(Insulin-Like Growth Factor-1 Long Arg3 | Extended-Action Anabolic Peptide)
IGF-1 LR3 is a long-acting recombinant analogue of native IGF-1 — engineered for 3× stronger receptor activity, minimal binding-protein interference, and significantly enhanced anabolic, regenerative, and metabolic signaling.
🧬 What Is IGF-1 LR3?
IGF-1 LR3 (Long Arg3 IGF-1) is an 83–amino-acid modified form of human IGF-1 with:
• A 13–amino-acid N-terminal extension • A Glutamic Acid → Arginine substitution at position 3 • Greatly reduced affinity for IGF binding proteins (IGFBPs) • ~20–30 hour half-life (vs ~15 minutes for native IGF-1)
Researchers study IGF-1 LR3 for:
• PI3K/Akt + MAPK pathway activation • Muscle cell hyperplasia & nutrient uptake • Protein synthesis & nitrogen retention • Accelerated tendon, nerve, and muscle repair • Improved glucose disposal & metabolic modulation • Vascular smooth-muscle support
📦 Product Breakdown — Paramount Peptides
• IGF-1 LR3 (1mg) HERE • Recombinant long-acting IGF analogue • High-purity anabolic research peptide • 👉 Use code BHGUIDE for discount
💉 Reconstitution Instructions Table (1mg IGF-1 LR3)
Step Details Sanitize Clean vial stoppers & workspace Add BAC Water Inject 1–2mL slowly down vial wall Dissolve Swirl gently — do not shake Final Conc. 1mg ÷ added mL Syringe U-100 insulin syringe Storage Refrigerate 2–8°C (~30 days)
Example: • 1mg + 1mL = 1mg/mL • 1mg + 2mL = 0.5mg/mL
📊 Dosing & Protocol Table (for research purposes only)
Goal Typical Research Dose Frequency Notes Muscle Cell Studies 20–50mcg 1× daily Strong anabolic signaling Tissue Regeneration 50–100mcg 1× daily Used in nerve, tendon, muscle models Performance & Hypertrophy 50–120mcg 1× daily Paired with resistance training Fat-Loss + Recomp 20–50mcg 1× daily Improved nutrient partitioning Localized Studies 20–40mcg site-specific 1× daily Localized protocols are common
Protocol Notes: • Long-acting LR3 → once-daily dosing is standard • Avoid combining with insulin (hypoglycemia risk) • LR3 is extremely potent — higher doses rarely needed
🧬 What to Expect Timeline
Timeline Common Research Observations Week 1–2 Improved pumps, glucose uptake, faster recovery Week 3–4 Noticeable performance changes, early recomposition Week 4–8 Strong nutrient partitioning, muscle hardness, tissue repair 8–12+ wk Peak performance, deep regeneration-marker changes
🔍 Researcher Notes (Important)
• LR3 binds receptors 3× stronger than native IGF-1 • Low IGFBP binding → more active circulating IGF-1 • Activates satellite-cell pathways • Enhances amino-acid + glucose uptake • Strong synergy with training stimulus • Often paired with: – CJC-1295 No DAC – GH fragments (AOD-9604) – BPC-157 for recovery
🧪 What You’ll Need (Checklist)
• IGF-1 LR3 vial HERE • Bacteriostatic Water HERE • 29–31g U-100 insulin syringes • Alcohol pads • Sharps container • Peptide Calculator
🔗 Quick Links
• BHGUIDE • Bacteriostatic Water • Peptide Calculator
⚠️ Disclaimer For research and educational purposes only. Not medical advice. Not for human consumption.