IGF-1 LR3 is a widely used long-acting IGF-1 analog in preclinical research. The two key modifications — Arg3 substitution and the MFPAMPLSSLFVNG N-terminal extension — dramatically reduce binding to IGF-binding proteins (IGFBPs), extending plasma half-life from ~10 minutes (native IGF-1) to 20–30 hours while increasing potency at the IGF-1 receptor. This allows sustained IGF-1 receptor signaling in laboratory models without the rapid clearance of natural IGF-1. First described in the 1990s, it remains a standard reference compound for studies requiring prolonged IGF-1 exposure. This research-grade lyophilized powder is produced under strict quality controls and provided with full analytical documentation. For Research Use Only. Not for human use.
Key Scientific Features
High-purity IGF-1 LR3 (≥98% by HPLC/MS, receptor-grade)
Verified 83-amino-acid sequence with Arg3 + 13-aa extension (MFPAMPLSSLFVNG)
Lyophilized formulation for maximum long-term stability
Full Certificate of Analysis (COA) with HPLC, MS, amino acid analysis, and bioactivity assay
Manufactured in GMP-aligned, ISO-compliant facilities
Suitable for IGF-1R signaling, satellite cell proliferation, and related preclinical studies
Research-Referenced Attributes (Based on scientific literature; for laboratory research use only. Not intended as therapeutic claims.)
Extended half-life compared to native IGF-1, supporting sustained IGF-1R activation in preclinical models ()
Increased potency at IGF-1R and downstream Akt/mTOR signaling pathways observed in laboratory settings ()
Investigated in preclinical models for cellular proliferation and differentiation pathways
Examined for glucose uptake and metabolic signaling in in-vitro laboratory models
Studied for neuroprotective signaling in preclinical brain injury models
Referenced in sarcopenia, muscular dystrophy, wound healing, and tissue regeneration research contexts
Why Researchers Choose Nationwide Peptides IGF-1 LR3
Receptor-grade sequence consistent with published preclinical research literature
Transparent analytical data (HPLC ≥98%, MS confirmation of full sequence)
Trusted by muscle physiology, regenerative medicine, and endocrinology laboratories
Competitive research pricing with bulk options
This product is for in-vitro and preclinical laboratory research use only. It has not been evaluated or approved by the FDA and is not intended to diagnose, treat, cure, or prevent any disease or condition. Not for human or animal use.