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Abstract
Objective
To document for the first time the successful treatment using human chorionic gonadotropin (hCG) and human menopausal gonadotropins (hMG) of anabolic steroid–induced azoospermia that was persistent despite 1 year of cessation from steroid use.
Design
Clinical case report.
Setting
Tertiary referral center for infertility.
Patient(s)
A married couple with primary subfertility secondary to azoospermia and male hypogonadotropic hypogonadism. The husband was a bodybuilder who admitted to have used the anabolic steroids testosterone cypionate, methandrostenolone, oxandrolone, testosterone propionate, oxymetholone, nandrolone decanoate, and methenolone enanthate.
Intervention(s)
Twice-weekly injections of 10,000 IU of hCG (Profasi; Serono) and daily injections of 75 IU of hMG (Humegon; Organon) for 3 months.
Main outcome measure(s)
Semen analyses, pregnancy.
Result(s)
Semen analyses returned to normal after 3 months of treatment. The couple conceived spontaneously 7 months later.
Conclusion(s)
Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG.
Keywords
Anabolic steroid
azoospermia
human chorionic gonadotropin
human menopausal gonadotropin
Copyright © 2003 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.