Case Reports
. 2003 Jun:79 Suppl 3:1659-61.
doi: 10.1016/s0015-0282(03)00365-0.
Affiliations
PMID: 12801577 DOI: 10.1016/s0015-0282(03)00365-0
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Case Reports
Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin
Dev Kumar Menon. Fertil Steril. 2003 Jun.
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Abstract
Objective: To document for the first time the successful treatment using human chorionic gonadotropin (hCG) and human menopausal gonadotropins (hMG) of anabolic steroid-induced azoospermia that was persistent despite 1 year of cessation from steroid use.
Design: Clinical case report.
Settings: Tertiary referral center for infertility.
Patient(s): A married couple with primary subfertility secondary to azoospermia and male hypogonadotropic hypogonadism. The husband was a bodybuilder who admitted to have used the anabolic steroids testosterone cypionate, methandrostenolone, oxandrolone, testosterone propionate, oxymetholone, nandrolone decanoate, and methenolone enanthate.
Intervention(s): Twice-weekly injections of 10,000 IU of hCG (Profasi; Serono) and daily injections of 75 IU of hMG (Humegon; Organon) for 3 months.
Main outcome measure(s): Semen analyses, pregnancy.
Result(s): Semen analyses returned to normal after 3 months of treatment. The couple conceived spontaneously 7 months later.
Conclusion(s): Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG.
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Comment in
Duration of azoospermia following anabolic steroids.
Drakeley A, Gazvani R, Lewis-Jones I. Drakeley A, et al. Fertil Steril. 2004 Jan;81(1):226. doi: 10.1016/j.fertnstert.2003.10.001. Fertil Steril. 2004. PMID: 14711580 No abstract available.