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Hepatotoxicity induced by MK-677

Case Reports . 2025 Jul 17;18(7):e265728. doi: 10.1136/bcr-2025-265728. Affiliations PMID: 40675653 DOI: 10.1136/bcr-2025-265728 Case Reports Hepatotoxicity induced by MK-677 Era Cobani et al. BMJ Case Rep. 2025. Abstract MK-677, a growth hormone secretagogue, is gaining popularity among performance-enhancing supplements. While its side effects include oedema, increased appetite and muscle pain, reports of hepatotoxicity are scarce. Here we present the case of an otherwise healthy man in his early 30s, who developed transaminitis after consuming MK-677 for 2 months before presentation. Liver function tests eventually returned to normal limits after stopping the supplement. Keywords: General practice / family medicine; Liver disease; Nutrition; Vitamins and supplements. © BMJ Publishing Group Limited 2025. No commercial re-use. See rights and permissions. Published by BMJ Group. PubMed Disclaimer Conflict of interest statement Competing interests: None declared.

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Case Reports

. 2025 Jul 17;18(7):e265728.

doi: 10.1136/bcr-2025-265728.

Affiliations

PMID: 40675653 DOI: 10.1136/bcr-2025-265728

Case Reports

Hepatotoxicity induced by MK-677

Era Cobani et al. BMJ Case Rep. 2025.

Abstract

MK-677, a growth hormone secretagogue, is gaining popularity among performance-enhancing supplements. While its side effects include oedema, increased appetite and muscle pain, reports of hepatotoxicity are scarce. Here we present the case of an otherwise healthy man in his early 30s, who developed transaminitis after consuming MK-677 for 2 months before presentation. Liver function tests eventually returned to normal limits after stopping the supplement.

Keywords: General practice / family medicine; Liver disease; Nutrition; Vitamins and supplements.

© BMJ Publishing Group Limited 2025. No commercial re-use. See rights and permissions. Published by BMJ Group.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

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