)-4 (s)-5 ( t)-16 (h)-4 (at)-6 ( ar)-11 (e s)-5 (i)-6 (m)-6 (i)-6 (l)-6 (ar)-1 ( t)-6 (o)-4 ( t)-6 (h)-4 (o)-4 (s)-5 (e)-10 ( s)-5 (een )-14 (af)-1 (t)-6 (e)-10 (r )]TJ 0 Tc 0 Tw -11.82 -1.15 Td [(t)-2 (he)4 (r)3 (a)4 (p)-20 (y)20 ( w)2 (i)-2 (t)-2 (h hum)-2 (a)4 (n )-10 (g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one)4 ( of)3 ( pi)-2 (t)-2 (ui)-2 (t)-2 (a)4 (r)-17 (y)10 ( or)3 (i)-2 (g)10 (i)-2 (n. )]TJ EMC /P <>BDC 0 -2.3 TD [(B)7 (ot)-2 (h )-350 (T)]TJ -0.004 Tc 0.004 Tw 3.15 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.35 Tw 3.57 0 Td [(a)4 (nd)-10 ( s)-11 (om)-2 (a)4 (t)-2 (r)3 (opi)-2 (n ha)4 (ve)-6 ( a)4 (l)-2 (s)-1 (o b)-10 (e)4 (e)4 (n s)-1 (how)2 (n)-10 ( t)-2 (o ha)4 (v)-10 (e)4 ( ot)-12 (he)4 (r )]TJ 0 Tw 24.1 0 Td [(a)-6 (c)4 (t)-2 (i)-2 (ons )]TJ -31.77 -1.15 Td [(i)-2 (nc)4 (l)-2 (udi)-2 (ng)10 (: )]TJ EMC /Span <>BDC /TT3 1 Tf -0.001 Tc 0 -1.15 TD (A. )Tj EMC /StyleSpan <>BDC 0.001 Tc -0.001 Tw 4.5 0 Td [(T)-3 (i)-1 (ssu)1 (e)5 ( G)3 (ro)1 (w)-2 (t)-1 (h )]TJ EMC /LI_Label <>BDC /TT1 1 Tf 0 Tc 0 Tw T* (1.)Tj /T1_0 1 Tf (\003 )Tj EMC /StyleSpan <>BDC /TT1 1 Tf 0.002 Tc 0.208 Tw 2 0 Td [(S)-2 (k)2 (e)6 (le)6 (ta)6 (l G)4 (r)5 (o)2 (w)4 (th)2 (. )]TJ EMC /LI_Title <>BDC 0 Tc 0 Tw 7.44 0 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.95 0 Td [(-)3 (T)-9 (r)3 (opi)-2 (n )]TJ 0.002 Tc 0.208 Tw 3.44 0 Td [(s)1 (timu)2 (la)6 (te)6 (s)1 ( s)1 (k)2 (e)6 (le)6 (ta)6 (l g)12 (r)5 (o)-8 (w)4 (th)2 ( in)2 ( p)2 (a)6 (tie)6 (n)2 (ts )]TJ 0 Tc 0.17 Tw -12.44 -1.15 Td [(w)2 (i)-2 (t)-2 (h g)10 (r)3 (ow)2 (t)-2 (h ho)-10 (r)3 (m)-2 (one)4 ( d)-10 (e)4 (f)3 (i)-2 (c)4 (i)-2 (e)4 (nc)-16 (y)20 (.)-10 ( T)1 (he)4 ( m)-2 (e)-6 (a)4 (s)-1 (ur)3 (a)4 (b)-10 (l)-2 (e)4 ( i)-2 (nc)4 (r)3 (e)-6 (a)4 (s)-1 (e)4 ( i)-2 (n bod)-20 (y )]TJ 0.002 Tc 0.008 Tw T* [(le)6 (n)2 (g)12 (th )-8 (a)6 (f)5 (te)-4 (r)5 ( a)6 (d)2 (min)2 (is)1 (tr)5 (a)6 (tio)-8 (n)2 ( o)2 (f)5 ( T)]TJ -0.004 Tc 0.004 Tw 12.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n )]TJ 0.002 Tc 0.008 Tw 3.24 0 Td [(r)5 (e)6 (s)1 (u)2 (lts)1 ( f)5 (r)-5 (o)2 (m its)1 ( e)6 (f)5 (f)-5 (e)6 (c)6 (t o)2 (n)-8 ( th)2 (e )]TJ 0 Tc 0.29 Tw -16.79 -1.15 Td [(e)4 (pi)-2 (ph)-10 (y)20 (s)-1 (e)-6 (a)4 (l)-2 ( g)10 (r)3 (o)-10 (w)2 (t)-2 (h pl)-2 (a)4 (t)-2 (e)4 (s)-1 ( of)3 ( l)-2 (ong)10 ( bone)4 (s)-1 (. C)-3 (onc)14 (e)4 (nt)-2 (r)3 (a)4 (t)-2 (i)-2 (on of )-7 (I)23 (G)-8 (F)]TJ 0 Tw 27.01 0 Td (-)Tj 0.01 Tc -0.01 Tw 0.33 0 Td (1, )Tj 0 Tc 0.16 Tw -27.34 -1.15 Td [(w)2 (hi)-2 (c)4 (h m)-2 (a)-6 (y)20 ( pl)-2 (a)-16 (y )10 (a)4 ( r)3 (ol)-2 (e)4 ( i)-12 (n s)-1 (ke)4 (l)-2 (e)4 (t)-2 (a)4 (l)-2 ( g)10 (r)3 (o)-10 (w)2 (t)-2 (h, a)4 (r)3 (e)4 ( l)-12 (ow)2 ( i)-2 (n t)-2 (he)4 ( s)-1 (e)4 (r)3 (um)-2 ( of )]TJ 0.02 Tw T* [(g)10 (r)3 (o)-10 (w)2 (t)-2 (h hor)3 (m)-2 (one)]TJ 0 Tw 6.65 0 Td (-)Tj 0.002 Tc 0.018 Tw 0.33 0 Td [(d)-8 (e)6 (f)5 (ic)6 (ie)6 (n)-8 (t c)6 (h)2 (ild)2 (r)5 (e)6 (n)2 ( b)2 (u)2 (t in)2 (c)6 (r)5 (e)-4 (a)6 (s)1 (e)6 ( d)2 (u)-8 (r)5 (in)2 (g)12 ( tr)-5 (e)6 (a)6 (tme)6 (n)2 (t w)4 (ith )]TJ 0 Tc 0 Tw -6.98 -1.15 Td (T)Tj -0.004 Tc 0.004 Tw 0.61 0 Td (ev)Tj 0 Tc 0 Tw 0.94 0 Td [(-)3 (T)1 (r)3 (opi)-2 (n. )]TJ 0.32 Tw 3.87 0 Td [(M)-1 (e)-6 (a)4 (n s)-1 (e)4 (r)3 (u)-10 (m)-2 ( a)4 (l)-2 (ka)4 (l)-2 (i)-2 (ne)4 ( phos)-1 (pha)4 (t)-2 (a)4 (s)-1 (e)-6 ( c)4 (onc)4 (e)4 (nt)-2 (r)-7 (a)4 (t)-2 (i)-2 (ons)-1 ( a)4 (r)-7 (e )]TJ -0.004 Tc 0 Tw -5.42 -1.15 Td [(i)-6 (n)-4 (cr)-1 (eas)-15 (ed)-4 (. )]TJ EMC /Artifact <>BDC 0 g /T1_1 1 Tf 0 Tc 10 0 0 10 44.6089 30.929 Tm (Reference ID: 3650153 )Tj EMC ET /Artifact <>BDC Q q 1 0 0 1 112.3570099 835.1204224 cm /GS0 gs /Fm0 Do Q EMC endstream endobj 589 0 obj <>>>/Resources 501 0 R/Subtype/Form>>stream 0 g 0 G 0 i 0 J []0 d 0 j 1 w 10 M 0 Tc 0 Tw 100 Tz 0 TL 0 Tr 0 Ts BT /ArialRoundedMTBold 10 Tf 0 0 1 rg 65.791 -7.9 Td (This ) Tj 22.92 0 Td (label ) Tj 26.055 0 Td (may ) Tj 22.71 0 Td (not ) Tj 18.12 0 Td (be ) Tj 14.692 0 Td (the ) Tj 18.023 0 Td (latest ) Tj 29.595 0 Td (approved ) Tj 48.974 0 Td (by ) Tj 14.17 0 Td (FDA. ) Tj -281.05 -12 Td (For ) Tj 18.96 0 Td (current ) Tj 38.765 0 Td (labeling ) Tj 41.055 0 Td (information, ) Tj 61.25 0 Td (please ) Tj 34.707 0 Td (visit ) Tj 22.299 0 Td (https://www.fda.gov/drugsatfda) Tj ET endstream endobj 590 0 obj <> endobj 591 0 obj <>stream ï»¿/ This label may not be the latest approved by FDA. 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