Growth Hormone General Information:
Growth Hormone Protein, Antibody, and Gene
APPROVED SYMBOL
GH1
APPROVED NAME
growth hormone 1
HGNC ID
4261
LOCUS TYPE
LOCUS NM_000515 860 bp mRNA linear PRI 01-JUL-2018
CHROMOSOMAL LOCATION
17q23.3
HCOP
Orthology Predictions for GH1
SYNONYMS
GH, GHN, GH-N, hGH-N, pituitary growth hormone, somatotropin
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Growth Hormone Protein Overview
Growth hormone (GH) is synthesized by acidophilic or somatotropic cells of the anterior pituitary gland. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges (Niall et al., 1971).
Approved name
growth hormone 1
Alternative name
Growth hormone Growth hormone 1 Pituitary growth hormone
Growth Hormone protein family
Belongs to the somatotropin/prolactin family.
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Growth Hormone Protein Function
Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
Growth Hormone Protein Sequence
Growth Hormone Protein length, MW and sequence in different species.
Growth Hormone Protein Structure
THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION
Deposited
1993-09-22 Released: 1994-01-31
Deposition Author(s)
Ultsch, M.H., Somers, W.S., Kossiakoff, A.A., De Vos, A.M.
Organism(s)
Homo sapiens
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.0000 Å
R-Value Work
0.185
1HUWFrom PDB
Human Growth Hormone protein Secondary structure
Growth Hormone Protein Interaction
This picture shows molecules that interact with Growth Hormone protein. Source: string-db.org
Growth Hormone Antibody Guideline: Preparation and Applications
There are 8 Growth Hormone antibodies which are validated in multiple tissues with various applications, including ELISA(Det), ELISA, ELISA(Cap), IHC-P. There are 1 Growth Hormone antibody for ELISA(Det), 4 Growth Hormone antibody for ELISA, 1 Growth Hormone antibody for ELISA(Cap), 3 Growth Hormone antibody for IHC-P. Among all these Growth Hormone antibodies, there are 5 anti-Growth Hormone mouse monoclonal antibodies, 2 anti-Growth Hormone rabbit monoclonal antibodies, 1 anti-Growth Hormone rabbit polyclonal antibodies. All the Growth Hormone antibodies are produced in house and all are in stock. Growth Hormone antibody customized service is available.
Anti-Growth Hormone antibodies Recommended Application Preparation 16122-MM03 ELISA This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Growth Hormone (rh Growth Hormone; Catalog#16122-H07E; P01241; Phe27-Phe217). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. 16122-T24 IHC Produced in rabbits immunized with purified, recombinant Human GH1 / Growth hormone 1 (rh GH1 / Growth hormone 1; Catalog#16122-H07E; P01241; Phe27-Phe217). GH1 / Growth hormone 1 specific IgG was purified by Human GH1 / Growth hormone 1 affinity chromatography.
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Growth Hormone cDNA / Gene Overview
GH1 gene / cDNA is a protein-coding gene which located on 17q23.3. 28 organisms have orthologs with human gene GH1.
LOCUS
LOCUS NM_000515 860 bp mRNA linear PRI 01-JUL-2018
DEFINITION
Homo sapiens growth hormone 1 (GH1), transcript variant 1, mRNA.
ACCESSION
NM_000515
VERSION
NM_000515.4
This sequence information is just for human Growth Hormone and for reference only.
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Growth Hormone cDNA / Gene Function and Expression
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
Restricted expression toward placenta (RPKM 13.6)